27 research outputs found
Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers
No full textDudnyk Veronika M., Pasik Valentyna Yu. Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers. Journal of Education, Health and Sport. 2021;11(11):169-181. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.11.015
https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.11.015
https://zenodo.org/record/5736359
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.10.2021. Revised: 22.10.2021. Accepted: 29.11.2021.
LIVER DYSFUNCTION IN CHILDREN WITH COMMUNITY-ACQUIRED PNEUMONIA: THE ROLE OF INFECTIOUS AND INFLAMMATORY MARKERS
Veronika M. Dudnyk, Valentyna Yu. Pasik
National Pirogov Memorial Medical University
Veronika M. Dudnyk, MD, PhD, professor, chef of the Department of Pediatric №2
Valentyna Yu. Pasik, assistant professor, Department of Pediatric №2
Abstract
Markers of infectious-inflammatory process were studied by determining the levels of pro-inflammatory cytokines - interleukin (IL) 1 and IL-6 and proteins of the acute phase of inflammation - C-reactive protein (CRP) and fibrinogen in the serum of children with community-acquired pneumonia.
It was found that the course of community-acquired pneumonia is accompanied by an increase in serum concentrations of IL-1 and IL-6 in children in parallel with the disease severity. The synthesis of pro-inflammatory cytokines stimulates the production of acute CRP, but reduces the concentration of fibrinogen in the serum of sick children. The revealed connections between the content of the studied cytokines at the systemic level and multidirectional changes in the indicators of the acute phase of inflammation indicate a violation of the liver, where proteins are synthesized in the study.
It is shown that with increasing severity of pneumonia, the enzyme activity of aminotransferases - alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum of children increases with a simultaneous decrease in the de Ritis coefficient, indicating "hepatic" genesis. High levels of aminotransferase is closely correlated with the activity of the infectious-inflammatory process, as indicated by the positive correlation between the level of IL-1 and ALT (r = 0.047) and AST (r = 0.111). At the same time, there is a negative correlation between the levels of IL-1, CRP and the activity of aminotransferases in blood serum.
Key words: cytokines; C-reactive protein; fibrinogen; alanine aminotransferase; aspartate aminotransferase; liver; community-acquired pneumonia in children; early age
Ідеологія бізнесу як рефлексивна реакція на соціально-економічні реалії в умовах конструктивної дестабілізації
No full textV. Prokhorova: ORCID 0000-0003-2552-2131; V. Protsenko: ORCID 0000-0003-4299-1298; O. Bozhanova: ORCID 0000-0003-2927-7356; A. Protsenko: ORCID 0000-0002-8073-9184ENG: The aim of the study is to generalize the theoretical and applied aspects of the formation of an ideological space of a unified nature as a reflexive reaction of business to socioeconomic realities in conditions of constructive destabilization. Based on the carried out analysis of statistical data, it is proved that a fundamentally new direction comes into being for domestic economic science, i. e., studies of business behavior for the faster recovery of the country’s economy, which requires the formalization of adequate instruments of a modern manager. Analyzing, systematizing and generalizing the scientific works of many scholars, the views of researchers on the definition of the concept of «ideology» were systematized, the principles of business ideology were allocated, the goal, types, signs, functions, principles, methods of ideological influence within the framework of building the ideology of management were defined. The presented publication forms theoretical and applied aspects of the ideological space of a unified nature as a reflexive reaction of business to socioeconomic realities. The issue of reflection as a system of reactions to socioeconomic realities is examined. The article considers the forms of reflection, the objective etiology of the formation of spheres of reflection through the prism of multidisciplinary connections. It is proved that the forms of reflection as a system of business reaction to socioeconomic realities in conditions of constructive destabilization have a tactical and strategic result. For a clear understanding and detailed analysis of the behavior of the problem under study, a block diagram of causal relationships is built. It is proved that reflection is an instrument for influencing the development of emotional intelligence, which explains the nature of the analytical choice of an alternative solution to the subject of economic relations and determines the possibilities of consolidated external information influence on this choice. Of practical importance is the universal model of the cognitive map of the behavioral model of business structures, which allows to explain the multi-vector format of development in rational, limited rational and irrational dimensions, combining the features of the model of constructive development of the destabilizing format and crisis phenomena.UKR: Метою дослідження є узагальнення теоретико-прикладних аспектів формування ідеологічного простору уніфікованого характеру як рефлексивної реакції бізнесу на соціально-економічні реалії в умовах конструктивної дестабілізації. На підставі проведеного аналізу статистичних даних доведено, що виникає принципово новий напрямок для вітчизняної економічної науки як дослідження поведінки бізнесу для скорішого відновлення економіки країни, що потребує формалізації адекватного інструментарію сучасного управлінця. Аналізуючи, систематизуючи та узагальнюючи наукові праці багатьох учених, було систематизовано погляди дослідників на визначення поняття «ідеологія», виділено принципи ідеології бізнесу, визначено мету, види, ознаки, функції, принципи, методи ідеологічного впливу в межах побудови ідеології управління. У роботі сформовано теоретико-прикладні аспекти ідеологічного простору уніфікованого характеру як рефлексивної реакції бізнесу на соціально-економічні реалії. Вивчено питання рефлексії як системи реакцій на соціально-економічні реалії. Розглянуто форми рефлексій, об’єктивну етіологію формування сфер рефлексії через призму мультипредметних зв’язків. Доведено, що форми рефлексії як система реакції бізнесу на соціально-економічні реалії в умовах конструктивної дестабілізації мають тактичний і стратегічний результат. Для чіткого розуміння та детального аналізу поведінки досліджуваної проблеми побудовано структурну схему причинно-наслідкових зв’язків. Доведено, що рефлексія є інструментом впливу на розвиток емоційного інтелекту, яка пояснює природу аналітичного вибору альтернативного рішення суб’єкта економічних відносин і визначає можливості консолідованого зовнішнього інформаційного впливу на цей вибір. Практичне значення має універсальна модель когнітивної карти поведінкової моделі структур бізнесу, яка дозволяє пояснити багатовекторний формат розвитку в раціональному, обмежено раціональному та ірраціональному вимірах, поєднуючи ознаки моделі конструктивного розвитку дестабілізаційного формату, кризових явищ.Ukrainian Engineering and Pedagogical Academy, Kharkіv, Ukraine; r, Odesa National Medical University, Odesa, Ukrain
Conceptual Aspects of Intensifying Management of the Economic Behavior of Production Railway Enterprises in the Context of Neo-Industrial Modernization
No full textThe aim of the article is to form conceptual aspects of intensifying management of the economic behavior of production railway enterprises in the context of neo-industrial modernization. It is determined that the modern market-type mechanism is based on a polycentric system of management and independence in forming effective tactical and strategic management decisions, as well as full responsibility for their results, through intensifying management of the economic behavior of production railway enterprises in the context of neo-industrial modernization.The prerogatives which are created by intensifying management of the economic behavior of production railway enterprises can neutralize and eliminate the negative effects of the external environment and form an integral part of their functioning including the goal-setting and formation of the concept, which are the basis for developing enterprise development strategies. The proposed concept of intensifying management of the economic behavior of production railway enterprises in the context of neo-industrial modernization is based on a significant decentralization of management functions.This is possible provided that the day-to day management considers problems and needs of the market and orients enterprises towards achieving the ultimate strategic goal of its activity, will allow taking into account the prospects for their balanced development and solve the problem of eliminating the negative effect of changes in the external and internal environment, and also will contribute to maintaining technological and logistic ties, and potential resources of enterprises; based on a wide apparatus of methods, methodologies and techniques for the collection and analysis of information
Methodological Aspects of Intensifying Management of Enterprise Economic Behavior in the Context of Neo-Industrial Modernization
No full textThe aim of the article is to form methodological aspects of intensifying economic behavior management in the context of neo-industrial modernization. The work notes that the sequence and success of market transformations is largely determined by economic behavior of enterprises, their adaptation to new requirements of modern reality. One of the main reasons for the inability of Ukrainian industrial enterprises to overcome the crisis is their unpreparedness to modernize production and increase the output of competitive products. The elimination of these causes requires that enterprises have a certain strategy and tactics of economic behavior. The intensification of management of enterprise economic behavior in the context of neo-industrial modernization as a phenomenon is the subject of study of both economic science and sociology. It is determined that the problem of intensifying management of enterprise economic behavior in the context of neo-industrial modernization can be methodologically overcome. This is possible in the case of bringing up the issue of its absolutist and relativistic assessment, stating that rationality as a fundamental characteristic of economic behavior is a civilized value, has both methodological and axiological orientation. The article highlights the main directions of research on the intensification of management of enterprise economic behavior in the context of neo-industrial modernization, and proposes a methodology for intensifying economic behavior management in the context of neo-industrial modernization
MENTAL SPACE AS A WAY OF PRESENTING AND STRUCTURING HUMAN KNOWLEDGE
No full textThe author raises one of the important issues of cognitive linguistics, namely the representation and
structuring of knowledge that a person receives during their life and discursive activity. This research is based on the «theory
of mental spaces» (G. Fauconnier and M. Turner), according to which language appears not only as an object of human
interpretation, but also as a constructive principle: it creates mental spaces and determines the relationship between them.
Mental spaces reflect reality, ways of thinking and speech of speakers. The main purpose is to model the mental space of the
French adjective vert, its usual and new images, which allow demonstrating the way of obtaining, processing and storing
human knowledge. The choice of idioms as research material is explained by the fact that these units vividly reflect the
mentality of the representatives of the language community, the peculiarities of their vision and understanding of reality, and
also demonstrate the cognitive mechanisms during the generation of new nominative units.
After analyzing the material, the author suggests that during the world perception and communication, mental
spaces can build up structured information. They are divided into three spheres, each of which has its own images: sacred,
profane and metaphorical. The study of new idioms showed that only 75% of them fit into the traditional model of the
metaphorical sphere. The mental space of other units contains new images of the adjective vert, which complement different
spheres and can further serve as the basis for the formation of new idioms
Формування міжпредметних зв’язків дисциплін циклу природничо-наукової підготовки як фактор оптимізації процесів навчання майбутніх психологів у вищих навчальних закладах.
No full textThe article focuses on the importance of interdisciplinary connections of science training of the future psychologists at higher education institutions as one of the major means of forming coherent scientific picture of the world, awareness of the place and role of a human in it, increase of the level of education and professional training. It is stressed that science education in higher education institutions in the first half of the XX century due to the reduction in number of teaching hours and set amount of training material has been subjected to a number of difficulties It is pointed out in the article that professional training of psychologists in higher education institutions is carried out according to the curriculum, which combines three cycles of disciplines: humanitarian and socio-economic, fundamental and science, professional and practical. The author shows the analysis of research and points to insufficient scientific development of content and interdisciplinary connections of the future psychologists’ science training at higher education institutions and allows focusing on the urgency of the issues raised. The author focuses on the relevance of the issues raised. It is substantiated at the example of science training of the future psychologists in M. P. Dragomanov NPU the necessity to establish interdisciplinary connections between disciplines of fundamental, science cycles disciplines and professional and practical training from the perspective of forming an intelligent, educated, highly cultured, competent professionals. The author states that proposed structure of training and work programs in the disciplines of fundamental and science training are based on competence approach taking into account interdisciplinary connections with disciplines of professional and practical training which is essentially new to the students studying in the field 0301 “Social and political Sciences” of training direction 6.030103 “Practical Psychology”. It is outlined in the article the prospects for further studies that are seen in identifying the ways to improve science training of the future psychologists at higher education institutions.У статті акцентується увага на значущості міжпредметних звя’язків природничо-наукової підготовки майбутніх психологів у вищих навчальних закладах як одного з провідних засобів формування цілісної наукової картини світу, усвідомлення місця й ролі людини в ньому, сприяння підвищенню рівня загальноосвітньої і професійної підготовки. Обґрунтовано необхідність установлення міжпредметних зв’язків між дисциплінами циклів фундаментальної, природничо-наукової та професійної і практичної підготовки майбутніх психологів у вищих навчальних закладах із позиції формування всебічно розвинених, освічених, висококультурних, компетентних спеціалістів. Відмічено, що подальші наукові дослідження будуть спрямовані на визначення шляхів удосконалення природничо-наукової підготовки майбутніх психологів у вищих навчальних закладах
Investigation of properties of sunflower and rapeseed oils obtained by the soxhlet and microwave extraction methods
No full textSaabunud / Received 01.02.2022 ; Aktsepteeritud / Accepted 15.04.2022 ; Avaldatud veebis / Published online 15.04.2022 ; Vastutav autor / Corresponding author: Valentyna Bandura ; [email protected] main purpose of the study was to evaluate the possibility
of replacing hexane, which is traditionally used for the extraction of vegetable
oils, with ethanol as a safer solvent when extracting oil from sunflower meals
and rapeseed in the microwave field. Thus, the influence of the solvent type
on physicochemical characteristics of oil and the low-fat meal was studied.
The main indicators of the composition and quality of sunflower and rapeseed
extraction oil were studied. The quality of oil and ways of its use in food
products are mostly determined by its fatty acid composition. Analysis of the
fatty acid composition of the oil was performed by the method of gas
chromatography using a column HP-88 100 m* 0.25 mm*0.20 µm. The
possibility of using oil in food was established by conducting pilot laboratory
studies and investigating changes in physicochemical parameters during
storage. The extraction by the Soxhlet method (hexane as a solvent) was
compared with the method of extraction of raw materials in a microwave field
(ethyl alcohol as a solvent). Studies of physicochemical parameters indicate
the degree of oil oxidation (determination of peroxide and anisidine values).
The peroxide value is an indicator of the content of primary oxidation
products. The peroxide value of the oil obtained by the method of Soxhlet
extraction (hexane as a solvent) was 5.0 (½O mmol) kg–1
. The peroxide value
of the oil obtained by extraction in a microwave field (ethyl alcohol as a
solvent) was 3.8 (½O mmol) kg–1
. The anisidine value is an indicator of the
content of aldehydes in vegetable oils (secondary oxidation products). The
anisidine value of the oil obtained by the method of Soxhlet extraction (hexane
as a solvent) was 0.3 s.u. The anisidine value of oil obtained by extraction in
a microwave field (ethyl alcohol as a solvent) was 0.2 s.u. Comparing the data
of peroxide and anisidine values, it can be argued that the oil obtained by
extraction of raw materials in a microwave field (ethyl alcohol as a solvent)
had the best indicators. The acid value is one of the main qualitative indicators
that characterize the degree of oil freshness. The acid value of the oil obtained
by the method of Soxhlet extraction (hexane as a solvent) was
3.1 (mg KOH) g
–1
. The acid number of the oil obtained by extraction in a
microwave field (ethyl alcohol as a solvent) was 2.1 (mg KOH) g
–1
. A
comparison of the acid values of oils extracted from the raw material by
different extraction methods shows that the oil obtained by the method of
extraction of raw materials in a microwave field using ethyl alcohol as a
solvent has the best acid value. Studies have shown that the oil, which was
obtained by extraction of raw materials in a microwave field using ethyl
alcohol as a solvent, had the best resistance to oxidation during storage (three
months)
On the Issue of Re-dating Lesya Ukrainka's Letters
No full textLesya Ukrainka's letters have been regularly published since 1911. Still, in the lifetime of the addressee, M. Pavlyk, compiling selection of Correspondence of Mykhailo Drahomanov with Mykhailo Pavlyk, included to it some short letters of the poetess. Subsequently, many of her epistolary texts were published in scientific collections and periodicals in Ukraine and abroad. Since then, six multi-volume editions of the writer's works have been published, in four of which a significant place is occupied by her correspondence, namely in 5-volume edition (Kyiv, 1951–1956); in 10-volume edition (Kyiv, 1963–1965); in 12-volume edition (Kyiv, 1975–1979); in 14- volume edition (Lutsk, 2021)). Fundamental work Lesya Ukrainka: Chronology of Life and Creativity (New York, 1970) by O. Kosach-Kryvyniuk, elucidates memoirs, documents, correspondence of the Drahomanov-Kosach family, including Lesya Ukrainka’s letters. Lesya Ukrainka’s correspondence also occupies a significant part in a separate 3-volume edition of Larysa Kosach-Kvitka's letters (Kyiv, 2016‒2018). At the same time, textologists and compilers worked hard on the correct dating of each of the epistolary texts found and prepared for publication, much of which required additional research on the issue of dating. The article focuses on the general principles used by the researchers when dating (sometimes re-dating) Lesya Ukrainka’s letters and the difficulties caused mostly by the existence of double chronology (Julian and Gregorian calendars) in the society of that time and some rare mechanical errors in the addressees’ notations, including Larysa Kosach-Kvitka. The author concentrates on the individual correspondence of the writer. The case study of individual letters helps to reveal the principles of a textologist's work on establishing the exact or approximate date of when the text was written and show the importance of such work. The publication is about clarifying and correcting the dating of some of Lesya Ukrainka's letters, published with relevant comments in the Complete Academic Collection of the Writer's Works in 14 volumes. The article attracts the attention of researchers because, in general, the issue of dating (re-dating) epistolary texts is an occasional subject of the studies
«Who goes ahead, the one always wanders»: to the concept of person in the tragedy by Gete «Faust»
No full text(uk) У статті, на основі аналізу першотвору та українського й російського перекладів, розглядається втілення морально-естетичної позиції Гете, його концепція людини у трагедії «Фауст». Стверджується думка про штучне випрямлення, лакування образу Фауста радянським літературознавством та однобічно негативне тлумачення пострадянською критикою. Підкреслюється складність та неоднозначність образу Фауста. Автор вважає, що головне в гетевському світогляді і творчості – ствердження цінності людського життя, заперечення будь-якої надмети, що виправдовує жертви в ім’я ідеологічних догм.
Чільне місце в етичній системі Гете посідає не стільки уславлення людини, скільки віра у її милосердя, силу любові, що здатна відродити душу.(en) In the article, based on the analysis of the original text and the Ukrainian and Russian translations, there has been considered the embodiment of the moral-aesthetic position of Goethe, his conception of a human in the tragedy «Faust».
Due to a great number of translations of the work, the Ukrainian reader can at maximum extent come close to achieving Goethe' s understanding of a human' s place in the world. The comparative analysis of the original and its translations into congenerous languages become an additional source of interpretation. The focus of the author – is the final of the tragedy, the fifth action of the second part. The main character of the work is in the thrall of dreams about the future happy life that he will arrange for the people at the seaside, having won a piece of a land from the sea. The author emphasizes upon the negative changes in behavior and worldviews of Faust, who completely relies on Mephisto: the main character is annoyed with the church bells, Baucis and Philemon, who do not want forced happiness. I n the analyzed translations of M. Lukash, B. Pasternak and word for word translation by N. Voronkova, it is traced the relationship of Faust with evil spirit on the lexical level, it is confirmed infernal, apocalyptical character of his activity: human wounds bled, crying sounded at night, ardent heat went into the sea. The author considers it to be symbolic that Faust, who, having believed in his own infallibility, got rid of any doubts about the correctness of his actions, lost his vision. The gloom that envelops the main character, is the evidence of not only his physical blindness, but above all it is an indicator of his soul blindness. Blind Faust represents Humanity which, having forgotten about the soul, blind with thirst for power, maintains its own greatness conceitedly, deceptively seeing shovels clank of the lemurs, digging a grave for him, for implementation and embodiment of his intentions.
It has been confirmed the idea of artificial straightening, varnishing of the image of Faust by the Soviet Study of Literature and one-sided negative interpretation of it by the post-Soviet criticism. I t has been highlighted the complexity and ambiguity of the image of Faust. The author believes that the main thing in Goethe' s worldview and creativity – is upholding of the values of human life, denying any extra-target that justifies the sacrifices for the sake of the ideological dogma.
The image of Faust helps to come to the opinion that only by means of mind, with the help of objective knowledge it is impossible to understand the meaning of a human being on the Earth. The higher truth can be learnt only by wisdom, which includes irrational knowledge and faith.
A prominent place in the ethical system of Goethe has not been occupied so much by glorifying of a man, but how much by faith in one' s mercy, power of love, which is able to revive the soul
FUTURE PHILOLOGISTS’ PROFESSIONAL COMPETENCES FORMATION BY MEANS OF COMPUTER ORIENTED TECHNOLOGIES
No full textThe article analyzes the problems of formation of professional competence of future philologists by means of computer oriented technologies in terms of introduction of computer-based education in higher education institutions (HEI). Author determined a model of future philologists professional competence formation by means of computer-oriented information and communication technologies (ICT); singled structural components of the model of professional competence of future philologists formed by means of computer oriented ICT (target, content, technical, productive) and revealed their relationship to the specific future linguists’ careers; proved the thesis that the studied problem is of particular importance because of the necessity of informatization of higher education and usage the computer-oriented ICT in the educational process of the university
