11 research outputs found
A model of American foreign trade policy
No full textIn this paper the author explains very complex and developed process of trade policy creation in the United States. He describes the institutional model of trade policy creation, main organs and procedures, and the legal setting for that process. He also gives the basic principles in the realization of American trade policy in all dimensions - bilaterally regionally and multilaterally, that is to say the bilateral relations with main American trading partners, the links of the United States with the main regional economic groupings in the world and the U. S. influence in international economic organizations
Review of the most significant caves in Montenegro
No full textThe most significant caves in Montenegro were distinguished in response to their physical-geographic, biological, archeological and morphometric characteristics (length and depth). Caves distribute in four distinctive regions: coastal karst, karst plateau (relict valley system), fluvial karst (recent hydrologic systems) and the high mountainous karst area. The most outstanding within the last, due to abundances of the major caves with depths from a few hundred meters to 1,162 m, are four mountain regions: Mt. Durmitor, Mt. Lovcen-Orjen, Mt. Maganik and Mt. Bjelic
Effects of the world economic crisis on exports in the CEEC: Focus on the Western Balkans
No full textThe effects of competing trade regimes on bilateral trade flows: case of Serbia
No full textThe aim of this paper is to investigate the effects of competing trade regimes on Serbian trade with its most significant (traditional) partners, like European Union and CEFTA 2006 signatories, and other untraditional trade partners with favourable trade regime, like the USA. To this end, gravity model with bilateral and time effects is estimated by Hausman-Taylor AR(1) instrumental variable estimator, using panel data on bilateral trade between Serbia and its main trade partners during the period 2001-2010. The results indicate that overall level of development and difference in factor endowments stimulate Serbia’s exports, which is in accordance with theoretical foundation that inter-industry trade is predominant in exports of less developed countries. Moreover, competing trade regimes appear as important determinant of Serbia’s trade relations, whereas additional liberalization of trade regime with the USA as untraditional trade partner, even asymmetrical to Serbia’s favour, cannot divert trade flows from traditional partners in the long-run. This could mean that distance plays more prominent role in bilateral trade than the degree of liberalization of trade regimes in case of Serbia. The result could be due to the contemporaneous effects of trade preferences granted to Serbia by the EU and other CEFTA 2006 signatories, main trading partners of Serbia
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Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data
No full textSeamless phase II/III clinical trials are conducted in two stages with treatment selection at the first stage. In the first stage, patients are randomized to a control or one of k > 1 experimental treatments. At the end of this stage, interim data are analysed, and a decision is made concerning which experimental treatment should continue to the second stage. If the primary endpoint is observable only after some period of follow-up, at the interim analysis data may be available on some early outcome on a larger number of patients than those for whom the primary endpoint is available. These early endpoint data can thus be used for treatment selection. For two previously proposed approaches, the power has been shown to be greater for one or other method depending on the true treatment effects and correlations. We propose a new approach that builds on the previously proposed approaches and uses data available at the interim analysis to estimate these parameters and then, on the basis of these estimates, chooses the treatment selection method with the highest probability of correctly selecting the most effective treatment. This method is shown to perform well compared with the two previously described methods for a wide range of true parameter values. In most cases, the performance of the new method is either similar to or, in some cases, better than either of the two previously proposed methods. © 2014 The Authors. Pharmaceutical Statistics published by John Wiley & Sons Ltd
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
No full textThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Abjection in the novels of Marlene Van Niekerk
No full textIncludes bibliographical references.In this thesis, three of Marlene van Niekerk's novels, translated from Afrikaans into English, are examined, with the focus on the representation of abjection in the texts under discussion.The theoretical point of departure of this study is Julia Kristeva's essay Powers of horror (1982), which addresses, in particular, the notion of abjection and how certain abject elements play a pivotal role in people's everyday lives. From a psychoanalytic perspective, abjection is viewed as a revolt against the mother and foregrounds particularly the influence of the maternal body over the subject. In this instance, the subject desires liberation from the hold of the maternal and seeks to subject the mother to abjection. Bodily fluids seeping out of the body, diseases, viruses, dirt and death (and in particular the corpse) are all elements that are encompassed in the concept of abjection. Manifestations of abjection in the form of the abject mother, abject spaces, abject bodies and the link between abjection and filth are comparatively analysed in the three texts. The thesis concludes by showing that Van Niekerk deliberately inscribes elements of the abject into her texts so as to transgress and deconstruct the norms associated with a patriarchal and racist society in South Africa. Van Niekerk also undermines the norms that underpin such a society: religious indoctrination, gender oppression and Othering. By writing her novel Triomf (1999) in a demotic register, Van Niekerk furthermore questions the prevalent assumptions about what is deemed proper language for writing a novel. Writing, for her, thus serves the purposes of abjecting, of rejecting the impositions of the symbolic order. Following the publication of her first collection of short stories, Die Vrou wat haar verkyker vergeet het [The woman who forgot her binoculars] in 1992, there was general consensus that the baroque nature of the language resulted in reader resistance to the text. This explains why she decided to write her first novel in the crude and obscene language of a low-class family, the Benades of Triomf
