323,780 research outputs found
Elementy pomp - Korki gwintowane BN-85/1389-01
No full textU góry s tyt: Norma branżowaZgłoszona przez Ośrodek Badawczo-Rozwojowy Pomp Przemysłowych ; Ustanowiona przez Dyrektora Ośrodeka Badawczo-Rozwojowego Pomp Przemysłowych dnia 26 lutego 1985 r jako norma obowiązująca od dnia 27 kwietnia 1985 r ; Zastępuje BN-73/1389-01wersja wydawnicz
Characterisation of the newly identified human Ump1 homologue POMP and analysis of LMP7(beta 5i) incorporation into 20 S proteasomes
No full textBiogenesis of mammalian 20 S proteasomes occurs via precursor complexes containing {alpha} and unprocessed {beta}units. A human homologue of the yeast proteasome maturation factor Ump1 was identified in 2D gels of 16 S precursor preparations and designated as POMP (proteasome maturation protein). We show that POMP is detected only in precursor fractions and not in fractions containing mature 20 S proteasome. Northern blot experiments revealed that expression of POMP is induced after treatment with interferon {gamma}. To analyse the role of the {beta}5 propeptide for proper maturation and incorporation of the {beta}5 subunit into the complex, human T2 cells, which highly express derivatives of the {beta}subunit (LMP7), were studied. In contrast to yeast, the presence of the {beta}5 propeptide is not essential for incorporation of LMP7 into the proteasome complex. Mutated LMP7 subunits either carrying the prosequence of {beta}2i (LMP2) or containing a mutation in the active threonine site are incorporated like wild-type LMP7, while a LMP7 derivative lacking the prosequence completely is incorporated to a lesser extent. Although the absence of the prosequence does not affect incorporation of LMP7, its deletion leads to delayed proteasome maturation and thereby to an accumulation of precursor complexes. As a result of the precursor accumulation, an increased amount of the POMP protein can be detected in these cells
Analiza energochłonności pomp głównego odwadniania kopalń podziemnych
No full textMine dewatering is one of the main tasks and problems in the mining sector which do not affect output directly but are necessary for correct mine operations. The main dewatering pumps are located at various levels, but the pumping head is always a few hundred metres underground. The number and operating time of the pumps depends on the water inflow and are specified in the applicable regulations. Due to the capacity and required head, the power demand may well be in excess of 1 MW. Consequently, the correct use of main dewatering pumps, at low energy consumption, is a basic condition of limiting water pumping costs. The analysed pumping station is located at level 500, is equipped with ten Q = 500 m3 /h (0.139 m3 /s) OW-250/8 pumps. The operating time of most pumps exceeds 20 000 h and the energy consumption is from 2.17 to 2.67 kWh/m3 of pumped water. The analysis results and the energy consumption ratios have been compared with the data for new pumps which operate at data sheet parameters (efficiency). This was the basis to evaluate the impact of exceeding the time between repairs on operating parameters and the increase in the operating costs of the main dewatering pumps.Odwadnianie kopalń należy do głównych zadań i problemów eksploatacji w górnictwie, które nie wpływają bezpośrednio na wydobycie, jednak stanowi nieodzowną działalność dla prawidłowej eksploatacji kopalń. Pompownie głównego odwadniana w kopalniach znajdują się na różnych poziomach, ale zawsze wysokość pompowania wynosi kilkaset metrów. Liczba pomp oraz czas ich pracy zależą od wielkości dopływów wód i jednoznacznie wynikają z przepisów. Ze względu na wydajność i wymaganą wysokość podnoszenia zapotrzebowanie mocy może znacznie przekraczać 1 MW. Dlatego prawidłowa eksploatacja pomp głównego odwadniania, przy niskiej energochłonności, stanowi podstawowy warunek ograniczenia kosztów wypompowania wody. Analizowana pompownia znajduje się na poziomie 500, jest wyposażona w dziesięć pomp OW-250/8 o wydajności Q = 500 m3 /h (0,139 m3 /s). Czas eksploatacji większości pomp przekracza 20 tysięcy godzin, co powoduje, że energochłonność wynosi od 2,17 do 2,67 kWh/m3 wypompowanej wody. Wyniki przeprowadzonej analizy eksploatacyjnej i wartości wskaźników określających energochłonność odniesiono do wskaźników dla nowych pomp pracujących z parametrami (sprawność) katalogowymi. Na tej podstawie oceniono wpływ przekroczenia czasów między remontami na parametry eksploatacyjne i zwiększenie kosztów eksploatacji pomp głównego odwadniania
Did South Dakota Make a Strategic Error in Drafting Its Wayfair Statute?
No full textIn this article, Professor Pomp questions whether South Dakota made a strategic error in drafting its Wayfair statute.
South Dakota, in preparation for its attack on Quill, passed S. 106. The law allows South Dakota to collect its sales tax from certain remote sellers. Pomp notes that Bellas Hess and Quill, in contrast, involved the collection of use taxes.
To aid in his analysis, Pomp considers a hypothetical case: a couple from South Dakota travels to New York City and purchases art from a gallery. The gallery packs and ships the art back to South Dakota. Must the gallery collect the South Dakota sales tax on this transaction?
To answer this question, Pomp reflects on two U.S. Supreme Court cases, Dilworth and General Trading, both decided in 1944 by Justice Frankfurter. In Dilworth, Arkansas tried to impose its sales tax on Tennessee corporations which sold machinery and mill supplies. The corporations were not qualified to do business in Arkansas and lacked sales offices, branch plant, and any place of business in Arkansas. Traveling salesmen, residents of Tennessee, provided orders to offices in Memphis via mail or telephone. Title to the goods passed upon delivery to the carrier in Memphis. The Court held that the sale took place in Tennessee, thus Arkansas could not impose its sales tax on the transaction.
Returning to the hypothetical, Pomp observes that the gallery would argue that, just like the businesses in Dilworth, it is not qualified to do business in South Dakota and has no sales office, branch plant, or any other place of business there. Lacking traveling salesmen, the gallery does not even solicit business in South Dakota. And title passes to the art in New York. Pomp argues that, under Dilworth, it does not seem that a remote vendor like the gallery is making a sale in South Dakota.
Whereas Dilworth involved the imposition of Arkansas\u27s sales tax, General Trading involved the collection of Iowa’s use tax. The facts of General Trading were nearly identical to those in Dilworth, yet Frankfurter upheld the state’s capacity under the constitution to have out-of-state vendors collect its use tax. Frankfurter distinguished General Trading in Dilworth, arguing that while the use of the Arkansas sales tax exceeded the constitutional limitations on state power, the similar application of a use tax would not.
General Trading gave market states a strategy for avoiding the constitutional difficulties of making a remote vendor collect sales tax: states should instead require the collection of their use tax. Pomp questions South Dakota’s decision to invite challenges regarding whether or not a taxable sale has occurred. General Trading provides a safer alternative: draft the statute, like those involved in Bellas Hess and Quill, around the collection of a use tax
Did South Dakota Make a Strategic Error in Drafting Its Wayfair Statute?
No full textIn this article, Professor Pomp questions whether South Dakota made a strategic error in drafting its Wayfair statute.
South Dakota, in preparation for its attack on Quill, passed S. 106. The law allows South Dakota to collect its sales tax from certain remote sellers. Pomp notes that Bellas Hess and Quill, in contrast, involved the collection of use taxes.
To aid in his analysis, Pomp considers a hypothetical case: a couple from South Dakota travels to New York City and purchases art from a gallery. The gallery packs and ships the art back to South Dakota. Must the gallery collect the South Dakota sales tax on this transaction?
To answer this question, Pomp reflects on two U.S. Supreme Court cases, Dilworth and General Trading, both decided in 1944 by Justice Frankfurter. In Dilworth, Arkansas tried to impose its sales tax on Tennessee corporations which sold machinery and mill supplies. The corporations were not qualified to do business in Arkansas and lacked sales offices, branch plant, and any place of business in Arkansas. Traveling salesmen, residents of Tennessee, provided orders to offices in Memphis via mail or telephone. Title to the goods passed upon delivery to the carrier in Memphis. The Court held that the sale took place in Tennessee, thus Arkansas could not impose its sales tax on the transaction.
Returning to the hypothetical, Pomp observes that the gallery would argue that, just like the businesses in Dilworth, it is not qualified to do business in South Dakota and has no sales office, branch plant, or any other place of business there. Lacking traveling salesmen, the gallery does not even solicit business in South Dakota. And title passes to the art in New York. Pomp argues that, under Dilworth, it does not seem that a remote vendor like the gallery is making a sale in South Dakota.
Whereas Dilworth involved the imposition of Arkansas\u27s sales tax, General Trading involved the collection of Iowa’s use tax. The facts of General Trading were nearly identical to those in Dilworth, yet Frankfurter upheld the state’s capacity under the constitution to have out-of-state vendors collect its use tax. Frankfurter distinguished General Trading in Dilworth, arguing that while the use of the Arkansas sales tax exceeded the constitutional limitations on state power, the similar application of a use tax would not.
General Trading gave market states a strategy for avoiding the constitutional difficulties of making a remote vendor collect sales tax: states should instead require the collection of their use tax. Pomp questions South Dakota’s decision to invite challenges regarding whether or not a taxable sale has occurred. General Trading provides a safer alternative: draft the statute, like those involved in Bellas Hess and Quill, around the collection of a use tax
HSCT corrects primary immunodeficiency and immune dysregulation in patients with POMP-related auto-inflammatory disease
No full textInborn errors of immunity that present with concomitant immunodeficiency and auto-inflammation are therapeutically challenging; furthermore, complexity is added when they are caused by mutations in genes that encode for proteins expressed beyond immune cells. The ubiquitin-proteasome system is the main intracellular proteolytic machinery and participates in most cellular processes by degrading ubiquitinated proteins. Mutations in proteasome subunits resulting in proteasome deficiency cause a severe auto-inflammatory disease characterized by chronic auto-inflammation neutrophilic dermatosis and fever, collectively referred to as Proteasome Associated Auto-inflammatory Syndromes (PRAAS). POMP is a chaperone for proteasome assembly and AD mutations in POMP cause a form of PRAAS with prominent immunodeficiency referred to as POMP-related auto-inflammation and immune dysregulation (PRAID) manifesting with recurrent, severe and opportunistic infections in addition to inflammatory features that are characteristic for all PRAAS disorders, most importantly early-onset neutrophilic dermatosis. JAK inhibitors partially control the disease in individuals with PRAAS, however life-threatening, recurrent and opportunistic infections in patients with POMP mutations limit immunosuppressive therapies and prompted consideration of hematopoietic stem cell transplant (HSCT). We describe successful HSCT in two patients with POMP deficiency. Despite POMP being ubiquitously expressed, the immunologic and auto-inflammatory phenotype were both ameliorated through HSCT which suggests that the clinical and immunological features of PRAID are predominantly derived from a proteasome defect in hematopoietic cells. To our knowledge, these are the first patients with a form of PRAAS cured by HSCT, opening new therapeutic possibilities for these diseases
siRNA silencing of proteasome maturation protein (POMP) activates the unfolded protein response and constitutes a model for KLICK genodermatosis
No full textKeratosis linearis with ichthyosis congenita and keratoderma (KLICK) is an autosomal recessive skin disorder associated with a single-nucleotide deletion in the 5'untranslated region of the proteasome maturation protein (POMP) gene. The deletion causes a relative switch in transcription start sites for POMP, predicted to decrease levels of POMP protein in terminally differentiated keratinocytes. To investigate the pathophysiology behind KLICK we created an in vitro model of the disease using siRNA silencing of POMP in epidermal air-liquid cultures. Immunohistochemical analysis of the tissue constructs revealed aberrant staining of POMP, proteasome subunits and the skin differentiation marker filaggrin when compared to control tissue constructs. The staining patterns of POMP siRNA tissue constructs showed strong resemblance to those observed in skin biopsies from KLICK patients. Western blot analysis of lysates from the organotypic tissue constructs revealed an aberrant processing of profilaggrin to filaggrin in samples transfected with siRNA against POMP. Knock-down of POMP expression in regular cell cultures resulted in decreased amounts of proteasome subunits. Prolonged silencing of POMP in cultured cells induced C/EBP homologous protein (CHOP) expression consistent with an activation of the unfolded protein response and increased endoplasmic reticulum (ER) stress. The combined results indicate that KLICK is caused by reduced levels of POMP, leading to proteasome insufficiency in differentiating keratinocytes. Proteasome insufficiency disturbs terminal epidermal differentiation, presumably by increased ER stress, and leads to perturbed processing of profilaggrin. Our findings underline a critical role for the proteasome in human epidermal differentiation
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
What Can the OECD Learn From the States?
No full textIn this article, Professor Pomp argues that the OECD should look to the American states for insight into taxing cross-jurisdictional corporations. In the early 20th century, the states had to respond to the challenge of taxing domestic interstate corporations. While these corporations posed no tax problem at the federal level, states had to respond to the reality of corporations shifting profits into neighboring tax havens. They needed a better alternative to federal transfer pricing and sourcing rules. In the 1930’s, some states began combining domestic related entities.
The growth of multinational corporations created new problems for both the states and the federal government. Some states continued to not only to combine domestic corporations, but also multinationals as well: an approach known as worldwide combined reporting. Political pressure, not administrative obstacles, eventually pushed these states back to a waters edge approach.
The states can shed light on the challenge of assigning the tax base between separate production and market countries. In 1957, the Uniform Law Commission adopted the Uniform Division of Income for Tax Purposes Act (UDITPA). UDITPA adopts an evenly weighted three-factor formula, using property, payroll, and sales. States have moved away from this fomula and instead have been using a single-factor sales formula, with market-based approaches to the sales factor. The MTC has developed different approaches to market based sourcing that reflect the type of transaction involved and include special formulas for special industries.
The OECD can look to the states for insight into economic nexus rules as well. The MTC incorporated economic nexus approaches into its “factor presence” rules for nexus.
Mandatory worldwide reporting provides many advantages over the OECD’s agenda: the approach effectively deals with tax havens, transfer pricing, defining specific types of businesses, profit shifting, and the allocation of overhead. And unlike the states, the OECD does not need to worry about accommodating the United States Commerce Clause.
The article acknowledges that the MTC and UDITPA do not shed light on the composition of the tax base to be combined. Pomp suggests looking to international accounting standards and the Common Consolidated Corporate Tax Base as starting points.
Finally, many countries will require help administering worldwide combined reporting. Pomp suggests that a nongovernmental organization take on the burden for all countries. Possible candidates include the OECD, the U.N., the IMF, or the World Bank
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