1,723,851 research outputs found
Emilio Villa - Poeta e scrittore
No full textMostra dal titolo "Emilio Villa. Poeta e scrittore" (Reggio Emilia, Chiesa di San Giorgio, 23 febbraio 2008-6 aprile 2008), a cura di Claudio Parmiggiani. Cura degli apparati iconografici e didattici per la mostra e per il catalogo (Emilio Villa, poeta e scrittore, Mazzotta, Milano 2008
Poetas-tradutores e o cânone da poesia traduzida no Brasil (1960-2009)
Full text linkTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Estudos da TraduçãoEsta tese faz um mapa das obras de poesia traduzidas por poetas-tradutores no Brasil entre 1960-2009. A pesquisa ainda identifica quem são os poetas que atuaram como tradutores de poesia nessas cinco décadas e discute a dimensão da sua atuação na constituição do cânone da poesia traduzida no Brasil. Ao escolher certos autores e/ou obras para traduzir, esses poetas ajudam a configurar o presente poético. Por intermédio da tradução, trabalham pela continuidade ou pelo rompimento de determinado cânone e, ao mesmo tempo, buscam suas filiações e caminhos no âmbito da poesia. Com este trabalho, também se busca contribuir para a escrita da história da literatura traduzida no Brasil
Il poeta e il compositore
No full textIl poeta e il compositore è la più antica tra le prose riprese da Hoffmann entro la cornice serapionica. Composta nel settembre-ottobre 1813, fu pubblicata autonomamente, nello stesso anno, nella “Allgemeine Musikalische Zeitung”, (anno 15, N. 49/50, 8 e 15 dicembre 1813, col. 793-806 e 809-817). Già nel 1809 H. illustra alla redazione della rivista l’idea di un saggio teorico sulle sfide che la musica pone alla poesia nella composizione operistica. Il progetto si trasforma in dialogo immaginario, confluito con poche varianti nella cornice dei Fratelli di Serapione. Scritto nel periodo in cui Hoffmann stesso si trova confrontato con la divisione dei ruoli tra poeta e musicista nella composizione operistica
Cell-Based Assays to Assess Neuroprotective Activity
No full textThe most common neurodegenerative diseases (NDDs), i.e. Alzheimer’s disease (AD), Parkinson’s disease (PD) and Amyotrophic Lateral Sclerosis (ALS), share common features both at molecular and cellular level: at molecular level, all these disorders are characterized by conformational changes of specific proteins leading to aggregates formation and mitochondrial dysfunctions together with impairment in ubiquitin-proteasome system and autophagy to this pathogenic mechanism; at cellular level, NDDs affect all brain cell types, leading to their dysfunction, which contributes to neurodegeneration. In fact, at early stages, all NDDs are characterized by degeneration and death of neurons in specific brain areas, often related to neural precursors cells (NPCs) proliferation/differentiation dysfunctions, making difficult the replacement of degenerated neurons. In the meanwhile, activation of microglia occurs, which initially acts to protect neurons and to support neuroregeneration, but, when activation is wide and/or prolonged, it contributes to neurodegeneration, to neurogenesis impairment and, together with astrocytes, to neuroinflammation. Finally, at later stages, most of NDDs are also characterized by white matter dysfunction, as a consequence of defects in oligodendrocytes functions or precursors cells (OPCs) proliferation/differentiation processes. Therefore, considering the cellular mechanisms involved in the complex process of neurodegeneration, to exactly characterize the neuroprotective potential of candidate molecules for central nervous system (CNS) drug discovery there is a need to use different brain cells-based assays.
To this aim, here we describe the drug screening pipeline that we have developed in more than 10 years of research and that involves the use of different in vitro brain cell models. First, rat primary cultures of cerebellar granule neurons (CGNs) are used to evaluate the potential dose-dependent toxicity of all molecules to be tested; then, the potential neuroprotective effect of selected, non-toxic molecules is evaluated on specific in vitro models of neurodegeneration (age-related, AD, PD or ALS). Then, the use of neurospheres isolated from the sub-ventricular zone (SVZ) of adult mice allows to investigate the potential neuroregenerative effects of selected molecules of interest.
Cultures of rat primary microglial cells or microglial cell lines (murine N9 or human HMC3), previously activated by commonly-used inflammatory stimuli (LPS or INFγ), are then set up, together with murine astrocytes cell line (IMA 2.1) or primary rat astrocytes, to assess immunomodulation, i.e. the shift from neurotoxic to neuroprotective phenotypes, of further selected compounds. In parallel, proliferation and differentiation mechanisms need to be analyzed in immortalized murine oligodendrocytes precursor cells (Oli-Neu cells) to evaluate effects on remyelination processes. Finally, to confirm the specific neuroprotective, neuroregenerative and immunomodulatory effects of selected molecules, different brain cells derived by human induced pluripotent stem cells (hiPSCs) from healthy donors or of patients with specific NDDs can be used to confirm the translational potential of the interesting candidates, as well as a strategy for the identification of more personalized and effective treatments for neuroprotection
Emilio Villa, poeta e scrittore
No full textE' il catalogo della mostra "Emilio Villa, poeta e scrittore", tenutasi a Reggio Emilia, nella chiesa di San Giorgio, dal 23 febbraio al 6 aprile 2008, e curata da Claudio Parmiggiani. L'Autrice ha collaborato al coordinamento redazionale, alla redazione dei testi (in gran parte manoscritti inediti), all'organizzazione degli apparati iconografici e didattici relativi sia alla mostra sia al catalogo
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Il poeta e la Gazzetta
No full textFor several years d’Annunzio plays an outstanding role in the cultural and political redefinition of Venice ruling classes. Whether from literary works or personal exploits, his success is mainly due to ideological messages and fanciful personality; so, at least from the first performance of La nave in 1908, the poet’s flag is hoisted by local nationalist movement and rising economic powers aiming to extend, in the name of a ‘Greater Venice’, italian influence on Adriatic Sea and Balcanic area. Later, during the 1915-18 war, his aerial and naval raids, mainly based in Venice, transform the prophet of the city’s warrior destinies in a hero himself – masterly mixing war of words and real military actions – and give him an unprecedented mediatic appeal. But the apex of his patriotic popularity comes with the post-war slavofobic campaign for venetiannes/italiannes of Istria and Dalmatia and, of course, with the Fiume expedition. The Gazzetta di Venezia, historical newspaper of city establishment, not only faithfully records d’Annunzio’s parable from Venice point of view, but often takes part in it
Vinícius de Moraes poeta e letrista
Full text linkThe central focus of this course study is to reflect with a keener understanding within the reality of some works by Vinícius de Moraes as a poet and lyricist, as well as his main wheels of friendship, as he establishes these environments, made understanding from the writings of Vinícius de Moraes. This course conclusion paper aims to understand how lyricist and poet Vinicius de Moraes builds passion in music I know I will love you? As in the specifics we will find analyzing passion in the literature; emphasize Vinícius de Moraes as a poet and write Vinícius de Moraes as a lyricist. Thus, a bibliographical research was carried out within the reality of poet and lyricist Vinícius de Moraes as a learning tool considering the contributions of authors such as Castello (1994), Candido, (2011), Bosi (2017), Taborda (2012), among others. others seeking to emphasize the reality of working with poet and lyricist Vinicius as a pedagogical tool for teaching learning. The passion for literature is a reality before the writings of the author, however his work becomes possible to explore communication within the reality of poetry and as the lyricist, enabling interpersonal exchanges, allowing the expression of feelings and emotions for meaningful learning. the literary proposal has an important role and contribution in the formation of readers and their role in society, enabling the reader to broaden critical thinking to go further and conquer new horizons.A presente pesquisa analisa Vinícius de Moraes como poeta e letrista, assim como suas principais rodas de amizades. Na medida que vai estabelecendo esses ambientes, tornará favorável a compreensão das escritas de Vinícius de Moraes. Este trabalho de conclusão de curso tem como objetivo geral compreender como o letrista e poeta Vinícius de Moraes constrói a paixão na música “eu sei que vou te amar”. Assim como nos específicos, analisaremos a paixão na literatura; destacando Vinícius de Moraes como poeta e descrever Vinícius de Moraes como letrista. Assim, realizou-se uma pesquisa bibliográfica do poeta e letrista Vinícius de Moraes como ferramenta para o aprendizado considerando as contribuições de autores como Castello (1994), Candido, (2011), Bosi (2017), Taborda (2012), entre outros. Procurando enfatizar a realidade em se trabalhar com o poeta Vinícius de Moraes como ferramenta pedagógica de ensino-aprendizagem. A paixão pela literatura é uma realidade diante das escritas do autor, contudo o seu trabalho torna-se possível explorar a comunicação dentro da realidade da poesia e como o letrista, possibilitando trocas interpessoais, permitindo a expressão de sentimentos e emoções para um aprendizado significativo. A proposta literária tem o papel importante e contribui na formação de leitores e sua função na sociedade, contribuindo para que o leitor possa ampliar o pensamento crítico para ir além e conquistar novos horizontes
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