947 research outputs found
Chronotherapy of hypertension: let's not throw the baby out with the bathwater!
No full textNo abstrac
‘Help yourself, so the (circadian) rhythms help you’:Chronobiological insights to promote physical and mental health
No full textno abstrac
A Florentine family in crisis: the Strozzi in the fifteenth century.
No full textPhDIn 1434 the Strozzi lineage had held a leading position in
Florentine society and government for at least one hundred and fifty
years, and was one of the largest and wealthiest of the city's
patrician lineages. The records of the catasto of 1427 and of the
scrutiny of 1433 are used to give a profile of the dominant social,
economic and political position of the Strozzi before the advent of
Medicean dominance. Their record of electoral success, and the
political and cultural leadership of influential and respected men
such as Palla di Nofri and Matteo di Simone, with other factors, put
the Strozzi amongst the greatest enemies of the victorious Medicean
regime of late 1434. The effects of political opposition and exile
on the lineage are examined both directly, through records of office-holding,
and indirectly through such indicators as marriage alliances
and household wealth. The two most prominent lines of the Strozzi
were exiled after 1434. Palla di Nofri's life and preoccupations in
his Paduan exile are examined, together with the lives of his sons;
none of these Strozzi ever returned to Florence, pursued as they were
by the enmity of the Medicean regime. The very different careers of
Filippo di Matteo and his brother Lorenzo are also examined: how they
succeeded in founding a lucrative bank in Naples, and in returning to
Florence to 'rebuild' (rifare) the position of the Strozzi lineage
there. The final decades of the century saw the Strozzi in an
economically more secure position, due substantially to the efforts
of Filippo. Except for a very small number of its members admitted
into the regime, most of the lineage is here shown to have remained
excluded from significant political office until after the fall of
the Medici regime in 1494
Prognostic role of education levels after cardiac surgery and inhospital cardiac rehabilitation
No full textCardiac calcium score on 2D echo: correlations with cardiac and coronary calcium at multi-detector computed tomography
No full textBackground: To test the hypothesis that a semi-quantitative echocardiographic calcium score (eCS) significantly correlates with cardiac calcium measured by coronary computed tomography angiography (CCTA) and, secondarily, severe coronary artery calcifications and stenosis. Methods: This is a retrospective, observational study, conducted in a tertiary centre. eCS was compared with CCTA scores of non-coronary cardiac calcium (nCACS), coronary cardiac calcium (CACS) and number of diseased coronary vessels, in 141 subjects without known coronary artery disease (CAD), who underwent both echocardiography and CCTA for clinical reasons. Results: Age, prevalence of hypertension and all measures of calcium (eCS, nCACS and CACS) differed significantly between the no-CAD and CAD subgroups. eCS was positively correlated with nCACS (Spearman rho = 0.64, p 400), a known predictor of cardiovascular morbidity and mortality. The eCS also predicts obstructive CAD, incrementally to age and clinical variables, although for this purpose CACS remains the most accurate score
Vues présentes sur le celtique cisalpin
No full textPresent views on Cisalpine Celtic.
During the last twenty years, the knowledge of Lepontic and of Italian Gaulish has been notably enriched by very important finds, and also by numerous studies. The author proposes a synthesis of all new linguistical and cultural data provided by epigraphy in this particular resort.Dans les vingt dernières années la connaissance du lépontique et du gaulois d’Italie a été notablement enrichie par certaines trouvailles fort importantes ainsi que par de nombreuses études. Tableau synthétique des nouvelles données linguistiques et culturelles apportées par l’épigraphie de ce domaine.Motta Filippo. Vues présentes sur le celtique cisalpin. In: Etudes Celtiques, vol. 29, 1992. Actes du IXe congrès international d'études celtiques. Paris, 7-12 juillet 1991. Deuxième partie : Linguistique, littératures. pp. 311-318
Occhi pieni e mani vaganti. Movimenti, emozioni, astrazioni.
No full textFilippo FIMIANI, Occhi pieni e mani vaganti. Movimenti, emozioni, astrazioni, «Fata Morgana», 12/2010, pp. 147-164. ISSN 1970-5786.
ITALIANO. Una piccola sequenza da un episodio della serie televisiva Mad Men in cui la relazione sensoriale emozionale tra lo spettatore e un corpo in movimento, precisamente un corpo danzante, è l’oggetto di questo articolo, che intende così verificare la cosiddetta naturalizzazione della fenomenologia e del corpo vissuto operata dalle scienze cognitive applicate agli studi visuali. L’autore mostra anche i rapporti tra la cosiddetta simulazione incarnata e una memoria simbolica e iconografica profonda, e discute in particolare la polarità tra proiezione e introiezione, attività e passività nell’esperienza empatica delle immagini in movimento.A short filmic example from the AMC's award-winning series Mad Men in which the sensorial and emotional relationship between the spectator and a moving body, i.e., a dancing body, is explicitly put into play. The essay wants to deal with the so called naturalization of phenomenology and of the living body, trained by the cognitive sciences reading the visuality. The author shows the relationship between the so called ‘embodied Simulation’ and a symbolic and iconographic deep memory of the pictures, and he gives an in-depth attention to the polarity between projections and introjections, activity and passivity of the spectator’s body during the empathic experience of the moving pictures
Chronobiological variation in takotsubo syndrome: an updated systematic review and meta-analysis
Full text linkTakotsubo syndrome (TTS) might exhibit particular chronobiological patterns in its onset, characterized by variations according to time of the day, day of the week, and month of the year. The aim of this study was to fully explore the temporal patterns (circadian, weekly and seasonal) in the onset of TTS. A systematic review and meta-analysis of literature were conducted for studies (2006-2024) reporting the temporal patterns (circadian, weekly and/or seasonal) in the onset of TTS. Among the 4257 studies retrieved, 20 (including 64,567 subjects) fulfilled all eligibility criteria. Data were aggregated used random effects model as pooled risk ratio and the attributable risk (AR). The proportion analysis (including 8 studies; n=853) showed a decreasing pattern of the pooled rates of TTS shifting from the morning to the night (pooled TTS rates: 34.0%; 32.1%; 21.7%; 12.7% in the morning, afternoon, evening and night, respectively). The same pattern was observed stratifying by type of preceding stressful factor or event, considering physical stressors (pooled rates in the morning and night: 37.6% and 9.8%, respectively), and also in case no event could be identified. The pooled rates of TTS onset peaked on Monday and Tuesday (17.3% and 18.4% respectively), then declined during the week, reaching the lowest rates on Friday and Saturday (10.6% and 10.8%, respectively), with no sex differences. TTS onset reached the highest values on summer, and the lowest in winter (27.9% versus 21.7% in summer and winter, respectively). The TTS morning peak based analyses (∼33% of all the registered events) account for a RR of 1.46 (95% CI: 1.38-1.54), the week-based for a RR of 1.26 (1.16-1.35), the season-based for a RR of 1.04 (1.04-1.05). TTS onset exhibits specific chronobiological patterns, characterized by a peak during the morning hours, and on Monday and Tuesday. Differing from other cardiovascular emergencies TTS was more frequent during summer. Further studies are needed to fully understand the underlying pathophysiological mechanisms in order to tailor relative management and preventive strategies
Multiple political geographies
No full textThis chapter delves into the multifaceted realm of political geography within the context of the journal Political Geography. The author, who has held various editorial positions within the journal, navigates the intricate terrain of diversity and inclusion, exploring the challenges posed by linguistic and cultural biases inherent in academic publishing. The chapter critically examines efforts to mitigate barriers and broaden the scope of political geography, questioning the adequacy of current approaches. Through a reflective analysis, the author elucidates the complex dynamics of political geography as a subdiscipline, shedding light on both the impediments and possibilities it offers to researchers and students
Profilo del trascriptoma piastrinico dell'infarto miocardico acuto
No full textAcute myocardial infarction (AMI) is a sudden event commonly attributed to coronary atherosclerotic plaque rupture with subsequent exposure of thrombogenic substances that promote platelet activation/aggregation as well as coagulation activation and, ultimately, intraluminal thrombus formation thus limiting coronary blood flow. Although plaque rupture or fissuring frequently occurs in atherosclerosis, only a small proportion of ruptured plaques develops thromboses. It has been suggested that individual reactivity to plaque rupture may have a causative role in provoking the clinical event of AMI.
Platelets contribute to the genesis and progression of atherosclerosis and to the precipitation of the atherothrombotic event after plaque rupture. Platelets are anucleate cells formed from the cytoplasm of megakaryocytes and circulate in the blood stream for about 7-10 days. Since platelets are without nucleus, they retain megakaryocytes–derived mRNAs that are unique in representing a nearly fixed transcriptome.
The present study was designed to test whether platelets transcriptome may predate the development of a future myocardial infarction.
The abundance of platelets transcripts levels were measured using Human Transcriptome Array 2.0 (Affymetrix). Bioinformatics analyses were conducted to identify the differentially expressed genes (p.value ≤ 0.05, fold-change ≥ ± 1.5) between patients with ST elevation myocardial infarction (STEMI, n=20), stable coronary artery disease (sCAD, n=20) and healthy donors (HD, n=20). REACTOME and DAVID analyses were performed respectively to identify pathways and biological processes associated with lists of differentially expressed genes (DEGs).
A total of 149 DEGs were observed comparing sCAD patients and HD platelet trascriptome. MNF2 and PRKCD were identified as the most up-regulated genes and CXCL8 as the most down-regulated. A number of 76 DEGs were detected in STEMI subjects compared with HD. S100A12 and CLEC4E, in STEMI patients, resulted the highest up-regulated mRNAs while CXCL8 was the most down-regulated followed by SNORD13, SNORD117 and RMRP. The comparison between STEMI and sCAD subjects allowed the identification of 138 de-regulated genes. S100A12 was again the most up-regulated gene in STEMI. From this preliminary analysis, we observed the presence of distinctive gene-expression patterns for sCAD and STEMI. These results suggested the possibility to find a more specific gene-set for STEMI condition. Thus, we focused on the characterization of a gene-signature able to discriminate patients with myocardial infarction and eventually we identified a STEMI signature consisting of 38 genes from these analyses.
In conclusion, our preliminary results show that variations in gene expression profile of megakaryocytes may occur before of an AMI and that platelet transcriptome could act as a fingerprint indicating the development of a future myocardial infarction.L’infarto miocardico acuto (IMA) è un evento improvviso comunemente attribuito alla rottura di una placca aterosclerotica coronarica cui consegue l’esposizione di sostanze trombogeniche che favoriscono l’attivazione/aggregazione piastrinica e l'attivazione della coagulazione con successiva formazione di un trombo endoluminale che interrompe il flusso sanguigno. Anche se la placca aterosclerotica va spesso incontro a rottura/fissurazione, solo in una piccola percentuale di rotture di placca si sviluppa trombosi. È stato suggerito che la reattività dell’individuo alla rottura di placca può avere un ruolo causale nel determinare un infarto miocardico acuto.
Le piastrine contribuiscono alla genesi e alla progressione dell'aterosclerosi e partecipano al processo di aterotrombosi dopo la rottura della placca aterosclerotica. Le piastrine sono cellule anucleate, si formano dal citoplasma dei megacariociti e circolano nel flusso sanguigno per circa 7-10 giorni. Le piastrine sono prive di nucleo e trasportano mRNA di origine megacariocitaria, pertanto il loro trascrittoma viene considerato essere abbastanza stabile.
Lo scopo del presente studio è di verificare se il trascrittoma piastrinico può essere utile nella predatazione dello sviluppo di un infarto miocardico acuto.
I livelli dei trascritti piastrinici sono stati misurati utilizzando Human Transcriptome Array 2.0 (Affymetrix). Analisi bioinformatiche sono state condotte per identificare i geni espressi in modo differenziale (p.value ≤ 0.05, fold change ≥ ± 1.5) tra i pazienti con infarto miocardico con sopraslivellamento del tratto ST (STEMI, n = 20), malattia coronarica stabile (SCAD, n = 20) e donatori sani (HD, n = 20). Inoltre, sono state effettuate ulteriori analisi utilizzando REACTOME e DAVID, rispettivamente per individuare pathways e processi biologici associati con le liste di geni differenzialmente espressi (DEGs).
Nel confronto del trascritto piastrinico tra pazienti sCAD e HD sono stati rilevati un totale di 149 DEGs. MNF2 e PRKCD sono stati identificati come i geni più up-regolati e CXCL8 come il più down-regolato. 76 DEGs sono stati quindi osservati nei soggetti con STEMI rispetto agli HD. S100A12 e CLEC4E, nei pazienti con STEMI, hanno rappresentato gli mRNA più up-regolati mentre CXCL8 il più down-regolato, seguito da SNORD13, SNORD117 e RMRP. Il confronto tra i soggetti con STEMI e sCAD ha permesso di identificare 138 geni deregolati. S100A12 è risultato essere nuovamente il gene più up-regolato negli STEMI. Da queste analisi preliminari abbiamo osservato la presenza di caratteristici modelli di espressione genica per i pazienti sCAD e STEMI. Questi risultati hanno suggerito la possibilità di trovare un set di geni più specifico per i pazienti con STEMI. Così, ci siamo concentrati sulla caratterizzazione di una gene-signature in grado di discriminare i pazienti con infarto miocardico e, alla fine, da questi analisi abbiamo individuato una “signature” dell’infarto miocardico con sopraslivellamento del tratto ST costituita da 38 geni.
In conclusione, i nostri risultati preliminari indicano che variazioni nel profilo di espressione genica potrebbero verificarsi nei megacariociti giorni prima di un infarto miocardico acuto e che il trascriptoma piastrinico potrebbe agire come un potente “fingerprint” indicativo dello sviluppo di un futuro evento coronarico acuto
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