101,854 research outputs found
Conservative treatment of Medication-Related Osteonecrosis of the Jaw (MRONJ) with topical ozone
No full textOBJECTIVES The aim of this case report is to describe the conservative treat ment of medication-related osteo necrosis of the jaw (MRONJ) using topical ozonated gel. Medication-related osteonecrosis of the jaw is defined as a “drug-re lated adverse reaction character ized by the progressive destruc tion and necrosis of the mandibu lar and/or maxillary bone in pa tients exposed to medications known to increase the risk of the condition, in the absence of previ ous radiation therapy”. Epidemiological data on this con dition are supported by robust studies, highlighting significant variability between patients re ceiving high-dose and low-dose treatments, with a higher inci dence in the former group, and across different drugs (class, ac tive ingredient, route of adminis tration, and dosage). Clinically, the most frequently ob served sign is the persistence of bone exposure for more than 8 weeks. However, there are other Ospedale-Università di Padova, from another region initially for suspicion of osteomyelitis in the right hemimandible. diagnostic criteria, referred to as ‘minor’ signs and symptoms. It is important to note that not all cas es of MRONJ present with bone exposure; therefore, in cases of suspicion, these criteria should be further investigated using radio graphic imaging. Radiological investigations are fundamental in the diagnostic work-up, particularly orthopanto mography (OPT) and intraoral ra diographs (first-line), along with computed tomography (CT) (sec ond-line), although radiological signs tend to be non-specific. Diagnosis of MRONJ is primarily based on clinical and radiological findings. MATERIALS AND METHODS A literature review was conducted by consulting the Pubmed data base. The clinical case of a patient referred to the all’Ambulatorio di Patologia e Medicina Orale e Diagnostica Odontostomatologica dell’Unità Operativa Complessa di Clinica Odontoiatrica dell’Azienda Based on the patient’s clinical his tory and the observed clinical and radiological signs and symptoms, a diagnosis of MRONJ was made, as the patient had been taking alendronate for 5 years. The case was classified (stage 2b according to the SIPMO-SICMF classification, with peri-implantitis affecting an implant in the left mandibular region) and treated with topical applications of ozo nated gel. RESULTS In the clinical case reported thanks to the use of topical ozone, a complete healing of the mucosa and partial bone re-mineralization of the site of MRONJ at stage 2b (according to SIPMO/SIMCF 2023 classification) and a total re gression of perimplantitis were achieved, with the possibility of maintaining the implant in arch was observed. ratterizzata dalla progressiva distruzione e necrosi dell’osso mandibolare e/o ma scellare di soggetti esposti al trattamento con farmaci per cui sia accertato un au MRONJ is associated with the use of certain drug classes, and it is crucial to be aware of drug-relat ed, systemic, and local risk fac tors. Early diagnosis enables a more conservative approach to treatment, minimizing the biologi cal burden on patients. CONCLUSIONS While stabilization is commonly regarded as the primary outcome for MRONJ treatment, in this case, complete healing was achieved with a non-invasive approach. CLINICAL SIGNIFICANCE This report describes a case of effective conservative treatment for MRONJ and peri-implantitis using an easy-to-use medical device
Quality of life in asthma and COPD: is it measurable in primary care?
No full textBackground. An observational cross-sectional study under the acronym CORDIS (Chronic Obstructive Respiratory
Disease - Italian Study), performed in primary care centers to evaluate the knowledge and the degree
of control of physician-diagnosed asthma and chronic obstructive pulmonary disease (COPD) by Italian General
Practitioners (GPs). The study consisted of two phases, CORDIS-A and CORDIS-B. The CORDIS-B study
included measurement of the quality of life (QoL) of physician-diagnosed asthma and COPD patients.
Aim. Aim of the study was to evaluate the applicability of QoL assessment by means of the SF-12 Questionnaire
in primary care in subjects with asthma or COPD. Secondary, to evaluate the impact of the two
respiratory diseases on patients’ QoL and to measure the correlation between patients’ and GPs’ opinion on
patients’ health status.
Methods. Patients enrolled in the study were males and females aged more than 18 years, with a physician
(GP or specialist) diagnosis of asthma and/or COPD and treated from at least 12 months with a short-term
inhaled β2-agonist, given alone or as component of a multiple therapy. Patients gave written informed consent
to participate to the study and for personal data use. Each patient enrolled in the study privately filled in the
QoL SF-12 questionnaire; both the patient and the GP gave independently the judgement of patient’s health
(Excellent, Very good, Good, Acceptable, Poor) and the two opinions were compared.
Results. Complete QoL data were available for 11,642 subjects with a mean age of 57 ± 17 years and a
prevalence of males of 55.3%. The percentage of patients with asthma, COPD, and asthma plus COPD was
47.2%, 29.2% and 23.6%, respectively. At least one concomitant disease was present in 67% of patients.
In terms of evaluation of patient’s health status, a perfect concordance between the two types of evaluators
was found in 54.6%; the percentage increased up to 95% when considering just one category of difference
between the GP’s and the patient’s evaluation. As for the general Italian population, no substantial gender
difference was found in our study for the SF-12 “Physical Component Summary” (PCS) and “Mental Component
Summary” (MCS) mean scores. However, the CORDIS-B subjects showed more impaired health status
in comparison to general population. Asthmatic patients showed better PCS and MCS scores in comparison
to patients with COPD or asthma plus COPD (p < 0.0001).
Conclusions. This study shows that a) the SF-12 Questionnaire is a simple and useful tool to measure the
QoL of patients with asthma and COPD in primary care; b) there was a very good agreement in the subjective
evaluation of the patient’s health status between GP and patient; c) mental/psychological component is
underestimated both by GP and patient
Bibliographie Hilarion G. Petzold 1958 – 2009 mit Anhang als Einführung
No full textDieses Archiv enthält die Gesamtbibliographie der Werke des Autors nebst einiger Texte „Über H. G. Petzold“ im Schlussteil der Bibliographie sowie einen Anhang mit einer Einführung in die Architektur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author and some texts about H. G. Petzold, moreover an epilogue with an introduction to the architecture of the works in its epistemological structure and composition and as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2009-petzold-h-g-gesamtbibliographie-h-g-petzold-1958-2009-updating-november2009/peerReviewedpublishedVersio
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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3346: Samuel G. Freedman, author, 2013
No full textPhotograph of author Samuel G. Freedman, at NT Daily Slash meeting in the Mayborn School of Journalism at UNT
The Right to Strike under the United States Constitution: Theory, Practice, and Possible Implications for Canada
No full textAnswering critics of the Canadian Supreme Court's judgment in B.C. Health, the author argues that the Court laid the foundation for a principled and durable doctrine protecting constitutional labour rights, one that goes directly to the heart of the matter — the inequality of workers’ power in the employment relation. In the author’s view, two paths could lead from B.C. Health to the recognition of Charter protec- tion for a right to strike: one that treats the right as an accessory to col- lective bargaining, and one that upholds the right directly on the basis of the Charter values of equality and participation. The author supports the latter approach, contending that constitutional rights should be defined in relation to fundamental values, in a way that is not contingent on time-bound or fact-sensitive assessments about the role of strikes within a particular collective bargaining regime. Although a Charter right to strike may involve the courts in difficult choices about when to defer to legislative policy decisions, and courts may lack the institutional capac- ity to deal effectively with labour law issues, the author points out that judges can look to ILO standards for expert guidance. Noting that the U.S. experience in this area might be of considerable use to Canadians, the author concludes by providing an overview of American case law concerning a constitutional right to strike.Peer reviewe
G-Rank: Unsupervised Continuous Learn-to-Rank for Edge Devices in a P2P Network
No full textRanking algorithms in traditional search engines are powered by enormous training data sets that are meticulously engineered and curated by a centralized entity. Decentralized peer-to-peer (p2p) networks such as torrenting applications and Web3 protocols deliberately eschew centralized databases and computational architectures when designing services and features. As such, robust search-and-rank algorithms designed for such domains must be engineered specifically for decentralized networks, and must be lightweight enough to operate on consumer-grade personal devices such as a smartphone or laptop computer. We introduce G-Rank, an unsupervised ranking algorithm designed exclusively for decentralized networks. We demonstrate that accurate, relevant ranking results can be achieved in fully decentralized networks without any centralized data aggregation, feature engineering, or model training. Furthermore, we show that such results are obtainable with minimal data preprocessing and computational overhead, and can still return highly relevant results even when a user’s device is disconnected from the network. G-Rank is highly modular in design, is not limited to categorical data, and can be implemented in a variety of domains with minimal modification. The results herein show that unsupervised ranking models designed for decentralized p2p networks are not only viable, but worthy of further research.https://github.com/awrgold/G-RankComputer Scienc
Author inscription in The Chinese slave-girl: a story of woman's life in China
No full textThis edition includes a gift inscription by author Rev. J.A. Davis, "To Rev. A. G. Russell with the warmest regards of the author J.A. Davis."Davis, John Agnell, 1839-1897
Wissenschaftliche Bibliographie Hilarion G. Petzold 1958 – 2014 mit Anhang von 2007 als Einführung
No full textDieses Archiv enthält die Gesamtbiliograpie der Werke des Autors bis Dez. 2013 nebst einiger Texte „Über H. G. Petzold“ und einen Anhang mit einer Einführung in die Struktur des Werkes in seinem wissenslogischen Aufbau als Ausarbeitung seines „Tree of Science Modells“ (2007).This archive contains the complete bibliography of the author up to Dec. 2013 and some texts about H. G. Petzold, moreover an appendix with an introduction to the structure of the work in its epistemological structure and composition as an elaborations of Petzold’s „Tree of Science Modell (2007).https://www.fpi-publikation.de/polyloge/01-2014-petzold-h-g-2014-wissenschaftliche-gesamtbibliographie-1958-2014/peerReviewedpublishedVersio
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