432 research outputs found
State of hydrogen sulfide system in the rats brain under combined hyperhomocysteinemia and its correction
No full textZaichko Natalia V., Yurchenko Peter A., Filchukov Denis A. State of hydrogen sulfide system in the rats brain under combined hyperhomocysteinemia and its correction. Journal of Education, Health and Sport. 2015;5(3):183-188. ISSN 2391-8306. DOI: 10.5281/zenodo.16349
http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%283%29%3A183-188
https://pbn.nauka.gov.pl/works/549846
http://dx.doi.org/10.5281/zenodo.16349
Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011 – 2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Deklaracja.
Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie.
Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r.
The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014).
© The Author (s) 2015;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License
(http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial
use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 20.01.2014. Revised 27.02.2015. Accepted: 12.03.2015.
STATE OF hydrogen SULFIDE SYSTEM IN the rats brain UNDER COMBINED hyperhomocysteinemia and its CORRECTION
Natalia V. Zaichko, Peter A. Yurchenko, Denis A. Filchukov
Department of biological and general chemistry,
National Pirogov Memorial Medical University, Vinnytsya, Ukraine
Abstract
The state of hydrogen sulfide (H2S) system was investigated in the brain of rat under combined hyperhomocysteinemia (HHC) and its correction by betaine, vitamins B6, B9, B12 and trace element complex Esmin. Animals hold 14-days on starch-casein diet with 1% methionine in the absence of vitamins B6, B9, B12 caused increase in homocysteine serum to 12.0 times. Combined HHC induced significant decrease in H2S content and inhibition of H2S-synthesizing enzymes in rat’s brain. Normalization of diet, administration of vitamins B6, B9, B12 and Esmin for 7 days caused a decrease in serum homocysteine and increasing H2S content in rat brain. Betaine administration also decreased HHC and but the effect on H2S system in rat brain was not significant.
Keywords: homocysteine, hydrogen sulfide, enzymes, metabolism, brain, betaine, vitamins, trace element complex
ExoMol line lists - III. An improved hot rotation-vibration line list for HCN and HNC
No full textA revised rotation-vibration line list for the combined hydrogen cyanide (HCN)/hydrogen isocyanide (HNC) system is presented. The line list uses ab initio transition intensities calculated previously and extensive data sets of recently measured experimental energy levels. The resulting line list has significantly more accurate wavelengths than previous ones for these systems. An improved value for the separation between HCN and HNC is adopted, leading to an approximately 25 per cent lower predicted thermal population of HNC as a function of temperature in the key 2000 to 3000 K region. Temperature-dependent partition functions and equilibrium constants are presented. The line lists are validated by comparison with laboratory spectra and are presented in full as supplementary data to the article and at www.exomol.com
Trypanosomatids are common and diverse parasites of Drosophila
No full textDrosophila melanogaster is an important model system of immunity and parasite resistance, yet most studies use parasites that do not naturally infect this organism. We have studied trypanosomatids in natural populations to assess the prevalence and diversity of these gut parasites. We collected several species of Drosophila from Europe and surveyed them for trypanosomatids using conserved primers for two genes. We have used the conserved GAPDH sequence to construct a phylogenetic tree and the highly variable spliced leader RNA to assay genetic diversity. All 5 of the species that we examined were infected, and the average prevalence ranged from 1 to 6%. There are several different groups of trypanosomatids, related to other monoxenous Trypanosomatidae. These may represent new trypanosomatid species and were found in different species of European Drosophila from different geographical locations. The detection of a little studied natural pathogen in D. melanogaster and related species provides new opportunities for research into both the Drosophila immune response and the evolution of hosts and parasites.</p
The Golden Horde between Governance and Religious Doctrine: Reflections on A.G. Yurchenko’s Duologue (Golden Horde: Between Yasa and Quran. Beginning of the Conflict. SPb: Evrazija, 2012; Khan Uzbek: Between Empire and Islam (structure of everyday life). Compendium Book. SPb.: Evrazija, 2013) »
No full textThis article contains a review of two monographs by A.G. Yurchenko. In both monographs Yurchenko explores religious situation in the ulus of Jochi in the 13th–15thcenturies. The author of duologue analyzes the structure of everyday life in the Horde State during the 13th–14th centuries, reflecting the ratio of its religious and administrative bases. Yurchenko comes to a conclusion about the existence of a more complex structure of the Horde society in terms of the confessional and political structure of the ulus of Jochi. According to the arguments presented by Yurchenko, one can conclude that the complex social structure preserved even after the Uzbek’s adoption of Islam. At the same time, the imperial “vertical of power” based on nomadic tradition and corresponding rituals changed slowly and reluctantly. However, at the highest administrative level, among the Horde elite, belonging to the Muslim faith became mandatory, and only this affiliation allowed to occupy senior posts in the State. This status of religious doctrine within the political system can justifiably be called a State ideology or religion of the State. At the same time, aspects highlighted by Yurchenko (a model of nomadic State, where religious institutions are separated from the State, and sacral-religious, philosophical discourses of sources on the history of the Horde) deserves attention and further development. To understand the current of social processes within the ulus of Jochi during the 13th–15th centuries, to get closer to scientific knowledge of the real history of the Horde, one should critically deal with the sources and consider the Horde’s reality through the prism of ideologico-religious and philosophical doctrines of the time, especially, in the Middle Ages. This article provides additional arguments both in favor of conceptual constructions of the author and in their rebuttal as well. Author of the review finds it necessary to carefully and critically deal with information of medieval sources on the history of the Horde, taking into account conclusions proposed by Yurchenko
Oxidative single-electron transfer activation of sigma-bonds in aliphatic halogenation reactions
No full textThe reactions of a series of structurally related large-ring propellanes with iodine monochloride were studied experimentally and computationally. In the case of 1,3-dehydroadamantane (1) and [3.3.1]propellane (2) free-radical addition was observed. [3.3.2]Propellane (3) and 3,6-dehydrohomoadamantane (4), which are less prone to radical attack, selectively form products of formal double nucleophilic (oxidative) addition, e.g., dichloro (in ICl/CH2Cl2), dimettloxy (in ICl/CH3OH), and diacetamino (in ICl/CH3CN) derivatives under otherwise identical conditions. Single-electron transfer pathways involving the alkane radical cations are proposed for the activation step for aliphatic hydrocarbons with relatively low oxidation potentials such as cage alkanes. Similar mechanisms are postulated for the activation of the tertiary C-H bonds of adamantane based on H/D-kinetic isotope effect data. The latter compare well to the k(H)/k(D) value for hydrogen atom loss from the adamantane radical cation (measured 2.78 +/- 0.21 and computed 2.0) and differ considerably from the kinetic isotope effects for electrophilic C-H bond activations (i.e., hydride abstraction) or for loss of a proton from a hydrocarbon radical cation (k(H)/k(D) = 1.0-1.4; computed 1.4). Hence, the reactions of alkanes with elementary halogens and other weak electrophiles (but strong oxidizers) do not necessarily involve three-center two-electron species but rather occur via successive single-electron oxidation steps. Upon C-C or C-H fragmentation, the incipient alkane radical cations are trapped by nucleophiles
Letter to Nature: An ultra-relativistic outflow from a neutron star accreting gas from a companion.
No full textCollimated relativistic outflows—also known as jets—are amongst the most energetic phenomena in the Universe. They are associated with supermassive black holes in distant active galactic nuclei1, accreting stellar-mass black holes and neutron stars in binary systems2 and are believed to be responsible for gamma-ray bursts3. The physics of these jets, however, remains something of a mystery in that their bulk velocities, compositions and energetics remain poorly determined. Here we report the discovery of an ultra-relativistic outflow from a neutron star accreting gas within a binary stellar system. The velocity of the outflow is comparable to the fastest-moving flows observed from active galactic nuclei, and its strength is modulated by the rate of accretion of material onto the neutron star. Shocks are energized further downstream in the flow, which are themselves moving at mildly relativistic bulk velocities and are the sites of the observed synchrotron emission from the jet. We conclude that the generation of highly relativistic outflows does not require properties that are unique to black holes, such as an event horizon
MANAGEMENT OF GOVERNEMENT PROCUREMENTS: MODERN PROBLEMS
No full textOpportunism is primarily identified with the policy. However, in the economic sphere is now quite often manifests this concept, which negatively affects the position of the owner of the resource. The opportunism in a prism of economic science is considered in Oliver Uilyamson’s works the Nobel Prize laureate on economy in 2009 with the formulation “for researches in the field of the economic organization”. O. Uilyamson understood as opportunism “following to the interests, including fraudulently, including such obvious forms of deception as lie, theft, fraud here…”. Market relations, this phenomenon does not cause such a violent public backlash, as the market is the market. However, in the field of public participation, namely public procurement market opportunistic behavior of agents is often a public outcry, which requires the development of specific preventive measures. The urgency of this problem is justified considering the constant tightening measures to combat corruption in the state order. In connection with what in this article on the basis of methods of analysis, deduction and systematic approach is considered opportunistic aspect of public procurement in the Russian Federation. The author gives a classification of opportunistic behavior in the current contract system of Russia in accordance with the position of the founder of the concept in economics O.Williamson.The dynamics of the positive economic effect of public procurement market, as well as the dynamics of opportunistic behavior identified by public authorities supervising the observance of the legislation in this area. Proposed focus of reducing the influence of negative trends on the operation of the contract system of the Russian Federation
Restoration of endometrial receptivity and reproductive function in infertile women with excess body weightand complex non-atypical endometrial hyperplasia
No full textNosenko O. M., Yurchenko S. V. Restoration of endometrial receptivity and reproductive function in infertile women with excess body weightand complex non-atypical endometrial hyperplasia. Journal of Education, Health and Sport. 2022;12(1):523-538. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.01.044
https://apcz.umk.pl/JEHS/article/view/41807
https://zenodo.org/record/7521636
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,
provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 05.01.2022. Revised: 21.01.2022. Accepted: 31.01.2022.
RESTORATION OF ENDOMETRIAL RECEPTIVITY AND REPRODUCTIVE FUNCTION IN INFERTILE WOMEN WITH excess body weightAND COMPLEX NON-ATYPICAL ENDOMETRIAL HYPERPLASIA
O. M. Nosenko, S. V. Yurchenko
Odessa National Medical University
Abstract
To date, there are several approaches to the treatment of endometrial hyperplasia, but it is quite unclear which approach provides a higher clinical response with a lower recurrence rate, in addition to preservation and restoration of fertility in infertile women with complex non-atypical endometrial hyperplasia (NEH) and excess body weight. The purpose of the study was to evaluate the effectiveness of the restoration of reproductive function in patients with infertility, complex NEH and with excess body weight according to the proposed method. Material and methods. 74 women of reproductive age with complex NEH, infertility and excess body weight were under observation, of which 34 patients of the main group after hysteroscopic resection of the lesion at the first stage of treatment, at the second stage of treatment received gonadotropin-releasing hormone agonists (aGnRH) and adjuvant therapy with drugs indole-3-carbinol, metformin, fenofibrate for three months, and then at the third stage of treatment dydrogesterone, metformin, a vitamin-mineral complex that included myo-inositol, banaba leaves, extract of 1% corosolic acid, vitamin D3, methylfolate-quatrafolic, chromium for 6 months. 40 patients of the control group after hysteroscopic resection of the lesion at the first stage of treatment were prescribed aGnRH for 3 months in the second stage of treatment, then methylfolate-mvatrafolic for 6 months. Anthropometric data, echometric and morphofunctional characteristics of the endometrium during the expected window of implantation, hormonal profile and levels of peripheral blood lipokines in the dynamics of treatment were studied. Reproductive results were evaluated within a year after the end of treatment. The results. Treatment of complex NEH in the main group led, compared to the control group, to a decrease in body mass index, improvement in echometric and morphofunctional characteristics of the endometrium, its receptivity during the expected window of implantation, hormonal profile and lipokines level in peripheral blood, a decrease in insulin resistance, and an increase in the frequency of pregnancy. Conclusion. The proposed scheme for the treatment of complex NEH in infertile women with excess body weight allowed to improve their reproductive results, is effective and can be recommended for implementation in wide clinical practice.
Key words: infertility; complex non-atypical endometrial hyperplasia; excess body weight; body mass index; endometrium; implantation window; endometrial receptivity; pinopodia; implantation molecules; hormones; steroid hormone receptors; lipokines; insulin resistance; hysteroscopy; gonadotropin-releasing hormone agonists; metformin; fenofibrate; indole-3-carbinol; myo-inositol; corosolic acid; pregnancy
ASSIGNMENT OF INFRARED AMMONIA SPECTRA
No full textAuthor Institution: Department of Physics and Astronomy, University College London, London, WC1E 6BT, UK; Technische Universitat Dresden, Physikalische Chemie, D--01062 Dresden, GermanyGlobal ammonia emissions have more than doubled during the period of industrialisation, largely due to widespread use of intensive agricultural techniques and in particular the use of fertilisers and are are set to double again by 2050. However the ammonia data in the present version of HITRAN is not only missing at key wavelengths, but also have significant problems. HITRAN contains 28~057 NH lines of which some 10~\%\ lack full quantum number assignments. Furthermore 1190 of the assigned lines have demonstrably incorrect assignments (for example are parity forbidden); others have incorrect lower state energies or symmetries leading to incorrect predictions of temperature-dependent spectra. We have undertaken a systematic (re-)analysis of the data in HITRAN. This has been done using both lower state and upper state combination differences starting from a consistent set of lower state energy levels [P. Chen {\it et al}, \textit{J. Mol. Spectrosc.}, {\bf 236}. 116 (2006)] and by using the newly computed variational line list BYTe [S.~N. Yurchenko, R.~J. Barber , and J.~Tennyson, \textit{Mon. Not. R. Astron. Soc., in press}, (2011)]. Previous errors and misassignments have been corrected and significant progress is being making new assignments. Comparisons with the BYTe line list suggest that HITRAN is also missing a significant number of important transtions, particular at frequencies above 5000 cm
Increased genetic diversity and prevalence of co-infection with Trypanosoma spp. in koalas (Phascolarctos cinereus) and their ticks identified using next-generation sequencing (NGS)
No full textInfections with Trypanosoma spp. have been associated with poor health and decreased survival of koalas (Phascolarctos cinereus), particularly in the presence of concurrent pathogens such as Chlamydia and koala retrovirus. The present study describes the application of a next-generation sequencing (NGS)-based assay to characterise the prevalence and genetic diversity of trypanosome communities in koalas and two native species of ticks (Ixodes holocyclus and I. tasmani) removed from koala hosts. Among 168 koalas tested, 32.2% (95% CI: 25.2-39.8%) were positive for at least one Trypanosoma sp. Previously described Trypanosoma spp. from koalas were identified, including T. irwini (32.1%, 95% CI: 25.2-39.8%), T. gilletti (25%, 95% CI: 18.7-32.3%), T. copemani (27.4%, 95% CI: 20.8-34.8%) and T. vegrandis (10.1%, 95% CI: 6.0-15.7%). Trypanosoma noyesi was detected for the first time in koalas, although at a low prevalence (0.6% 95% CI: 0-3.3%), and a novel species (Trypanosoma sp. AB-2017) was identified at a prevalence of 4.8% (95% CI: 2.1-9.2%). Mixed infections with up to five species were present in 27.4% (95% CI: 21-35%) of the koalas, which was significantly higher than the prevalence of single infections 4.8% (95% CI: 2-9%). Overall, a considerably higher proportion (79.7%) of the Trypanosoma sequences isolated from koala blood samples were identified as T. irwini, suggesting this is the dominant species. Co-infections involving T. gilletti, T. irwini, T. copemani, T. vegrandis and Trypanosoma sp. AB-2017 were also detected in ticks, with T. gilletti and T. copemani being the dominant species within the invertebrate hosts. Direct Sanger sequencing of Trypanosoma 18S rRNA gene amplicons was also performed and results revealed that this method was only able to identify the genotypes with greater amount of reads (according to NGS) within koala samples, which highlights the advantages of NGS in detecting mixed infections. The present study provides new insights on the natural genetic diversity of Trypanosoma communities infecting koalas and constitutes a benchmark for future clinical and epidemiological studies required to quantify the contribution of trypanosome infections on koala survival rates
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