624 research outputs found
What Did Matthieu Beroald Transmit to François Béroalde de Verville?
No full text Many tangible and intangible goods were passed down within early modern families. The goods included texts and the knowledge that texts communicated. But how did they relate to the other goods transmitted within families? That question is explored in relation to the scholar Matthieu Beroald and his son François Béroalde de Verville, author of the famous Moyen de parvenir. Matthieu transmitted to François a humanist education, at least one printed volume (probably more), an interest in certain topics (especially chronology), a network of contacts, but little wealth. And François soon donated to his sisters what wealth he did receive. His relationship to his intellectual inheritance from his father was complex and ambivalent. Aspects of François's attitude towards knowledge may have stemmed, via his father, from two grandfather-figures: Matthieu's own father (a barber-surgeon) and Matthieu's relative and benefactor François Vatable (the Hebraicist). </jats:p
Understanding drivers of experimental malaria sub-unit vaccine induced immunity in Tanzania volunteers
No full textDespite being a preventable and treatable disease, Plasmodium falciparum malaria remains a major threat, especially in children and pregnant women in sub-Saharan Africa. Considerable progress has been achieved during the past decade, however, these positive trends have stalled in 2017. Efforts towards better disease control and focal elimination are hindered by development and spread of insecticide and drug resistance, leaving a malaria vaccine as a required tool to complement these approaches. RTS, S a subunit pre-erythrocyte stage vaccine is the only advanced malaria vaccine that has received approval for pilot administration in three countries in sub-Saharan Africa. This vaccine is however challenged by low efficacy and fast waning of protection. There is, therefore, an urgent need for the development of more potent malaria vaccines. WHO targets malaria elimination by 2030 and achieving this goal will depend on stopping malaria transmission. This goal will largely depend on reducing asexual blood stage Plasmodium parasites – which are not only the cause of morbidity and mortality -but also responsible for the development of gametocytes. Induction of parasite growth inhibitory antibodies has been shown to be key for protection following natural exposure and therefore, many vaccine development approaches try to follow this guidance from nature.
In order to reach this goal of a highly protective vaccine targeting asexual blood stages with acceptable longevity of duration, more research is needed understand mechanisms of optimal induction of long-lived antibody responses in a population that is also affected from other co-infections like helminths or HIV. Therefore, this thesis aimed to 1) investigate a novel blood stage sub-unit malaria vaccine candidate, P27A, for its potential to induce long-lasting antibody responses when formulated in the novel adjuvant GLA-SE in malaria pre-exposed populations, 2) understanding magnitude and cytokine production of the CD4 T cell responses induced by this novel vaccine formulation and the interaction with ongoing helminth co-infections, 3) shed more light on the mechanism of GLA-SE adjuvant being able to induce high and long-lasting antibody responses by studying follicular helper T cells in peripheral blood, 4) implement lymph node excision biopsy in rural Tanzania for detailed investigation of germinal centre responses which are crucial for production of potent antibody response.
The antigen P27A, when formulated with GLA-SE, induced a robust humoral immunity, with enhanced production of cytophilic antibodies, IgG1 and IgG3 and expansion of CD4 Th1 cells producing IL2, TNFa and IFNg, and subsequent memory development. In addition, the adjuvant GLA-SE promoted the expansion of peripheral follicular helper T cells and recruitment of T cells bearing common T cell receptors, which is essential for a vaccine intended for the general population
Location, dynamics and expression of functional proteins in the HIV viral reservoir
No full textAfter HIV infection, the virus quickly spreads throughout the body and establishes a viral reservoir. Although effective Antiretroviral therapy (ART) can inhibit viral replication, functional virus persists in CD4+ T cells and is difficult to clear in large numbers in lymphoid organs. To better characterize these CD4+ T cells carrying replication-competent viruses, we established the HIV Gag and Envelope Reactivation co-Detection Assay (GERDA) and analyzed the tissue homing properties of cells that transiently appear in circulating blood. The presence and function of HIV in key body compartments was confirmed by GERDA in combination with proviral DNA and poly-A transcripts, with low viral activity in circulating cells early after diagnosis. CD4+ T cells carrying replication-competent virus were more likely to be lymph node homing, with TN and TCM being the primary viral reservoirs. We then performed an in- depth analysis of the env regions of circulating PBMCs and T cell subsets, and we found that individual immune system function was negatively correlated with the diversity of viral reservoirs, with archived viral sequences often containing inactivating mutations and showing higher genetic diversity in TTM and TEM.
HIV Tat can activate viral transcription by interacting with transactivation response element (TAR), Rev is needed for expression of late genes (eg Env, Gag). With a series of Tat and Rev mutants, we revealed a regulatory role for Rev in the early events of viral infection, and we found that premature expression of Rev in an artifact produced a dominant negative phenotype that interfered with wild-type viral production, suggesting that the non- complementary negative effects of Rev when expressed prior to HIV infection or prior to Tat expression suggest that i) Tat and Rev functions can be decoupled (Env expression without Tat) and ii) strict kinetic dependence is critical for a productive HIV infection in vitro. Our results provide an overall analysis of not only the location and dynamics of the viral reservoir but also the protein function of the virus, which provides a theoretical basis for understanding and clearing HIV latent reservoirs
Social protection
No full textThis chapter analyses models of social protection. The author (Matthieu Clément) first discusses several recent programmes and proceeds by implementing Esping-Andersen’s analytical framework accounting for the plurality of social protection logics and actors. He finds that the two main dimensions that help differentiate social protection types across countries are the extent of decommodification and the extent of informal social protection. Four models of social protection are identified. Although China, India or Brazil, together with Latin American reformers, all fall into the USA-like liberal type, the other emerging countries fall into the social insecurity model, with migrant remittances playing a key role in bolstering family income in the country of origin. The last two models, which are specific to developing economies, are described in detail
L'Ouvrage incomplet sur Matthieu (Opus imperfectum in Matthaeum) et les commentaires en latin sur l'évangile de Matthieu de l'Antiquité. Comparaison exégétique et stylistique ciblée sur la partie A (Mt 1-8)
No full textAs part of the critical edition project of the Incomplete Work on Matthew (Opus imperfectum in Matthaeum, OIM), the present thesis analyzes the links between this anonymous commentary on the Gospel of Matthew, coming from a Riminian subordinationist environment (i.e. “Homean”), and other Latin exegetical works on the same gospel. After recalling, in a state of research, the main characteristics of the corpus taken into account, we carried out a continued exegetical comparison relating to the section Mt 1-8, corresponding to the first part of the OIM, with the fragments remains of the commentary on Matthew by Origen (3rd century), the commentaries on Matthew by Fortunatian of Aquileia and Hilary of Poitiers (mid-4th century), those of Jerome and Chromatius of Aquileia (late 4th century), and the texts by an anonymous Latin author from late Antiquity known as pseudo-Origen. This study was accompanied by a stylistic comparison on certain aspects (appellations of Christ, exegetical vocabulary, personal marks), highlighting the profound originality of the OIM in this regard. The results of this double comparison confirm the deep link of the OIM with Origen's Commentary on Matthew, an influence that the anonymous author shares with Jerome. Furthermore, our study shows for the first time the use in the OIM of the Commentary on Matthew by Chromatius of Aquileia. Finally, the results of the stylistic comparison, accompanied by a theological analysis of the translator's positions, tend to confirm that it is indeed to the author of the OIM that we owe the ancient Latin translation of the Commentary on Matthew of Origen.S'inscrivant dans le projet d'édition critique de l'Ouvrage incomplet sur Matthieu (Opus imperfectum in Matthaeum, OIM), la présente thèse analyse les liens entre ce commentaire anonyme sur l'évangile de Matthieu, provenant d'un milieu subordinationiste riminien (i.e. « homéen »), et d'autres ouvrages exégétiques latins sur le même évangile. Après avoir rappelé, dans un état de la recherche, les principales caractéristiques du corpus pris en compte, nous avons procédé à une comparaison exégétique suivie portant sur la section Mt 1-8, correspondant à la première partie de l'OIM, avec les commentaires sur Matthieu de Fortunatien d'Aquilée et d'Hilaire de Poitiers (milieu IVe siècle), ceux de Jérôme et Chromace d'Aquilée (fin IVe siècle), et les textes d'un auteur latin anonyme de la fin de l'Antiquité surnommé le pseudo-Origène. Cette étude s'est doublée d'une comparaison stylistique sur quelques aspects (appellations du Christ, vocabulaire exégétique, marques de personne), faisant ressortir la profonde originalité de l'OIM à cet égard. Le bilan de cette double comparaison confirme l'influence profonde du Commentaire sur Matthieu d'Origène sur l'OIM, ce qui rapproche l'auteur anonyme de Jérôme. De plus, notre étude met en évidence pour la première fois son utilisation du Commentaire sur Matthieu de Chromace d'Aquilée. Enfin, les résultats de la comparaison stylistique, assortis d'une analyse théologique des positions du traducteur, tendent à confirmer que c'est bien à l'auteur de l'OIM que nous devons l'ancienne traduction latine du Commentaire sur Matthieu d'Origène
How Autistic Brains Grow Differently: Hippocampal Neurogenesis in the 16p11.2 Heterozygous Mouse, a Model of Non-syndromic Autism
No full textThis work was produced while the author was an undergraduate student in the Summer Research Institute of the Ronald E. McNair Post Baccalaureate Degree Achievement Program at Rutgers University
Van last naar les: Hoe publiek-private samenwerking de regenwateroverlast voor inwoners, woningeigenaren en klanten kan verlagen. Een analyse van schadegegevens en de factoren die van invloed zijn op regenwaterschade
No full textIn het Impactproject ‘Samen met verzekeraars naar een regenbestendige stad’ hebben we de werelden van een verzekeraar, onderzoeker en gemeente/waterbeheerder bij elkaar gebracht. Amsterdam Rainproof, Waternet, Achmea en TU Delft zijn de samenwerking aangegaan om de impact van extreme regenval op bewoners in Amsterdam te analyseren en te verkennen hoe hierop te anticiperen om zo de waterschade te verminderen en het woongenot te vergroten. Het vertrekpunt van het Impactproject is de wateroverlast en schade die inwoners van Amsterdam, waaronder de klanten van Achmea, ondervonden als gevolg van extreme regenval. We willen hierbij in eerste instantie de manieren inzichtelijk maken waarop eigenaren van woningen, huurders, verzekeraars en Waternet alleen en in samenhang met elkaar kunnen anticiperen op een wolkbreuk om waterschade te verminderen. In tweede instantie willen we de werkwijze verbeteren waarmee betrokken organisaties informatie over schade inwinnen en delen. We hebben de schade van de wolkbreuk van 28 juli 2014 onderzocht door middel van een analyse van bestaande verzekeringsdata van Achmea verrijkt met andere openbare data, en meldingen van wateroverlast bij Waternet, de gemeente Amsterdam en de Brandweer. Daarnaast hebben we door middel van een bewonersenquête in Oud-Zuid en Oud-West gekeken naar de factoren die bijdragen aan waterschade en naar de werkelijk ervaren schade. Deze onderzoeken geven een beeld van de wateroverlast en schade die optreedt tijdens en na een wolkbreuk, en inzicht in de effectieve voorzorgsmaatregelen die genomen kunnen worden om schade te verminderen. Om de persoonsgegevens van alle betrokken bewoners in het onderzoeksgebied te beschermen hebben we gezorgd dat bij de aanpak van de onderzoeken informatie van verschillende bronnen (verzekeringsdata, meldingen bij Waternet) niet te combineren is op adresniveau, maar slechts op 6-cijferig postcode niveau. Individuele resultaten van de bewoners enquête heeft de TU Delft niet onderling gedeeld met Waternet en Achmea. In dit rapport zijn alleen geaggregeerde resultaten van de bewonersenquête terug te vinden; zonder verwijzing naar een individueel adres of persoon
Traduire, imiter et réécrire Agamemnon à la Renaissance : les tragédies de Charles Toutain (1556), Roland Brisset (1589) et Pierre Matthieu (1589)
No full textLe théâtre de Sénèque a exercé une influence majeure sur le développement de la tragédie française au XVIe siècle. Sa tragédie Agamemnon est ainsi à l’origine des pièces de Charles Toutain, Roland Brisset et Pierre Matthieu. D’un auteur à l’autre, l’écart avec le texte-source devient toutefois de plus en plus important. D’abord entreprise, chez Toutain, avec le souci d’enrichir la langue française, la traduction se fait davantage imitation chez Brisset, dans l’objectif d’instruire le public en lui offrant à méditer le destin malheureux des Grands. La pièce de Matthieu propose quant à elle une interprétation nouvelle du mythe en recourant à l’invention de scènes et de dialogues. Les modifications apportées à l’intrigue originale contribuent à donner une orientation plus politique au mythe d’Agamemnon, par le développement de la thématique de la destruction de Troie et l’inflexion donnée au personnage d’Agamemnon, envisagé à la fois comme une victime expiatoire et un roi devant payer le prix de son ambition.
The drama of Seneca exercised a major influence on the development of French tragedy in the sixteenth century. His tragedy Agamemnon is thus the origin of plays by Charles Toutain, Roland Brisset and Pierre Matthieu. From one author to another, divergence from the source text became more and more considerable. Initially undertaken by Toutain to enrich the French language, translation became more like imitation with Brisset, in order to educate the public by offering to mediate the unlucky fate of the ancients. The play by Matthieu proposed a new interpretation of the myth by resorting to the invention of scenes and dialogues. The modifications to the original intrigue contributed to a more political orientation of the myth of Agamemnon, through the development of the theme of the destruction of Troy and the inflexion given to the character of Agamemnon, portrayed as both an expiatory victim and a king paying the price of his ambition
Analyse factorielle dynamique multifréquence appliquée à la datation de la conjoncture française
No full textThe author describes a dynamic-factor model to date the French economic cycle on a monthly basis from 1985 to the present, using the methodology proposed by Murasawa and Mariano. The model, estimated using a Kalman filter, assumes a common monthly dynamic between quarterly GDP and other major quantitative indicators of the French economy. The resulting indicator enables us to distinguish seven cyclical phases during the period. Only one recession appears, from September 1992 to May 1993. We also apply the method to business surveys in manufacturing in order to re-examine the “ synthetic ” business-climate indicator published by INSEE.Un modèle à facteurs dynamiques est proposé pour dater au niveau mensuel la conjoncture française de 1985 à nos jours, en suivant la méthodologie proposée par Murasawa et Mariano. Ce modèle suppose une dynamique mensuelle commune entre le PIB trimestriel et d'autres grands indicateurs mensuels quantitatifs de l’économie française. L’estimation est effectuée par un filtre de Kalman. Au vu de l’indicateur ainsi construit, nous distinguons sept phases de conjoncture durant cette période. Une seule récession apparaît, de septembre 1992 à mai 1993. Enfin, cette méthode est appliquée aux enquêtes de conjoncture dans l’industrie afin de revisiter l’indicateur synthétique du climat des affaires publié par l’Insee.Cornec Matthieu. Analyse factorielle dynamique multifréquence appliquée à la datation de la conjoncture française. In: Économie & prévision, n°172, 2006-1. pp. 29-43
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