125,231 research outputs found
Colloquia dua et viva humanae vitae eiusdem
No full textBecker, Johannes Arbor eruditionis VD16 B 1359Becker, Johannes Colloquia duo ... alterum adulationis et paupertatis VD16 B 1360Collenuccio, Pandolfo Agenoria VD16 C 4562Collenuccio, Pandolfo Alithia VD16 C 4565Collenuccio, Pandolfo Bombarda VD16 C 4567Collenuccio, Pandolfo Misopenes VD16 C 4570Bibliografischer Nachweis.: VD16 B 1361Erscheinungsvermerk in Vorlageform im Kolophon: Basileae. Ex Officina Ioannis Oporini, Anno M.D.XLVII. Mense Maio
SPK
No full textA new technology recently became readily available in the field of advanced manufacturing and the question of how this manufacturing innovation could be applied to the design of objects arose. Existing manufacturing methods require either time consuming handcraft skills or costly and restrictive industrial methods such as injection moulding or sheet metal pressing. Selective Laser Sintering (SLS) and Direct Metal Lasering Sintering (DMLS) technologies enable rapid manufacture of objects in high performance materials using 3D CAD models and are predicted to challenge traditional manufacturing systems. The SPK bowl emerged out of research into the extent of suitability of SLS and DMLS technologies as alternative manufacturing methods. The SPK bowl provides a unique solution that maintains the ability to satisfy the dual functions of a container and an appealing visual object. It is an object that could not be made using any other method. Exploiting the inherent peculiarities of the SLS technology enabled me to uncover a design solution that would be virtually impossible using other methods. The SPK bowl is significant as it represents an outcome from a practice-led research investigation into a new manufacturing paradigm. The Selective Laser Sintering technology can generate final (market ready) objects direct from 3D CAD models providing designers and manufacturers with a new method for evaluation when considering manufacturing options. The SPK bowl also provides a platform for the development of new objects that can now be distinguished from existing products, therefore creating a new typology of product
The pathogenesis of Friedreich ataxia and the structure and function of frataxin.
No full textUnderstanding the role of frataxin in mitochondria is key to an understanding of the pathogenesis of Friedreich ataxia. Frataxins are small essential proteins whose deficiency causes a range of metabolic disturbances, which include oxidative stress, deficit of iron-sulphur clusters, and defects in heme synthesis, sulfur amino acid and energy metabolism, stress response, and mitochondrial function. Structural studies carried out on different orthologues have shown that the frataxin fold consists of a flexible N-terminal region present only in eukaryotes and in a highly conserved C-terminal globular domain. Frataxins bind iron directly but with very unusual properties: iron coordination is achieved solely by glutamates and aspartates exposed on the protein surface. It has been suggested that frataxin function is that of a ferritin-like protein, an iron chaperone of the iron sulphur cluster machinery and heme metabolism and/or a controller of cellular oxidative stress. To understand FRDA pathogenesis and to design novel therapeutic strategies, we must first precisely identify the cellular role of frataxin.Journal ArticleResearch Support, Non-U.S. Gov'tReviewinfo:eu-repo/semantics/publishe
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
LOOK
No full textThe LOOK series of mirrors was included in the exhibition, Safety Catch (UTS Gallery 8 August- 1 September 2006). A prime objective of the Safety Catch project was the presentation of a response from an Australian perspective to the emergent issue of critical design. In the exhibition, the concept of critical design was understood as design that asks questions and engages the user in reflective and speculative processes, challenging preconceptions and givens about the role products play in everyday life. As curator of the exhibition, I invited a range of Australian object designers to respond to issues of safety and security. Following the framing concept, I selected the mirror as an object that could be investigated further. The LOOK series of mirrors emerged out of questions around the extent of impact an object could have on the user's awareness of and interaction with things and people around them. The series was composed of three round, same-sized mirrors, each incorporating a different component that literally challenged the user's view. The mirrors were configured in such a way that while maintaining their primary reflective function, users also looked 'into' the mirror, inviting a reflection beyond themselves. Confronted with elegantly incorporated yet disturbing elements such as red laser target lights, tangles of barbed wire and rifle bulles, the tone of the design intervention was provocative and used the strategy of a 'double-take' to elicit response
Tris(pyrazol-1-yl)borate and tris(pyrazol-1-yl)methane: A DFT study of their different binding capability toward Ag(I) and Cu(I) cations
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Inorganica Chimica Acta
Volume 362, Issue 12, 15 September 2009, Pages 4358-4364
Tris(pyrazol-1-yl)borate and tris(pyrazol-1-yl)methane: A DFT study of their different binding capability toward Ag(I) and Cu(I) cations (Article)
Casarin, M.acd , Forrer, D.ad, Garau, F.a, Pandolfo, L.ad, Pettinari, C.b, Vittadini, A.cd
a Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35131 Padova, Italy
b Dipartimento di Scienze Chimiche, Camerino, Italy
c Istituto di Scienze Molecolari, CNR, Padova, Italy
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Abstract
Density functional theory has been used to study the electronic structure of [M(tp)] and [M(tpm)]+ conformers (M = Cu, Ag; tp = tris(pyrazol-1-yl)borate anion, tpm = tris(pyrazol-1-yl)methane) and the energetics of their interconversions. Results for the free tp ligand are similar to those of tpm [M. Casarin, D. Forrer, F. Garau, L. Pandolfo, C. Pettinari, A. Vittadini, J. Phys. Chem. A 112 (2008) 6723], indicating an intrinsic instability of the tripodal conformation (κ3-like). This points out that, though frequently observed, the κ3-coordinative mode is unlikely to be directly achieved through the interaction of M(I) with the κ3-like tp/tpm conformer. Analogously to the [M(tpm)]+ molecular ions, the energy barrier for the κ2-[M(tp)] → κ3-[M(tp)] conversion is computed to be negligible. Though κn-[M(tp)] and κn-[M(tpm)]+ (n = 1, 2, 3) have similar metal-ligand covalent interactions, the negative charge associated to the tp ligand makes the M-tp bonding stronger
JOOGE, BUCO, LOR and CYL
No full textThe exhibition 'Conversation of Things New' curated by Heidi Dokulil and held at Object Gallery, St Margaret's Complex, Sydney, September 2-24, 2006, explored 'a unique collaborative process between some of Australia's freshest and youngest designers, and Italy's rich heritage of manufacturers'. (Exhibition Catalogue, p. 4.). The designers included Abi Alice, Simone LeAmon, Matrc Newson, Steven Blaess, Susan Cohn, Berto Pandolfo, Helen Kontouris, Brodie Neill, Adam Goodrum, Lisa Vinicitorio, Brian Steendyk and Shareen Joel. The manufacturers included: Alessi; B&B Italia, Cappellini, Edra, \Erreti, Flos, Kundalini, Magis, Moroso, Oluce, Outlook Design Italis, Progetti and Serralunga. Four of my designs were selected for exhibition: JOOGE outdoor lighting fixture, BUCO door stop, LOR clock and CYL photo frame. Secondary support material presented in the exhibition included: anecdotal conversations between myself and the Italian manufacturers, sketches, photographs, prototypes and production samples of each design. Together my four designs form a unique collection of objects. They represent design projects that have utilised both advanced and low-tech manufacturing methods, they are objects manufactured by both large and small companies and they target markets both low and high. My contribution to the industrial design field demonstrates that international collaborative design projects can operate with radically different project parameters and produce innovative and diverse of design outcomes
“A New Entry to Benzo[4,5]furo[3,2-b]pyridines via Benzofuran-3-yl phosphorane.”
No full textMild thermal reaction of enones with N-(benzofuran-3-
yl)iminophosphorane, newly prepared by Staudinger reaction of 3-
azidobenzofuran with triphenylphosphine, provides a synthetic entry to virtually unknown benzo[4,5]furo[3,2-b]pyridines via a tandem aza-Wittig–electrocyclization process.
Key words: iminophosphoranes, azides, aza-Wittig, electrocyclizatio
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
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