530 research outputs found
Living Books
No full textOne of the most delightful experiences I have had in a long time. There are two modes for experiencing this program. One runs through the twelve pages one by one, with plenty of animation and music for each event in the story. The other is especially entertaining. The viewer can play with each page, clicking on various objects in the individual picture. Rows of carrots turn into dancers, and tomatoes on the vine turn into a vocal group. Other carrots take off like space missiles. Click on the water and you are liable to see a fish jump up and fly around a bit before bringing the program and picture back to the starting point. Gives new meaning for me to the word interactive. I love it! The boxed CD-ROM comes with a booklet by the same title.This is a hardbound book (hard cover)Language note: English and SpanishProduct Managers: Todd Power and Liza Weiman. English and Spanish. Product Design: Mark Schlichting. Art Direction: Bridget Erdman
Effects of thermal processing on antioxidant, phenolic and anthocyanin levels in blackcurrant juice
No full textHealth and Wellness continues to be a major driver for consumers within the current marketplace. Given this climate, superfruits such as blackcurrant (Ribes nigrum) are gaining interest among beverage manufacturers due to their high content of antioxidants and anthocyanins. Blackcurrant juice, while very popular in Europe, is just beginning to gain acceptance in the domestic marketplace.
Various thermal processes are required throughout the production of a shelf stable juice product at both the raw material and finished beverage stages. The goal of this research is to evaluate the effect of these thermal processes on the retention of heat sensitive compounds such as phenolics, anthocyanins and overall antioxidants in the final consumer beverage. To this end, bulk samples of 13 brix flash pasteurized and 65 brix concentrated blackcurrant juice were obtained and further processed at beverage scale. The beverage scale processing entailed the three key thermal processes utilized by retail manufacturers: aseptic, hotfill and tunnel pasteurization. The raw material juices and fully processed samples were then analyzed for anthocyanin content, total phenolic content and antioxidant capacity to understand retention of these nutrients in the post process beverage.
The findings of this study show marked losses at the raw material level of all measured components with a reduction in Phenolic Content of approximately 35%, a reduction of Antioxidant Capacity by 48% and, most significantly, a reduction of Anthocyanin Content of approximately 80% in the concentrated juice as compared to the flash pasteurized Not From Concentrate (NFC) juice. The anthocyanin content was seen to undergo additional degradation (40-50%) by further processing the juice at beverage level, while little or no further change in either antioxidant capacity or phenolic content was seen. There was little to no difference in the impact of aseptic, hotfill or tunnel pasteurization as compared to each other.
Understanding the relationship between process and retention will allow industry to leverage the proper processes required to deliver the desired health benefits to consumers.M.S.Includes bibliographical references (p. 53-56)by Bridget A. Skahil
Examining co-teaching practices, models and support in a large suburban high school district
No full textSubmission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-11 without embargo termsThe student, Bridget La Porte, accepted the attached license on 2022-01-30 at 12:48.The student, Bridget La Porte, submitted this Dissertation for approval on 2022-01-30 at 13:03.This Dissertation was approved for publication on 2022-02-01 at 09:26.DSpace SAF Submission Ingestion Package generated from Vireo submission #17493 on 2022-11-11 at 13:04:18When school districts do not have established policies to guide training, practice and professional development for all co-teaching staff, inconsistencies and inequities may arise for the student populations most directly impacted by the lack of those policies, including both general and special education students. In order to best serve the students of all abilities that populate co-taught classes, it is necessary to establish a culture of inclusion that is founded upon research-based models and practices, along with built-in training and support for co-teachers that will provide the most effective learning environment for the students and the most positive working environment for the co-teachers. Co-teaching (or collaborative teaching) requires the coordinated efforts of at least two teachers, typically one general education and one special education, who share their expertise and skills in order to teach a class with students of all abilities (Bauwens & Hourcade, 1997b). This research identified the current state of co-teaching training, practices and support at a large suburban high school district in the Midwest of the United States, referred to as Sample High School throughout this study. In order to accomplish this research, a qualitative study was performed using a Google form survey, which consisted of questions that gathered data from the co-teachers within the district, and interviews with eight building and district administrators, in order to identify current training and support practices for co-teaching. The culturally sustaining pedagogy described by Waitoller and Thorius (2016) was used to analyze the findings from this study, in order to support a sustainable culture of inclusion in practice. The results from both the co-teacher surveys and the administrator interviews revealed gaps in communication and understanding of co-teaching practices in the district, identified the lack of formality in regards to co-teaching team formation, training and professional development, showed impacts from the 2020-2021 pandemic school year restrictions and acknowledged a desire to improve current practices. Based on these findings, several implications for improvements to the district’s current practices, including the establishment of a clear co-teaching mission and vision, improving the reputation of co-taught classes and establishing leveled co-teacher training and in-district professional development were suggested, in order to maintain a sustainable culture of inclusion in practice within the district
Pilgrims and Saints: Here Comes Everybody!
No full textBridget Burke Ravizza is a Professor of Theology and Religious Studies at St. Norbert College. Bridget earned her doctorate in Theological Ethics at Boston College. Her work focuses on sexual ethics and the ethics of marriage and family. She is co-author (with Julie Donovan Massey, M.Div.) of Project Holiness: Marriage as a Workshop for Everyday Saints. The book draws on the experience of married couples in Catholic parishes to identify the virtues and values that lead to flourishing marriages and to the holiness of married partners.
About the Lecture
Oh, how I want to be in that number, when the saints go marching in. Christians are a people on the move, and we do not travel alone. Rather, we journey together toward God as part of “the communion of saints.” Join us as we consider the theological and ethical implications of belonging to the communion of saints
The edge of meaning: Polish translations of the Bridget Jones film series
No full textNiniejszy artykuł poświęcony jest analizie translatorskiej polskich tłumaczeń ekranizacji Dziennika Bridget Jones i Bridget Jones 3. Głównym zadaniem tekstu tłumaczenia jest przybliżenie znaczenia tekstu wyjściowego. Jednak nigdy dwie osoby nie wykonają tłumaczenia identycznie. Zawsze jest ono indywidualnym, niepowtarzalnym tekstem autora – tłumacza filmowego, odzwierciedleniem jego idiolektu. Forma tekstu docelowego uzależniona jest od poziomu umiejętności translatorskich, które determinują poszczególne rozwiązania tłumaczeniowe fragmentów problematycznych (nieoczywistych) tekstu wyjściowego. Sposób radzenia sobie z tymi trudnościami określa format tłumacza. W artykule omówiono dwa tłumaczenia dwóch różnych tłumaczek i podjęta próba oceny ich warsztatu.This paper analyses Polish translations of two romantic comedy films Bridget Jones’ Diary and Bridget Jones’ Baby. The main goal of a translated text is to convey the meaning of an original. However, it is impossible for any two persons to deliver identical translations. It is always an individual, unique text of the particular author – a film translator and it reflects his or her idiolect. The form of the translated text depends on translator’s skills as they determine particular solutions for problematic fragments (not selfevident) of the original. The choices of translators define their level of mastery. The paper analyses two translations of two different persons and attempts to assess their craft
Screenwriting:Creative labor and professional practice
No full textScreenwriting: Creative Labor and Professional Practice analyzes the histories, practices, identities and subjects which form and shape the daily working lives of screenwriters. Author Bridget Conor considers the ways in which contemporary screenwriters navigate and make sense of the labor markets in which they are immersed. Chapters explore areas including: • Screenwriting histories and myths of the profession • Screenwriting as creative labor • Screenwriters’ working lives • Screenwriting work and the how-to genre • Screenwriting work and inequalities Drawing on historical and critical perspectives of mainstream screenwriting in the USA and UK, as well as valuable interviews with working screenwriters, this book presents a highly original and multi-faceted study of screenwriting as creative labor and professional practice.</p
Managing food safety and hygiene: governance and regulation as risk management
No full textFood safety and hygiene is of critical importance to us all. In this wide ranging book, Bridget Hutter explores how we are all dependent on others to ensure that the food we consume from food in the retailing and hospitality sectors is safe. This has prompted a governance system embracing state regulation and groups beyond the state such as consumers, insurance, media and businesses themselves. The book argues that state regulation is ‘necessary but not sufficient’ as an influence on business risk management practices. Using research data from the UK, the author examines the relative importance of these other groups, in relation to each other and in relation to state regulation
Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486
No full textFragile X syndrome (FXS) is the most common inherited form of autism and intellectual disability and is caused by the silencing of a single gene, fragile X mental retardation 1 (Fmr1). The Fmr1 KO mouse displays phenotypes similar to symptoms in the human condition—including hyperactivity, repetitive behaviors, and seizures—as well as analogous abnormalities in the density of dendritic spines. Here we take a hypothesis-driven, mechanism-based approach to the search for an effective therapy for FXS. We hypothesize that a treatment that rescues the dendritic spine defect in Fmr1 KO mice may also ameliorate autism-like behavioral symptoms. Thus, we targeted a protein that regulates spines through modulation of actin cytoskeleton dynamics: p21-activated kinase (PAK). Our results demonstrate that a potent small molecule inhibitor of group I PAKs reverses dendritic spine phenotypes in Fmr1 KO mice. Moreover, this PAK inhibitor—which we call FRAX486—also rescues seizures and behavioral abnormalities such as hyperactivity and repetitive movements, thereby supporting the hypothesis that a drug treatment that reverses the spine abnormalities can also treat neurological and behavioral symptoms. Finally, a single administration of FRAX486 is sufficient to rescue all of these phenotypes in adult Fmr1 KO mice, demonstrating the potential for rapid, postdiagnostic therapy in adults with FXS.National Institutes of Health (U.S.) (Grant R01-MH078821)National Institutes of Health (U.S.) (Grant P50-MH58880)RIKEN Brain Science InstituteMassachusetts Institute of Technology. Simons Center for the Social Brai
Rescue of FXS phenotypes in Fmr1 knockout mice by the small molecule p21-activated kinase inhibitor FRAX486
No full textThesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2012.Cataloged from PDF version of thesis.Includes bibliographical references (p. 192-226).Autism is a diverse and complex family of disorders, and its prevalence is on the rise: 1 in 110 children have autism. There is no effective treatment for the symptoms which often include language and communication deficits, repetitive behavior, intellectual disability, epilepsy, attention deficits, and hyperactivity. The quest for a cure is challenging due to the heterogeneity of the disorder, but also because more than 90% of cases of autism are idiopathic, meaning the cause is unknown. Fortunately, one cause of autism has been discovered: silencing of a single gene causes an autism-like disorder called Fragile X Syndrome (FXS). The knowledge of the genetic basis of FXS allowed for the development of a mouse model of autism. The fmr1 knockout (KO) mouse displays phenotypes similar to symptoms in the human condition - including hyperactivity, repetitive behaviors, and seizures. Humans and mice share not only behavioral expression of the disease, but also analogous abnormalities in the density and morphology of dendritic spines - the sites of connections between neurons and critical substrates for learning. Abnormal dendritic spines is a common feature in FXS, idiopathic autism, and intellectual disability. Thus, this neuroanatomical abnormality may contribute to disease symptoms and severity. Here we take a hypothesis-driven, mechanism-based approach to the search for an effective therapy for FXS. We hypothesize that a treatment that rescues the dendritic spine defect may also ameliorate behavioral symptoms. Thus, we targeted a protein that regulates spines through modulation of actin cytoskeleton dynamics: p21-activated kinase (PAK). In a healthy brain, PAK and FMRP - the protein product of fmr1 - antagonize one another to regulate spine number and shape. Inhibition of PAK with a strategy utilizing mouse genetics reverses spine abnormalities as well as cognitive and behavioral symptoms in fmr1 KO mice, as we demonstrated in our previous publication. This discovery highlights PAK as a potential target for drug discovery research. In this thesis work, we build on this finding to test whether the small molecule FRAX486 - selected for its ability to inhibit PAK - can rescue behavioral, morphological, and physiological phenotypes in fmr1 KO mice. Our results demonstrate that seizures and behavioral abnormalities such as hyperactivity, repetitive movements, and habituation to a novel environment can all be rescued by FRAX486. Moreover, FRAX486 reverses spine phenotypes in adult mice, thereby supporting the hypothesis that a drug treatment which reverses the spine abnormalities can also treat neurological and behavioral symptoms.by Bridget M. Dolan.Ph.D
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