7,268 research outputs found
Siam and Laos, 1767-1827
No full textArticle on the history of Thai invasions and rebellions against Vientiane and the Chakri DynastySiam and Laos, 1767-1827
David K. Wyatt
Journal of Southeast Asian History
Vol. 4, No. 2 (Sep., 1963), pp. 13-3
Cult: A Composite Novel
No full textCult (redacted)
The first component of the thesis is a composite novel called Cult which falls into two parts with seven narratives in each. Part 1 tracks the protagonist, Ellen, from her first involvement with the cult through to her eventually leaving it. Although fiction, the first half of the book answers the kinds of questions the author is asked when people discover that she was once a sannyasin (a follower of the guru Bhagwan Shree Rajneesh). While the experiences of meditation, group therapy and communal living are all faithfully rendered within the stories, the need for strong characters, narrative drive and a lightness of touch takes precedence.
Part 2 picks up Ellen’s story some twenty or so years later and explores what becomes of her in middle age. It also looks at other groups in society, such as academia, the law and the internet dating community which each have their own jargon, hierarchies, rituals and rules but are not considered to be cults.
The book examines the question raised in the Epigraph, ‘how do we be together when we feel so alone’ with a focus on relationships other than the familial and the romantic.
Collisions, Chasms and Connections: a Performative Exploration of the Composite Novel Form
The second part of the thesis is both a critical and creative response to three contemporary American books: Olive Kitteridge by Elizabeth Strout; A Visit from the Goon Squad by Jennifer Egan; and Legend of a Suicide by David Vann. The critical element comprises a close reading of the three books; a chronological reconstruction of their overarching storylines; and a consideration of what their authors have said about writing the books. It concludes that, in the composite novel, the simultaneous presentation of multiple views and storylines operate much like a 3D image to give the impression of depth to the characters and situations rendered. The creative element of the essay is a playful and personal response to the texts
Long-term safety and efficacy of sodium zirconium cyclosilicate for hyperkalaemia in patients with mild/moderate versus severe/ end-stage chronic kidney disease: Comparative results from an open-label, Phase 3 study
No full textBACKGROUND: Sodium zirconium cyclosilicate (SZC; formerly ZS-9) is a selective potassium (K+) binder for the treatment of adults with hyperkalaemia. This post hoc analysis of an open-label, single-arm trial (NCT02163499) compared SZC efficacy and safety >12 months among outpatients with hyperkalaemia and Stages 4 and 5 chronic kidney disease (CKD) versus those with Stages 1-3 CKD. METHODS: Adults with serum K+ ≥5.1 mmol/L (measured by point-of-care i-STAT device) received SZC 10 g three times daily for 24-72 h until normokalaemia (i-STAT K+ 3.5-5.0 mmol/L) was achieved [correction phase (CP)], followed by once daily SZC 5 g for ≤12 months [maintenance phase (MP)]. Here, patients were stratified by baseline estimated glomerular filtration rate (eGFR <30 or ≥30 mL/min/1.73 m2). Study endpoints included percent achieving normokalaemia during CP and MP, mean serum K+ and bicarbonate during MP, and adverse events (AEs). RESULTS: Of 751 patients enrolled, 289 (39%), 453 (60%) and 9 (1%) had baseline eGFR values of <30, ≥30 mL/min/1.73 m2 or missing, respectively. During the CP, 82% of patients achieved normokalaemia in both eGFR subgroups within 24 h, and 100 and 95% with baseline eGFR <30 and ≥30 mL/min/1.73 m2, respectively, within 72 h. Corresponding proportions with normokalaemia during the MP were 82 and 90% at Day 365, respectively. Mean serum K+ reduction from baseline during the CP was sustained throughout the MP and serum bicarbonate increased. AEs during the MP were more common in the eGFR <30 ≥30 mL/min/1.73 m2 subgroup. CONCLUSIONS: SZC corrects hyperkalaemia and maintains normokalaemia among outpatients regardless of the CKD stage
Ad Hoc Procedure
No full text“Ad hoc procedure” seems like an oxymoron. A traditional model of the civil justice system depicts courts deciding cases using impartial procedures that are defined in advance of specific disputes. This model reflects a process-based account of the rule of law in which the process through which laws are made helps to ensure that lawmakers act in the public interest. Judgments produced using procedures promulgated in advance of specific disputes are legitimate because they are the product of fair rules of play designed in a manner that is the opposite of ad hoc.
Actual litigation frequently reveals the inadequacy of procedures created according to this traditional model. To fix the procedural problems that arise in such cases, litigants, judges, lawyers, and legislatures can design procedure on the fly, changing the “rules of the road” as the case proceeds. Ad hoc procedure-making allows the civil justice system to function when ordinary procedure fails, but it challenges the rule-of-law values reflected in the traditional model of procedural design. Instead of being created by lawmakers who operate behind a veil of ignorance, ad hoc procedure is made by actors seeking specific outcomes in pending cases. The circumstances in which ad hoc procedure is created raise concerns about lawmakers’ motivations, the transaction costs of one-off procedural interventions, the wisdom and fairness of those interventions, and the separation of powers.
This Article introduces the phenomenon of ad hoc procedure and considers its place in a world where much procedure continues to be made through the traditional model. Focusing on ad hoc procedural statutes, the Article contends that such statutes’ legitimacy—or lack thereof—depends on different factors than ordinary civil procedure. Unable to claim legitimacy from the circumstances in which it is crafted, ad hoc procedural legislation must instead derive legitimacy from the need to address a procedural problem and the effort to produce substantively just outcomes
Pattern-Responsive Lexicon Optimization
No full textIn this paper, we show that current interpretations of Lexicon Optimization (Prince and Smolensky 1993), in particular that of Archiphonemic Underspecification (Inkelas 1995), incorrectly predict the distribution of underspecification in lexical entries. We present cases from three vowel harmony languages in which speakers treat harmonic and disharmonic roots differently under reduplication. The assumption of full specification entails a ranking paradox, which can be resolved if underspecification is admitted in certain contexts not predicted by the principles of Lexicon Optimization. We point the way towards an expanded model of Lexicon Optimization that would both allow for and predict such cases of underspecification.The definitive version of this paper was published in NELS 30: Proceedings of the North East Linguistic Society 30 (2000) and is available at http://glsa.hypermart.net/cgi-bin/list.cgi?NELS%NELS30%5%NFunding for fieldwork was provided by the International Research and Exchanges Board (IREX).Harrison, David K. & Kaun A. (2000). Pattern-Responsive Lexicon Optimizat. In M. Hirotani, North East Linguistic Society & Rutgers University (Eds.), Proceedings of the North East Linguistic Society 30 (NELS 30)
The future of scholarly communications
No full textThe academic publishing industry is set to celebrate 350 years of peer-reviewed scientific journals. However, there are significant shifts in the practice of scholarship, as scholars and citizens alike participate in an increasingly digital world. Is the scholarly article still fit for its purpose in this data-driven world, with new interdisciplinary methodologies and increasing automation? How might it be enhanced or replaced with new kinds of digital research objects , so as not to restrict innovation but rather create a flourishing sense-making network of humans and machines? The emerging paradigm of social machines provides a lens onto future developments in scholarship and scholarly collaboration, as we live and study in a hybrid physical-digital sociotechnical system of enormous and growing scale.Copyright 2014 David De Roure. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, http://creativecommons.org/licenses/by/4.0/ which permits unrestricted use and distribution provided the original author and source are credited. If reusing please acknowledge "Insights: the UKSG journal" as the place of first publication. Please cite using the full DOI as specified at the end of the article: De Roure, D, The future of scholarly communications, Insights, 2014, 27(3), 233–238; DOI: http://dx.doi.org/10.1629/2048-7754.17
Microbial enrichment culture responsible for the complete oxidative biodegradation of 3‑Amino-1,2,4-triazol-5-one (ATO), the reduced daughter product of the insensitive munitions compound 3‑Nitro-1,2,4-triazol-5-one (NTO)
No full text3-Nitro-1,2,4-triazol-5-one (NTO) is one of the main ingredients of many insensitive munitions, which are being used as replacements for conventional explosives. As its use becomes widespread, more research is needed to assess its environmental fate. Previous studies have shown that NTO is biologically reduced to 3-amino-1,2,4-triazol-5-one (ATO). However, the final degradation products of ATO are still unknown. We have studied the aerobic degradation of ATO by enrichment cultures derived from the soil. After multiple transfers, ATO degradation was monitored in closed bottles through measurements of inorganic carbon and nitrogen species. The results indicate that the members of the enrichment culture utilize ATO as the sole source of carbon and nitrogen. As ATO was mineralized to CO₂, N₂, and NH₄⁺, microbial growth was observed in the culture. Co-substrates addition did not increase the ATO degradation rate. Quantitative polymerase chain reaction analysis revealed that the organisms that enriched using ATO as carbon and nitrogen source were Terrimonas spp., Ramlibacter-related spp., Mesorhizobium spp., Hydrogenophaga spp., Ralstonia spp., Pseudomonas spp., Ectothiorhodospiraceae, and Sphingopyxis. This is the first study to report the complete mineralization of ATO by soil microorganisms, expanding our understanding of natural attenuation and bioremediation of the explosive NTO.Journal ArticleFinal article publishe
Six principles that help you improve your life: constructive living
No full textRecensão crítica da obra de David K. Reynolds "Six principles that help you improve your life: constructive living", 2014David K. Reynolds is a College professor and therapist. The theories he describes in his book are based on two Japanese psychotherapies, the Morita therapy and Naikan therapy, both influenced by Buddhism.
Fundamentally, the book tries to give us, readers, tools to deal well with reality. One of the things the book stresses is to accept the reality around and inside us in the present moment. But that doesn´t mean that we should move through life passively. Actually, the book recommends that we act in a very practical way.
The author describes us six principles that explain how feelings function. In my opinion, the simple acknowledgement of these principles can transform our life for the bette
The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma
No full textRecent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms. The anti-CD20 monoclonal antibody, Rituximab, has resulted indramatic improvements in survival for patients with B cell Non Hodgkin’slymphoma. Histone deacetylase inhibitors are a novel class of anti canceragents targeting epigenetic regulation.This thesis addresses the interaction between histone deacetylase inhibitorsand anti-CD20 monoclonal antibodies, including Rituximab, both in vitro andin vivo. The initial approach identified synergistic induction of apoptosis in anumber of B cell lines. In a Ramos xenograft model, combination treatmentwith suberoylanilide hydroxamic acid (SAHA) and Rituximab reduced tumourgrowth compared to either agent alone, without discernable toxicity. Thiseffect appears specific to CD20 since monoclonal antibodies directed to othersurface molecules (CD32b, CD22, CD37) did not exhibit cooperative effect.Analysis of apoptotic pathways demonstrated that PARP cleavage andcaspase processing is significantly higher in cells receiving both treatments.Co-treatment of Ramos cells with the pan caspase inhibitor QVD-OPHabolished the synergy observed with CD20 monoclonal antibodies,suggesting that caspase processing is necessary for synergy. Treatment ofRamos cells stably transfected to overexpress Bcl-2 resulted in loss ofsynergy with Rituximab, but not with the type II CD20 mAb B1 (Tositumomab).Gene expression array analysis of Ramos cells was performed. Genesetenrichment analysis identified significant regulation of NF?B target genes insome genesets (Rituximab Vs control, p<0.001) with a number associatedwith apoptosis and B cell activation (Bcl2A1, LTA, CD69) which wereconfirmed using RT-Q-PCR.This novel combination elicits the induction of apoptosis in vitro, potentiallythrough regulation of Bcl-2 family proteins and should be tested in a phaseI/II clinical trial
“The land of Byamee”: K. Langloh Parker, David Unaipon, and popular Aboriginality in the assimilation era
No full textPopular Aboriginal legendary tales have been one of the most significant ways in which Aboriginality has been constructed in Australia, but they have not received much attention prior to this paper. Beginning with missionary accounts of Baiame, a deity associated with Gamilaraay (Kamilaroi) and Wiradhuri (Wiradjuri) speaking peoples of colonial Australia, the author examines the way in which the theme of the Great Spirit or Baiame is developed in popular mythology. The focus is placed on two key writers: K. Langloh Parker and David Unaipon. It is argued that the popular discourse of “The Land of Byamee” reflected the political constraints of the assimilation era
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