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Studio del metabolismo primario e secondario di colture di radici di Hypericum perforatum mediante risonanza magnetica nucleare
No full text"A non-targeted metabolic profiling”di radici rigenerate in vitro di Hypericum perforatum L.
No full textIn the present study, a metabolomic platform, which integrates an nuclear magnetic resonance (NMR)-based metabolic profiling and analysis of variance-simultaneous component analysis (ASCA), has been applied in order to characterize the changes of the primary and secondary metabolism of H. perforatum regenerated roots induced by an achieved high biomass density in a confined growth environment or in response to chitosan treatment.The ASCA modelling applied to NMR-based metabolic profiling allowed to recognize the effects due to biomass growth rate changes and chitosan treatment
A 1-H NMR-BASED METABOLOMIC APPROACH REVEALS SIGNIFICANT CHANGES IN BREAST MILK COMPOSITION INDUCED BY ORAL PROBIOTIC SUPPLEMENTATION
No full textPregnancy and the first two years of life are the most critical time periods for interventions to improve child growth and development. In this scenario, both the microbiota and breast milk which are ‘transmitted’ from mother to infant seem to play a crucial role for the promotion of a healthy growth in newborn. Perinatal supplementation with probiotics has been recently proposed as a possible strategy to manipulate maternal physiology, from gut microbiota to breast milk composition, in
order to orchestrate the infant development.
In this study, we applied a 1H NMR-based metabolomic approach to characterize the breast milk metabolome and possible changes
in breast milk composition induced by oral supplementation with VSL#3 probiotic mixture.
Our metabolomic approach revealed a systemic effect of the maternal probiotic supplementation on the production or secretion of human milk oligosaccharides (HMOs) and lipids in the mammary gland. Such an approach may become increasingly
useful as a tool to design and evaluate dietary and therapeutic strategies aimed at improving the health status of the mother-infant dyad
Urinary metabolic profiling and symptomatic uncomplicated diverticular disease of the colon
No full textThis study shows that urinary metabolic profiling is able to find significant differences between HC, AD and SUDD. In particular, it interesting to note that the only two metabolites that significantly differed between two of the three groups, namely hippurate and methanol, seem to have a profiling opposite than in IBD. Why this occurs is unknown, but it clearly identifies a different metabolic profile not only when compared with healthy people, but also when compared with other inflammatory intestinal conditions, such as IBD
Application of NMR-based Metabolomics to the Study of Gut Microbiota in Obesity
No full textLifestyle habits, host gene repertoire, and alterations in the intestinal microbiota concur to the development of obesity. A great deal of research has recently been focused on investigating the role gut microbiota plays in the pathogenesis of metabolic dysfunctions and increased adiposity. Altered microbiota can affect host physiology through several pathways, including enhanced energy harvest, and perturbations in immunity, metabolic signaling, and inflammatory pathways. A broad range of "omics" technologies is now available to help decipher the interactions between the host and the gut microbiota at detailed genetic and functional levels. In particular, metabolomics--the comprehensive analysis of metabolite composition of biological fluids and tissues--could provide breakthrough insights into the links among the gut microbiota, host genetic repertoire, and diet during the development and progression of obesity. Here, we briefly review the most insightful findings on the involvement of gut microbiota in the pathogenesis of obesity. We also discuss how metabolomic approaches based on nuclear magnetic resonance spectroscopy could help understand the activity of gut microbiota in relation to obesity, and assess the effects of gut microbiota modulation in the treatment of this condition
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Biomarkers of food intake for Allium vegetables
Get PDFPratico, Giulia Gao, Qian Manach, Claudine Dragsted, Lars O.1865-3499Biomarkers of food intake for Allium vegetable
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