1,720,983 research outputs found
Sistemi specializzati di risoluzione stragiudiziale delle controversie bancarie e finanziarie
Full text linkLa tutela della clientela nella regolamentazione bancaria e finanziaria: le linee guida. I sistemi di ADR del settore bancario e finanziario nel diritto dell'Unione Europea. L'Ombudsman: Giurì bancario. La camera di conciliazione e di arbitrato presso la Consob. L’arbitro bancario e finanziario.La tutela della clientela nella regolamentazione bancaria e finanziaria: le linee guida. I sistemi di ADR del settore bancario e finanziario nel diritto dell'Unione Europea. L'Ombudsman: Giurì bancario. La camera di conciliazione e di arbitrato presso la Consob. L’arbitro bancario e finanziario.LUISS PhD Thesi
Continuous renal replacement therapies (CRRT) will remain the most widely adopted dialysis modality in the critically ill.
No full textNegli ultimi 10-15 anni, la disponibilità di apparecchiature dedicate alle CRRT ha facilitato la diffusione di queste metodiche nelle UTI. Allo stato attuale, non esiste una chiara evidenza su quale debba essere la terapia sostitutiva ottimale nel paziente critico con IRA e la scelta della metodica non può derivare da ipotetici vantaggi in termini di “outcomes” ma deve basarsi su criteri prevalentemente clinici. Nel paziente ipercatabolico, le CRRT e le SLED consentono di ottenere un controllo metabolico paragonabile ma alcuni studi non controllati hanno suggerito una migliore stabilità emodinamica in corso di CRRT, intesa come ridotta necessità di incrementare il dosaggio di inotropi e valori più elevati di pressione arteriosa media. Il rischio di complicanze emorragiche è tendenzialmente maggiore con le CRRT ma in particolari situazioni cliniche, caratterizzate da rischio emorragico elevato, il trattamento può essere eseguito senza anticoagulanti o utilizzando protocolli alternativi. Tra le diverse opzioni, l’anticoagulazione regionale con citrato sembra essere la più promettente e l’introduzione di protocolli semplificati potrebbe portare alla sua definitiva affermazione come metodica di scelta nel paziente ad alto rischio emorragico. La presenza di una discrepanza tra dose dialitica prescritta e dose somministrata è spesso riportata come svantaggio delle CRRT. A dimostrazione che questa caratteristica non è peculiare delle CRRT, in un recente studio, finalizzato alla valutazione dell’impatto prognostico della dose dialitica, il Kt/V desiderato è stato ottenuto solo nel 67-69% dei trattamenti IHD. Numerosi studi hanno messo a confronto i costi delle diverse terapie sostitutive. Dall’analisi dei dati emerge che le CRRT hanno costi più elevati delle IHD e delle SLED. Tuttavia, l’entità della spesa relativa alle SLED potrebbe variare considerevolmente in relazione al modello organizzativo della struttura ospedaliera ed alla necessità di dedicare a queste terapie personale infermieristico specializzato. Inoltre, i costi delle CRRT potrebbero essere almeno in parte giustificati da vantaggi logistici e organizzativi. Il conseguimento di ulteriori sviluppi nelle caratteristiche dei monitors per CRRT, nell’ottimizzazione dei protocolli di anticoagulazione e nelle possibilità di “personalizzazione” delle soluzioni di dialisi/reinfusione potrà contribuire a mantenere, anche nei prossimi anni, il ruolo prevalente di queste metodiche nel trattamento del paziente critico con IRA, soprattutto nelle fasi di maggiore instabilità emodinamica
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Pharmacokinetic principles and drug-dosing adjustments during continuous renal replacement therapies (CRRT).
No full textIn the critically ill, acute renal failure (ARF) and “Multiple Organ Dysfunction Syndrome” (MODS) can be associated with significant modifications of many pharmacokinetic parameters, such as protein binding, volume of distribution and total body clearance. The start of renal replacement therapy (RRT) represents an additional variable to take in consideration for drug-dosing adjustments. Drugs significantly eliminated by the kidney are likely to be removed during RRT and a supplemental dose or further dosing adjustments are required if extracorporeal clearance is more than 25-30% of total body clearance. The impact of RRT on plasma drug concentrations can be substantially different in relation to the type of treatment (diffusive, convective or both), membrane characteristics (low-flux or high-flux), filter surface area and prescribed dialysis dose. The molecular weight cut-offs of high-flux membrane are much higher than the molecular weight of most drugs. Therefore, molecular size will not be a limitation for the removal of the unbound fraction of the drugs most commonly used in the critically ill undergoing continuous renal replacement therapy (CRRT). However, diffusive clearance could be significantly lower than convective clearance for drugs in the middle molecular weight range. In any case, the extracorporeal clearances reported with the use of high-volume CRRT (50-60 L/24 h) are often surprisingly elevated and can lead to drug underdosing in clinical conditions where adequate antibiotic treatment is essential. (G Ital Nefrol 2006; 23 (suppl 36): S127-38
Is Cronkhite-Canada Syndrome necessarily a late-onset disease?
No full textCronkhite-Canada Syndrome is a non-inherited, non-congenital disease characterized by juvenile hamartomatous gastrointestinal polyps with a typically late onset. In the case described herein the disease was diagnosed in a 17-year-old male with type I diabetes and thalassaemia minor, in coincidence with severe symptomatic intestinal candidiasis. Following the disappearance of the mycosis and correction of the protein and electrolyte imbalance, the ectodermal abnormalities returned to normal and the patient remained asymptomatic during a 7-year follow-up period, despite proteinuria resulting from membranous glomerulopathy. The concept that Cronkhite-Canada Syndrome is a late-onset disease should probably be reconsidered as it may remain asymptomatic, and thus not diagnosed, for a long a time
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Continuous venovenous hemodiafiltration with a low citrate dose regional anticoagulation protocol and a phosphate-containing solution: effects on acid--base status and phosphate supplementation needs.
No full textInsufficienza renale acuta post-cardiochirurgica associata a MODS: fattori prognostici in pazienti sottoposti a CRRT.
No full textAbstract Congresso Nazionale Società Italiana di Nefrologia
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