242 research outputs found
R. Josefson et P. Stjernquist, Ràttens ursprung och grund
No full textR. Josefson et P. Stjernquist, Ràttens ursprung och grund. In: Revue internationale de droit comparé. Vol. 18 N°3, Juillet-septembre 1966. p. 768
JBD912012_supplemental_material - Sex differences in associations between early adversity, child temperament, and behavior problems
No full textJBD912012_supplemental_material for Sex differences in associations between early adversity, child temperament, and behavior problems by Jesse L. Coe, Lauren Micalizzi, Brittney Josefson, Stephanie H. Parade, Ronald Seifer and Audrey R. Tyrka in International Journal of Behavioral Development</p
Proteostasis beyond chaperones - Auxiliary systems in the management of damaged proteins
No full textAging entails loss of functionality and increased risk of death, even for unicellular organisms, such as the yeast Saccharomyces cerevisiae. On a cellular level, aging is accompanied by an accumulation of harmful aging factors, e.g. damaged and aggregated proteins. Environmental stress can also cause a protein to misfold, leading to loss of function and aggregation. Protein misfolding is counteracted by systems of protein quality control. The temporal protein quality control system acts to refold or degrade the misfolded protein, while the spatial protein quality control system sorts damaged proteins to specific inclusion sites to prevent toxicity.
The proteostasis network is defined as the cellular machineries involved in protein synthesis, folding and degradation. Other systems affecting proteins and protein folding status are considered auxiliary systems to proteostasis. This thesis is based on genome-wide studies of S. cerevisiae aimed at finding new components in asymmetric inheritance of damaged proteins and the overall capacity of the cell to prevent protein aggregates. Vac17 was identified as a limiting factor for asymmetric inheritance, inclusion formation, endocytosis and lifespan. The effect of Vac17 on these processes requires endosomal components and fusion to the vacuole. In addition, I found that the GET pathway is a limiting factor in protein folding, as disruption causes massive aggregation of several proteins, not only substrates of the GET pathway. Given the major impact of these auxiliary systems on proteostatic processes, they should be considered part of the proteostasis network
Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions
No full textSummaryAge can be reset during mitosis in both yeast and stem cells to generate a young daughter cell from an aged and deteriorated one. This phenomenon requires asymmetry-generating genes (AGGs) that govern the asymmetrical inheritance of aggregated proteins. Using a genome-wide imaging screen to identify AGGs in Saccharomyces cerevisiae, we discovered a previously unknown role for endocytosis, vacuole fusion, and the myosin-dependent adaptor protein Vac17 in asymmetrical inheritance of misfolded proteins. Overproduction of Vac17 increases deposition of aggregates into cytoprotective vacuole-associated sites, counteracts age-related breakdown of endocytosis and vacuole integrity, and extends replicative lifespan. The link between damage asymmetry and vesicle trafficking can be explained by a direct interaction between aggregates and vesicles. We also show that the protein disaggregase Hsp104 interacts physically with endocytic vesicle-associated proteins, such as the dynamin-like protein, Vps1, which was also shown to be required for Vac17-dependent sequestration of protein aggregates. These data demonstrate that two physiognomies of aging—reduced endocytosis and protein aggregation—are interconnected and regulated by Vac17
Polychaete assemblages of a sub-arctic Newfoundland fjord: habitat, distribution, and identification
No full textThis study explores the association of 24 polychaete species with sandy and muddy habitats located in a sub-arctic fjord, and across Atlantic Canada including Labrador, Newfoundland, and the Gulf of St. Lawrence. Key characters used to facilitate species identification are also summarized. Within Bonne Bay, distinctive polychaete assemblages were associated with specific sediment types and polychaete species richness and density were significant both predictors of corresponding total (infaunal) density and species richness. Polychaetes were denser and more diverse in sandy sediments, partly because sandy locales were associated with the outer portion of the bay, and therefore were closer to the more productive and diverse Gulf of St. Lawrence. In general, species that occupied both sediment types were more widely distributed within Bonne Bay and across the region. The biogeography of most species also suggests that the Bonne Bay fauna is transitional between Labrador and Acadian biogeographic provinces.PT: J; CR: *NRC, 1995, UND MAR BIOD RES AG APPY TD, 1980, FISH MAR SERV TECH R, V920, P124 ARMONIES W, 2003, HELGOLAND MAR RES, V56, P279 AURE J, 1989, ESTUAR COAST SHELF S, V28, P59 BANSE K, 1974, B FISH RES BOARD CAN, V185, P111 BARRIE JD, 1979, THESIS MEMORIAL U NE, P113 BARRIE JD, 1980, BENTHOS NEARSHORE ST, P158 BHAUD M, 1998, HYDROBIOLOGIA, V375, P35 BLACKBURN TH, 1996, MAR ECOL-PROG SER, V141, P283 BLAKE JA, 1995, ANNELIDA BOUSFIELD M, 1981, THESIS DALHOUSIE U H, P140 BRIGGS JC, 1974, MCGRAWHILL SERIES PO BRUNEL P, 1998, CAN SPEC PUBL FISH A, V126, P405 BUHLMORTENSEN L, 1996, J NAT HIST, V30, P23 CARLTON JT, 1999, ANNU REV ECOL SYST, V30, P515 COCHRANE SJ, 2000, THESIS U ST ANDREWS DAUVIN JC, 1994, MEMOIRES MUSEUM NATL, V162, P384 DAY JH, 1967, MONOGRAPH POLYCHAETA FAUCHALD K, 1977, NAT HIST MUS LOS ANG, V28, P1 FAUCHALD K, 1979, OCEANOGR MAR BIOL AN, V17, P193 GABRIEL KR, 1971, BIOMETRIKA, V58, P453 GIANGRANDE A, 1997, OCEANOGR MAR BIOL AN, V35, P323 GIANGRANDE A, 2003, AQUAT CONSERV, V13, P451 GLASBY CJ, 1999, J BIOGEOGR, V26, P507 GRASSLE JF, 1976, SCIENCE, V12, P567 GRASSLE JF, 1992, AM NAT, V139, P313 GRAY JS, 1974, OCEANOGR MAR BIOL AN, V12, P223 HOBSON KD, 1981, CANADIAN B FISHERIES, V209, P1 HOLTE B, 1998, POLAR BIOL, V19, P375 HOLTE B, 1998, SARSIA, V83, P55 HOOPER RG, 1975, PARKS CANADA CONTRAC, V3, P74 HUTCHINGS P, 1998, BIODIVERS CONSERV, V7, P1133 HUTCHINGS P, 2000, INVERTEBR TAXON, V14, P225 HUTCHINGS PA, 1991, OPHELIA S, V5, P565 IRISH KE, 1996, CONSERV BIOL, V10, P680 JOSEFSON AB, 1985, SARSIA, V70, P229 JOSEFSON AB, 1986, ESTUAR COAST SHELF S, V23, P147 KLITGAARDKRISTENSE, 1999, J NAT HIST, V33, P317 KNOWLTON N, 1993, ANNU REV ECOL SYST, V24, P189 KNOX CA, 1977, ESSAYS POLYCHAETOUS, P547 LENIHAN HS, 2001, MARINE COMMUNITY ECO, P253 LIGHT WJ, 1978, INVERTEBRATES SAN FR, P211 LONGHURST A, 1998, ECOLOGICAL GEOGRAPHY MANCHENKO GP, 1998, MAR BIOL, V131, P489 MAURER D, 2000, MAR POLLUT BULL, V40, P98 MYERS N, 1996, P NATL ACAD SCI USA, V93, P2764 NORSE EA, 1993, GLOBAL MARINE BIOL D NOWELL ARM, 1984, ANNU REV ECOL SYST, V15, P303 OLAFSSON EB, 1994, OCEANOGR MAR BIOL, V32, P65 OLSGARD F, 2000, J AQUAT ECOSYST STRE, V7, P25 OLSGARD F, 2003, BIODIVERS CONSERV, V12, P1033 OUG E, 2000, SARSIA, V85, P1 PEARSON DL, 1994, PHILOS T ROY SOC B, V345, P75 PEER DL, 1972, EFFECTS ELEMENTAL PH PETERSEN ME, 1998, J MAR BIOL ASSOC UK, V78, P1373 PETERSON CH, 1991, AM SCI, V79, P236 PETTIBONE MH, 1956, P US NATL MUS, V105, P531 PETTIBONE MH, 1963, B US NATL MUSEUM 1, V227 POCKINGTON P, 1989, POLYCHAETES E CANADA POCKLINGTON P, 1987, CAN J ZOOL, V65, P391 POCKLINGTON P, 1992, MAR POLLUT BULL, V24, P593 QUIJON PA, IN PRESS OECOLOGIA RAMEY PA, 2001, THESIS MEMORIAL U NE, P210 RAMEY PA, 2003, MAR ECOL-PROG SER, V262, P215 REISE K, 2001, ECOL STUD, V151, P1 RIVARD DH, 1970, SURVEY MARINE FAUNA, P18 ROBERTS CM, 1999, TRENDS ECOL EVOL, V14, P241 ROUSE GW, 2001, POLYCHAETES SIGVALDADOTTIR E, 2002, SARSIA, V87, P207 SNELGROVE P, 1997, AMBIO, V26, P578 SNELGROVE PVR, 1994, OCEANOGR MAR BIOL, V32, P111 SNELGROVE PVR, 1998, BIODIVERS CONSERV, V7, P1123 STEELE DH, 1975, NAT CAN QUE, V102, P189 TRUEBLOOD DD, 1994, LIMNOL OCEANOGR, V39, P1440 WIECZOREK S, 1991, THESIS U MUNSTER MUN, P97 WIECZOREK SK, 1995, J CRUSTACEAN BIOL, V15, P236 WILLIAMS SJ, 1984, P 1 INT POL C SYDN A, P118 ZAJAC RN, 2003, J EXP MAR BIOL ECOL, V294, P101; NR: 78; TC: 1; J9: POLAR BIOL; PG: 11; GA: 934TBSource type: Electronic(1
Syttende mai
No full textArtikeln uppmärksammar 50-årsjubileet av Frigjöringsdagen 8 maj 1945, då Norge blev fritt, och rekapitulerar huvudpunkterna i den norska kyrkokampen. Vidare redovisas hur SKT med redaktören Ruben Josefson klart tog ställning för den förföljda norska kyrka</p
Piękno, świat i moment. Estetyczne tło polityki Hannah Arendt w interpretacji Jima Josefsona.
No full textThis paper analyzes the aesthetic form of politics by Hannah Arendt as interpreted by Jim Josefson. According to the author of „Hannah Arendt's Aesthetic Politics: Freedom and the Beautiful", the philosopher was looking for her own "transcendent moment" (der Augenblick) and, in order to identify it, she studied the works of such thinkers as: Nietzsche, Kierkegaard, Jaspers, Heidegger, Kafka, and Benjamin. Thoughtful criticism of each of the above methods allowed her to formulate her own concept, defined by Josefson as the "aesthetic moment". By distinguishing "the freedom of beauty" as the third face of freedom on a par with the freedom of action and mind known to Arendt readers, Josefson in his book focuses on showing how this freedom, rooted in Jaspers' phenomenology and the non-metaphysical reading of Kant, is to serve as an antidote to alienation from world, which, in his opinion, is the theme that binds all Arendt's works together.Artykuł analizuje estetyczną formę polityki Hannah Arendt w interpretacji Jima Josefsona. Zdaniem autora „Hannah Arendt’s Aesthetic Politics: Freedom and the Beautiful” - filozofka poszukiwała swego własnego „transcendentnego momentu” (der Augenblick) i w celu zidentyfikowania go analizowała prace takich myślicieli jak: Nietzsche, Kierkegaard, Jaspers, Heidegger, Kafka, Benjamin. Przemyślana krytyka każdego z powyższych nurtów pozwoliła jej sformułować własną koncepcję określoną przez Josefsona mianem „momentu estetycznego”. Wyodrębniając „wolność piękna”, jako trzecią twarz wolności na równi ze znanymi czytelnikom Arendt wolnością działania i umysłu, amerykański filozof w swej książce skupia się na wykazaniu, jak ta wolność, zakorzeniona w fenomenologii Jaspersa i niemetafizycznym odczytaniu Kanta, ma posłużyć za antidotum na wyobcowanie ze świata, które jego zdaniem, jest tematem spajającym wszystkie prace Arendt.
Banach limits
No full textBanach limits Bachelor thesis abstract Jáchym Mierva Banach limit is a continuous linear functional on the Banach space of real bounded sequences, which naturally extends the limit - in particular, it is positive and translation invariant. In this thesis we construct Banach limits with some additional properties and subquently give examples of their use in several proofs from measure theory and functional analysis. Using the theory of Banach limits, the existence of Lebesgue measure and the Josefson-Nissenzweig theorem are proven, the former being an original work of the author.
SOLUTIONS TO PERTURBATION EQUATIONS
No full textAuthor Institution: Department of Chemistry, Southern Illinois UniversityThe advantages and disadvantages of non-variational and variational solutions to perturbation equations will be compared. Frequency-dependent polarizability calculations including new numerical techniques for helium will be used as an example
Receptionen av belgiska modernister i Frankrike och Norden - – om kulturklimatet i förra sekelskiftets vänsterkretsar
No full textDuring the 1990’s, the specificity of Belgian symbolist poetry has been analysed in a number of studies treating the reception of Maurice Materlinck and Emile Verhaeren in different countries, France among others. In these studies, one question keeps coming back: Does the fact that a work is written in French by an author, born in another country than France influence the reception of his work? In this article, I shall discuss how political elements in literary texts may affect the reception in different countries: One purpose of this comparison is to show that the study of the above authors can give us knowledge of the cultural climate in these countries
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