5,143 research outputs found
A modelling study of the atmospheric chemistry of DMS using the global model STOCHEM-CRI
No full textThe tropospheric chemistry of dimethylsulfide (DMS) is investigated using a global three-dimensional chemical transport model, STOCHEM with the CRIv2-R5 chemistry scheme. The tropospheric distribution of DMS and its removal at the surface by OH abstraction, OH addition, NO3 oxidation, and BrO oxidation is modelled. The study shows that the lifetime and global burden of DMS is ca. 1.2 days and 98 Gg S, respectively. Inclusion of BrO oxidation resulted in a reduction of the lifetime (1.0 day) and global burden (83 Gg S) of DMS showing that this reaction is important in the DMS budget. The percentage contribution of BrO oxidation to the total removal of DMS is found to be only 7.9% that is considered a lower limit because the study does not include an inorganic source of bromine from sea-salt. BrO oxidation contributed significantly in the high latitudes of the southern hemisphere (SH). Inclusion of DMS removal by Cl2 showed that potentially a large amount of DMS is removed via this reaction specifically in the remote SH oceans, depending on the flux of Cl2 from the Southern Ocean. Model DMS levels are evaluated against measurement data from six different sites around the globe. The model predicted the correct seasonal cycle for DMS at all locations and correlated well with measurement data for most of the periods
"And they fastened his body to the wall of Beth-shan" (1 Sm 31, 10). The problem of a suicide in the Old Testament. This paper addresses a multi-faceted, intriguing issue of suicide in the Bible, especially in Jewish and ancient tradition. The author aims to show all cases of suicide in the Old Testament (Abimelech, Samson, King Saul and his armor-bearer, Ahithophel, Zimri, Ptolemy Macron, Razis), focusing on a theological, linguistic and cultural analysis of selected biblical excerpts. In addition, there are many of suicide prevention in the Bible in which God’s intervention prevented the accomplishment of suicidal behavior (Moses, David, Elijah, Job, Jeremiah, Jonah). Suicide in the Bible occurs for a variety of complicated, ambiguous reasons, including intense personal guilt, sense of hopelessness, human inclination to despair or tremendous personal loss. The Bible nowhere proscribes suicide distinctly, and the question of self-killing in Hebrew Scriptures is a still live dilemma
Alternative HER/PTEN/Akt Pathway Activation in HPV Positive and Negative Penile Carcinomas
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Abstract P2-09-18: High VEGFR1 and VEGFR3 Protein Expression Is Associated with Improved Response to the Combination of Paclitaxel (P) and Bevacizumab (Bev) Therapy in Patients with HER2-Negative Metastatic Breast Cancer (MBC)
No full textAbstract
Background: Treatment with weekly P and 2-weekly Bev has been established as an active 1st line treatment in patients with MBC. However, robust predictive or prognostic biomarkers for this treatment have not been identified as yet.
Patients and Methods: In this retrospective analysis, we evaluated the activity of this combination in patients with HER2-negative MBC. Further, we explored the role of a panel of biomarkers on patients’ outcome. VEGF-A, VEGF-C, VEGFR1, VEGFR2, and VEGFR3 were centrally assessed by immunohistochemistry (IHC) in 70 tissue blocks. P was administered either weekly 90 mg/m2 x12 with 2-weekly Bev 10 µg/kg (86 patients) or 3-weekly 175 mg/m2 x6 with 3-weekly Bev 15µg/kg (38 patients). Bev was administered until progression in the majority of the patients.
Results: The ORR did not differ significantly between the weekly or 3-weekly P schedule (55.8% vs 55.3%). In contrast to the published literature with P monotherapy, median PFS was significantly longer in the 3-weekly compared to the weekly P schedule (20.4 months vs 10.2 months, p=0.029). Median survival has not been reached yet. 2-year survival was 76.1% and 67.3%, respectively (p=0.085). High VEGFR1 and VEGFR3 protein expression, assessed by IHC, was associated with higher response rates (p=0.010 and p=0.039, respectively).
Conclusions: This retrospective analysis confirmed the activity of P and Bev in patients with HER2-negative MBC. Protein expression of VEGFR1 and VEGFR3 was found to be of predictive value. These findings need to be validated in a larger cohort of patients treated with this combination. VEGF polymorphisms (VEGF-2578 and VEGF-1154) are currently assessed in peripheral blood DNA from our patients for possible predictive value.
Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-09-18.</jats:p
South Africa and political change : an analysis of selected studies of South African politics
No full textBibliography: p. 217-229.To a political scientist the challenge.is irresistible of trying to explain and understand a conflict society which is generally characterised in the world as historically anachronistic, politically untenable, economically wasteful and morally unacceptable. It is common cause that South Africa will change. What are the likely ways in which the conflict will be resolved, and which is most likely? These are the questions to which this thesis will attempt to provide answers: it is an effort to determine, as far as possible, the nature, direction and pace of change in South Africa, as seen by a selected group of recent studies of South African politics. The method will be to test the validity of the respective positions on this and related issues embedded in the selected studies of South African politics. Part II, the major part of the work, therefore, is an examination of the explicit or implicit assumptions and values, the conceptual and theoretical frameworks, the use of evidence, the existence of counter evidence, the omissions, inconsistencies and conclusions of various studies of South Africa, in order to assess the strengths and weaknesses of each as explanations of the political, social and economic process. In the course of the examination, an alternative analysis of the issues will be presented and defended. A synopsis of the analysis will be given in Part III. This will be used as a means for testing the analyses of the selected studies, before selecting what is valid in all of them in terms of providing possible answers to the questions posed about the resolution of conflict
Thematic labeling of Twitter accounts using DBpedia properties
No full textIn this paper, we propose an iterative algorithm towards the automatic labeling of Twitter accounts in respect to thematic categories derived from DBpedia properties. We describe the rationale behind the selection of these thematic categories, and discuss their evaluation assessment. Finally, we propose and analyze two generic and adaptable methodologies for discovering the necessary linked data resources for further enhancing the thematic description of Twitter accounts. © 2016 IEEE
Measurement of exclusive p(+)p(-) production in mid-virtuality two-photon interactions and study of the yy* -\u3e pp process at LEP
No full textExclusive p(+)p(-) production in two-photon collisions between a quasi-real photon, gamma, and a mid-virtuality photon, gamma*, is studied with data collected at LEP at centre-of-mass energies 183 GeV \u3c= root s- \u3c= 209 GeV with a total integrated luminosity of 684.8 pb(-1). The cross section of the gamma gamma* -\u3e p(+)p(-) process is determined as a function of the photon virtuality, Q(2), and the two-photoncentre-of-mass energy, W-gamma gamma, in thekinernatic region: 0.2 GeV2 \u3c Q(2) \u3c 0.85 GeV2 and 1.1 GeV \u3c W gamma gamma \u3c 3 GeV. These results, together with previous L-3 measurements of p(0) p(0) and p(+) to p(-) production, allow a study of the gamma gamma* -\u3e pp process over the Q(2)-region 0.2 GeV2 \u3c= Q(2) \u3c= 30 GeV2. (c) 2005 Published by Elsevier B.V
- …
