105 research outputs found
Studio geominerario e mineralurgico di una miniera di Feldspato nell'area Masserano - S.Liberata (BI)
No full textActivity-dependent transcriptional dynamics in mouse primary cortical and human iPS-derived neurons
No full text<p>Poster presented at Lorne Genome 2012. Subsequently formed part of manuscript:</p>
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<p>Barry G, Briggs JA, Vanichkina DP, Poth EM, Beveridge NJ, Ratnu VS, Nayler SP, Nones K, Hu J, Bredy TW, Nakagawa S, Rigo F, Taft RJ, Cairns MJ, Blackshaw S, Wolvetang EJ, Mattick JS (2013). The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molecular psychiatry doi: 10.1038/mp.2013.45</p
What does the future hold for the study of nucleic acid modifications in the brain?
No full textFor the past 40 years, technological advances have made it possible to interrogate the entire genome; thus, the understanding of DNA modification has evolved significantly. Once considered to be a relatively static epigenetic mechanism, with its primary function restricted to the regulation of transcriptional programming during early cellular development, we now know that DNA methylation is a highly dynamic process in postmitotic neurons and plays a particularly important role in neuronal gene expression that directly impacts behavior. For example, in the adult brain, neuronal activity–induced changes in 5-methylcytosine frequently occur outside gene promoters and 5-hydroxymethylcytosine accounts for almost half of DNA methylation detected in the brain. Moreover, the base sequence can also dictate the relative probability that a region of the genome will be epigenetically modified. This is important because it suggests that gene–epigenetic interactions should be considered in the context of a multilevel and bidirectional landscape, with other epigenetic regulators also acting to coordinate the function of the genome in a cell- and context-specific manner
p300/CBP-associated factor selectively regulates the extinction of conditioned fear
No full textIt is well established that the activity of chromatin-modifying enzymes is crucial for regulating gene expression associated with hippocampal-dependent memories. However, very little is known about how these epigenetic mechanisms influence the formation of cortically dependent memory, particularly when there is competition between opposing memory traces, such as that which occurs during the acquisition and extinction of conditioned fear. Here we demonstrate, in C57BL/6mice, that the activityofp300/CBP-associated factor (PCAF) within the infralimbic prefrontal cortex is required for long-term potentiation and is necessary for the formation of memory associated with fear extinction, but not for fear acquisition. Further, systemic administration of the PCAF activator SPV106 enhances memory for fear extinction and prevents fear renewal. The selective influence of PCAF on fear extinction is mediated, in part, by a transient recruitment of the repressive transcription factor ATF4tothe promoter of the immediate early genezif268, which competitively inhibits its expression. Thus, within the context of fear extinction, PCAF functions as a transcriptional coactivator, which may facilitate the formation of memory for fear extinction by interfering with reconsolidation of the original memory trace
Control interno y los procesos de contratación de bienes y servicios del programa nacional de dotación de materiales educativos, Lima, 2018
No full textEl presente trabajo de investigación se tituló “Control interno y los procesos de contratación
de bienes y servicios del programa nacional de dotación de materiales educativos, Lima,
2018”; tuvo como problema general la siguiente interrogante: ¿Qué relación hay entre
control interno y procesos contratación bienes y servicios programa nacional dotación
materiales educativos, Lima, 2018?, y como objetivo general es determinar si el Control
interno se relaciona con los procesos de contratación de bienes y servicios del programa
nacional de dotación de materiales educativos, Lima, 2018.
En el aspecto metodológico el trabajo de investigación fue de tipo básico. El nivel es
descriptivo, correlacional y el diseño es no experimental de corte transversal. La población
estuvo conformada por 80 trabajadores, la misma que tiene constante relación con el proceso
de contratación del programa nacional de dotación de materiales educativos. La muestra fue
de tipo no probabilístico que equivale a 80 personas.
Como resultados se obtuvo que el control interno si se correlaciona con el proceso de
contratación siendo el coeficiente de correlación de Spearman de r= 0,284* y con un p valor
= 0.011 < 0.05, (correlación baja) por lo que existe evidencia estadística para rechazar la Ho
y aceptar la alterna, es decir existe relación directa y significativa entre el control interno y
los procesos de contratación de bienes y servicios del programa nacional de dotación de
materiales educativos, Lima, 201
Singlet and triplet states dissociation of doubly charged HDO, H2O
No full textInternational audienceContent from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI
Microstructure and Porosity of Metakaolin Blended Cements
No full textABSTRACTFive compositions with 10% to 50% metakaolin for cement substitution were studied. The rate of hydration was studied from the compressive strength after up to 6 months of curing and from the hydrates formed (DTA-XRD). The metakaolin addition considerably reduced portlandite content in the hydrated cement and contributed to the formation of hydrated gehlenite which is not present in OPC paste. The microstructure study (SEM) shows that pozzolanic cement pastes were less crystallized than plain pastes. Mercury intrusion was used to measure porosity of hydrated cement pastes. The porosity with blended cements was higher than that with OPC, except for 10 and 20% metakaolin substitution. Evolution of the pore size distribution was studied: the pozzolanic pastes enhance small diameters.</jats:p
Microstructure and Porosity of Metakaolin Blended Cements
No full textAbstractFive compositions with 10% to 50% metakaolin for cement substitution were studied. The rate of hydration was studied from the compressive strength after up to 6 months of curing and from the hydrates formed (DTA-XRD). The metakaolin addition considerably reduced portlandite content in the hydrated cement and contributed to the formation of hydrated gehlenite which is not present in OPC paste. The microstructure study (SEM) shows that pozzolanic cement pastes were less crystallized than plain pastes. Mercury intrusion was used to measure porosity of hydrated cement pastes. The porosity with blended cements was higher than that with OPC, except for 10 and 20% metakaolin substitution. Evolution of the pore size distribution was studied: the pozzolanic pastes enhance small diameters.</jats:p
THE EFFECTS OF SIX ENVIRONMENTAL VARIABLES ON PASTEURELLA MULTOCIDA POPULATIONS IN WATER
No full text- …
