7 research outputs found
Effect of Body Mass Index on Middle Ear Resonance Frequency
No full textOBJECTIVE: Multifrequency tympanometry (MET) analyzes tympanograms obtained using different probe tones between 226 and 2000 Hz. An important parameter of MET is resonance frequency (RF). Studies have recently demonstrated that the RF value can vary depending on many factors. To provide new data regarding MET, middle ear RF values were investigated with regard to body mass index (BMI).
MATERIALS and METHODS:This study included 78 volunteers (i.e., 156 ears) aged 18-40 years who did not have healing loss and whose otoscopic examinations were normal. Hearing thresholds were measured using pule tone audiometry, and RF values were recorded with immitansmetric measurements. The participants were divided into the following three groups according to their BMI: 25 kg/m(2), Group 3. The RE values were also analyzed.
RESULTS: Although there was no significant difference between Groups 1 and 2 in terms of RF values, a significant difference was observed between Groups 1 and 3 and between Groups 2 and 3.
CONCLUSION: In the light of these data, BMI values should be considered when middle ear RF values are assessed
Effects of Glycerol Test on Resonance Frequency in Patients with Meniere's Disease
No full textObjective: To evaluate resonance frequency (RF) values via dehydration effects in the inner ear caused by the glycerol test, which is used as a diagnostic method for Meniere's disease (MD). Methods: Twenty adult patients with unilateral MD were included in the study. Before, and then at 1, 2, and 3 h after administration of glycerol (1 g/kg), pure-tone hearing levels (125-8,000 kHz) and multifrequency tympanometry tests were performed. As a control, the RF values of the ears of 25 healthy subjects (i.e., 50 ears) were compared to the affected and unaffected ears in the 20 MD patients. Results: There was a significant difference between the RF values of affected and healthy ears before glycerol administration (p = 0.047). The RF values before and after glycerol administration into affected ears were compared. The average RF values decreased significantly from 748.0 +/- 402.1 to 808.0 +/- 410.1 Hz at 1 h after glycerol intake, and this value increased during the subsequent hours. There were no statistically significant differences between the pure-tone levels before and 1 h after glycerol administration, but a significant decrease was observed at 3 h. Conclusion: We suggest that MD has different inner-ear dynamics and normal RF values when compared to healthy ears. Furthermore, decreased inner ear pressure causes reduction of the mass effect and a stiffening of the annular ligament. We conclude that pre- and post-RF tests should be added to the test battery for diagnosis of MD
Associação de polimorfismos do gene Ugrp2 com hipertrofia de adenoide na população pediátrica
No full textIntroduction: Adenoid hypertrophy is a condition that presents itself as the chronic enlargement of adenoid tissues; it is frequently observed in the pediatric population. The Ugrp2 gene, a member of the secretoglobin superfamily, encodes a low-molecular weight protein that functions in the differentiation of upper airway epithelial cells. However, little is known about the association of Ugrp2 genetic variations with adenoid hypertrophy. Objective: The aim of this study is to investigate the association of single nucleotide polymorphisms in the Ugrp2 gene with adenoid hypertrophy and its related phenotypes. Methods: A total of 219 children, comprising 114 patients suffering from adenoid hypertrophy and 105 healthy patients without adenoid hypertrophy, were enrolled in this study. Genotypes of the Ugrp2 gene were determined by DNA sequencing. Results: We identified four single nucleotide polymorphisms (IVS1-189G>A, IVS1-89T>G, c.201delC, and IVS2-15G>A) in the Ugrp2 gene. Our genotype analysis showed that the Ugrp2 (IVS1-89T>G) TG and (c.201delC) CdelC genotypes and their minor alleles were associated with a considerable increase in the risk of adenoid hypertrophy compared with the controls (p = 0.012, p = 0.009, p = 0.013, and p = 0.037, respectively). Furthermore, Ugrp2 (GTdelCG, GTdelCA) haplotypes were significantly associated with adenoid hypertrophy (four single nucleotide polymorphisms ordered from 5' to 3'; p = 0.0001). Polymorfism-Polymorfism interaction analysis indicated a strong interaction between combined genotypes of the Ugrp2 gene contributing to adenoid hypertrophy, as well as an increased chance of its diagnosis (p < 0.0001). In addition, diplotypes carrying the mutant Ugrp2 (c.201delC) allele were strongly associated with an increased risk of adenoid hypertrophy with asthma and with allergies (p = 0.003 and p = 0.0007, respectively). Conclusion: Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy. Therefore, we tried to underline the importance of genetic factors associated with adenoid hypertrophy and its related clinical phenotypes. (C) 2017 Associacao Brasileira de Otorrinolaringologia e Cirurgia C ervico-Facial. Published by Elsevier Editora Ltda.Hacettepe University Scientific Research Project Coordination Unit [2012-898]This work was approved by the Hacettepe University Ethics Committee and financially supported by the Hacettepe University Scientific Research Project Coordination Unit (Project no 2012-898). There was no involvement in the design or conduct of the study; collection, management, analysis, or interpretation of the data; or preparation, review, or approval of the manuscript
Role of Single Nucleotide Polymorphisms of Mammaglobin-A Gene in Nasal Polyposis: A Case Control Study
No full textObjective: Nasal Polyposis (NP) is a chronic inflammatory disease and genetic factors play an important role in the pathophysiology. Mammaglobin-A (MGA) gene expression was significantly higher in patients with NP and chronic rhinosinusitis compared to normal mucosa. In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the MGA gene and nasal polyposis in the Turkish population
An ıdadı Arabıc notebook whıch was wrıtten ın the last Ottoman perıod (h. 1323 / gc. 1905-1906)
No full textBu çalışmada 20. yüzyıl başlarında imla edilmiş bir Arapça öğrenci defteri ve onun Arapça tedris usulü içerisindeki yeri incelenmiştir. Araştırma somut bir örnek sunması ve döneme ışık tutması bakımından önem arz etmektedir. Çalışmada Osmanlı klasik dönem Arapça eğitiminden modern eğitime geçilen süreç adım adım ele alınmıştır. İncelemesi yapılan defter H. 1323/ M.1905-1906 yıllarında, Mercan İdadîsinde eğitim görmekte olan Mehmed adlı 3. sınıf öğrencisine aittir. İnceleme sonunda dönemin Arapça eğitimine dair çıkarımlar yapılmış, o dönemin ders kitapları ve ders anlatım metoduyla defter arasındaki ilişki araştırılmıştır. Bu bağlamda ders işleniş şekil ve sürecine ışık tutulmuştur. Araştırmanın gelecekteki araştırmacılara, eğitmenlere ve dilcilere yol göstereceği ve kaynak niteliğinde olacağı düşünülmektedir.This study discusses an Arabic student notebook written in the early 20th century and its place in the Arabic teaching method of the period. The research is essential in presenting a concrete example and shedding light on the period. The process from classical Ottoman period Arabic education to Modern Education has been discussed step by step. The analyzed notebook belongs to a 3rd-grade student named Mehmed, who was studying at Mercan High School in H. 1323/ M.1905-1906. Inferences were made about the Arabic education of that period, the relationship between the textbooks of that period and the lecture method, and the notebook investigated. In this context, the author aimed to shed light on the way and process of teaching the course. The research will hopefully guide and be a resource for future researchers, educators, and linguists
Significant Association Between SCGB1D4 Gene Polymorphisms and Susceptibility To Adenoid Hypertrophy in a Pediatric Population
No full textBackground/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods: We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results: We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of AH. In addition, those SNPs were significantly associated with asthma, allergy, sleep-disordered breathing, AH grade + 4, and a high level of IgE. As indicated on multifactor dimensionality reduction analysis, single-locus (rs35328961), two-locus (rs35328961_rs56196602), and three-locus models (rs200327820_rs35328961_rs56196602) had the highest synergistic interaction effect on AH. The three-factor model was also significantly associated with some genotypes of rs35328961 and allergic-asthmatic AH. Conclusion: SNPs of SCGB1D4 and their combinations are associated with an increased risk for developing AH. We highlighted the importance of genetic factors on AH and AH-related clinical phenotypes.WoSScopu
