112 research outputs found
African origin of the malaria parasite Plasmodium vivax.
No full textPlasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa
Jmodeltest.org: selection of nucleotide substitution models on the cloud
No full textThis is a pre-copyedited, author-produced version of an article accepted for publication in Bioinformatics following peer review. The version of record Jose Manuel Santorum, Diego Darriba, Guillermo L. Taboada, David Posada; jmodeltest.org: selection of nucleotide substitution models on the cloud, Bioinformatics, Volume 30, Issue 9, 1 May 2014, Pages 1310–1311, https://doi.org/10.1093/bioinformatics/btu032[Abstract] The selection of models of nucleotide substitution is one of the major steps of modern phylogenetic analysis. Different tools exist to accomplish this task, among which jModelTest 2 (jMT2) is one of the most popular. Still, to deal with large DNA alignments with hundreds or thousands of loci, users of jMT2 need to have access to High Performance Computing clusters, including installation and configuration capabilities, conditions not always met. Here we present jmodeltest.org, a novel web server for the transparent execution of jMT2 across different platforms and for a wide range of users. Its main benefit is straightforward execution, avoiding any configuration/execution issues, and reducing significantly in most cases the time required to complete the analysis.
Availability and implementation:jmodeltest.org is accessible using modern browsers, such as Firefox, Chrome, Opera, Safari and IE from http://jmodeltest.org. User registration is not mandatory, but users wanting to have additional functionalities, like access to previous analyses, have the possibility of opening a user account.European Research Council; 2007-Stg 203161- PHYGENOMMinisterio de Ciencia e Innovación; TIN2010-1673
Narraciones para tres. Hacia una comprensión del cuidado en la terapia familiar
No full textConcebido como material de apoyo para la formación ética de los terapeutas familiares o de los profesionales interesados en la salud mental, este libro nace de procesos investigativos de sus autores y del diálogo académico que surge de esas prácticas académicas. El resultado es una comprensión triádica del cuidado, basada en la propuesta terapéutica de Michael White y David Epston, promotores del enfoque narrativo en terapia familiar, en conversación con Hoffman, Sluzki, Andersen, Agudelo y Ochoa, y con filósofos como Foucault y Ricoeur. Aquí, lo tríadico se manifiesta en la conjunción entre el cuidado de sí (el terapeuta), el cuidado del otro (el consultante) y el cuidado de lo otro (el sistema terapéutico). Se da entonces una comprensión simultánea de los participantes del sistema terapéutico y de sus encuentros, en los que tiene lugar una atención mutua, que beneficia la recuperación y la construcción identitaria mediante prácticas como la reflexión y la remembranza
BEAGLE 3: Improved Performance, Scaling, and Usability for a High-Performance Computing Library for Statistical Phylogenetics
No full text© 2019 The Author(s). BEAGLE is a high-performance likelihood-calculation library for phylogenetic inference. The BEAGLE library defines a simple, but flexible, application programming interface (API), and includes a collection of efficient implementations for calculation under a variety of evolutionary models on different hardware devices. The library has been integrated into recent versions of popular phylogenetics software packages including BEAST and MrBayes and has been widely used across a diverse range of evolutionary studies. Here, we present BEAGLE 3 with new parallel implementations, increased performance for challenging data sets, improved scalability, and better usability. We have added new OpenCL and central processing unit-threaded implementations to the library, allowing the effective utilization of a wider range of modern hardware. Further, we have extended the API and library to support concurrent computation of independent partial likelihood arrays, for increased performance of nucleotide-model analyses with greater flexibility of data partitioning. For better scalability and usability, we have improved how phylogenetic software packages use BEAGLE in multi-GPU (graphics processing unit) and cluster environments, and introduced an automated method to select the fastest device given the data set, evolutionary model, and hardware. For application developers who wish to integrate the library, we also have developed an online tutorial. To evaluate the effect of the improvements, we ran a variety of benchmarks on state-of-the-art hardware. For a partitioned exemplar analysis, we observe run-time performance improvements as high as 5.9-fold over our previous GPU implementation. BEAGLE 3 is free, open-source software licensed under the Lesser GPL and available at https://beagle-dev.github.io
Oportunidad en el ingreso de la gestante al programa de control prenatal según la resolución 3280 de 2018 durante el año 2019
No full textEl ingreso oportuno al control prenatal representa un aspecto muy importante para las gestantes ya que por medio de este se pueden detectar a tiempo posibles riesgos que puedan afectar la salud durante el embarazo, parto y puerperio. De acuerdo a la normatividad vigente el programa de control prenatal en Colombia se encuentra definido bajo la Resolución 3280 de 2018 donde establece que el ingreso de la gestante se debe realizar antes de la semana 10 de gestación, sin embargo, se evidencia que en las instituciones de salud la oportunidad de ingreso a este programa no se cumple en su totalidad. Por ende, el presente estudio monográfico pretende como objetivo general determinar la oportunidad en el ingreso al control prenatal durante el año 2019 de acuerdo a la normatividad vigente, mediante la compilación de la información pertinente que existe al respecto, para lograrlo se estudiaron 40 referencias bibliográficas entre ellos libros, estudios, artículos de revistas, tesis y trabajos de grados, donde se realizó una etapa de búsqueda de información, análisis o interpretación de los trabajos investigativos elaborados acerca de este tema, lo que permitió concluir que el ingreso al control prenatal en Colombia se ve afectado por diversos factores asociados a barreras socio económicas, bajo nivel de escolaridad, y falta de captación temprana por parte de las instituciones prestadoras de servicios de salud, los cuales influyen negativamente en el acceso al programa, debido a esta problemática se han implementado estrategias enfocadas en minimizar los riesgos de morbimortalidad materna y perinatal con el fin de medir, monitorear y evaluar el cumplimiento de este programa.Timely admission to prenatal control represents a very important aspect for pregnant women, since it can detect possible risks in time that could affect health during pregnancy, childbirth and the puerperium. According to current regulations, the prenatal control program in Colombia is defined under Resolution 3280 of 2018 where it establishes that the pregnant woman must be admitted before week 10 of gestation, however, it is evident that in institutions The opportunity to enter this program is not fully met. Therefore, the present monographic study intends as a general objective to determine the opportunity to enter prenatal control during 2019 according to current regulations, by compiling the pertinent information that exists in this regard, to achieve this, 40 bibliographic references were studied. among them books, studies, magazine articles, theses and degree works, where a stage of information search, analysis or interpretation of the research work carried out on this topic was carried out, which allowed us to conclude that admission to prenatal control in Colombia is affected by various factors associated with socio-economic barriers, low level of schooling, and lack of early recruitment by the institutions providing health services, which negatively influence access to the program, due to this problem have been implemented strategies focused on minimizing the risks of maternal morbidity and mortality na and perinatal in order to measure, monitor and evaluate compliance with this program.RESUMEN .................................................................................................................... 7ABSTRACT .................................................................................................................... 8INTRODUCCION .......................................................................................................... 91. METODOLOGÍA ...................................................................................................... 111.1. TIPO DE ESTUDIO ............................................................................................... 111.2. OBJETIVO GENERAL ........................................................................................... 111.3. OBJETIVOS ESPECÍFICOS .................................................................................... 111.4. UNIDAD DE ANÁLISIS ........................................................................................ 111.5. POBLACIÓN ........................................................................................................ 121.6. MUESTRA ............................................................................................................ 121.7. FUENTES DE INFORMACION ............................................................................ 121.8. MÉTODOS ........................................................................................................... 121.9. ORGANIZACIÓN DE LA INFORMACION ........................................................... 121.10. PRESENTACION DE LA INFORMACION ......................................................... 131.11. ASPECTOS ETICOS .......................................................................................... 131.12. ASPECTOS DE PROPIEDAD INTELECTUAL .................................................... 132. MONOGRAFÍA ....................................................................................................... 142.1 CONTROL PRENATAL EN LAS INSTITUCIONES DE SALUD ............................ 142.1.1 El sistema nacional de salud ......................................................................... 142.1.2 Control prenatal ............................................................................................. 152.1.3 Aspectos históricos del control prenatal ..................................................... 162.2 FACTORES QUE INFLUYEN EN LA OPORTUNIDAD AL INGRESO DEL CONTROL PRENATAL ................................................................................................................... 182.2.1 Calidad de la atención en salud ...................................................................... 212.2.2 Factores ............................................................................................................ 182.3. MEDIDAS QUE IMPLEMENTAN LAS INSTITUCIONES PRESTADORAS DE SERVICIOS DE SALUD PARA MEJORAR LA OPORTUNIDAD ............................................ 262.3.1 Estrategias .......................................................................................................... 282.3.2. Implementación de estrategias en el sector salud ..................................... 303. CONSIDERACIONES FINALES ............................................................................... 324. CONCLUSIONES .................................................................................................... 345. RECOMENDACIONES ........................................................................................... 356. REFERENCIAS ......................................................................................................... 36EspecializaciónEspecialista en Auditoria de la Calidad en SaludMonografí
Author Correction: A comparison of tools for the simulation of genomic next-generation sequencing data
No full textNarratives that emerge from fears in Therapist training
No full textEl artículo hace parte de los hallazgos obtenidos en la investigación denominada “Narrativas del Self del terapeuta en formación y sus familias de origen”, en la que uno de los objetivos planteados fue explorar los temores y expectativas de los estudiantes en formación clínica-terapéutica como preparación al ejercicio profesional. Para esto, se hizo uso del paradigma cualitativo con enfoque hermenéutico y el modelo biográfico-narrativo que permitió conocer aspectos de la vida de los participantes y de sus familias de origen, y que acompaña al ejercicio clínico práctico. Con la participación de diez estudiantes de pregrado en Psicología, y trece en posgrado de la Maestría en Terapia Familiar, de dos Universidades en el contexto nacional colombiano a través el uso de técnicas como el diario de campo, la entrevista grupal, el genograma, entre otras técnicas, se recolectó información fue procesada en matrices categoriales para el análisis del contenido, teniendo en cuenta la confidencialidad de la información de los participantes. Por consiguiente, al hacer énfasis en las narrativas que surgen en estos espacios íntimos se dieron pasos para adquirir comprensiones de los aspectos de la vida de los terapeutas en la profundidad de sus familias de origen, en orden a la integralidad de su formación profesional, así se aportaron consideraciones que permitieron identificar narrativas sobre los temores en el desarrollo del ejercicio del profesional en terapia debido a que, según los hallazgos, permitieron reconocer en los miedos significados y recursos que favorecen la consolidación de la construcción de las identidad y de la historia de vida del Self tanto personal como profesional.In this article, part of the findings obtained in the research called "Narratives of the Self of the therapist in training and their families of origin", in which one of the objectives was to explore the fears and expectations of students in clinical-therapeutic training in preparation for the professional practice. For this, we used the qualitative paradigm with a hermeneutic approach and the biographical-narrative model that allowed us to know aspects of the life of the participants and their original families, and that accompanies the practical clinical practice. With the participation of ten undergraduate students in Psychology, and thirteen graduate students of the Master's Degree in Family Therapy, from two Universities in the Colombian national context through the use of techniques such as the field diary, group interview, genogram, among other techniques, information was collected and processed in categorical matrices for content analysis, taking into account the confidential nature of the participants' information. Consequently, by placing emphasis on the narratives that emerge in these intimate spaces, a study was carried out to acquire an understanding of the aspects of the therapists' lives in the depths of their original families, with a view to the comprehensiveness of their professional training, thus providing considerations that allowed the identification of narratives on fears in the development of the professional's practice in therapy that, according to the findings, allowed to recognize in the fears meanings and resources that favor the consolidation of the construction of the identity and the life history of the Self, both personal and professional
Narrativas que surgen de los temores en la formación del Terapeuta
No full textIn this article, part of the findings obtained in the research called "Narratives of the Self of the therapist in training and their families of origin", in which one of the objectives was to explore the fears and expectations of students in clinical-therapeutic training in preparation for the professional practice. For this, we used the qualitative paradigm with a hermeneutic approach and the biographical-narrative model that allowed us to know aspects of the life of the participants and their original families, and that accompanies the practical clinical practice. With the participation of ten undergraduate students in Psychology, and thirteen graduate students of the Master's Degree in Family Therapy, from two Universities in the Colombian national context through the use of techniques such as the field diary, group interview, genogram, among other techniques, information was collected and processed in categorical matrices for content analysis, taking into account the confidential nature of the participants' information. Consequently, by placing emphasis on the narratives that emerge in these intimate spaces, a study was carried out to acquire an understanding of the aspects of the therapists' lives in the depths of their original families, with a view to the comprehensiveness of their professional training, thus providing considerations that allowed the identification of narratives on fears in the development of the professional's practice in therapy that, according to the findings, allowed to recognize in the fears meanings and resources that favor the consolidation of the construction of the identity and the life history of the Self, both personal and professional.El artículo hace parte de los hallazgos obtenidos en la investigación denominada “Narrativas del Self del terapeuta en formación y sus familias de origen”, en la que uno de los objetivos planteados fue explorar los temores y expectativas de los estudiantes en formación clínica-terapéutica como preparación al ejercicio profesional. Para esto, se hizo uso del paradigma cualitativo con enfoque hermenéutico y el modelo biográfico-narrativo que permitió conocer aspectos de la vida de los participantes y de sus familias de origen, y que acompaña al ejercicio clínico práctico. Con la participación de diez estudiantes de pregrado en Psicología, y trece en posgrado de la Maestría en Terapia Familiar, de dos Universidades en el contexto nacional colombiano a través el uso de técnicas como el diario de campo, la entrevista grupal, el genograma, entre otras técnicas, se recolectó información fue procesada en matrices categoriales para el análisis del contenido, teniendo en cuenta la confidencialidad de la información de los participantes. Por consiguiente, al hacer énfasis en las narrativas que surgen en estos espacios íntimos se dieron pasos para adquirir comprensiones de los aspectos de la vida de los terapeutas en la profundidad de sus familias de origen, en orden a la integralidad de su formación profesional, así se aportaron consideraciones que permitieron identificar narrativas sobre los temores en el desarrollo del ejercicio del profesional en terapia debido a que, según los hallazgos, permitieron reconocer en los miedos significados y recursos que favorecen la consolidación de la construcción de las identidad y de la historia de vida del Self tanto personal como profesional
D7.1 ASHVIN technology demonstration plan
No full textDeliverable D7.1 of project ASHVIN (Assistants for Healthy, Safe, and Productive Virtual Construction Design, Operation & Maintenance using a Digital Twin Project Acronym)ASHVIN aims at the digitalization of the construction industry to increase productivity, resource efficiency, and safety. Towards this goal, digital twin technology is only one means to an end. Therefore, the core of all ASHVIN development aims at introducing two major process innovations enabled by the possibility to closely match as-build information with as-designed information throughout the product development lifecycle that is made possible by digital twin technology. This report presents a plan for implementation of the ASHVIN platform and tools in the demonstration projects. For each of the demonstration project relevant challenges and needs are described, based on that appropriate tools and monitoring devices can be planned. It is significant to show that various type of structures (buildings, bridges, and industrial buildings) has different problems and boundary condition. Only after examination and understanding of the problems and challenges that each construction site faces it is possible to correctly apply new solution. The document that presents the implementation of digital twin technologies on demonstration projects: #1 Bridges for highspeed railways in Spain, #2 Building renovation in Poland, #3 Airport runway in Croatia, #4 Logistics hall construction in Germany, #5 Kineum office building in Sweden, #6 Office buildings in Spain, #7 Bridges in highway network in Spain, #8 Footbridge in Germany, #9 Sport stadium roof structure, #10 Quay wall in the Netherlands.Task leader/Main author: Agnieszka Łukaszewska, Marek Giluń (FASADA)
Contributing partners: Felicia Johansson, Rogier Jongeling (Plan B), Rahul Tomar (DTT), Christina Claeson-Jonsson (NCC); Manuel Jungmann (TUB), Jorge Campos, João Gonçalves (EUR), Vasilis Papanikolaou (AUS); Rolando Chacon (UPC), David García Carrera (UPC), Carlos Ramonell (UPC), Hector Posada (UPC), Lucian Ungureanu (TUB), Sandra Skaric Palic (INFCON)
Reviewer(s): Irina Stipanovic (INFCON), Burkhard Krenn,(SPB)Preprin
Corrigendum to: The epidemiology of alcohol use disorders cross-nationally: findings from the World Mental Health Surveys [Addict. Behav. 102 (2020) 106128] (Addictive Behaviors (2020) 102, (S0306460319304897), (10.1016/j.addbeh.2019.106128))
No full textThe authors regret that the abovementioned article published online September 16, 2019, had an error in the author affiliations. The edited author affiliations are shown above. The authors also regret that the names of the WHO World Mental Health Survey Collaborators were omitted from the end of the article. “The WHO World Mental Health Survey collaborators are Sergio Aguilar-Gaxiola, MD, PhD; Ali Al-Hamzawi, MD; Mohammed Salih Al-Kaisy, MD; Jordi Alonso, MD, PhD; Laura Helena Andrade, MD, PhD; Lukoye Atwoli, MD, PhD; Corina Benjet, PhD; Guilherme Borges, ScD; Evelyn J. Bromet, PhD; Ronny Bruffaerts, PhD; Brendan Bunting, PhD; Jose Miguel Caldas-de-Almeida, MD, PhD; Graça Cardoso, MD, PhD; Somnath Chatterji, MD; Alfredo H. Cia, MD; Louisa Degenhardt, PhD; Koen Demyttenaere, MD, PhD; Silvia Florescu, MD, PhD; Giovanni de Girolamo, MD; Oye Gureje, MD, DSc, FRCPsych; Josep Maria Haro, MD, PhD; Meredith Harris, PhD; Hristo Hinkov, MD, PhD; Chi-yi Hu, MD, PhD; Peter de Jonge, PhD; Aimee Nasser Karam, PhD; Elie G. Karam, MD; Norito Kawakami, MD, DMSc; Ronald C. Kessler, PhD; Andrzej Kiejna, MD, PhD; Viviane Kovess-Masfety, MD, PhD; Sing Lee, MB, BS; Jean-Pierre Lepine, MD; John McGrath, MD, PhD; Maria Elena Medina-Mora, PhD; Zeina Mneimneh, PhD; Jacek Moskalewicz, PhD; Fernando Navarro-Mateu, MD, PhD; Marina Piazza, MPH, ScD; Jose Posada-Villa, MD; Kate M. Scott, PhD; Tim Slade, PhD; Juan Carlos Stagnaro, MD, PhD; Dan J. Stein, FRCPC, PhD; Margreet ten Have, PhD; Yolanda Torres, MPH, Dra.HC; Maria Carmen Viana, MD, PhD; Daniel V. Vigo, MD, DrPH; Harvey Whiteford, MBBS, PhD; David R. Williams, MPH, PhD; and Bogdan Wojtyniak, ScD.” The authors would like to apologise for any inconvenience caused
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