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The effect of Irisin on bone cells in vivo and in vitro
No full textREVIEW ARTICLE| JANUARY 15 2021
The effect of Irisin on bone cells in vivo and in vitro
Cinzia Buccoliero; Angela Oranger; Graziana Colaianni; Patrizia Pignataro; Roberta Zerlotin; Roberto Lovero; Mariella Errede; Maria Grano
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Biochem Soc Trans (2021) BST20200978.
https://doi.org/10.1042/BST20200978
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The myokine Irisin, produced during physical exercise, has an anabolic effect on bone, both in vitro and in vivo. Very recently, using a controlled in vitro 3D cell model to mimic the bone microenvironment aboard the International Space Station, it has been shown that Irisin treatment in microgravity prevents the down-regulation of the transcription factors Atf4, Runx2 and Osterix, as well as Collagen I and Osteoprotegerin proteins, crucial for osteoblast differentiation in physiologic conditions. Irisin action has also been investigated in human subjects, in which it correlates with bone health status, supporting its physiological importance also in human bone, both in healthy subjects and in patients suffering from diseases related to bone metabolism, such as hyperparathyroidism and type 1 diabetes. Low levels of circulating Irisin have been found in post-menopausal women affected by hyperparathyroidism. Furthermore, Irisin is positively correlated with bone strength in athletes and bone mineral density in football players. Moreover, in healthy children, Irisin is positively associated with bone mineral status and in children with type 1 diabetes, Irisin is positively correlated with improved glycemic control and skeletal health. In this review, we will focus on recent findings about Irisin action on microgravity induced bone loss and on osteocyte activity and survival through its αV/β5 integrin receptor
Professor Angela Shannon
No full textAngela Shannon shares her poetry with the Taylor community.
Angela Shannon is the author of Singing the Bones Together, a 2004 Minnesota Book Awards Finalist. She teaches English at Bethel University. Her work has been published in journals, textbooks, and anthologies, including TriQuarterly, Ploughshares, Where One Ends Another Begins: 150 Years of Minnesota Poetry, and Beyond the Frontier: African American Poetry for the 21st Century. Her choreopoem Root Woman premiered at the Fleetwood-Jourdain Theater in Evanston, Ill
Angela Shanté : 2022 Irma Black Award Silver Medal Acceptance Speech
No full textAuthor Angela Shanté gives an acceptance speech for When My Cousins Come to Town, illustrated by Keisha Morris (West Margin Press)https://educate.bankstreet.edu/irma_black_awards/1004/thumbnail.jp
The Family History of Angela Ruth Weidert
No full textAngela Ruth Weidert authored this family history as part of the course requirements for HIST 550/700 Your Family in History offered online in Spring 2018 and was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]
Materia-autore = Author-Matter
No full textThe etymology of the word author refers to an act of creation, an act of augmentation, from the Latin verb augere. Author instantiates creation, the expansion of the pre-existing. In 1967 Roland Barthes declared the death of the author in his famous essay to state once more that the crisis is that of the author as a single subjectivity and as a term that condenses prestige, undermined by the de-subjectivation strategies of automatism, fortuity and fragmentation of the historical avant-gardes, as well as by the machinic act and by the reproducibility of the second avant-gardes.
Fifty years after Barthes’ paradigmatic formula, this lack of authorship appears to be a successful brand. The ten- sions between the anomie of matter, the law that establishes authorship and the economy that makes the work pos- sible, invoke discordant perspectives. Artists make the self-destruction of their work the real work, and appeal is made for the demolition of architectures, whether by a recognised author or not, in order to re-design, or better still, re-claim the territory. Artificial intelligence consolidates its logics and its design by progressively shedding human ingenuity. The space of criticism becomes, finally, increasingly ephemeral. However, there is an acceptation of criti- cism that is, rather than an individual ‘signature’, an exploration and explanation of how design makes theory.
The binomial author-matter seeks to mark these tensions and contradictions: the featured term author is main- tained to underline the persistence of that prestigious subjectivity, at the very moment when the rhetoric of “mat- ter as an author” promises other forms of authorship
Giussani Sansoni, Angela
No full textLa scheda ricostruisce la vita e l'apporto della scrittrice Angela Giussani Sansoni alla letteratura per l'infanzia.The headword explains the biography and the contribution of the author Angela Giussani Sansoni to the children's literature
Deliberation and journalism
No full textThe first chapter in 'International Journalism and Democracy' re-examines current ideas about the role of journalism in promoting democracy, introducing the concept of "deliberative journalism". 'Deliberation and Journalism' lists the ways in which journalists can assist deliberation and politics in communities around the world. The chapter defines deliberation as a specific form of conversation that precedes and promotes decision-making and action by members of a community. The author recognises the difficulty of engaging in deliberation in communities that are divided by different interests, identities, backgrounds, resources and needs. She provides examples of strategies that journalists can use to encourage inclusive and productive deliberation in the face of community diversity.\ud
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The chapter introduces examples of types of deliberative journalism that have emerged around the globe. These include strategies that have been sometimes been labeled as public journalism, civic journalism, peace journalism, development journalism, citizen journalism, the street press, community journalism, environmental journalism, and social entrepreneurism. The chapter also includes models of journalism that have not yet been given any particular name. Although the book identifies problems surrounding the theory and practice of these forms of journalism, the author notes that this is to be expected. Most models of deliberative journalism are relatively new, with none being more than a few decades old. The author concludes that resolution of these problems will only occur incrementally
Cellular Mechanisms of Multiple Myeloma Bone Disease
No full textMultiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease that results in severe bone pain, osteolytic lesions, and pathologic fractures. These skeletal complications have not only a negative impact on quality of life but also a possible effect in overall survival. MM osteolytic bone lesions arise from the altered bone remodeling due to both increased osteoclast activation and decreased osteoblast differentiation. A dysregulated production of numerous cytokines that can contribute to the uncoupling of bone cell activity is well documented in the bone marrow microenvironment of MM patients. These molecules are produced not only by malignant plasma cells, that directly contribute to MM bone disease, but also by bone, immune, and stromal cells interacting with each other in the bone microenvironment. This review focuses on the current knowledge of MM bone disease biology, with particular regard on the role of bone and immune cells in producing cytokines critical for malignant plasma cell proliferation as well as in osteolysis development. Therefore, the understanding of MM pathogenesis could be useful to the discovery of novel agents that will be able to both restore bone remodelling and reduce tumor burden
Il tempo perduto delle donne nei racconti di Adriana Bittel: Cum încărunţeste o blondă, Soi bun, Departe-n zare, spre Azuga
No full textIl contributo comprende la prima traduzione in italiano di tre racconti della scrittrice rumena Adriana Bittel, e un saggio sulle strategie narrative messe in atto da Bittel per descrivere lo spazio della socialità femminile nella Romania del periodo precedente al 1989The contribution consists of the translation into Italian of three short stories authored by the Romanian woman writer Adriana Bittel, entitled respectively, "How a Blond turns white", "Good Quality", “Far away in the horizon, towards Azuga”. Angela Tarantino, the author of the translation, adds to her work a presentation of Adriana Bittel and the narrative strategies used to describe the space of the women's sociality in Romania during the years previous to 198
Erratum: Lack of immunity against rubella among Italian young adults. [BMC Infect Dis., 17, (2017) (199)] Doi: 10.1186/s12879-017-2295-y
No full textAfter publication of this article [1], the authors noted that the given names and family names of all authors had been inverted, and are therefore incorrect in the original article. In the original article, the author names appear as the following: Gallone Maria Serena, Gallone Maria Filomena, Larocca Angela Maria Vittoria, Germinario Cinzia and Tafuri Silvio. However, this is incorrect, and the author names should appear as per the below: Maria Serena Gallone, Maria Filomena Gallone, Angela Maria Vittoria Larocca, Cinzia Germinario, Silvio Tafuri. The author names have been corrected in the author list and the citation for this Erratum
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