395,078 research outputs found
Non-muscle invasive bladder cancer tissues have increased base excision repair capacity
No full textThe molecular mechanisms underlying the development and progression of bladder cancer (BC) are complex and have not been fully elucidated. Alterations in base excision repair (BER) capacity, one of several DNA repair mechanisms assigned to preserving genome integrity, have been reported to influence cancer susceptibility, recurrence, and progression, as well as responses to chemotherapy and radiotherapy. We report herein that non-muscle invasive BC (NMIBC) tissues exhibit increased uracil incision, abasic endonuclease and gap-filling activities, as well as total BER capacity in comparison to normal bladder tissue from the same patient (p<0.05). No significant difference was detected in 8-oxoG incision activity between cancer and normal tissues. NMIBC tissues have elevated protein levels of uracil DNA glycosylase, 8-oxoguanine DNA glycosylase, AP endonuclease 1 and DNA polymerase beta protein. Moreover, the fold increase in total BER and the individual BER enzyme activities were greater in high-grade tissues than in low-grade NMIBC tissues. These findings suggest that enhanced BER activity may play a role in the etiology of NMIBC and that BER proteins could serve as biomarkers in disease prognosis, progression or response to genotoxic therapeutics, such as Bacillus Calmette-Guerin.Muftuoglu, M (corresponding author), Acibadem Mehmet Ali Aydinlar Univ, Dept Med Biotechnol, TR-34752 Istanbul, Turkey ; Acibadem Mehmet Ali Aydinlar Univ, Dept Mol Biol & Genet, TR-34752 Istanbul, Turkey.
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Hermite-Hadamard type inequalities for harmonically (?, m)-convex functions
No full textThe author introduces the concept of harmonically (?, m)-convex functions and establishes some Hermite-Hadamard type inequalities of theseclasses of functions
Risk of prostate cancer after diagnosis of atypical glands suspicious for carcinoma on saturation and traditional biopsies - Comment
No full textCombination of Perianal-Intrarectal Lidocaine-Prilocaine Cream and Periprostatic Nerve Block for Pain Control During Transrectal Ultrasound Guided Prostate Biopsy: Randomized, Controlled Trial COMMENT
No full textDisease in Peyami Safa’s novels
No full textYüksek Lisans TeziSanatçı bir ailenin çocuğu olan Peyami Safa, Türk edebiyatının önemli kalemlerindendir. Yazar, romanları dışında fikir eserleri, gazeteciliği, köşe yazarlığı ve polemikleriyle de ünlüdür. Peyami Safa, Batılıların otodidakt dediği, kendi kendini yetiştirmiş nadir şahsiyetlerdendir. Kırk üç yıl gibi uzun denecek bir süre boyunca yazmıştır. Edebî değeri olmayan eserlerini Server Bedi takma adı ile yayımlamıştır. Yazarın eserlerinde tahliller önemli yer tutar. Zıt kavramları eserlerinde ustalıkla işlemiştir. Peyami Safa?nın hayatı, eserleri ve sanatı daha önce çok sayıda araştırmacı tarafından incelenmiş, fakat yazarın hayatında büyük yeri olan ve eserlerinde de kendisini yoğun olarak hissettiren hastalık konusu işlenmemiştir. Bu sebeple tarafımızdan araştırma konusu olarak seçilmiştir. Küçük yaşlardan itibaren hastalıklarla boğuşan Peyami Safa, başta Dokuzuncu Hariciye Koğuşu olmak üzere bütün eserlerinde bu durumu yansıtmaya çalışmıştır. Amacımız Peyami Safa?nın romanlarını hastalıklar bakımından inceleyerek hayatının ve bu arada hastalık ve hastalıklara dair fikirlerinin eserlerine nasıl yansıdığını göstermek ve okura bu yolla anlatmak istediklerini gün ışığına çıkarmaktır.AbstractPeyami Safa, is the one of the most important writers in Turkish Literature, has an artist family. He also has worked as a journalist and columnist. Also known as intellectual works and some polemics. Peyami Safa one of the rare people himself trained. He has written articles for 43 years. The author has written works of non-literary values Server Bedi name. Analysis holds an important place in the author's works. The author skillfully opposite concepts have been committed. The author's life, works and art and has been previously studied by many researchers but author of life a great location issues that disease has not been studied. Therefore, it is selected as the subject of research by our research group. The author's life is filled with diseases since his childhood. The author particularly in the Dokuzuncu Hariciye Koğuşu, including all the works have tried to reflect this situation. Our goal; the author of the novel is the study of diseases also, the author is reflected in the works show how the ideas of the diseases and expose what they want to tell the reader in this way
Mapping the Discipline of the Olympic Games An Author-Cocitation Analysis
No full textThe authors conducted an author cocitation analysis on prominent authors writing about the Olympics during the 1990s. Author cocitation is an established bibliometric technique that can be used to measure the relative similarities of topics written about by the cited authors. This enables a visual representation of the “intellectual space” of the discipline, in this case the Olympics, to be created for the period under review. So core and peripheral research areas are identified, along with their major contributors. The representation appears as a two-dimensional cluster-enhanced map. Subject expertise was then applied to the results to place labels on the generated clusters of authors and their topics
jDHBenelux Author Template
No full textThis repository contains the latest official GitHub hosted versions of the LaTeX template that authors are required to use when they finalize their contribtions to the DH Benelux Journal. The repository synchronises with the corresponding easy-to-use and well-documented Overleaf Template that provides authors with a low threshold environment for writing LaTeX – but can be used with any LaTeX compiler.
About this Release: Apart from some minor changes to the .cls, v2.0 introduces a number of new files to improve open source development with git and GitHub, including a README, a CC-BY 4.0 License, and a .gitignore file. It also prepares the repository for synchronisation with Zenodo, to improve sustainability.
Full Changelog: https://github.com/DHBenelux/jDHBenelux-author-template/compare/v1.1...v2.
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
SOME GENERAL INTEGRAL INEQUALITIES FOR LIPSCHITZIAN FUNCTIONS VIA CONFORMABLE FRACTIONAL INTEGRAL
No full textIn this paper, the author establishes some Hadamard-type and
Bullen-type inequalities for Lipschitzian functions via Riemann Liouville fractional integral
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