7,954 research outputs found

    <i>No se sabe</i>: entrevista a José Eduardo Jorge

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    Entrevista al investigador de la UNLP José Eduardo Jorge, especialista en cultura política. Jorge, además, es miembro del Consejo Directivo del Instituto de Investigación en Comunicación (IICOM), director de proyectos de investigación acreditados y autor de un centenar de artículos científicos y de divulgación sobre Cultura Política y Comunicación Política. Autor también del libro Cultura Política y Democracia en Argentina (Edulp, 2010). Revisor de artículos científicos de la revista Questión.Al hacer clic en el enlace que figura en "Documentos relacionados", pueden accederse a todos los trabajos de José Eduardo Jorge presentes en el repositorio.Radio Universidad Nacional de La Plat

    Statistische Mechanik unter Anwendung der Werkzeuge der Informationstheorie

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    0 Cover and acknowledgements i-xiv 1 Introduction 1 1.1 Biological thermodynamics 1 1.2 An intuitive notion of energy and entropy 2 1.3 From steam engines to actin filaments: the laws of thermodynamics 5 1.4 Free energy in processes involving proteins 6 1.4.1 Predicting ligand binding and protein- protein interactions 7 1.4.2 Conformational entropy 8 1.5 The statistical in mechanics 9 1.5.1 Information over matter and energy 10 1.6 Entropy is a logarithmic counting of microstates 11 1.6.1 Stabilization by conformational entropy 13 1.6.2 Acceptable errors in theoretical estimations of protein thermodynamics 15 1.7 The entropy of polymers 16 1.7.1 Connection of thermodynamics to information theory 17 1.8 Medical applications of protein and drug thermodynamics 17 1.9 Aim of this work 19 1.10 References for Chapter 1 20 2 Balanced and bias-free computation of conformational entropy differences for molecular trajectories 27 2.1 Introduction 27 2.1.1 Experimental measurements of conformational entropy 28 2.1.2 Theoretical estimation of conformational entropy 29 2.2 Analytical derivation: Configurational entropy of a macromolecule 30 2.2.1 Absolute and relative configurational entropies 30 2.2.2 Sackur-Tetrode equation as a limiting case for ideal gas 33 2.2.3 Entropy using local spherical polar (BAT) coordinates 34 2.2.3.1 Relative conformational entropy in terms of BAT coordinates 37 2.3 Numerical method to estimate conformational entropy differences 38 2.3.1 Automated selection of BAT coordinates 39 2.3.1.1 Continuity maximization for torsions 39 2.3.1.2 Phase angles 40 2.3.2 Mutual Information expansion in low dimensional subspaces 40 2.3.3 Discretization 42 2.3.4 Bias-Removal 44 2.3.5 Balancing 44 2.3.6 Generating molecular conformations in a canonical ensemble 46 2.3.7 Benchmark Entropy 46 2.4 Model system 1: Monte Carlo simulation of a three-atom molecule in a cage 48 2.4.1 Simulation procedure 48 2.4.1.1 Monte Carlo algorithm 49 2.4.2 Clustering of conformations 49 2.4.3 Entropy estimation 50 2.5 Model system 2: Molecular Dynamics simulation of trialanine 52 2.5.1 Simulation procedure 52 2.5.2 Clustering of conformations 53 2.5.3 Entropy estimation 54 2.5.4 Convergence of benchmark entropy, energy and free energy 54 2.5.5 Detailed results for entropy estimates using the MI expansion (MIE) 57 2.5.5.1 MIE1 using all BAT coordinates 57 2.5.5.2 MIE2 using all BAT coordinates 58 2.5.5.3 MIE3 using all BAT coordinates 59 2.5.5.4 MIE Using only soft degrees of freedom 60 2.5.6 Convergence of the entropy estimates 63 2.5.6.1 Importance of choosing frames at random in the balancing method 64 2.5.7 Summary of results for model system 2 64 2.6 Discussion 69 2.6.1.1 BAT coordinates represent phase space compactly 69 2.6.1.2 Approximate cancellation of the Jacobian term of the entropy 70 2.6.1.3 Entropy estimation in signal processing versus molecular simulations 70 2.7 Conclusion 71 2.8 References for Chapter 2 74 3 Influence of Spacer-Receptor Interactions on the Stability of Bivalent Ligand-Receptor Complexes 81 3.1 Introduction 81 3.1.1 Biological and pharmaceutical relevance of multivalency 81 3.1.2 Polymer spacer-receptor interactions 82 3.1.3 Comparison of our model to experiment 82 3.2 Conclusions 83 3.2.1 Receptor topography: concave, planar or convex 83 3.2.2 Interaction thermodynamics: repulsive or attractive 83 3.3 References for Chapter 3 84 4 Summary 87 4.1 Abstract in English 87 4.1.1 Balanced and bias-free computation of conformational entropy differences for molecular trajectories 87 4.1.2 Influence of spacer-receptor interactions on the stability of bivalent ligand-receptor complexes 88 4.2 Zusammenfassung in deutscher Sprache 90 4.2.1 Ausbalancierte und von systematischen Fehlern bereinigte Berechnung konformationeller Entropiedifferenzen für molekulare Trajektorien 90 4.2.2 Einfluss von Spacer-Rezeptor-Wechselwirkungen auf die Stabilität von bivalenten Ligand-Rezeptor-Komplexen 91 Submitted manuscript Influence of Spacer-Receptor Interactions on the Stability of Bivalent Ligand- Receptor Complexes (print version only) 94 Supporting information for manuscript (print version only) 119Although thermodynamics was born from the desire to optimize industrial processes, its wide applicability has recently afforded it a place in biology. Accurate estimation of thermodynamic variables for processes involving biological macromolecules is an important goal in theoretical chemistry. For macromolecules and soft matter in general, understanding of the driving forces that comprise a given free energy or binding constant requires consideration of flexibility for all molecular degrees of freedom. The entropic contribution to free energy is thus an essential ingredient, whether explicitly quantified or included in a model in the form of a correct enumeration of the multiplicity of conformations. This doctoral thesis offers two contributions to the problem of computing entropy: (a) A numerical method for estimating conformational entropy differences for macromolecules was developed. It uses techniques borrowed from information theory and applies them to statistical mechanics. The method is applicable to conformational transitions and protein- ligand binding. (b) A model to describe the enhancement of the binding affinity for a bivalent ligand tethered with a polymer spacer was expounded. The novelty of the model consists in the inclusion of spacer-receptor interactions. (a) Balanced and bias-free computation of conformational entropy differences for molecular trajectories The mutual information expansion (MIE) is applied to estimate conformational entropy differences of macromolecules applicable to molecular dynamics or Monte Carlo simulation data on oligopeptides, polymers, proteins and ligands. The MIE serves to reduce the high dimensionality of the probability density of the conformational space of a macromolecule. The individual terms of the MIE are evaluated with a histogram method. Internal bond-angle-torsion (BAT) coordinates are used to avoid spurious correlations present when using Cartesian coordinates, which would demand using higher order terms in the MIE. Practically all entropy estimation methods from finite samples suffer from an inherent systematic error or bias. Two approaches are applied that compensate for systematic errors that occur with a histogram method: (1) Simulation data are balanced by using the same number of coordinate sets (frames) for both conformer domains. Balancing puts fluctuations of the histogram bin contents on the same level for both conformers, allowing for efficient error cancellation. (2) Bias- removal corrects for systematic deviations due to finite number of frames per bin. Applying both corrections improves the precision of entropy differences enormously. Estimates of entropy differences are compared to thermodynamic benchmarks of polymer and peptide models, where excellent agreement is found. For trialanine as model system, the average error for the estimated conformational entropy difference is only 0.3 J/(mol K), which is 100 times smaller than without applying the two corrections. Guidelines are provided for efficiently estimating conformational entropies. The complete method, including 1st to 3rd order MI expansion, balancing and bias-removal can be performed with the program ENTROPICAL. It can be obtained from the author and used with CHARMM and NAMD topologies and trajectories. (b) Influence of spacer-receptor interactions on the stability of bivalent ligand-receptor complexes Experiments show that a ligand-receptor complex formed by binding a bivalent ligand (D) in which the two ligating units are joined covalently by a flexible polymeric spacer (S) can be orders of magnitude more stable than the corresponding complex formed with monomeric ligands. Up until now, the molecular models that have been proposed to rationalize this "enhancement effect" neglect spacer-receptor (S-R) interactions. These interactions can nevertheless substantially influence the relative stability of complexes. Here, the results of a computational study designed to assess the impact of S-R interactions in the prototypic bivalent complex are presented and compared with results of experiments. The S-R interactions mimicking general features of biological systems are modeled by contoured R surfaces with hills (or depressions) at the binding sites. In the fictitious limit of vanishing S-R interactions, the enhancement is pronounced. This enhancement is in line with the experimental observations, although the S-R interactions, which surely occur in reality, were neglected. For strictly repulsive S-R interactions (hard R surface) the enhancement vanishes, or even reverses. This is particularly the case if the R surface is convex (i.e. rising between the binding sites), while the enhancement is only moderately reduced if the R surface is concave. Alternatively, a weak S-R attraction close to the R surface can increase the enhancement. It is concluded that large enhancement should be observed only if both features are present: a concave R surface plus a weak S-R attraction. The latter occurs for spacer material such as polyethylene glycol (PEG), which is weakly hydrophobic and thus attracted by protein surfaces. It is shown that the enhancement of bivalent binding can be characterized by a single key parameter, which may also provide guidelines for the design of multivalent complexes with large enhancement effect.Obwohl die Thermodynamik ursprünglich zur Optimierung industrieller Prozesse entwickelt wurde, hat sie sich durch ihre breiten Anwendungsmöglichkeiten in letzter Zeit auch einen Platz in der Biologie gesichert. Ein wichtiges Ziel in der theoretischen Chemie stellt die genaue Abschätzung thermodynamischer Variablen für Prozesse dar, an denen biologische Makromoleküle beteiligt sind. Das Verständnis der Triebkräfte, die eine gewisse freie Energie bei Makromolekülen und allgemein weicher Materie ausmachen, bedarf der Miteinbeziehung der Flexibilität aller molekularen Freiheitsgrade. Der entropische Beitrag zur freien Energie ist also ein unentbehrlicher Bestandteil, unabhängig davon, ob er explizit quantifiziert wird oder bei einem Modell in Form einer richtigen Aufzählung der Vielfachheit der Konformationen mit einbezogen wird. Die vorliegende Dissertation liefert zu dem Problem der Entropieberechnung zwei Beiträge: (1) Eine numerische Methode zur Berechnung von Entropiedifferenzen bei Makromolekülen wurde entwickelt. Sie entlehnt Techniken aus der Informationstheorie und wendet sie in der statistischen Mechanik an. Die Methode ist bei Konformationsänderungen und Protein-Ligandbindung verwendbar. (2) Zur Beschreibung der Verstärkung der Bindungsaffinität bei bivalenten Liganden, die mit einem Polymer-Spacer verknüpft sind, wurde ein geeignetes Modell entwickelt. Neu bei diesem Modell ist die Einbeziehung von Spacer-Rezeptor-Wechselwirkungen. (a) Ausbalancierte und von systematischen Fehlern bereinigte Berechnung konformationeller Entropiedifferenzen für molekulare Trajektorien Die Reihenentwicklung der wechselseitigen Information (mutual information expansion, MIE) wird benutzt, um Differenzen in konformationeller Entropie bei Makromolekülen zu berechnen. Die Methode ist auf Moleküldynamik- oder Monte-Carlo-Simulationsdaten von Polymeren, Proteinen und Liganden anwendbar. Die MIE dient der Dimensionsreduktion der Wahrscheinlichkeitsdichte des konformationellen Raums eines Makromoleküls. Die einzelnen Entwickungsterme der MIE werden mit Hilfe einer Histogrammmethode ausgewertet. Ein internes Koordinatensystem (Bindungslänge, Bindungswinkel und Torsionswinkel, das sogenannte BAT-System) wird benutzt, um die, bei kartesischen Koordinaten anwesenden, störenden Korrelationen zu vermeiden, die Entwickungsterme höherer Ordnung in der MIE benötigen würden. Praktisch alle Entropieschätzungsmethoden, die über eine endliche Menge von Daten verfügen, leiden an systematischen Fehlern (Bias). Zwei Korrekturmethoden werden eingesetzt, um diese systematischen Fehler von Histogrammmethoden auszugleichen: (1) Die Simulationsdaten werden ausbalanciert, indem die gleiche Anzahl von Koordinatensätzen (Einzelbildern) für beide Konformerdomänen benutzt wird. Durch dieses Ausbalancieren werden die Schwankungen der Belegungen einzelner Histogrammsäulen für beide Konformere im Mittel gleich groß. Dies führt zu einem effizienten Fehlerausgleich. (2) Die Bereinigung der systematischen Fehler (Bias) kompensiert Abweichungen, die auf Grund der endlichen Menge von Daten pro Histogrammsäule entstanden sind. Die gleichzeitige Verwendung beider Korrekturen verbessert die Genauigkeit der Abschätzung von Entropiedifferenzen erheblich. Die geschätzten Entropiedifferenzen werden mit thermodynamischen Bezugswerten für Polymer- und Peptidmodelle verglichen und stimmen mit diesen ausgezeichnet überein. Für das Modellsystem Trialanin betrug der durchschnittliche Fehler für die geschätzte konformationelle Entropiedifferenz nur 0.3 J (mol K), welcher 100-mal kleiner ist als bei Weglassen beider Korrekturmethoden. Leitlinien zur effizienten Berechnung konformationeller Entropie werden angegeben. Die komplette Methode, einschließlich MIE 1. bis 3. Grad, Ausbalancieren und Bereinigung von systematischen Fehlern, kann mit Hilfe des Programms ENTROPICAL ausgeführt werden. Das Programm arbeitet auf CHARMM- und NAMD-Topologien und -Trajektorien und wird vom Autor auf Anfrage zur Verfügung gestellt. (b) Einfluss von Spacer-Rezeptor-Wechselwirkungen auf die Stabilität von bivalenten Ligand-Rezeptor-Komplexen Experimente zeigen, dass ein durch einen bivalenten Liganden (D) gebildeter Ligand-Rezeptor- Komplex, in dem beide bindenden Einheiten mit Hilfe eines flexiblen Polymer- Spacers kovalent verknüpft werden, um Größenordnungen stabiler sein kann als der entsprechende, durch monomere Liganden gebildete Komplex. Bislang haben molekulare Modelle der bivalenten Bindung den Verstärkungseffekt erklärt, ohne die Wechselwirkungen zwischen Spacer und Rezeptor (S-R) zu berücksichtigen. Letztere können aber die relative Stabilität der Komplexe entscheidend beeinflussen. Wir haben Computersimulationen an geeigneten, prototypischen Modellsystemen für den bivalenten Komplexe durchgeführt, um die Auswirkungen der S-R-Wechselwirkungen auf die Bindungseffizienz zu untersuchen und mit experimentellen Ergebnissen verglichen. Die modellierten S-R-Wechselwirkungen bilden die allgemeinen Merkmale biologischer Systeme nach und werden als R-Oberfläche mit Bergen (bzw. Tälern) an den Bindungsstellen modelliert. Im fiktiven Grenzfall verschwindender S-R-Wechselwirkungen ist die Verstärkung der Bindungseffizienz groß. Dies deckt sich mit experimentellen Beobachtungen, obwohl die in der Realität sicher auftretenden S-R-Wechselwirkungen vernachlässigt wurden. Bei rein abstoßenden S-R-Wechselwirkungen (harter R-Oberfläche) verschwindet die Verstärkung oder kehrt sich gar um. Das ist insbesondere bei konvexer (also zwischen den Bindungsstellen gewölbter) R-Oberfläche der Fall, wobei die Verstärkung bei einer konkaven Oberfläche nur unwesentlich verringert ist. Alternativ kann eine schwache S-R-Anziehung nahe der R-Oberfläche die Verstärkung erhöhen. Es wird geschlussfolgert, dass nur in dem Fall, dass beide Merkmale anwesend sind, eine hohe Verstärkung zu erwarten ist: d. h. bei einer konkaven R-Oberfläche und einer schwachen S-R-Anziehung. Letzteres tritt bei Spacermaterialien wie Polyethylenglycol (PEG) auf, welches geringfügig hydrophob ist und aus diesem Grund von Proteinoberflächen angezogen wird. Es wird gezeigt, dass die Verstärkung bivalenter Bindung mit einem einzelnen Parameter gekennzeichnet werden kann, woraus sich Leitlinien für den Entwurf multivalenter Komplexe mit hoher Verstärkung gewinnen lassen

    Miradas Al Sur: a criação mitológica do bairro sur na obra de Jorge Luis Borges

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    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2014Este estudo investiga como Jorge Luis Borges constrói o Sur como espaço mítico, em seus três primeiros livros de poesia. Para tanto, analisou-se de que forma a representação de tal espaço torna-o simbólico e, posteriormente, mítico, tanto no conjunto da obra do autor, como também, a partir desse movimento individual de Borges, no imaginário coletivo da cidade. Estudou-se ainda como a memória própria e o imaginário criaram espaços afetivos, que permeiam a totalidade dos textos do autor.Abstract: This study investigates how Jorge Luis Borges builds Sur neighborhood as mythic space in his first three books of poetry. To this end, we analyzed how the representation of such a space make of it a symbolic and later a mythical space, both in the overall work of the author, but also that individual movement of Borges that achieve the collective imagination of the city. Still we have studied how the personal memory and the imagery is able to create emotional spaces, which constitute the totality of texts by the author

    Enlaces: memória e subjetividades no acervo Jorge Amado

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    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Literatura, Florianópolis, 2015.O objetivo central da minha dissertação é apresentar o resultado das relações afetivas constituídas e apreendidas no Acervo Jorge Amado (NuLIME). A minha subjetividade foi ao encontro da memória material das cartas destinadas ou remetidas por dois comunistas: Juan e Joaquim. A leitura delas me permitiu ressignificar a questão da autoria e da literatura epistolar. O trabalho, em parte, foi apresentado como cartas. A escrita, situada no limite entre ficcional e factual, faz referências ao contexto político e social do Brasil no período da ditadura de Vargas. O trabalho está inserido no contexto específico da memória e da narrativa dos comunistas e perseguidos políticos que viveram esta fase da vida intelectual, social, política e literária brasileira.Abstract : My dissertation´s main objective is to present the result of the affective relations constituted and apprehended from Jorge Amado´s collection (NuLIME). My subjectivity is connected to the material memory of the letters destined or posted by two communists: Juan and Joaquim. Reading them has enabled me to reframe the questions of authorship and epistolary literature. The work was partially presented as letters. The writing, classified in between fictional and factual, refers to the social and political context and to the narrative from communists and political persecuted who lived this period of Brazilian intellectual, social, political and literary life

    Dancing with Napster: Predictable consumer behavior in the New Digital Economy

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    The Internet is often characterized as a "disruptive technology," as recently argued by the music industry against Napster and by Sony against PC emulations of its PlayStation. Three questions are raised: 1) How much does the Internet replace traditional media? 2) As another information channel, does the Internet supplement traditional media? 3) How much do Internet users navigate the Web in order to download relevant information goods (news, music, movies) as part of their consumption and purchase strategies?Data from the Pew Internet and American Life Project are used to test two competing hypotheses: 1) Easily copied and distributed digital content encouragesconsumers to exploit the "information wants to be free" character of the Internet, thereby hampering the growth of the market for information goods and services, and 2)Information consumers practice a sophisticated arbitrage process across different media, by weighing the value of online and offline information and thereby reinforcing active participation in the electronic marketplace. The efforts of the music industry to obstruct the downloading of MP3s may represent a serious misunderstanding of consumer arbitrage practices, much as book publishers characterize library use as a threat to book sales. Policy implications of thiswork extend into ongoing public and corporate policy debates about digital content and intellectual property.The original publication is available at: http://www.stanford.edu/group/siqss/itandsociety/v01i02/v01i02a11.pd

    Ethics of dust:visual essay on the artistic works by Jorge Otero-Pailos

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    The works of artist and preservation architect Jorge Otero-Pailos on experimental preservation provoke deep reflections about some of the fundamental questions dealing with heritage: temporality of objects, changeability of inscribed cultural values, the greater purpose of architectural preservation as a cultural practice, and the societal role of an architect and preservationist in formulating narratives around heritage. As the artistic installations featured in this visual essay — The Ethics of Dust (2014–2016) and Watershed Moment (2020) — demonstrate, Jorge Otero-Pailos combines various elusive elements, such as water sounds and dust, to conceive meditative and contemplative spaces. His installations invite visitors to pause and reflect on the memories, both personal, social, and environmental, that define each of us; they probe deep into the past and deep into the future.Since these are some of the issues we wanted to explore in this special issue, ‘Embodiment and Meaning-making: Interdisciplinary Perspectives on Heritage Architecture’, we invited various artists and scholars to write a very short caption in reaction to the images provided by the author through one of these three ‘lenses’:- affect, embodied experience, atmosphere;- politics of heritage;- processes of meaning-making.The results reveal the power of images to provoke imagination through atmospheric and embodied experiences, and the power of experimental heritage work to convey (political) meaning across distance and different analogue or digital media.This visual essay includes contributions from (in order of appearance): Tenna Doktor Olsen Tvedebrink, Federico De Matteis, Michael Hirschbichler, Jovana Popić, Maria De Piedade Ferreira, Uta Pottgiesser, Marcus Weisen and Brady Wagoner, with an epilogue from Jorge Otero-Pailos.Situated ArchitectureHeritage & Technolog

    Cantiga de ceilão, com Jorge de Sena em Santa Bárbara

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    Um estudo de uma cantiga em crioulo indo-português da comunidade de descendentes de portugueses da costa oriental do Sri Lanka, gravada pelo autor em pesquisa de campo, incluindo uma orientação à história e persistência da língua portuguesa crioula na ilha. Relata a origem do poema “Cantiga de Ceilão” de Jorge de Sena e a relevância dos versos para o pensamento e a situação do poeta, separado da língua portuguesa.A study of a cantiga in Indo-Portuguese creole from a community of descendants of Portuguese on the East coast of Sri Lanka, recorded by the author during fieldwork, including a survey of the history and persistence of the Portuguese creole language on the Island. The study addresses the origin of the poem “Cantiga from Ceylon” by Jorge de Sena and its relevance to the thought and situation of the poet, separated physically and culturally from the Portuguese language

    What have we learned?

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    Debate over the potential and efficacy of the Telecommunications Act of 1996 arose at the moment of its first consideration, continued right through the President’s signature, and shows no sign of diminishing. In cosidering the impact of the Act five years later, three central issues emerge: competition, regulation, and access.The original publication is available at: http://newmillenniumresearch.org/archive/schement.pd

    Jorge Vinatea Reinoso. Una propuesta indigenista en su lenguaje pictórico [Capítulo 1]

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    La publicación es una investigación sobre la propuesta indigenista encontrada en el lenguaje pictórico de las obras del reconocido pintor arequipeño Jorge Vinatea Reinoso. La autora del libro, Philarine Villanueva, se enfoca en el análisis del espacio cultural andino de las obras del artista y cómo su visión personal buscó destacar la imagen de hombres y mujeres de la sierra sur del Perú en sus pinturas, por medio de técnicas pictóricas que priorizan la presencia de sus personajes y las acciones de sus vidas cotidianas. El libro presenta, en una primera parte, un recuento histórico sobre la producción artística de Jorge Vinatea Reinoso y en su contexto social, político y cultural. En la segunda parte, la autora, mediante el análisis de las pinturas A Amancaes, Tantahuasi y Caballitos de totora, deconstruye el estilo pictórico del pintor y cómo las estructuras, trazos y colores responden a su propia cosmovisión andina. Finalmente, se explican los hallazgos de las composiciones dinámicas de las obras analizadas y la manera en que estas logran generar una experiencia sensorial sobre un indigenismo crítico y endógeno.The publication is a research about the indigenist proposal found in the pictorial language of the works by Jorge Vinatea Reinoso, renowned painter from Arequipa. The book's author, Philarine Villanueva, focuses on the analysis of the Andean cultural space in his works and how his personal view sought to spotlight the image of Peru's southern highlands men and women in his paintings using pictorial techniques that feature the characters and their daily activities. In the first part of the book, there is a historical review of Jorge Vinatea Reinoso's artistic production and its social, political, and cultural background. In the second part, through the analysis of the A Amancaes, Tantahuasi and Caballitos de totora paintings, the author deconstructs the painter's pictorial style and how the structures, strokes, and colors respond to his own Andean world view. Finally, the findings about the dynamic compositions of the analyzed paintings are explained, as well as the way they manage to generate a sensory experience regarding critical and endogenous indigenism

    3rd Floor: University Author Reception

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    Jorge Leon walks with students through the new 3rd floor.https://digitalcommons.pittstate.edu/unihistoryphotos/1119/thumbnail.jp
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