69 research outputs found
発熱起因性のQT延長およびトルサードドポアントが生じるメカニズム
No full text金沢大学博士(医学）博士論文 要旨Abstract/本文Full 以下に掲載：EP Europace 25(6) euad 161- 2023. Oxford Academic. 共著者：Keisuke Usuda, Kenshi Hayashi, Tadashi Nakajima, Yasutaka Kurata, Shihe Cui, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Kenji Sakata, Soichiro Usui, Noboru Fujino, Yoshihiro Tanaka, Yoshiaki Kaneko, Masahiko Kurabayashi, Shoichi Tange, Takekatsu Saito, Kunio Ohta, Masakazu Yamagishi, Masayuki Takamuradoctoral thesi
発熱起因性のQT延長およびトルサードドポアントが生じるメカニズム
No full text博士論文 要旨Abstract/本文Full 以下に掲載：EP Europace 25(6) euad 161- 2023. Oxford Academic. 共著者：Keisuke Usuda, Kenshi Hayashi, Tadashi Nakajima, Yasutaka Kurata, Shihe Cui, Takashi Kusayama, Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Kenji Sakata, Soichiro Usui, Noboru Fujino, Yoshihiro Tanaka, Yoshiaki Kaneko, Masahiko Kurabayashi, Shoichi Tange, Takekatsu Saito, Kunio Ohta, Masakazu Yamagishi, Masayuki Takamur
The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants
No full text金沢大学博士(医学）博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Molecular and Cellular Cardiology 177 pp.50-61 2023. Elsevier. 共著者：Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi, Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, Tetsuo, Nishikawa, Hiroshi Furusho, Takekatsu Saito, Hiroaki Hirase, Kunio Ohta, Manabu Fujimoto, Yuki Horita, Takashi Kusayama,Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Soichiro Usui, Kenji Sakata, Noboru Fujino, Atsushi Tajima, Masakazu, Yamagishi, Masayuki Takamuradoctoral thesi
The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants
No full text博士論文 要旨Abstract/本文Full 以下に掲載：Journal of Molecular and Cellular Cardiology 177 pp.50-61 2023. Elsevier. 共著者：Shihe Cui, Kenshi Hayashi, Isao Kobayashi, Kazuyoshi, Hosomichi, Akihiro Nomura, Ryota Teramoto, Keisuke Usuda, Hirofumi Okada, Yaowen Deng, Jingjing Kobayashi-Sun, Tetsuo, Nishikawa, Hiroshi Furusho, Takekatsu Saito, Hiroaki Hirase, Kunio Ohta, Manabu Fujimoto, Yuki Horita, Takashi Kusayama,Toyonobu Tsuda, Hayato Tada, Takeshi Kato, Soichiro Usui, Kenji Sakata, Noboru Fujino, Atsushi Tajima, Masakazu, Yamagishi, Masayuki Takamur
Effect of hypercapnia on self-sustained muscle activity
No full textThe aim of the present study was to determine the effect of hypercapnia on motor neuromuscular activity of the human triceps surae muscle. Nine subjects participated in trials in a normal breathing condition and a CO2 rebreathing condition. In both conditions, in order to provoke self-sustained muscle activity, percutaneous electrical train stimulation was applied to the tibial nerve while each subject lay on a bed. Self-sustained muscle activity, which is an indirect observation of plateau potentials in spinal motoneurons, was measured for 30 s after the train stimulation by using surface electromyography. The sustained muscle activity was increased by CO2 rebreathing (P < 0.05). This finding suggests that motor neuromuscular activity may be linked to the respiratory system that is activated during hypercapnia
Coherence between cardiorespiratory system and TOI
No full textIt has been shown that the tissue oxygen index (TOI) measured by near-infrared spectroscopy oscillates at very low frequencies during recovery after exercise and that this oscillation is derived from interactions among biochemical substances involved in oxidative metabolism in skeletal muscle. As a further step, we examined whether TOI in muscle interacts through oscillation with factors related to oxygen in the cardiorespiratory system. For this examination, coherence and phase difference between the TOI in the vastus lateralis and heart rate (HR) and between TOI and arterial oxygen saturation (SpO2) were sequentially determined during recovery (2–60 min) after severe cycle exercise with a workload of 7.5% of body weight for 20 s. Significant coherence between TOI and HR was obtained in the very low-frequency band (approximate range: 0.002–0.03 Hz) and in the low-frequency band (approximate range: 0.06–0.12 Hz). The phase difference was negative in the low-frequency band and positive in the very low-frequency band. The coherence between TOI and SpO2 was significant in the very low-frequency band. The phase difference was negative. There were no sequential changes in these coherences and phase differences. The results suggest that TOI in skeletal muscle interrelates with factors related to the heart and lungs
Implementing rubrics as formative assessment in English writing classes in Japan.
No full textThis study explored how the implementation of formative assessment with the use of rubrics in high school English classes in Tokyo, Japan, improved students' motivation and encouraged ownership of learning. The researcher implemented rubrics as a formative assessment strategy in her two English writing classes over two terms with her co-inquirer/team-teaching partner and reflected on student responses and her own teaching practice. The study was carried out using professional inquiry informed by action research, based on the cycle of actions and reflection developed by Brown and Cherkowski (2011). As a theoretical framework, learning community theory identified this inquiry as an act of leadership, one that began to build interpersonal and organizational capacity in a school by sharing personal learning. Findings focused on student responses, teacher learning, and the school-level organizational response. --Leaf ii.The original print copy of this thesis may be available here: http://wizard.unbc.ca/record=b186055
Muscle-Specific Modulation of Spinal Reflexes in Lower-Limb Muscles during Action Observation with and without Motor Imagery of Walking
No full textAction observation (AO) and motor imagery (MI) are useful techniques in neurorehabilitation. Previous studies have reported that AO and MI facilitate corticospinal excitability only in those muscles that are active when actually performing the observed or imagined movements. However, it remained unclear whether spinal reflexes modulate multiple muscles simultaneously. The present study focused on AO and MI of walking and aimed to clarify their effects on spinal reflexes in lower-limb muscles that are recruited during actual walking. Ten healthy males participated in the present study. Spinal reflex parameters evoked by transcutaneous spinal cord stimulation were measured from five lower-limb muscles during rest, AO, and AO combined with MI (AO + MI) conditions. Our results showed that spinal reflexes were increased in the tibialis anterior and biceps femoris muscles during AO and in the tibialis anterior, soleus, and medial gastrocnemius muscles during AO + MI, compared with resting condition. Spinal reflex parameters in the vastus medialis muscle were unchanged. These results indicate the muscle-specific modulations of spinal reflexes during AO and AO + MI. These findings reveal the underlying neural activities induced by AO, MI, and their combined processes
Forth Report on Olympic memorabilia, constituting sports cultural assets, relating to the 1928 Amsterdam Olympic Games
No full textThe author has presented part of a collection of Olympic memorabilia relating to the 1928 Amsterdam Olympic Games. The fourth report includes the autographed photo of Mikio Oda who became the first Japanese Olympic gold medalist, the autographed writing book by Kinue Hitomi who became the first Japanese woman to be an Olympian and a medalist, and the autographed photo of Leni Junker who was a German female sprinter and won the bronzemedal in the 4×100m relay. In addition, the commemorative photo album owned by an officer of Japanese team, the Olympic memorial shield presented to Kintaro Usuda who participated in boxing, and a commemorative report on the welcome party for Olympic athletes were showed. Finally, Olympic spectators, including the media, should watch the competitions without undue expectations and pressure on athletes, reflecting on what happened when Hitomi lost in the women’s 100m semifinal.research repor
Testing protoplanetary disc dispersal with radio emission
No full textWe consider continuum free–free radio emission from the upper atmosphere of protoplanetary discs as a probe of the ionized luminosity impinging upon the disc. Making use of previously computed hydrodynamic models of disc photoevaporation within the framework of extreme-ultraviolet (EUV) and X-ray irradiation, we use radiative transfer post-processing techniques to predict the expected free–free emission from protoplanetary discs. In general, the free–free luminosity scales roughly linearly with ionizing luminosity in both EUV- and X-ray-driven scenarios, where the emission dominates over the dust tail of the disc and is partial optically thin at cm wavelengths. We perform a test observation of GM Aur at 14–18?GHz and detect an excess of radio emission above the dust tail to a very high level of confidence. The observed flux density and spectral index are consistent with free–free emission from the ionized disc in either the EUV- or the X-ray-driven scenario. Finally, we suggest a possible route to testing the EUV- and X-ray-driven dispersal model of protoplanetary discs, by combining observed free–free flux densities with measurements of mass-accretion rates. On the point of disc dispersal one would expect to find an M?2? scaling with free–free flux in the case of EUV-driven disc dispersal or an ?* scaling in the case of X-ray-driven disc dispersa
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