1,720,986 research outputs found
European Journal of Chemistry
Full text linkThe study was conducted with the purpose to develop and validate a high performance liquid\ud
chromatography method with UV detector to determine ketoprofen content in tablet\ud
preparation using ethanol???phosphate buffer (pH = 6.0, 80:20, v:v). The method was validated\ud
toward parameters of accuracy, precision, linearity, selectivity, LOD and LOQ. The results\ud
obtained fulfill the validation requirement of the ketoprofen tablet in the form of LOD =\ud
0.5302 ppm and LOQ = 1.7676 pp
Fermentasi dan Karakterisasi Antibiotik T1O81MY1O-B Asal Streptoverticillium olivorticuly
Full text linkSejak penemuan Streptomisin oleh Waksman 1994, maka perkembangan penelitian yang mengarah pada penemuan antibiotika baru terus dikembangkan. Hingga saat ini antibiotika masih tetap merupakan obat produk mikroorganisme pilihan dan memegang peranan yang penting dalam pengobatan penyakit infeksi. Penelitian ini bertujuan untuk memproduksi antibio??tika yang diperoleh dari proses fermentasi, memanfaatkan jasa Streptoverticillium olivoriticuly dengan cara pengocokan menggunakan "reciprocal shaker", T1O81MY1O-B diperoleh dengan mengisolasi kaldu fermentasi dengan sentrifugasi dan penyaringan untuk memisahkan miselia dari filtrat. kemudian bagian miselia diekstraksi menggunakan MeOH dan AcOEt. Pemurnian dilakukan dengan kromatografi kolom, dimana aktivitas komponen aktifnya selama proses fermentasi, ekstraksi dan pemurnian dideteksi menggunakan Candida albicans Yu1200 sebagai mikroorganisme uji. T1O81MY1O-B berupa bubuk warna putih, titik leleh 61 ??? 64?? C. Larut dalam etil asetat, etanol, kloroform dan eter, tidak larut dalam air, heksan dan petroleum eter. Larutannya tidak stabil pada larutan alkali. Analisis spektrofotometer ultra violet menunjukkan serapan pada 213 nm (CH3OH) dan 236 nm (NaOH). Sedang analisis spektrofotometer infra merah menunjukkan adanya gugusan hidroksi pada bilangan gelombang 3250 cm, metil pada 2920 cm dan ikatan rangkap -C=CH- pada 1650 cm-1. Aktivitas antimikroorganisme khas pada Trichophyton asteriodes, filtenaria kikuchiana dan Helminthosporium oryzae
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
ANALISIS MIKROBIOLOGI BEBERAPA SUSU KEDELAI TANPA MEREK YANG BEREDAR DI KABUPATEN MAROS SULAWESI SELATAN
Full text linkResearch about the micribiological analyze has been of some soys milk without brand marketed in Maros, South Sulawesi. The research to be compared with the requirements that have been determined by the director-general of the POM. The research conducted by determining the number plate total (ALT) bacteria, Total Plate Number (ALT) moulds as well as the presence of microbial pathogens in some soys milk without brand. The research methods using Standard Plate Count (SPC) to calculate the total amount of bacteria and mold, as wel as the identification method to determine the number of pathogenic bacteria. The results of this study indicating that the sample of C, E and H microbial has fulfilled the requirements of soy milk pathogenic bacteria test of Coliform (-), Salmonella sp (-), Staphylococcus aureus (-) and Bacillus cereus (-). Sample C, E and H has fulfilled the requiremqnts of ALT bacteria and sample C has fulfilled the requiremqnts of ALT moulds. But the E dan H sample have has not fulfilled the requirements
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Antibacterial Activity of N-Hexane and Ethyl Acetate Fractions Of Pandanus Nut (P. Julianettii) Against Oral Pathogens
Full text linkOral infections caused by Streptococcus mutans and Porphyromonas gingivalis are common health problems. This in vitro study aimed to evaluate the antibacterial activity of Pandanus nut (Pandanus julianettii) with n-hexane and ethyl acetate fractions against these pathogens through agar diffusion assays. The n-hexane and ethyl acetate fractions were subjected to agar diffusion testing, with Minimum Inhibitory Concentration (MIC) values determined at 0.8% and 0.2% respectively against both bacterial strains. Subsequent Minimum Bactericidal Concentration (MBC) testing revealed values of 6.4-12.8% for n-hexane fraction and 3.2-6.4% for ethyl acetate fraction. In agar diffusion assays, the n-hexane fraction at 12.8% concentration produced inhibition zones of 15.54±0,20 mm on S. mutans and 15.46±0,35 mm on P. gingivalis. The ethyl acetate fraction showed significantly larger inhibition zones of 18.76±0,79 mm against S. mutans and 15.59±0,42 mm against P. gingivalis at the same concentration. These findings demonstrate that both n-hexane and ethyl acetate fractions of Pandanus nut possess substantial antibacterial activity against oral pathogens
STUDI BIOEKIVALENSI AMSTUDI BIOEKIVALENSI AMOKSISILIN GENERIK DAN DAGANG MENGGUNAKAN MATRIKS URINOKSISILIN GENERIK DAN DAGANG MENGGUNAKAN MATRIKS URIN
No full textBioequivalence studies of amoxicillin which derived from generic drugs (OGB) had been done as a product test with branded amoxicillin as a comparison using urine matrix. The purpose of this study is to measure the bioavailability parameters based on 24 hours urine, so it is known as bioequivalent or bioinequivalent. Based on approach to cheap and quality generic drugs, and referring to the BPOM RI guidelines for bioequivalence, so this study using 12 healthy people aged 18 -21 years as a subject. The study design is the design crossed two-way (2 way) for 2 periods of treatment in two drug products, according to the selection of 24-hour urine matrix and determination of amoxicillin level by spectrophotometry UV Vis at wavelength of 273 nm, whereas the bioavailability parameters determined by using the cumulative profile of amoxicillin in the 24 hours urine and the rate of excretion. The results of the geometric mean and ratio CI 90% based on cumulative levels of amoxicillin were 104.67% and 117.65%, while based on the rate of amoxicillin excretion in 24 hours urine is 105.23% and 118.29%. All within the range 80-125% as a drug with a broad therapeutic index. Means that amoxicillin generic product (OGB) which had been studied is bioequivalet with the product branded amoxicillin
Antibacterial Activity of Ethanolic Extract of Pandanus Nut (Pandanus julianettii) Gastrointestinal Bacteria Using The Agar Diffusion Method
Full text linkGastrointestinal infections are a major global health concern, often caused by pathogenic bacteria. This study aimed to evaluate the antibacterial activity of the ethanolic extract of Pandanus nut (Pandanus julianettii) against gastrointestinal pathogens using the agar diffusion method. The Minimum Inhibitory Concentration (MIC) of the extract was determined to be 6.4% for Shigella dysenteriae, Salmonella typhi, and Escherichia coli, and 3.2% for Vibrio cholerae. The Minimum Bactericidal Concentration (MBC) for all tested bacteria was 12.8%. Antibacterial activity analysis revealed that at the 12.8% concentration, the largest inhibition zones were observed: 22.68 mm for Salmonella typhi, 22.20 mm for Shigella dysenteriae, 21.26 mm for Escherichia coli, and 20.80 mm for Vibrio cholerae. These findings indicate that the ethanolic extract of Pandanus julianettii possesses strong antibacterial properties and holds potential as a natural therapeutic agent for managing gastrointestinal infections
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