1,720,960 research outputs found
Pengaruh Kitosan terhadap Gambaran Histopatologis Testis, Kuantitas dan Kualitas Sperma Tikus Putih Jantan (Rattus sp.) setelah Dipapari Plumbum Asetat
No full textBackground: Plumbum as one of the contaminants can affect people's
health such as reproductive health, so that should be the prevention of
and protection against interference.
Objective: Looking at the effect of chitosan extract shrimp shells against
testicular histopathology male rats (Rattus sp.) which has exposed of lead.
Research methods: Method purely experimental approach post test only
control group design to measure the effect of treatment (intervention) in
the experimental group by comparing four intervention groups (P1, P2, P3,
and P4) with 2 controls (K1 and K2), which is ; K1 = distilled water, K2 =
distilled water+ Pb, P1 = Pb+ chitosan 0.5%, P2 = Pb+ chitosan 0.75%,
P3 = Pb + chitosan 1 %, and P4 = chitosan 1 %.
Methods: True experimental method, approach post test only control
group design to measure the effect of treatment (intervention) in the
experimental group by comparing four intervention groups (P1, P2, P3,
and P4) with 2 controls (K1 and K2), which is; K1 = distilled water, distilled
water + Pb = K2, P1 = Pb + 0.5% chitosan, P2 = Pb + 0.75% chitosan,
chitosan P3 = Pb + 1 %, P4 = 1 % chitosan. Pb concentration of 1 0 mg / kg
of body weight of rats. Administration of Pb and chitosan each are 0.5 ml
per rat by a margin of 1 hour.
Results: The results of morphological description of shrimp chitosan
powder with SEM surface looks rough. Chitosan can improve Pb and MDA
levels in the blood of male rats due to exposure of lead acetate (9.52±1.12
mg/dl), lower levels of malondialdehyde (MDA) testes (23.56±7.30
mg/dl), repair of testicular interstitial connective tissue thickness
(11.98±1.37μm) and a diameter of seminiferous tubules (294.33±59.38
μm), as well as reducing apoptosis of testicular germ cells (31.40±20.11).
Chitosan can maintain the number of Sertoli (12.60 ±2:42) and leydig
cells (10.75±1.05), and the normal quantity (amount) sperma (87.00±0.97
million/ml), as well as the morphology of sperma of normal quality
(76.30±0.76%), motility (76.70±3.40%), and viability (77.70±1.30%) male
rats that are infertile due to exposure of lead acetate.
Conclusion: Chitosan from shrimp shells can repair partially testicular
histopathology male rats (Rattus sp.) and sperm quality after tampered
exposed to lead acetate244 HalamanDisertasi Dokto
Pengaruh Kitosan terhadap Gambaran Histopatologis Testis, Kuantitas dan Kualitas Sperma Tikus Putih Jantan (Rattus sp.) setelah Dipapari Plumbum Asetat
No full textBackground: Plumbum as one of the contaminants can affect people's
health such as reproductive health, so that should be the prevention of
and protection against interference.
Objective: Looking at the effect of chitosan extract shrimp shells against
testicular histopathology male rats (Rattus sp.) which has exposed of lead.
Research methods: Method purely experimental approach post test only
control group design to measure the effect of treatment (intervention) in
the experimental group by comparing four intervention groups (P1, P2, P3,
and P4) with 2 controls (K1 and K2), which is ; K1 = distilled water, K2 =
distilled water+ Pb, P1 = Pb+ chitosan 0.5%, P2 = Pb+ chitosan 0.75%,
P3 = Pb + chitosan 1 %, and P4 = chitosan 1 %.
Methods: True experimental method, approach post test only control
group design to measure the effect of treatment (intervention) in the
experimental group by comparing four intervention groups (P1, P2, P3,
and P4) with 2 controls (K1 and K2), which is; K1 = distilled water, distilled
water + Pb = K2, P1 = Pb + 0.5% chitosan, P2 = Pb + 0.75% chitosan,
chitosan P3 = Pb + 1 %, P4 = 1 % chitosan. Pb concentration of 1 0 mg / kg
of body weight of rats. Administration of Pb and chitosan each are 0.5 ml
per rat by a margin of 1 hour.
Results: The results of morphological description of shrimp chitosan
powder with SEM surface looks rough. Chitosan can improve Pb and MDA
levels in the blood of male rats due to exposure of lead acetate (9.52±1.12
mg/dl), lower levels of malondialdehyde (MDA) testes (23.56±7.30
mg/dl), repair of testicular interstitial connective tissue thickness
(11.98±1.37μm) and a diameter of seminiferous tubules (294.33±59.38
μm), as well as reducing apoptosis of testicular germ cells (31.40±20.11).
Chitosan can maintain the number of Sertoli (12.60 ±2:42) and leydig
cells (10.75±1.05), and the normal quantity (amount) sperma (87.00±0.97
million/ml), as well as the morphology of sperma of normal quality
(76.30±0.76%), motility (76.70±3.40%), and viability (77.70±1.30%) male
rats that are infertile due to exposure of lead acetate.
Conclusion: Chitosan from shrimp shells can repair partially testicular
histopathology male rats (Rattus sp.) and sperm quality after tampered
exposed to lead acetate244 HalamanDisertasi Dokto
Faktor-faktor yang mempengaruhi ibu-ibu rumah tangga untuk mengambil tindakan pencegahan dan pengobatan ispa anak balitanya di Kecamatan Umbulharjo Kotamadya Yogyakarta
No full textKinerja perawat di ruangan rawat inap Rumah Sakit Bhayangkara Tingkat II Medan ditinjau dari kompetensi, motivasi dan beban kerja
No full textProfesi perawat memiliki peranan penting dalam memberikan kualitas pelayanan kesehatan di rumah sakit, karena jenis pelayanan yang diberikannya dengan pendekatan biologis, psikologis, sosial, spiritual dan dilakukan dengan berkelanjutan. Kinerja tenaga perawat dipengaruhi oleh karakteristik perawat, kompetensi, motivasi dan beban kerja. Tujuan penelitian ini adalah untuk mengetahui analisis pengaruh kompetensi, motivasi dan beban kerja perawat pelaksana dengan kinerja perawat di ruang rawat inap RS Bhayangkara Tk II Medan. Penelitian menggunakan rancangan cross sectional dengan survey analytic. Sampel berjumlah 45 perawat pelaksana di ruang rawat inap yang diambil dengan menggunakan teknik total sampling. Data dikumpulkan dengan kuesioner dan lembar observasi, lalu dianalisis bivariat dengan uji chi-square dan multivariat dengan uji regresi logistik. Hasil penelitian menunjukkan ada hubungan bermakna antara kompetensi (0,023), motivasi (0,009) dan pendidikan (0,043) dengan kinerja perawat. Sedangkan beban kerja (0,136) tidak memiliki hubungan bermakna dengan kinerja perawat pelaksana di ruang rawat inap. Analisis multivariat menunjukkan aspek kompetensi merupakan variabel mempengaruhi kinerja dengan nilai Adjusted Odds Ratio (AOR) 12,953 dan bermakna secara statistik (p=0,041). Nilai Adjusted Odds Ratio pada status pendidikan sebesar 3,663 dan bermakna secara statistik (p=0,027). Aspek motivasi merupakan variabel paling dominan mempengaruhi kinerja dengan nilai Adjusted Odds Ratio (AOR) 36,943 dan bermakna secara statistik (p=0,008). Penelitian ini menyimpulkan bahwa kinerja perawat sangat berhubungan dengan kompetensi dan motivasi kerja perawat, sehingga aspek-aspek yang dapat meningkatkan kompetensi dan motivasi kerja perlu dikelola dengan baik untuk mendapatkan hasil kinerja perawat yang baik
Unraveling The Nephroprotective Potential of Curcuma zedoaria Against Chronic Kidney Disease: A Network Pharmacology Approach
Full text linkChronic kidney disease (CKD) remains a major global health concern with limited treatment options. Curcuma zedoaria , a traditional medicinal plant, has shown potential in managing inflammatory and oxidative stress-related conditions. This study aimed to explore its nephroprotective mechanisms through a network pharmacology approach. A total of 12 bioactive compounds were identified from C. zedoaria and screened for drug-likeness. SwissTargetPrediction revealed multiple molecular targets, with curdione, dehydrocurdione, and curcumin showing the highest connectivity. Integration with CKD-associated genes from GeneCards and GSE66494 datasets yielded 241 common targets. Using Cytoscape, a compound–target–disease network was constructed, highlighting key biological processes such as inflammation, apoptosis, and fibrosis. PPI analysis identified top hub proteins including HSP90AA1, STAT3, SRC, AKT1, MAPK1, and MAPK3. Functional enrichment via GO and KEGG pathways revealed significant involvement of EGFR tyrosine kinase inhibitor resistance and HIF-1 signaling pathways. These findings suggest that C. zedoaria exerts protective effects through a multitarget mechanism modulating critical pathways in CKD progression. This study provides a theoretical basis for further experimental validation and supports the potential use of C. zedoaria as a complementary therapy in CKD management.
Submitted: 21-05-2025, Revised: 15-06-2025, Accepted: 17-06-2025, Published regularly: June 202
Analisis tingkat kepuasan pasien rawat inap pengguna Jaminan Kesehatan Nasional di Rumah Sakit Bhayangkara Tingkat II Medan
No full textPembangunan kesehatan sebagai salah satu upaya pembangunan nasional yang dilaksanakan oleh semua komponen bangsa Indonesia. Survey BPJS Kesehatan tahun 2014 menunjukkan kepuasan peserta BPJS Kesehatan yang datang ke RS pemerintah (80%) lebih rendah dari RS swasta (83%). Dimensi tangible serta responsiveness merupakan titik lemah dari RS pemerintah jika dibandingkan RS swasta yang pada akhirnya mempengaruhi tingkat kepuasan. Penelitian ini bertujuan untuk menganalisis tingkat kepuasan pasien rawat inap pengguna Jaminan Kesehatan Nasional berdasarkan dimensi tangibles, reliability, responsiveness, assurance dan empathy di RS Bhayangkara Tingkat II Medan. Jenis penelitian ini adalah kuantitatif survey analitik dengan pendekatan cross-sectional. Sampel berjumlah 100 orang pasien yang diambil dengan menggunakan teknik purposive sampling. Data dikumpulkan melalui penyebaran kuesioner, lalu dianalisis menggunakan uji Chi-square dan uji regresi logistik. Hasil uji menunjukkan hubungan yang signifikan antara variabel tangibles, reliability, responsiveness, assurance dan empathy dengan tingkat kepuasan pasien. Hasil analisis multivariat dengan logistic regression menunjukkan bahwa variabel reliability merupakan yang paling dominan dalam memengaruhi kepuasan pasien di ruang rawat inap Rumah Sakit Bhayangkara Tingkat II Medan (Exp (B)= 101.776). Dapat disimpulkan bahwa dimensi yang paling domi-nan memengaruhi tingkat kepuasan pasien di ruang rawat inap rumah sakit Bhayangkara Tingkat II Medan adalah reliability. Untuk menyusun strategi peningkatan pelayanan di Rumah Sakit Bhayangkara Tingkat II Medan perlu dipertimbangkan strategi yang difokuskan pada kepuasan pelanggan
Analisis Faktor yang Memengaruhi Kepuasan Pasien BPJS Rawat Jalan
No full textKemenkes RI menyatakan kualitas pelayanan kesehatan merupakan segala hal yang meliputi kinerja yang menunjukkan tingkat kesempurnaan pelayanan kesehatan, tidak saja yang dapat menimbulkan kepuasan bagi pasien sesuai dengan kepuasan rata-rata penduduk tetapi juga sesuai dengan standar dan kode etik profesi yang telah ditetapkan. Mutu menjadi salah satu elemen penting dalam setiap pelayanan kesehatan. Oleh sebab itu, dalam memberikan pelayanan kesehatan bagi masyarakat, pihak penyedia jasa pelayanan kesehatan harus selalu menjaga mutu pelayanan yang diberikan. Tujuan yang ingin dicapai dalam penelitian ini adalah untuk menganalisis pengaruh pelayanan terhadap kepuasan pasien BPJS. Jenis penelitian ini menggunakan survei analitik deskriptif dengan rancangan cross sectional. Populasi dalam penelitian ini adalah seluruh pasien rawat jalan di klinik spesialis mata SMEC Palu tahun 2023 dengan rata-rata pasien yaitu sebanyak 322 orang pasien kunjungan pengambilan sampel dengan metode accidental sampling, dengan sampel berjumlah 76 orang. Analisa data dilakukan dengan analisis univariat, bivariat dan multivariat. Berdasarkan hasil uji chi-square diketahui bahwa kepuasan pasien berpengaruh terhadap bukti fisik p-value = 0.054, kehandalan p-value = 0.007, daya tanggap p-value = 0.025, jaminan p-value = 0.572 dan empati p-value p = 0,001, artinya ada pengaruh bukti fisik, kehandalan, daya tanggap, jaminan dan empati terhadap kepuasan pasien. Dari hasil analisis multivariat diketahui variabel yang paling berpengaruh dalam penelitian ini adalah variabel kehandalan dengan nilai OR 83.966. Kesimpulan dalam penelitian ini adalah variabel Kehandalan bernilai lebih dominan, artinya variabel Kehandalan paling berpengaruh terhadap kepuasan pasien di Klinik Spesialis Mata SMEC Palu. Bagi rumah sakit dapat mengambil kebijakan guna meningkatkan kinerja petugas kesehatan sehingga menghasilkan kinerja yang optimal
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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