1,457 research outputs found
Intersubjetividade, natureza e sentimentos morais. A teoria crítica de A. Honneth e a regra de ouro
No full textThe text raises the question of the conditions for the possibility of intersubjectivity in the theory of recognition. An analysis of the theory of recognition formulated by Axel Honneth shows how the conflict determined by moral motivations relativizes the Habermasian premise of the linguistic understanding and brings the normative dimension back to social theory. The author returns to the pages of the Encyclopedia of Hegel to recover the objective dimension of intersubjectivity and highlights problems in Honneth’s theoretical project. He confronts both the linguistic-hermeneutic and the recognition paradigm with his pressuposition of this intersubjectivity that yet have to be established, and concludes that the theory of recognition can not explain the normative basis of intersubjectiv recognition. This theory, so Testa, describes contexts of interaction and not moral imperatives. The golden rule, especially his negative formulation is seen as a better codification of the requirement to give recognition without neglecting the experience of offenses and fight; it is seen as a better positive justification of the norms of reciprocity.O texto coloca a questão das condições de possibilidade da intersubjetividade na teoria do reconhecimento. Uma análise da teoria do reconhecimento formulada por Axel Honneth mostra como o conflito determinado por motivações morais relativiza o postulado Habermasiano do entendimento lingüístico e traz de volta a dimensão normativa à teoria social. O autor faz um retorno às páginas da Enciclopédia de Hegel para recuperar a dimensão objetiva da intersubjetividade e destacar problemas teóricos no projeto de Honneth. Com isso passa a confrontar tanto o paradigma lingüísticohermenêutico como o do reconhecimento com o fato de pressuporem a intersubjetividade a ser ainda constituída, para concluir que a teoria do reconhecimento não consegue explicitar um núcleo normativo do reconhecimento intersubjetivo; ela descreve contextos de interação e não imperativos morais. A da regra de ouro, em especial na formulação negativa (“não faças a ninguém aquilo que não gostarias que fosse feito a ti – Tb 4,15) é vista como melhor codificação da exigência de reconhecimento sem prescindir da experiência da ofensa e da luta, como melhor justificação positiva das normas de reciprocidade. Palavras-chave: Regra de ouro; Reciprocidade; Reconhecimento; Axel Honnet
PASCOLI E CESARIO TESTA. SCAMBI DI TRADUZIONI E DI POESIA
No full textIl saggio punta a ricostruire i rapporti tra Pascoli e il letterato Cesario Testa (Papiliunculus), autore di una ben poco conosciuta traduzione del poemetto latino pascoliano Centurio, che vinse la medaglia d’oro al Certamen Hoeufftianum nel 1902. Nel pubblicare l’inedita corrispondenza Pascoli-Testa, l’A. mette a fuoco sia la storia della versione, sia alcuni retroscena della partecipazione di Pascoli al concorso di poesia latina bandito a Roma in occasione del Cinquantenario dell’Unità d’Italia.
The aim of this article is to reconstruct the literary relationship between Pascoli and the writer Cesario Testa, author of a very little known translation of Pascoli’s Latin poem Centurio (gold-medal Hoeufft Prize from Amsterdam International Latin Verse Competition in 1902). While editing the unpublished correspondence Pascoli-Testa, the A. focuses both on the history of Centurio’s translation, and on the ‘backstage’ of Pascoli’s participation in the competition held in Rome in honor of the fiftieth anniversary of the Unification of Italy
First person – Erika Testa
No full textABSTRACT
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Erika Testa is the first author on ‘H2afx and Mdc1 promote maintenance of genomic integrity in male germ cells’, published in Journal of Cell Science. Erika is a PhD student in the lab of Dr Marco Barchi at the University of Rome Tor Vergata, Rome, Italy, investigating meiosis, DNA repair, genome stability of meiotic cells and male fertility.</jats:p
Altered growth factor sensitivity in EL2 rat fibroblasts: influence of this biological characteristic on cell growth
No full textExtensive evidence indicate that platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) play a key role in the stimulation of the 3T3 fibroblast replication: in this connection, PDGF and EGF act as a competence and a progression factor, respectively. We have previously demonstrated that EGF alone leads density-arrested EL2 rat fibroblasts to synthesize DNA and proliferate in serum-free cultures. Here, we have analyzed the role of EGF in the control of EL2 cell proliferation. Our data show a dose-related effect of EGF on DNA synthesis and cell growth, with maximal stimulation for both parameters at 20 ng/ml. On the other hand, autocrine production of PDGF or PDGF-like substances by EL2 cells is seemingly excluded by experiments with anti-PDGF serum or medium conditioned by EL2 fibroblasts. EGF binding studies show that EL2 cells possess high affinity EGF receptors, at a density level 3 to 4-fold higher than other fibroblastic lines. In addition, EL2 cells show a normal down-regulation of EGF receptors, following exposure to EGF, but PDGF, fibroblast growth factor (FGF), transforming growth factor beta (TGF beta) and bombesin have not decreased the affinity of EGF receptor for its ligand. Moreover, in EL2 cells, the EGF is able to induce the synthesis of putative intracellular regulatory proteins that govern the PDGF-induced competence in 3T3 cells. Our data indicate that EGF in EL2 cells may act as both a competence and a progression factor, via induction of the mechanisms, regulated in other cell lines by cooperation between different growth factors.(ABSTRACT TRUNCATED AT 250 WORDS
DETERMINATION OF PHARMACEUTICALS’ RESIDUES IN WASTEWATER OBTAINED WITH AN OPTIMIZED LC-FTICR MS METHOD
No full textThe presence of pharmacologically active molecules or their derivatives found in wastewater is a problem of wide interest (1,2). Pharmaceutical compounds (PhCs) and their metabolites, even if present in the order of μg/L and ng/L, can affect the bioconcentration factor, and then be subject to bioaccumulation and biomagnification showing toxic effects for both flora and fauna and mankind.
The high resolution liquid chromatography mass spectrometry (LC-MS) coupled to tandem mass spectrometry MS/MS has gained popularity in recent decades thanks to its versatility, specificity and selectivity, finding application as the preferred method for the analysis of PhCs in complex matrices such as waste and/or discharge water. (3,4)
Most methods developed in the past have focused on specific therapeutic classes, such as antibiotics for their potential resistance to biotic degradation.
In this work we focus on the development of an analytical multi-residual method by using LC-FT/ICR-MS and IRMPD for a particular class of pharmaceuticals chosen according to the 10 mostly diffused and consumed products in the Mediterranean area (4-8).
A solid phase extraction from spiked tap water followed by LC-FTICR MS determination has been proposed for the simultaneous analysis of these pharmaceuticals as in Figure 1: (peak 1) metformin hydrochloride (exact m/z 130.10872), (peak 2) amoxicillin (exact m/z 366.11182), (peak 3) caffeine (exact m/z 195.08765), (peak 4) erythromycin (exact m/z 734.46852), (peak 5) clarithromycin (exact m/z 748.48417), (peak 6) carbamazepine (exact m/z 237.10224), (peak 7) naproxen (exact m/z 231.10157), (peak 8) diclofenac sodium (exact m/z 294.00941), (peak 9) ibuprofen (exact m/z 205.12340), (10) aspirin (exact m/z 181.04954). In order to ascertain the identity of all chromatographic peaks, the measurements and interpretation of IRMPD-FTICR data was accomplished. All precursor ions were photon irradiated for 200 ms at 100% laser power by a 20 W continuous CO2 laser source at a wavelength of 10.6 μm.
The method optimized was applied to samples collected from influent and effluent from a Wastewater Treatment Plants (WWTP) in order to assess the efficiency of the plant for removing this kind of recalcitrant compounds. Among the PhCs considered in this study, only carbamazepine and clarithromycin were found in the effluent of the WWTP
Occurrence of Fipronil in residential house dust in the presence and absence of pets: a hint for a comprehensive toxicological assessment
No full textThe presence of the insecticide Fipronil and its main products of toxicological relevance, namely Sulfone and Desulfinyl, was assessed in 161 residential house dust samples in the absence (N = 101) and presence (N = 60) of cats and dogs in Italy. High-resolution mass spectrometry analysis revealed a significant difference (p < 0.001) in the dust contamination in the presence of pets (median: 467 vs. 24 ng/g dry weight), even if the highest value was found in the absence of pets (82,069 vs. 67,799 ng/g dry weight). Fipronil intake estimates from dust in toddlers, computed according to US-EPA and EU-ECHA guidelines, ranged from 333 to 556 and from 20 to 34 ng/kg per day for acute and chronic scenario, respectively. Dust seemed not able itself to lead to Fipronil overexposure with respect to acute and chronic toxicity health-based guidance values. Kittens were potentially overexposed to Fipronil under both acute (26,076 ng/kg per day) and chronic (1,633 ng/kg per day) scenarios. The mild symptomatology associated with acute intoxication could possibly determine case underreporting within pharmacosurveillance schemes. Its administration was estimated in 7.3–9.7 tons per year. Such a range suggests its prudent use under strict veterinary control to prevent pest resistance and ecotoxicological outcomes
Mitos, pestes y aullidos dibujados por Clorindo Testa: denuncia y relato
No full textThis work proposes to revisit a set of drawings of myths, plagues, and howls by the Italo-Argentine architect Clorindo Testa, which is articulated through the series La Peste en Ceppaloni (1977-1997). This collection of maps, drawings and murals is a journey in which the author metaphorically denounces the impact of environmental problems on the human condition and the air of its habitat. Methodologically, the text uses a triple account of the work: narrative-visual, archaeological, and anthropological. It deciphers the structure of the drawn myth that develops in the Middle Ages in the Italian town of Ceppaloni, where Testa’s family comes from. The medieval town and its castle are explored, as well as the itinerary of the Black Plague during the 14th century. These series correlate with the work of this artist, who recovers figuration to find a certain idea of humanism. For Testa, art, architecture, and ecology cohabit.Este trabajo propone revisitar un conjunto de dibujos de mitos, pestes y aullidos del artista arquitecto ítalo argentino Clorindo Testa que se articulan a través de la serie La Peste en Ceppaloni (1977-1997). Este conjunto de mapas, dibujos y murales son un viaje donde el autor, metafóricamente, denuncia la incidencia de los problemas ecológicos en la condición humana y el aire de su hábitat. Metodológicamente, el texto acude a un triple relato de la obra: narrativo-visual, arqueológico y antropológico. Se descifra la estructura de mito dibujado que se desarrolla en el Medievo en la ciudad italiana de Ceppaloni, de donde procede la familia de Testa. Se recorre la villa medieval y su castillo, así como el itinerario de la peste negra durante el siglo XIV. Esta serie tiene un correlato en el trabajo de este autor que recupera la figuración para recobrar cierta idea de humanismo. Para Testa arte, arquitectura y ecología cohabitan
The effects of prolonged peritendinous administration of PGE1 to the rat Achilles tendon: a possible animal model of chronic Achilles tendinopathy.
No full textWe studied the effects of peritendinous Achilles tendon injections of prostaglandin E1 (PGE1) on the Achilles tendon of rats. Five groups of Sprague-Dawley rats (n = 24 each) were studied. Groups 1 to 4 received weekly peritendinous injections. In group 1, one side was injected with 800 ng of PGE1 in 0.5 ml of 0.9% NaCl and the contralateral side was injected with 0.5 ml of 0.9% NaCl. In group 2, one side was injected with 800 ng of PGE1. In group 3, one side was injected with 0.5 ml of 0.9% NaCl. In group 4, a syringe needle was inserted in the peritenon unilaterally, but no substances were administered. In groups 2, 3, and 4, the contralateral tendon was used as the control. In group 5, treatment was not administered. Eight rats in each group were killed at each time point, after 7, 21, and 35 days of treatment. On day 7, values for average water content and average wet weight of the tendons treated with PGE1 were significantly higher than those in the control tendons (analysis of variance [ANOVA]; P = 0.02), with a histological picture of acute inflammation. On day 21, approximately half of the PGE1-treated tendons showed fibrosis of the paratenon, with adhesions and intra-tendinous degeneration, with the other half still showing a picture of acute inflammation. On day 35, all of the PGE1-treated tendons showed fibrosis of the paratenon, with adhesions and intra-tendinous degeneration. At all time points, there was no evidence of pathology in the tendons that had not received PGE1. Sham peritendinous injections and injections of normal saline did not produce inflammation in the Achilles tendons. Initially, local administration of PGE1 produced acute inflammation of the tendon and its surrounding tissues. Prolonged PGE1 administration produced peri- and intra-tendinous degeneration, providing a cheap, reproducible model of Achilles tendinopathy, which would allow studies of the effects of conservative and surgical management of the condition
Single-Port Cholecystectomy for Cholecystitis Versus Non-Cholecystitis
No full textBACKGROUND AND OBJECTIVES: To assess the safety and efficacy of single-port laparoscopic cholecystectomy (SPLC) for the treatment of symptomatic cholelithiasis in different gallbladder pathologic conditions. METHODS: All patients who underwent SPLC in our department between October 1, 2017 and March 31, 2020 were registered consecutively in a prospective database. Patients’ charts were retrospectively divided according to histological diagnosis: normal gallbladder (NG) (n = 13), chronic cholecystitis (CC) (n =47), and acute cholecystitis (AC) (n = 10). The parameters for assessing the procedure outcome included operative time, blood loss, use of additional trocars, conversion to laparotomy, intraoperative and postoperative complications, and length of hospital stay. Patient groups were statistically compared. RESULTS: Seventy patients underwent SPLC. Duration of surgery increased from NG (55 ± 22.7 min) to CC (70 ± 33.5 min), and to AC patients (110.5 ± 50.5 min), which is statistically significant (P = .001). Postoperative complication rates were 7.6% in NG patients, 17% in CC, and 30% in AC (P = .442). Length of hospitalization was shorter for NG patients (1.0 ± 0.6 days) versus CC (2.0 ± 1.1 days) and AC patients (2.0 ± 4.7 days), with statistical significance (P = .020). Multivariate analysis found that pathology type and the occurrence of postoperative complications were independent predictors for prolonged operative times and prolonged hospital stay, respectively. CONCLUSION: SPLC is feasible for acute and chronic cholecystitis with good procedural outcomes. Since SPLC technique itself can be sometimes challenging with the existing technology, its application, especially in cases of acute cholecystitis, should be done with caution. Only prospective randomized studies on this approach for acute and chronic gallbladder diseases will assess the complete reliability of this technique
Giving form to future branding realities
No full textPurpose – The purpose of this study is to question the prospective relevance of conceptual articles on
branding.
Design/methodology/approach – The paper advocates the development of conceptual articles with
prospective relevance by emphasizing two key elements – the form and the context of discovery. The paper is
illustrated with empirical data on how some branding researchers have produced such conceptual articles.
Findings – To author such articles the researchers might focus more on the initial phase of theorizing, when
their intuition makes it possible to imagine new reality through alternative forms. The paper also highlights a
need to reconsider the role of essays in branding research, particularly in writing conceptual pieces of
prospective relevance.
Research limitations/implications – The connection between intuition and form is crucial to producing
prospectively relevant conceptual articles. By evolving along the middle ground, without falling into empirical
production on the one hand or guruization on the other, the researcher can give form to emerging branding
phenomena.
Originality/value – The paper renews the debate on the need for more conceptual articles by focusing on a
forgotten but crucial dimension: foresight relevance
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