755 research outputs found
High prevalence of essential hypertension and enhanced activity of the renin angiote nsin system in psoriatic patients.
No full textA KALLIKREIN-LIKE ENZYME IN HUMAN VASCULAR TISSUE
No full textWe attempted to identify the presence of kallikrein in human vascular tissue obtained from patients undergoing surgery. Sections of thoracic (n = 9) and abdominal aorta (n = 6), renal artery (n = 6), and saphenous vein (n = 17) were rinsed with 0.01 mol/L Tris-HCl buffer, cleaned, minced, and homogenized at 4 degrees C. The homogenates were centrifuged and supernatants were assayed for protein content and for active and total (trypsin activation) enzymatic activity on the peptide H-D-Val-Leu-Arg-paranitroanilide (S2266), a synthetic substrate for glandular kallikrein. Enzymatic activity was inhibited by aprotinin and polyclonal antibodies against human glandular kallikrein. Kallikrein was resistant to soybean trypsin inhibitor and had an optimum pH of 8.2. A significant correlation was found between the amidolytic and kininogenase activities measured on S2266 and dog kininogen, respectively (r = 0.83, P < .01). The kallikrein-like enzyme was present mainly in the inactive form. Higher levels were found in the homogenates of renal artery (active: 190 +/- 36, total: 5036 +/- 908 pkat/g protein) than in those of thoracic (active: 38 +/- 9, total: 973 +/- 350 pkat/g protein) and abdominal aorta (active: 44 +/- 10, total: 3031 +/- 709 pkat/g protein). In the homogenates of saphenous vein, active and total enzymatic activities averaged 188 +/- 90 and 2003 +/- 450 pkat/g protein, respectively. A significant inverse correlation was found between the levels of total enzymatic activity in saphenous vein homogenates and mean blood pressure values (r = 0.78, P < .005). These results suggest that a kallikrein-like enzyme is present in human vasculatur
High prevalence of essential hypertension and enhanced activity of the renin angiotensin system in psoriasic patients.
No full text
Baroreflex sensitivity is not altered by central administration of HOE 140, a novel bradykinin B2-receptor antagonist
No full textScleromixedema. A proposito di un caso con lesioni recidivanti a risoluzione spontanea.
No full textGli autori riporta il caso di scleromixedema in un paziente di un paziente di 66 anni con lesioni sclerodermiformi recidivanti risoluzione spontanea. Nel siero non era stata messa in evidenza alcuna anomalia qualitativa delle immunoglobuline. Nella diagnosi differenziale vengono prese in considerazione , il lichen amiloidosico, il mi xedema tireotossico, dalle quali lo scleromixedema si distingue per i reperti istologici ed istochimici
El Monitoreo Pedagógico Y Desempeño Docente En La Institución Educativa Primaria N° 71 013 Glorioso San Carlos De Puno - 2016.
No full textLa presente investigación responde a la siguiente interrogante: ¿Qué relación existe
entre monitoreo pedagógico y los niveles de desempeño de los docentes en la institución
educativa primaria N° 71 013 Glorioso San Carlos de Puno - 2016? El objetivo fue: Determinar
la relación que existe entre el monitoreo pedagógico y desempeño docente en la institución
educativa primaria N° 71 013 Glorioso San Carlos de Puno - 2016. La hipótesis general
formulada fue: Existe una relación directa y significativa entre el monitoreo pedagógico y
desempeño docente en la institución educativa primaria N° 71 013 Glorioso San Carlos de
Puno - 2016.
La investigación, pertenece a la investigación básica y como método se utilizó el
método cuantitativo, con un diseño descriptivo – correlacional, para la muestra se tomó a 74
docentes de la institución educativa primaria N° 71 013 Glorioso San Carlos de Puno - 2016.
Finalmente se concluye, determinado con un nivel de significancia del 5% que existe
una relación directa muy fuerte (r=0,943) y significativa (t = 23,96) entre el monitoreo
pedagógico y desempeño docente en la institución educativa primaria N° 71 013 Glorioso
San Carlos de Puno - 2016, estableciéndose que a mejor monitoreo pedagógico, existe mejor
desempeño docente
Effetto di un antagonista delle chinine sull'azione ipotensiva dell'enalaprilat in ratti anefrici
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