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Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats
Get PDFPopovych Igor, Mysula Igor, Popovych Andriy, Mysula Yuriy, Sydliaruk Nataliya, Bilas Volodymyra, Zukow Walery. Role of organic carbon and nitrogen of mineral waters in their immunomodulating effects at female rats. Journal of Education, Health and Sport. 2021;11(9):886-894. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.09.104
https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.09.104
https://zenodo.org/record/5856299
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
© The Authors 2021;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 10.09.2021. Revised: 20.09.2021. Accepted: 30.09.2021.
ROLE OF ORGANIC CARBON AND NITROGEN OF MINERAL WATERS IN THEIR IMMUNOMODULATING EFFECTS AT FEMALE RATS
Igor Popovych1, Igor Mysula2, Andriy Popovych1, Yuriy Mysula2, Nataliya Sydliaruk2, Volodymyra Bilas1, Walery Zukow3*
1OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine
2IY Horbachevs’kyi National Medical University, Ternopil’, Ukraine
3Nicolaus Copernicus University, Torun, Poland
*[email protected]
Abstract
Background. Drinking mineral water is one of the ethnopharmacologic factors. Organic substances, despite their presence in all drinking mineral waters, are still considered to be active only in the water of Naftussya type (which, due to mineralization less than 1 g/L, are not formally mineral), whereas the physiological activity of true mineral waters (which mineralization is greater than 1-2 g/L) are associated with electrolytes and trace elements. Previously, we identified the role of organic carbon and nitrogen of mineral waters in their effects on certain metabolic and neuro-endocrine parameters. The purpose of this study is to clarify the role of organic substances of same mineral waters in their effects on immunity parameters. Material and methods. Experiment was performed on 48 healthy female Wistar rats 240-290 g divided into 5 groups. Animals of the first group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. In the second group we administered the water Naftussya from the Truskavets’ layer (Galychyna, Ukraine), in the third group the water Sophiya of the Truskavets’ field. The rats of the fourth group received the native water from the Hertsa (Bucovyna, Ukraine) field, and the last group received its artificial salt analogue. The day after the completion of the drinking course in all rats immunne parameters were registered. Results. On the basis of the correlation analysis with step-by-step exclusion, 9 immune parameters (Endotheliocytes of Thymus, Spleen Mass Index, Entropy of Splenocytogram, Natural Killers, B- and 0-Lymphocytes, Rod-shaped Neutrophils, Phagocytic Index and Microbian Count of Monocytes of Blood) are included in the regressive model for organic nitrogen (R=0,818) and 6 parameters (Endotheliocytes of Thymus, Fibroblastes and Reticulocytes of Spleen, Pan-Lymphocytes, Microbian Count of Neutrophils and Phagocytic Index of Monocytes of Blood) for organic carbon (R=0,690). Together, the organic components of the chemical composition of loading fluids determine their effect on the immune parameters by 77%. Conclusion. Organic substances of mineral waters play an essential role in their effects on the immune parameters of female rats.
Key words: Mineral waters, organic carbon and nitrogen, female rats, immunity
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Особливості когнітивних порушень у хворих з первинним епізодом біполярного афективного розладу
Get PDFThe aim of the work was to study the features of cognitive disorders in the primary episode of bipolar affective disorder, taking into account the gender factor and clinical variant.Materials and methods. 153 patients with primary episode of bipolar affective disorder: with prevalence of depressive symptomatology (44 men and 75 women), with prevalence of manic symptoms (15 men and 8 women) and with simultaneous presence of depressive and manic symptomatology or with rapid or severe manic symptoms and 5 women) were examined using the Stroop test.Results and discussion. In patients with the depressed primary episode variant, a general slowdown in the performance of all four subtests of the Stroop test was detected: reading time of the names of colors printed in black font (TNFb) in all patients 63.7±8.1 sec., in men 65.0±9.6 sec., in women 63.0±7.0 sec.; names of colors (NС) were respectively 96.6±9.2 sec, 96.5±9.1 sec and 96.6±9.3; reading time of color names where the font color is different from the word value (TNCd) – respectively 153.5±20.3 sec., 153.8±23.3 sec., 153.3±18.6 sec.; name of the word color where the font color is different from the word value (NCWd) – 62.6±7.9 sec., 63.8±9.3 sec. and 61.9±6.9 sec. In patients with a manic variant, the time to perform the Strup test is the smallest of all groups: TNFb – 44.3±4.0 sec., 44.5±4.1 sec. and 43.8±4.1 sec.; NC – 62.7±4.9 sec., 61.7±5.5 sec. and 64.6±3.2 sec.; TNCd – 116.2±9.5 sec., 118.0±10.5 sec. and 112.9±6.4 sec.; NCWd – 43.3±4.0 sec., 43.5±4.1 sec. and 42.8±4.1 sec, respectively. In patients with mixed variant indicators occupy an intermediate position: TNFb – 59,8±16,1 sec., 57,3±14,6 sec. and 62.8±19.0 sec.; NC – 79.1±10.1 sec., 76.5±10.3 sec. and 82.2±10.0 sec.; TNCd – 124.3±22.5 sec., 120.7±18.9 sec. and 128.6±27.7 sec.; NCWd – 58.5±15.7 sec., 56.2±14.3 sec. and 61.4±18.5 sec. in accordance. Gender differences in Stroop test performance are not significant.Conclusions. The primary episode of BAD is characterized by the presence of cognitive impairment, the structure and expressiveness of which is determined by the clinical variant. In the depressive variant revealed the greatest overall slowdown in the execution of the Stroop test with a significant number of errors, with manic - deterioration of attention, behavioral inhibition and maximal impulse control when mixed - a marked slowdown in the performance of the Stroop test with a significant number of errors. Gender differences in cognitive impairment are insignificantЦель работы – изучить особенности когнитивных нарушений при первичном эпизоде биполярного аффективного расстройства с учетом гендерного фактора и клинического варианта.Материалы и методы. С помощью теста Струпа обследовано 153 больных с первичным эпизодом биполярного аффективного расстройства: с преобладанием депрессивной симптоматики (44 мужчины и 75 женщин), с преобладанием маниакальной симптоматики (15 мужчин и 8 женщин) и с одновременным наличием депрессивной и маниакальной симптоматики или с быстрой сменой фаз (6 мужчин и 5 женщин).Результаты и обсуждение. У больных с депрессивным вариантом первичного эпизода было обнаружено общее замедление выполнения всех четырех субтестов теста Струпа: чтение названий цветов, напечатанных черным шрифтом (ЧНЦч) у всех больных 63,7±8,1 сек., у мужчин 65,0±9,6 сек., у женщин 63,0±7,0 сек .; называние цветов (НЦ) – соответственно 96,6±9,2 сек., 96,5±9,1 сек. 96,6±9,3; чтение названий цветов, где цвет шрифта отличается от значения слова (ЧНЦо) – соответственно 153,5±20,3 сек., 153,8±23,3 сек., 153,3±18,6 сек.; называние цвета слова, где цвет шрифта отличается от значения слова (НЦСо) – соответственно 62,6±7,9 сек., 63,8±9,3 сек. и 61,9±6,9 сек. У больных с маниакальным вариантом время выполнения теста Струпа является самым маленьким из всех групп: ЧНЦч – 44,3±4,0 сек., 44,5±4,1 сек. и 43,8±4,1 сек.; НЦ – 62,7±4,9 сек., 61,7±5,5 сек. и 64,6±3,2 сек.; ЧНЦо – 116,2±9,5 сек., 118,0±10,5 сек. и 112,9±6,4 сек.; НЦСо – 43,3±4,0 сек., 43,5±4,1 сек. и 42,8±4,1 сек соответственно. У больных со смешанным вариантом показатели занимают промежуточное положение: ЧНЦч – 59,8±16,1 сек., 57,3±14,6 сек. и 62,8±19,0 сек.; НЦ – 79,1±10,1 сек., 76,5±10,3 сек. и 82,2±10,0 сек.; ЧНЦо – 124,3±22,5 сек., 120,7±18,9 сек. и 128,6±27,7 сек.; НЦСо – 58,5±15,7 сек., 56,2±14,3 сек. и 61,4±18,5 сек. соответственно. Различия в характеристиках выполнения теста Струпа не значащие.Выводы. Первичный эпизод БАР характеризуется наличием когнитивных нарушений, структура и выраженность которых определяется клиническим вариантом. При депрессивном варианте выявлено наибольшее общее замедление времени выполнения теста Струпа при значительном количестве ошибок, при маниакальном – ухудшение концентрации внимания, поведенческого торможения и контроля импульсивности при максимальном количестве ошибок, а при смешанном – выраженное замедление выполнения теста Струпа с существенным количеством ошибок. Гендерные различия в когнитивных нарушениях незначимыМета роботи – вивчити особливості когнітивних порушень при первинному епізоді біполярного афективного розладу з урахуванням гендерного фактору і клінічного варіанту.Матеріали і методи. За допомогою тесту Струпа обстежено 153 хворих з первинним епізодом біполярного афективного розладу: з переважанням депресивної симптоматики (44 чоловіка і 75 жінок), з переважанням маніакальної симптоматики (15 чоловіків і 8 жінок) та з одночасною наявністю депресивної та маніакальної симптоматики або зі швидкою зміною фаз (6 чоловіків і 5 жінок).Результати та обговорення. У хворих з депресивним варіантом первинного епізоду було виявлено загальне сповільнення виконання усіх чотирьох субтестів тесту Струпа: читання назв кольорів, надрукованих чорним кольором (ЧНКч) у всіх хворих 63,7±8,1 сек., у чоловіків 65,0±9,6 сек., у жінок 63,0±7,0 сек.; називання кольорів (НК) – відповідно 96,6±9,2 сек., 96,5±9,1 сек. і 96,6±9,3; читання назв кольорів, де колір шрифту відрізняється від значення слова (ЧНКв) – відповідно 153,5±20,3 сек., 153,8±23,3 сек., 153,3±18,6 сек.; називання кольору слова, де колір шрифту відрізняється від значення слова (НКСв) – відповідно 62,6±7,9 сек.,63,8±9,3 сек. і 61,9±6,9 сек. У хворих з маніакальним варіантом час виконання тесту Струпа є найменшим з усіх груп: ЧНКч – 44,3±4,0 сек., 44,5±4,1 сек. і 43,8±4,1 сек.; НК – 62,7±4,9 сек., 61,7±5,5 сек. і 64,6±3,2 сек.; ЧНКв – 116,2±9,5 сек., 118,0±10,5 сек. і 112,9±6,4 сек.; НКСв – 43,3±4,0 сек., 43,5±4,1 сек. і 42,8±4,1 сек. відповідно. У хворих зі змішаним варіантом показники займають проміжне положення: ЧНКч – 59,8±16,1 сек., 57,3±14,6 сек. і 62,8±19,0 сек.; НК – 79,1±10,1 сек., 76,5±10,3 сек. і 82,2±10,0 сек.; ЧНКв – 124,3±22,5 сек., 120,7±18,9 сек. і 128,6±27,7 сек.; НКСв – 58,5±15,7 сек., 56,2±14,3 сек. і 61,4±18,5 сек. відповідно. Гендерні відмінності у характеристиках виконання тесту Струпа не значущі.Висновки. Первинний епізод БАР характеризується наявністю когнітивних порушень, структура і виразність яких визначається клінічним варіантом, При депресивному варіанті виявлено найбільше загальне сповільнення часу виконання тесту Струпа при значній кількості помилок, при маніакальному – погіршання концентрації уваги, поведінкового гальмування та контролю імпульсивності при максимальній кількості помилок, а при змішаному – виражене сповільнення виконання тесту Струпа з суттєвою кількістю помилок. Гендерні відмінності у когнітивних порушеннях є незначущим
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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