117,398 research outputs found
Gene expression profiling of DBA/2J mice cochleae treated with l-methionine and valproic acid
No full textAbstractDBA/2J mice, which have homozygous mutations in Cdh23 and Fscn2, are characterized by early onset hearing loss at as early as three-weeks of age (Noben-Trauth et al., 2003 [1]) and are an animal model for progressive hearing loss research. Recently, it has been reported that epigenetic regulatory pathways likely play an important role in hearing loss (Provenzano and Domann, 2007 [2]; Mutai et al., 2009 [3]; Waldhaus et al., 2012 [4]). We previously reported that DBA/2J mice injected subcutaneously with a combination of epigenetic modifying reagents, l-methionine (MET) as methyl donor and valproic acid (VPA) as a pan-histone deacetylases (Hdac) inhibitor, showed a significant attenuation of progressive hearing loss by measuring their auditory brainstem response (ABR) thresholds (Mutai et al., 2015 [5]). Here we present genome wide expression profiling of the DBA/2J mice cochleae, with and without treatment of MET and VPA, to identify the genes involved in the reduction of progressive hearing loss. The raw and normalized data were deposited in NCBI's Gene Expression Omnibus (GEO ID: GSE62173) for ease of reproducibility and reanalysis
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
West Nile Region, Uganda - Integrated and Multi Scalar Planning (Koboko, Arua, Nebbi)
No full textArua, due to its strategic geographical position, is a rapidly growing
urban centre in Ugandan West Nile region and an important base
for humanitarian operations. Refugees from South Sudan and the
Democratic Republic of Congo (DRC) currently form 23% of the regional
population, with around 700.000 registered refugees (UNHCR, 2018)
and unregistered migrants contributing to the figures The Ugandan
Government plans to upgrade Arua to a “regional city”, to include
the enlargement of its boundaries and the enhancement of air and
rail infrastructure among others, envisioning it as a potential logistic
node for North-Western Uganda. However, no strategic framework
is provided at regional, city or neighbourhood scales to promote a
synergic development with neighbouring towns (Koboko and Nebbi),
districts and countries (DRC and South Sudan). Although rapid
urbanization is already threatening existing socio-ecological assets and
increasing conflict potential related to land rights and access to basic
infrastructure and services, there is a lack of appropriate assessment
and strategic tools to address the complex transformation of these
territories.
Moving from the results of previous capacity development initiatives
in the framework of the Ugandan Support for Municipal Infrastructure
Development (USMID) program, a project for a comprehensive profiling
of the region across different planning scales has been initiated by UNHabitat in August 2018 with the financial support from the Booyoung
Foundation, with the aim of supporting a better understanding of
the West Nile Region as a metropolitan system along the Nebbi-AruaKoboko development corridor. Among other priorities, exploring
how decision making at territorial scale would also influence city
and neighbourhood level was in the focus of the regional profile.
Politecnico di Milano has been selected as the implementing partner
with UN-Habitat to draft a multidisciplinary analysis of the existing
situation at regional and territorial scale, including development of
specific metropolitan cartography, while UN-Habitat’s Public Space
and Urban Economy teams have conducted in-dept research on urban
economy and municipal finance, as well as a public space assessment
and recommendations at neighbourhood scale in each municipality.
This report outlines the results of the research activity, including desktop
research and field studies, complemented by a factfinding mission and
workshops held in the West Nile Region in October and November
2018 for the effective interaction with local experts and stakeholders,
at both national and local level. The following chapters synthesize
main findings with the aim of providing a set of recommendations
Square Dancing with the Stars to Enhance Dynamic Hirschman Linkages?
No full textIn this Presidential Address, the author takes the reader on a reconnaissance of his life and time as a regional scientist. He points out scenery he found scintillating along the way, hoping that some may pick up the banner and chew on a few of the ideas for a while. He suggests a revisit to Albert O. Hirschman’s notion of key sectors and more empirical analysis related to Marcus Berliant’s and Masahisa Fujita’s notion of knowledge creation and transfer.Presidential Address, San Antonio, Texas, March 29, 2014 (53rd Meetings of the Southern Regional Science Association
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Letter from unknown writer to Jesse L. Boyce
No full textLetter to Jesse L. Boyce from unknown author (possibly Jack) about the investigation into the powder magazine located in the Grand Canyon. Some personal news is included in the letter such as the writer's marriage to the daughter of C.A. Taylor, former Supervisor of Cochise County
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Sarah L. Blum Author Visit - Warrior Nurse: PTSD and Healing
No full textHear Sarah L. Blum, author of Women Under Fire: Abuse in the Military, discuss her newest book, Warrior Nurse: PTSD and Healing followed by a Q&A and book signing.
Sarah L. Blum is a decorated Vietnam veteran who served as an operating room nurse during the intense fighting of 1967. In recognition of her service, she was awarded the Army Commendation Medal.
Sponsored by CWU Veterans Center and CWU Libraries.https://digitalcommons.cwu.edu/libraryevents/1252/thumbnail.jp
Lillian L. Lambert, Author, Speaker, and Entrepreneur
No full textLillian L. Lambert, Author, Speaker, and Entrepreneu
Letter to Alfred L. Shoemaker, February 10, 1948
No full textA handwritten letter from an unknown author addressed to Alfred L. Shoemaker, dated February 10, 1948. Within, the author discusses the Pennsylvania Dutch word for Ash Wednesday, along with traditions associated with this day.https://digitalcommons.ursinus.edu/shoemaker_documents/1118/thumbnail.jp
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