3,626 research outputs found
[Tasman's manuscript of his discovery of Australia] [cartographic material] : with notes by Mr. J. E. Heeres and Mr. C.H. Coote.
Facsimiles of original manuscript maps from Abel Tasman's journal of discovery in 1642. Depth shown by bathymetric soundings.; Title supplied by cataloguer.; Originally published as folded maps in: Abel Jansz. Tasman's journal of his discovery of Van Diemen's Land and New Zealand in 1642, with documents relating to his exploration of Australia in 1644, being photolithographic facsimiles of the original manuscripts at The Hague and elsewhere with English translation / edited with introduction, biographical and geographical notes by Mr. J. E. Heeres, of the Dutch State Archives and Mr. C.H. Coote, of the British Museum.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.map-rm2056. Anthony Van Diemen's Landt -- 1. Company's New Netherlands -- 2. Denoort Cust van Ceram -- 3. Verhooninohostr Aenwysinghe der Coursih landin Eylandin -- 4. [Philippines and northern New Guinea coast] -- 5. Isogonic map for the Indian and Pacific Ocean for the epoch 1640 after the observations of Abel Jansz. Tasman and contemporaries by W. Van Bemmelen
Response to the Round Table on Why Did We Choose to Industrialize? Montreal 1819–1849
Author Robert C.H. Sweeny responds to comments on his award-winning book, Why Did We Choose to Industrialize? Montreal 1819–1849.L’auteur Robert C.H. Sweeny répond aux commentaires de son livre récompensé, Why Did We Choose to Industrialize? Montreal 1819–1849
PKL-Optimality Criterion in Copula Models for Efficacy-Toxicity Response
In recent years, there has been an increasing interest in developing dose
finding methods incorporating both efficacy and toxicity outcomes. It is reasonable
to assume that efficacy and toxicity are associated; therefore, we need to model
their stochastic dependence. Copula functions are very useful tools to model different
kinds of dependence with arbitrary marginal distributions. We consider a binary
efficacy-toxicity response with logit marginal distributions. Since the dose which
maximizes the probability of efficacy without toxicity (P-optimal dose) changes depending
on different copula functions, we propose a criterion which is useful for
choosing between the rival copula models but also protects patients against doses
that are far away from the P-optimal dose. The performance of this compromise
criterion (called PKL) is illustrated for different choices of the parameter values
Recommended from our members
Fuer enine neue qualitaet politischer und wissenshaftlicher zusammentarbeit
eds. P.J. Crutzen & M. Muller, Verlag C.H. Beck, Munich, pp. 114-131.Version of Recor
Using Genetic Analysis to Evaluate Hybridization as a Conservation Concern for the Threatened Species Quercus hinckleyi C.H. Muller (Fagaceae)
Premise of research. Hybridization among oaks is well documented and is of special concern in conservation
efforts directed toward threatened or endangered Quercus, species such as Quercus hinckleyi.
Methodology. This study uses DNA microsatellite analysis to characterize hybridization between the threatened
oak Q. hinckleyi C.H. Muller and two putative hybridizing species, Quercus pungens Liebmann and Quercus
vaseyana Buckley. The two potential hybridizers were sampled at Guadalupe Mountains National Park
(GUMO), approximately 320 km from the current range of Q. hinckleyi. Quercus pungens and two possible
hybrids located in near proximity to the relict populations of Q. hinckleyi were also sampled.
Pivotal results. Genetic variability was high in all three species, with mean number of alleles per locus
ranging from 12.625 to 17.875, mean observed heterozygosity from 0.734 to 0.807, and mean expected heterozygosity
from 0.851 to 0.869. Quercus hinckleyi is genetically differentiated from the putative hybridizers
and has two distinct genetic clusters within its metapopulation. The two hybridizer species from GUMO,
where they are sympatric, are not differentiated. The population identified as Q. pungens found near Q. hinckleyi
is genetically distinct from the GUMO samples and has five of eight genets with greater than 90%
Q. hinckleyi introgression. Two of the 14 identified Q. hinckleyi in close proximity to this population had
Q. pungens introgression. Bayesian clustering analysis showed that 5% of the samples identified as Q. hinckleyi
in the field were hybrids, and one putative hybrid was confirmed genetically.
Conclusions. While there is some hybridization in the Q. hinckleyi population, we found no evidence of
genetic swamping. This may be explained by the spatial isolation of the Q. hinckleyi remnants relative to other
oak species and by its common asexual (cloning) method of reproduction
Using Genetic Analysis to Evaluate Hybridization as a Conservation Concern for the Threatened Species Quercus hinckleyi C.H. Muller (Fagaceae)
Premise of research. Hybridization among oaks is well documented and is of special concern in conservation
efforts directed toward threatened or endangered Quercus, species such as Quercus hinckleyi.
Methodology. This study uses DNA microsatellite analysis to characterize hybridization between the threatened
oak Q. hinckleyi C.H. Muller and two putative hybridizing species, Quercus pungens Liebmann and Quercus
vaseyana Buckley. The two potential hybridizers were sampled at Guadalupe Mountains National Park
(GUMO), approximately 320 km from the current range of Q. hinckleyi. Quercus pungens and two possible
hybrids located in near proximity to the relict populations of Q. hinckleyi were also sampled.
Pivotal results. Genetic variability was high in all three species, with mean number of alleles per locus
ranging from 12.625 to 17.875, mean observed heterozygosity from 0.734 to 0.807, and mean expected heterozygosity
from 0.851 to 0.869. Quercus hinckleyi is genetically differentiated from the putative hybridizers
and has two distinct genetic clusters within its metapopulation. The two hybridizer species from GUMO,
where they are sympatric, are not differentiated. The population identified as Q. pungens found near Q. hinckleyi
is genetically distinct from the GUMO samples and has five of eight genets with greater than 90%
Q. hinckleyi introgression. Two of the 14 identified Q. hinckleyi in close proximity to this population had
Q. pungens introgression. Bayesian clustering analysis showed that 5% of the samples identified as Q. hinckleyi
in the field were hybrids, and one putative hybrid was confirmed genetically.
Conclusions. While there is some hybridization in the Q. hinckleyi population, we found no evidence of
genetic swamping. This may be explained by the spatial isolation of the Q. hinckleyi remnants relative to other
oak species and by its common asexual (cloning) method of reproduction
Recourse against Judgments in the Netherlands
In the 1980s, the Netherlands witnessed the start of a comprehensive programme of reform in the fields of judicial organisation and procedure. The reform programme consists of three stages, of which the first has now been completed. This has, amongst other things, resulted in the consolidation of several administrative procedures which were formerly adjudicated by different judicial bodies, in the Arrondissementsrechtbank. Consequently, the Arrondissementsrechtbank has obtained extensive administrative jurisdiction together with its jurisdiction in civil and criminal cases. As part of the reforms in the second stage, a bill has been submitted to Parliament which contains changes in the court structure. It is proposed to abolish the Kantongerecht and to reallocate its jurisdiction to the Arrondissementsrechtbank, transforming the latter court into a general first-instance court. In addition, the bill contains changes in the Code of Civil Procedure. In the present report the author discusses the current situation January 1998
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