102,708 research outputs found
Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist
No full textSince the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles. We have shown previously that a new analogue, cis-1S,2R-aminocyclohexanecarboxylic acid2-endomorphin-2 (ACHC-EM2), had elevated mu-receptor affinity, selectivity, and proteolytic stability over the parent compound. In the present work, we have studied its antinociceptive effects and receptor regulatory processes. ACHC-EM2 displayed a somewhat higher (60%) acute antinociceptive response than the parent peptide, EM2 (45%), which peaked at 10 min after intracerebroventricular (icv) administration in the rat tail-flick test. Analgesic tolerance developed to the antinociceptive effect of ACHC-EM2 upon its repeated icv injection that was complete by a 10-day treatment. This was accompanied by attenuated coupling of mu-sites to G-proteins in subcellular fractions of rat brain. Also, the density of mu-receptors was upregulated by about 40% in the light membrane fraction, with no detectable changes in surface binding. Distinct receptor regulatory processes were noted in subcellular fractions of rat brains made tolerant by the prototypic full mu-agonist peptide, DAMGO, and its chloromethyl ketone derivative, DAMCK. These results are discussed in light of the recently discovered phenomenon, that is, the “so-called biased agonism” or “functional selectivity
Estimation of evapotranspiration in the Mu Us Sandland of China
No full textEvapotranspiration (ET) was estimated from 1981–2005 over Wushen County located in the Mu Us Sandland, China, by applying the Advection-Aridity model, which is based on the complementary relationship hypothesis. We used National Oceanic and Atmospheric Administration (NOAA) Advanced Very High Resolution Radiometer (AVHRR), Moderate Resolution Imaging Spectroradiometer (MODIS), and meteorological data. Our results show that the estimated daily ET was about 4.5% higher than measurements using an Eddy Covariance (EC) system after forcing energy balance closure over an alfalfa field from 22 July 2004 to 23 August 2004. At a regional scale, the estimated monthly ET was about 8.7% lower than measurements using the EC system after forcing energy balance closure over an alfalfa field in August 2004. These results were about 3.0% higher than ET measurements by microlysimeter over sand dunes during June 1988. From 1981 to 2005, the average annual ET and precipitation levels were 287 mm and 336 mm, respectively, in Wushen County. The average annual ET varied from 230 mm in western parts of Wushen County to 350 mm in eastern parts of the county. Both inter-annual and seasonal variations in ET were substantial in Wushen County. The annual ET was 200–400 mm from 1981–2005, and the seasonal pattern of ET showed a single peak distribution. The cumulative ET during the June–September 2004 period was 250 mm, which was 87% of the total annual ET. The annual ET, precipitation, and the maximum Normalized Difference Vegetation Index (NDVI<sub>max</sub>) showed positive correlations temporally and spatially
Search for in the gauge-symmetric model at Belle
No full textWe search for a new gauge boson that couples only to heavy leptons and their corresponding neutrinos in the process , using a 643 fb data sample collected by the Belle experiment at or near the resonances at the KEKB collider. For the first time, effects due to initial state radiation are used in estimating the detection efficiency. No signal is observed in the mass range of and we set an upper limit on the coupling strengh, , constraining as a possible contributor to the anomalous magnetic dipole moment of muon
Modelling Z -> tau tau processes in ATLAS with tau-embedded Z -> mu mu data
No full textÇetin, Serkant Ali (Dogus Author)This paper describes the concept, technical realisation and validation of a largely data-driven method to model events with Z -> tau tau decays. In Z -> mu mu events selected from proton-proton collision data recorded at root s = 8 TeV with the ATLAS experiment at the LHC in 2012, the Z decay muons are replaced by tau leptons from simulated Z -> tau tau decays at the level of reconstructed tracks and calorimeter cells. The tau lepton kinematics are derived from the kinematics of the original muons. Thus, only the well-understood decays of the Z boson and tau leptons as well as the detector response to the tau decay products are obtained from simulation. All other aspects of the event, such as the Z boson and jet kinematics as well as effects from multiple interactions, are given by the actual data. This so-called tau-embedding method is particularly relevant for Higgs boson searches and analyses in tau tau final states, where Z -> tau tau decays constitute a large irreducible background that cannot be obtained directly from data control samples. In this paper, the relevant concepts are discussed based on the implementation used in the ATLAS Standard Model H -> tau tau analysis of the full datataset recorded during 2011 and 2012
Consequences of chirally enhanced explanations of for and
No full textWith the long-standing tension between experiment and Standard-Model (SM)
prediction in the anomalous magnetic moment of the muon recently
reaffirmed by the Fermilab experiment, the crucial question becomes which other
observables could be sensitive to the underlying physics beyond the SM to which
may be pointing. While from the effective field theory (EFT) point of
view no direct correlations exist, this changes in specific new physics models.
In particular, in the case of explanations involving heavy new particles above
the electroweak (EW) scale with chiral enhancement, which are preferred to
evade exclusion limits from direct searches, correlations with other
observables sensitive to EW symmetry breaking are expected. Such scenarios can
be classified according to the representations and the hypercharges
of the new particles. We match the resulting class of models with heavy new
scalars and fermions onto SMEFT and study the resulting correlations with
and decays, where, via symmetry, the latter
process is related to and modified -- couplings.Comment: 19 pages, 3 figures; factors correcte
New type of polymeric indium tellurides: Low-temperature synthesis and structure characterization of [M(en)(3)]In2Te6 (M=Fe, Zn) and alpha- and beta-[Mo-3(en)(3)(mu(2)-Te-2)(3)(mu(3)-Te)(mu(3)-O)]In2Te6
No full textCrystal growth of metal tellurides and tellurometalates employing solvothermal reactions at temperatures below 200 degrees C have resulted in four new indium tellurium phases, [Fe(en)(3)](In2Te6) (I), [Zn(en)(3)](In2Te6) (II), and alpha- and beta-[Mo-3(en)(3)(mu(2)-Te-2)(3)(mu(3)-Te)(mu(3)-O)]In2Te6 (III-alpha and III-beta). Single crystal X-ray diffraction analyses show that I and II are isostructural and belong to the orthorhombic crystal system, space group P2(1)2(1)2(1) (No. 19). Compound I: a = 11.654 (1) Angstrom, b = 12.968(2) Angstrom, c = 16.273(2) Angstrom, Z= 4. Compound II: a b = 12.948(2) Angstrom, c = 16.285(1) Angstrom, Z = 4. The two polymorphs III-alpha and III-beta crystallize in the monoclinic system. Compound III-alpha: a = 11.815(2) Angstrom, b = 21.769(3) Angstrom, c = 14.498(4) Angstrom, beta = 95.43(2)degrees, Z = 4, space group P2(1)/c (No. 14). Compound III-beta: a = 22.154(3) Angstrom, b = 11.550(2) Angstrom, c = 14.230(2) Angstrom, beta = 99.05(1)degrees, Z = 4, space group P2(1)/a (No. 14). All four are Zintl compounds containing novel one-dimensional polymeric chains of (1)(infinity)[(In2Te6)(2-)] that can be described as alternating fused five-membered rings [(In3+)(2)(Te2(2-))(Te2-)], joined at the In atoms
Photon Energy Scale with events
No full textThe photon energy scale of the CMS Electromagnetic Calorimeter, measured using FSR photons from events, based on the 2011 pp data sample
Measurement of and rates in CMS
No full textWe discuss the possibility of performing precise measurements of the rates of pp->Z->mu^+ mu^- and pp->W->mu nu processes in CMS. The systematic uncertainties in a conservative scenario, assuming a non-optimal detector and leading-order estimates, are found to be 2.3% for Z->mu mu and 3.3% for W->mu nu. These uncertainties will be largely reduced with the use of improved calibrations and next-to-leading-order (NLO) programs. Some preliminary studies on parton-density-function sets and NLO Monte Carlos are also presented. A measurement of the luminosity from these rates with a 6-7% accuracy seems also feasible
Inclusive , production at CMS
No full textThe production of Z bosons in association with at least one b-jet and
Z decaying into muons or electrons is studied. This analysis is done by using proton-proton collisions delivered by the Large Hadron Collider (LHC) at a centre of mass energy of 7 TeV and with data recorded by the CMS detector (CMS) in 2010, representing an integrated luminosity of 36 pb. We require a final state of two well identified muons or electrons and at least one b-tagged jet in order to perform this
study. The event yields and shapes of kinematic variables are compared
with Monte Carlo predictions from MADGRAPH. The ratio is found to be 0.0540.016 (0.0460.014) in the data for the Zee (Z)
selection, compared to 0.0430.005 (0.0470.005) estimated from NLO theory predictions
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