17,288 research outputs found
AFM study of the oxide film formed on dual phase Fe3Al-Fe3AlC intermetallies
No full textThe topography of the oxide film formed during initial stage of oxidation at 800 degreesC on the Fe3Al and Fe3AlC phases in an Fe- 16Al-0.5C alloy was analyzed using atomic force microscopy. The oxide film formed on the carbide phase was found to be thicker than that on the matrix, and the difference in thickness between two layers was around 0.5 mum. This was related to the presence of low Al content in the Fe3AlC phase compared with that in the Fe3Al phase. Due to different rate of oxidation in Fe3Al and Fe3AlC phases, the Fe- 16Al-0.5C alloy does not follow the parabolic rate behaviour. (C) 2004 Elsevier Ltd. All rights reserved.The author VSR thanks Prof. V.S. Raja of corrosion
science and engineering program, Indian Institute of
Technology, Bombay and Dr R.G. Baligidad of Defense
Metallurgical Research Laboratory, Hyderabad, India for
providing the material
Open access self-archiving: An author study
No full textThis, our second author international, cross-disciplinary study on open access had 1296 respondents. Its focus was on self-archiving. Almost half (49%) of the respondent population have self-archived at least one article during the last three years. Use of institutional repositories for this purpose has doubled and usage has increased by almost 60% for subject-based repositories. Self-archiving activity is greatest amongst those who publish the largest number of papers. There is still a substantial proportion of authors unaware of the possibility of providing open access to their work by self-archiving. Of the authors who have not yet self-archived any articles, 71% remain unaware of the option. With 49% of the author population having self-archived in some way, this means that 36% of the total author population (71% of the remaining 51%), has not yet been appraised of this way of providing open access. Authors have frequently expressed reluctance to self-archive because of the perceived time required and possible technical difficulties in carrying out this activity, yet findings here show that only 20% of authors found some degree of difficulty with the first act of depositing an article in a repository, and that this dropped to 9% for subsequent deposits. Another author worry is about infringing agreed copyright agreements with publishers, yet only 10% of authors currently know of the SHERPA/RoMEO list of publisher permissions policies with respect to self-archiving, where clear guidance as to what a publisher permits is provided. Where it is not known if permission is required, however, authors are not seeking it and are self-archiving without it. Communicating their results to peers remains the primary reason for scholars publishing their work; in other words,
researchers publish to have an impact on their field. The vast majority of authors (81%) would willingly comply with a mandate from their employer or research funder to deposit copies of their articles in an institutional or subject-based repository. A further 13% would comply reluctantly; 5% would not comply with such a mandate
The effect of intraperitoneally administered morphine (MOR), carbamazepine (CBZ) or combination of MOR/CBZ on tactile allodynia in the tibial nerve injury (TNI) model at post-injury day (PID) 28.
No full text<p>(A) Neither MOR or CBZ affect tactile allodynia induced by TNI. Each line represents the groups mean and SEM of 6–10 female rats. Drug group behavior at 60 minute or 120 minute vs TNI baseline (BL) behavior. (B) Effect of co-administered MOR and CBZ on tactile allodynia in the tibial nerve injury (TNI) model at post-injury day 28. The ability of MOR/CBZ to attenuate tactile allodynia induced by TNI was dose-dependent. Each line represents the groups mean and SEM of 6–10 rats. (*P<0.05; combination therapy group vs TNI baseline (BL) behavior).</p
Average per-author h-index vs Average REF Impact Score.
No full textAverage per-author h-index vs Average REF Impact Score.</p
The dependence of catalytic activity for N2O decomposition on the exchange extent of cobalt or copper in Na-MOR, H-MOR and Na-MFI
No full textCatalytic decomposition of N2O was studied on Na-MOR, H-MOR, and Na-MFI samples exchanged to various extents with cobalt or copper. Co-MOR samples were characterized by FTIR and volumetric measurements of NO adsorption. The most abundant species on Co-MOR was Co2+(NO)(2). In agreement, the volumetric data yielded NO/Co = 1.8 +/- 0.2. On Co-MOR, N2O conversion progressively increased as the cobalt content increased. All samples yielded similar apparent activation energy, E-a = 75 +/- 5 kJ mol(-1). The reaction order was 0.9 +/- 0.1 for N2O, and 0.0 +/- 0.1 for O-2. For samples having a Co-exchange percentage up to 61%, the turnover frequency per total Co atom was independent of the cobalt content and was significantly lower for more extensively exchanged samples. On all Co-MOR samples, the turnover frequency per isolated Co atom was nearly constant, indicating isolated Co2+ as the active site. On Cu-MOR and Cu-MFI samples, N2O conversion markedly increased with the copper contet. Samples having a Cu-exchange percentage up to 62% yielded higher E-a. than more extensively exchanged samples (150 5 kJ mol-1 vs. 100 5 kJ mol-1). The reaction order was 0.5 +/- 0.1 for N2O, and 0.0 0.1 for O-2. We conclude that in Co-MOR and Co-MFI catalysts the active site for N2O decomposition is isolated Co2+, whereas in Cu-MOR and Cu-MFI isolated Cu2+ is nearly inactive. In extensively exchanged Cu-MOR and Cu-MFI, the active site for N2O decomposition is most probably Cu1+. A similar reaction mechanism for N2O decomposition operates over Co-zeolites and extensively exchanged Cu-zeolites. (C) 2009 Elsevier B.V. All rights reserved
Structured medicines reviews in HIV outpatients: a feasibility study (The MOR Study)
No full textObjectives Polypharmacy in people living with HIV (PLWH) increases the risks of medicine-related problems (events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes). We aimed to examine the feasibility and acceptability of a Medicines Management Optimisation Review (MOR) toolkit in HIV outpatients. Methods This was a multi-centre randomized controlled study across four HIV centres. In all, 200 PLWH on combination antiretroviral therapy, either > 50 years old or < 50 years with other comorbidities, were enrolled to have a MOR or received standard pharmaceutical care. The primary outcome was the difference in the number of medicine-related problems (MRPs) between intervention and standard care groups at baseline and 6 months. Acceptability, cost of the intervention and health-related quality of life were also examined. Results In all, 164 patients were analysed: 70 in the intervention group and 94 in the standard care group. A significant number of MRPs were detected in those patients receiving MOR compared with the standard care group at baseline (93 vs. 2; p = 0.001, z = -8.6, r = 0.6) and 6 months (33 vs. 3; p = 0.001, z = -5.7, r = 0.4). A significant reduction in the number of new MRPs at 6 months in the intervention group versus baseline was also observed (p = 0.001, Z = -3.7, r = 0.2); 44% of MRPs were fully resolved at baseline and 51% at 6 months. No changes in health-related quality of life following MOR or between MOR and standard care groups were observed. The MORs were highly acceptable among patients and healthcare professionals. Conclusions The MOR toolkit was feasible and acceptable, suggesting that HIV outpatient services might consider implementing MOR for targeted populations under their care
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Structured medicines reviews in HIV outpatients: a feasibility study (The MOR Study)
No full textObjectives Polypharmacy in people living with HIV (PLWH) increases the risks of medicine-related problems (events or circumstances involving drug therapy that actually or potentially interfere with desired health outcomes). We aimed to examine the feasibility and acceptability of a Medicines Management Optimisation Review (MOR) toolkit in HIV outpatients. Methods This was a multi-centre randomized controlled study across four HIV centres. In all, 200 PLWH on combination antiretroviral therapy, either > 50 years old or < 50 years with other comorbidities, were enrolled to have a MOR or received standard pharmaceutical care. The primary outcome was the difference in the number of medicine-related problems (MRPs) between intervention and standard care groups at baseline and 6 months. Acceptability, cost of the intervention and health-related quality of life were also examined. Results In all, 164 patients were analysed: 70 in the intervention group and 94 in the standard care group. A significant number of MRPs were detected in those patients receiving MOR compared with the standard care group at baseline (93 vs. 2; p = 0.001, z = -8.6, r = 0.6) and 6 months (33 vs. 3; p = 0.001, z = -5.7, r = 0.4). A significant reduction in the number of new MRPs at 6 months in the intervention group versus baseline was also observed (p = 0.001, Z = -3.7, r = 0.2); 44% of MRPs were fully resolved at baseline and 51% at 6 months. No changes in health-related quality of life following MOR or between MOR and standard care groups were observed. The MORs were highly acceptable among patients and healthcare professionals. Conclusions The MOR toolkit was feasible and acceptable, suggesting that HIV outpatient services might consider implementing MOR for targeted populations under their care
<i>E</i>. <i>coli</i> (at YER, WAR, DFS and MOR) and enterococci (at ELW, FRA, and RYE): concentrations vs time since last rainfall of >1 mm over 24 hours.
No full textE. coli (at YER, WAR, DFS and MOR) and enterococci (at ELW, FRA, and RYE): concentrations vs time since last rainfall of >1 mm over 24 hours.</p
Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen
No full textAbstractMorphine binding to opioid receptors, mainly to μ opioid receptor (MOR), induces alterations in intracellular pathways essential to the initial development of addiction. The activation of the dopamine D4 receptor (D4R), which is expressed in the caudate putamen (CPu), mainly counteracts morphine-induced alterations in several molecular networks. These involve transcription factors, adaptive changes of MOR signaling, activation of the nigrostriatal dopamine pathway and behavioural effects, underlining functional D4R/MOR interactions. To shed light on the molecular mechanisms implicated, we evaluated the transcriptome alterations following acute administration of morphine and/or PD168,077 (D4R agonist) using whole-genome microarrays and a linear regression-based differential expression analysis. The results highlight the development of a unique transcriptional signature following the co-administration of both drugs that reflects a countereffect of PD168,077 on morphine effects. A KEGG pathway enrichment analysis using GSEA identified 3 pathways enriched positively in morphine vs control and negatively in morphine + PD168,077 vs morphine (Ribosome, Complement and Coagulation Cascades, Systemic Lupus Erythematosus) and 3 pathways with the opposite enrichment pattern (Alzheimer’s Disease, Neuroactive Ligand Receptor Interaction, Oxidative Phosphorilation). This work supports the massive D4R/MOR functional integration at the CPu and provides a gateway to further studies on the use of D4R drugs to modulate morphine-induced effects.</jats:p
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