332,680 research outputs found
and H‐MOR Catalysts
No full textA combined catalyst comprising TiO2-supported Re (Re(1)/TiO2; Re=1 wt\%) and H-MOR (SiO2/Al2O3=90) was found to promote the methylation of benzene using CO2 and H2. This catalytic system exhibited high performance with regard to the synthesis of methylated benzenes and gave high yields of total methylated products (up to 52 \% benzene-based yield and 42 \% CO2-based yield) under the reaction conditions employed in this study (pCO2=1 MPa; pH2=5 MPa; T=250 °C; t=20 h) in a batch reactor. Catalyst screening demonstrated that a combination of Re(1)/TiO2 and H-MOR (SiO2/Al2O3=90) exhibited superior performance compared to other combinations of supported metal catalysts and zeolites in terms of both yield and selectivity for methylated benzenes
Differenze di stile cognitivo tra gli studenti dell’Ateneo genovese: suggerimenti per l’orientamento universitario
No full text
Biphasic modulation of mu-opoid receptor (MOR) transcription by nociceptin in neuroblastoma cells co-expressing MOR and NOP receptors
No full textNociceptin (NC), the endogenous NOP receptor
(NOPr) ligand, counteracts several effects of opioids
and is involved in the development of morphine
tolerance and in the modulation of neuropathic
pain in animal models. In this study we found that
NOP receptor activation by nociceptin-amide [NCNH2
], a NC derivative more resistant to peptidases,
caused a biphasic, concentration-dependent
modulation of MOR expression in SH-SY5Y cells:
10-100nM NC-NH2 determined an initial upregulation of MOR mRNA levels followed by a
significant down-regulation after 18h-24h exposure.
Ongoing transcription is required for NC-NH2-
induced modulation of MOR expression, whereas
the translational inhibitor cycloheximide prevented
only the reduction of MOR mRNA levels. A series
of MOR-luciferase promoter/reporter constructs
showed that NC-NH2-induced down-regulation of
MOR transcription requires a CRE element within
the MOR promoter (-1599/-1579). These findings
suggest that a de novo-synthesised transcriptional
repressor is involved in NC-NH2-induced downregulation of MOR mRNA levels. Any involvement
of the inducible cAMP early repressor (ICER) is
under investigation
Confirmation of MORIP/MOR-IL2 interactions.
No full text<p>GST pulldown assays were performed to interrogate the interaction between selected full-length MORIPs and the MOR-IL2 domain. In the top three panels, MORIP-GST fusion proteins were used to pull down the S-tagged MOR-IL2. In the bottom three panels, MOR-IL2-GST fusion proteins were used to pull down S-tagged MORIPs. Pulldown products were purified on glutathione beads, separated by SDS-PAGE, and probed on Western blots using HRP-conjugated anti-S-tag antibodies. S-tagged MORIPs or MOR-IL2 domains produced in bacteria are shown in lysate lanes (Ly), while uncoated glutathione sepharose beads (Beads) or GST-coated glutathione sepharose beads (GST) incubated with S-tagged proteins served as negative controls. PD indicates pull-down lanes.</p
Diffusive author(s), cohesive author: Analysis of S/N (1994)
No full textThis study indicates the ways in which various aspects of the author(s) are brought forth in Dumb type’s performance art, the S/N production. Previous research has suggested a non-hierarchical organization of Dumb type and the absence of a “privileged author” in Dumb type’s collaborative work, S/N. However, the results that I have investigated from member’s interviews on the creative process of S/N along with my analysis of the recorded images of S/N, indicate a different aspect of the author(s). First, S/N was created through, so to speak, the collective ideas of the members of Dumb type. Further, S/N has at least nine quotations from previous performances, installations, and printed writings, besides the work-in-progress technique. Explicating one of the “author functions” as given by Michel Foucault, each text has plural subjects of the author. However, it has been revealed from members’ interviews that Teiji Furuhashi had a decision-making role in selecting the members’ ideas within the performance. Since then, S/N has had plural subjects of creation; however, Furuhashi is one of the subjects of creation along with the “privileged author.” S/N has plural authors (diffusive authors) yet at the same time, it has a “privileged author,” Teiji Furuhashi (cohesive author)
Paula Winkels emosjonalitet i Ragnhild Jølsens Ve´s mor (1903). En affektiv narratologisk analyse.
No full textRagnhild Jølsen var en kvinne forut for sin tid. Debutverket Ve´s mor (1903) skildrer tabubelagte temaer som kvinnelige drifter og utroskap. Hovedpersonen Paula Winkel er en typisk Jølsen-kvinne med en kraftig seksualitet og en ustabil psyke. Dyptliggende affekter og emosjoner styrer Paulas følelsesliv. Gjennom handlingen i Ve´s mor utvikler emosjonaliteten hennes seg drastisk, og leseren kan forstå at store hendelser har skjedd ut fra affektene og emosjonene teksten skildrer. Affektiv narratologi handler blant annet om hvordan karakterers affekter er det drivende for en litterær handling, og avhandlingen argumenterer for at dette perspektivet er godt egnet som teorigrunnlag i en analyse av Ve´s mor. I denne affektiv narratologiske analysen er det karakterers emosjonelle følelsesregistre som tolkes, med fokus på hvilke affekter og emosjoner som kommer til uttrykk. Analysekapitlet strukturerer handlingen i Ve´s mor i ni affektive perioder, hvor hver periode har sitt eget særtrekk hva gjelder Paulas emosjonalitet. Høydepunktet og problematikken som antydes i verkets tittel, kommer til syne i det siste kapitlet, hvor all smerte og lidelse Paula har vært gjennom personifiseres gjennom den vanskapte sønnen Ve. Romanens slutt er uforutsigbar, men Paula har godtatt sin rolle både som Ves mor og som mor til all smerte, med alt det innebærer. Denne avhandlingen søker å finne ut av utviklingen i Paulas emosjonalitet, og hvordan affektiv narratologi kan belyse endringene som oppstår. Analysen viser at de største affektive endringene hos Paula skjer etter livsomfattende hendelser som fødsel og død. Disse vendepunktene preger både den narrative og den emosjonelle utviklingen, og åpner opp Paulas emosjonalitet for leseren. Etter at Paula har gjennomgått dramatiske og traumatiserende hendelser, og emosjonaliteten hennes har utviklet seg i takt med disse, ender hun opp på et stadium der hun er avhengig av å ha et «anker» i livet sitt. Dette ankeret må bære hennes emosjonalitet, og blir avgjørende for Paulas følelsesmessige utvikling
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
IDENTIFICATION AND MOLECULAR CHARACTERIZATION OF PORCINE KOBUVIRUS IN U. S. SWINE FARMS
No full textVerma, Harsha; Mor, Sunil; Goyal, Sagar. (2012). IDENTIFICATION AND MOLECULAR CHARACTERIZATION OF PORCINE KOBUVIRUS IN U. S. SWINE FARMS. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/151705
Insights in the Mechanism of Action and Inhibition of N-Acylethanolamine Acid Amidase by Means of Computational Methods
No full textComputer-aided approaches are widely used in modern medicinal chemistry to improve the efficiency of the discovery phase. N-Acylethanolamine acid amidase (NAAA) is a cysteine amidase belonging to the N-terminal nucleophile (Ntn) hydrolases that primarily degrades anti-inflammatory and analgesic lipid amide palmitoylethanolamide. In this chapter, we review our contribution to (i) the determination of the reaction mechanism of amide hydrolysis catalyzed by cysteine Ntn-hydrolases and (ii) the discovery and optimization of active-site-directed inhibitors of NAAA characterized by a β-lactone warhead. The combination of different computational tools, ranging from homology modeling, docking, and mechanistic simulations based on hybrid quantum mechanics/molecular mechanics potentials, contributed to the elucidation of the mechanism of action and inhibition of NAAA enzyme and to the design of more potent inhibitors
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