174 research outputs found
Understanding safety-critical interactions with a home medical device through Distributed Cognition
No full textAs healthcare shifts from the hospital to the home, it is becoming increasingly important to understand how patients interact with home medical devices, to inform the safe and patient-friendly design of these devices. Distributed Cognition (DCog) has been a useful theoretical framework for understanding situated interactions in the healthcare domain. However, it has not previously been applied to study interactions with home medical devices. In this study, DCog was applied to understand renal patients’ interactions with Home Hemodialysis Technology (HHT), as an example of a home medical device. Data was gathered through ethnographic observations and interviews with 19 renal patients and interviews with seven professionals. Data was analyzed through the principles summarized in the Distributed Cognition for Teamwork methodology. In this paper we focus on the analysis of system activities, information flows, social structures, physical layouts, and artefacts. By explicitly considering different ways in which cognitive processes are distributed, the DCog approach helped to understand patients’ interaction strategies, and pointed to design opportunities that could improve patients’ experiences of using HHT. The findings highlight the need to design HHT taking into consideration likely scenarios of use in the home and of the broader home context. A setting such as home hemodialysis has the characteristics of a complex and safety-critical socio-technical system, and a DCog approach effectively helps to understand how safety is achieved or compromised in such a system
The value of native bird conservation: A New Zealand case study
No full textDuring December 2007 and January 2008, telephone surveys were used to randomly sample Waikato, New Zealand residents. The purpose of the surveys was to determine whether respondents valued native bird conservation programmes in their area. We elicited the contingent valuation approach to determine the value in terms of their willingness-to-pay (WTP) to support regional conservation initiatives aimed at protecting, or restoring, native bird populations. Results indicated that local birdlife was regarded positively by residents and that they were in favour of local conservation and restoration initiatives. 86% of respondents were willing-to-pay an annual addition to their rates (taxes) to support these initiatives. Conservatively, the value of native bird conservation in the region was approximately ). Willingness to support these initiatives depended strongly on income, ethnicity and age. The positive WTP for additional regional rates for local birdlife conservation suggests that there could potentially be an underinvestment in birdlife conservation in the Waikato region, and that regional bodies could draw upon local funding, as opposed to relying on central government funding, to support these initiatives
The Symbolics of Death and the Construction of Christian Asceticism: Greek Patristic Voices from the Fourth through Seventh Centuries
No full textThis thesis examines the role which death plays in the development of a uniquely Christian identity in John Climacus’ seventh-century work, the Ladder of Divine Ascent and the Greek ascetic literature of the previous centuries. I argue that John Climacus deploys language of death, inherited from a range of Greek Christian literature, as the symbolic framework within which he describes the ascetic lifestyle as developing a Christian identity. This framework is expressed by thee ascetic practice of ‘memory of death’ and by practices of renunciation described as ‘death’ to oneself and others.
In order to understand Climacus’ unique achievement in regard to engagement with death it is necessary first to situate the Ladder and its author within the literature of the Greek ascetic tradition, within which Climacus consciously wrote. In the Introduction I develp ways Climacus draws on and develops traditional material, while arguing that it must be treated and interpreted in its own right and not simply as his ‘sources.’ I then examine the vocabulary of death and the lines of thought opened up in the New Testament. Chapter One argues that the memory of death plays an important role in Athanasius’ Vita Antonii. Chapter Two surveys material from the fifth- and sixth-century Egyptian and Palestinian deserts in which memory and practice of death are deployed in a wider variety of ways and are increasingly connected to ascetics’ fundamental understanding of self and salvation. Chapter Three examines the sixth-century Quaestiones et Responsiones of Barsanuphius and John of Gaza in which further elaboration of the same thematic is discernible. Chapter Four concludes this thesis with a sustained reading of John Climacus’ Scala Paradisi in which the various thematics centring on memory and practice of death are synthesized into the existential framework and practical response, respectively
The role of the international patent system in the transfer of technology to West Africa : case studies : Ghana and Nigeria
No full textThe principal aim of this thesis is to undertake a critical
examination of the role of the international patent system in the
transfer of technology to West Africa, particularly Ghana and Nigeria.
It focuses mainly on the patent systans and technology regulatory
regimes of the two countries. The study is intended to identify and
evaluate the impact of the international patent system on the transfer
and development of technology in this area.
The first chapter provides a theoretical foundation to some of
the more practical issues to be discussed in the subsequent chapters.
The Paris Convention and the diplomatic revision exercise thereof, as
well as other efforts and policies regarding patents and technology
transfer at various levels are discussed in Chapter Two. Chapters
Three to Eight consider the two case-studies undertaken in this
thesis. Chapter Three begins with the historical development of the
patent system in both Ghana and Nigeria, and the remaining chapters
continue with a discussion of the present patent and technology
regulatory regimes of both countries. Based on facts and figures the
two case-studies examine critically the patent law and systems and
technology transfer laws of these two countries including other
related institutional measures highlighting their strengths and
weaknesses.
The study argues that if the patent systems of both countries
are to play a meaningful role in the transfer and developnent of
technology they nust be utilized as a tool of economic policy and also
be related to the technology transfer regimes which nust necessarily
be integrated into the national technology policy which should, in
turn, be made an integral part of the entire national developnent
plan. It is concluded that it is only in this way that the patent
system can effectively contribute to the transfer of technology and
the development of indigenous technological capabilities in the two countries
Living stones : the practice of remembrance at Lincoln Cathedral, (1092-1235)
No full textThis thesis analyses four different aspects of devotional life at one of England’s largest and
wealthiest medieval cathedrals between the years 1092 and 1235. Each of these is associated with
the remembrance of the dead. It is an area of religious practice that was subject to momentous
change over the course of the period. These changes would have a profound effect on the
organization of Christian worship for centuries to come. The thesis assesses how contrasting
approaches to the practice of remembrance were able to enhance and shape the composition of
the church, and explores what they reveal about the distinctive fellowship of a secular cathedral
Replication fork collisions cause pathological chromosomal amplification in cells lacking RecG DNA translocase
No full textThis is an open access article, shared under a Creative Commons licence. Copyright © 2009 The Authors.Duplication and transmission of chromosomes require precise control of chromosome replication and segregation. Here we present evidence that RecG is a major factor influencing these processes in bacteria. We show that the extensive DnaA-independent stable DNA replication observed without RecG can lead to replication of any area of the chromosome. This replication is further elevated following irradiation with UV light and appears to be perpetuated by secondary events that continue long after the elimination of UV lesions. The resulting pathological cascade is associated with an increased number of replication forks traversing the chromosome, sometimes with extensive regional amplification of the chromosome, and with the accumulation of highly branched DNA intermediates containing few Holliday junctions. We propose that the cascade is triggered by replication fork collisions that generate 3′ single-strand DNA flaps, providing sites for PriA to initiate re-replication of the DNA and thus to generate linear duplexes that provoke recombination, allowing priming of even further replication. Our results shed light on why termination of replication in bacteria is normally limited to a single encounter of two forks and carefully orchestrated within a restricted area, and explain how a system of multiple forks and random termination can operate in eukaryotes.The Medical Research Council and the Leverhulme Trust
Biological, clinical and population relevance of 95 loci for blood lipids
No full textPlasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD
Stratified medicine for mental disorders
No full textThere is recognition that biomedical research into the causes of mental disorders and their treatment needs to adopt new approaches to research. Novel biomedical techniques have advanced our understanding of how the brain develops and is shaped by behaviour and environment. This has led to the advent of stratified medicine, which translates advances in basic research by targeting aetiological mechanisms underlying mental disorder. The resulting increase in diagnostic precision and targeted treatments may provide a window of opportunity to address the large public health burden, and individual suffering associated with mental disorders. While mental health and mental disorders have significant representation in the "health, demographic change and wellbeing" challenge identified in Horizon 2020, the framework programme for research and innovation of the European Commission (2014-2020), and in national funding agencies, clear advice on a potential strategy for mental health research investment is needed. The development of such a strategy is supported by the EC-funded "Roadmap for Mental Health Research" (ROAMER) which will provide recommendations for a European mental health research strategy integrating the areas of biomedicine, psychology, public health well being, research integration and structuring, and stakeholder participation. Leading experts on biomedical research on mental disorders have provided an assessment of the state of the art in core psychopathological domains, including arousal and stress regulation, affect, cognition social processes, comorbidity and pharmacotherapy. They have identified major advances and promising methods and pointed out gaps to be addressed in order to achieve the promise of a stratified medicine for mental disorders
Targeting RTK signaling pathways in cancer
No full textThe RAS/MAP kinase and the RAS/PI3K/AKT pathways play a key role in the regulation of proliferation, differentiation and survival. The induction of these pathways depends on Receptor Tyrosine Kinases (RTKs) that are activated upon ligand binding. In cancer, constitutive and aberrant activations of components of those pathways result in increased proliferation, survival and metastasis. For instance, mutations affecting RTKs, Ras, B-Raf, PI3K and AKT are common in perpetuating the malignancy of several types of cancers and from different tissue origins. Therefore, these signaling pathways became prime targets for cancer therapy. This review aims to provide an overview about the most frequently encountered mutations, the pathogenesis that results from such mutations and the known therapeutic strategies developed to counteract their aberrant functions
Analysis of the effects of a Constructivist-Based Mathematics Problem Solving Instructional Program on the achievement of Grade Five Students in Belize, Central America.
No full textThis thesis examined whether social constructivist activities can improve the mathematical competency of grade five students in Belize, Central America. The sample included 342 students and eight teachers from two rural and urban schools. A switching replication design was employed enabling students in the experimental groups to be taught using social constructivist activities for 12 weeks and the controls exposed to similar instructional practices from weeks 7 to 12. Students‘ performance was assessed using Pre-test, Post test 1 and 2 with an internal consistency of 0.89, 0.90 and 0.93 respectively. As revealed by the repeated measures ANOVA within subject analysis, there were significant differences among the pre-test and post test 1 and 2 results. That is, students in the control groups, who were instructed using a procedural approach from weeks 1 to 6, demonstrated higher gains than the experimental groups who were immersed in social constructivist activities. Furthermore, when the control groups became immersed in similar activities from weeks 7 to 12, they continued to outperform the experimental groups who were exposed to social constructivist activities alone. Hence, due to this unexpected result, the aim of this thesis became to explain why these results came about and what implications for teaching were highlighted by the consideration.
Besides the quantitative results highlighted above, qualitative data was also obtained as part of the study. For example, students were videoed within constructivist math groups and their performance analyzed using Pirie and Kieren‘s (1994) Model of Growth for Mathematical Understanding. The data from the video recording revealed that use of one step math problems did not enabled students to restructure their thinking to solve innovative problems. Data from semi-structured interviews also revealed that some students lacked basic math skills and were not exposed or guided to solve complex problems. Besides the need for careful examination of social constructivist activities on performance, this thesis underscores the importance of relevant teaching and learning activities, the important role of teachers during social constructivist activities and the need to identify suitable forms of assessment to measure performance
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