95 research outputs found
Focusing in on use of pharmacokinetic profiles in routine hemophilia care
No full textEmergence of population pharmacokinetic models for prediction of individual pharmacokinetic (PK) profiles facilitates individualization of prescribed prophylactic therapy for patients with hemophilia A and B and may have a favorable impact on clinical outcomes and annual factor utilization. How providers approach the integration and application of these data into routine clinical practice is not clear.
To explore the potential application of and barriers to incorporating PK profiles into current hemophilia prophylaxis decision making.
A facilitated group discussion of hematologists practicing within the federally-supported United States Hemophilia Treatment Center Network was conducted. Separately, a group of parents of patients with severe hemophilia less than 18 years of age participated in a focus group on individualizing prophylactic factor regimens with the use of PK data.
Physician participants constructed a conceptual model for factors that determined their selection of hemophilia prophylaxis. These factors clustered in five groupings. When charged with creating a prophylaxis regimen for a specific clinical case including PK data, eight of nine providers generated a unique regimen. Parent focus group supported PK data use as they preferred data driven treatment decisions.
Clinician application of PK data for prophylaxis decision making is heterogeneous. Prospective evaluation of the use of PK-tailored prophylaxis in routine care and its impact on patient outcomes is needed. Parents perceived that, while obtaining blood draws could be challenging, images of factor activity decay informed their decisions about physical activity timing and provided an opportunity for partnership and shared decision making with their provider
Geodynamic implications derived from Numidian-like distal turbidites deposited along the Internal–External Domain Boundary of the Betic Cordillera (S Spain)
No full textNew data reveal Early Burdigalian ‘Numidian-like lithofacies’ in successions of the internal (southernmost) part of the South Iberian Margin (SIM) and the south-western margin of the Mesomediterranean Microplate (MM). The well-known Numidian Formation was deposited in the external (Massylian) sub-domain of the Maghrebian Flysch Basin (a south-western branch of the Tethys Ocean). The anomalous occurrence of ‘Numidian-like lithofacies’ is induced by the particular Early Miocene palaeogeographical and geodynamic complexity of the sector. This consisted of a ‘triple point’ with a dextral transform fault between the SIM and the MM-Maghrebian Flysch Basin system. In this framework, the ageing of Iberian reliefs and the MM collapse, coupled with an African Margin upbulging, and a shortening of the Maghrebian Flysch Basin (both related to the subduction), could have resulted in the arrival of the Numidian depositional system from so far away.This research was supported by Urbino University ‘Carlo Bo’ grant (responsible F. Guerrera), Spanish CICYT Research Projects CGL2009-09249, CGL2011-30153-CO2-02, and CGL2012-32169, Portuguese FCT Research Project PTDC⁄CLI⁄72585⁄2006, Research Groups and projects of the Generalitat Valenciana from Alicante University (CTMA-IGA), and Research Group 146 of the Junta de Andalucía. The first author is also grateful to the Portuguese FCT ‘Ciência 2008’ Programme Contract C2008-IST⁄CVRM.1
UA19/16/3 Student Athlete Biographical File - Soccer
No full textStudent athlete biographical sheets for soccer players 1994: Alois, Bunjira Barbato, Andrea Bertotti, Robert Cecil, William Gill, Michael Guerrera, Alejandro Hickey, Joseph Hunt, Leon Karken, Allan Lykos, Alex McGraw, David Murphy, Thomas Olson, Ryan Robinson, Stephen Robson, Mark Rodosky, Ryan Smith, Jason Sparks, Gregory Tellier, Andrew Theuerkauf, Corey Webb, Michael Zutterman, Christophe
Massimo Guerrera : Darboral
No full textHighlighting the poetic, physical and corporeal metaphors in Guerrera’s works, Ninacs delineates the founding idea of his practice, namely, the conception of the human being as a “constantly reconfigured agglomeration.” The author analyzes Guerrera’s production since 1990 and elaborates on the concepts of “self” and “us” and on the theme of feeding in the artist’s relational installations/performances. Texts in English and French; list of works. Bio-bibliography 5 p., 8 bibl. ref
Aproximación al estudio de los motivos caballerescos en "El Vasauro" de Pedro de Oña: la doncella guerrera
No full textEste artículo se propone el estudio de los motivos caballerescos en El Vasauro
de Pedro de Oña como una perspectiva de análisis. Así, es posible ubicar claramente
esta obra del siglo XVII dentro de lo que consideramos literatura caballeresca
hispánica. Focaliza su atención en la figura de la doncella guerrera y las variantes
del motivo asociadas a ella. Concluye la importancia de las funciones que tiene este
motivo en la obra y destaca cómo pervive y continúa la tradición caballeresca, adaptándose
a las necesidades e ideología de ese momento. Asimismo, se indica que el
poeta lleva a cabo la adaptación del motivo sobre una base de hechos históricos que
recrea literariamente.This article proposes the study of the chivalric motives in El Vasauro by
Pedro de Oña, as a way to approach the literary analysis of the work. In this perspective,
it is possible to understand this poem from Seventeenth Century within the
Hispanic literature of chivalry. The article focuses on the character of the warrior
lady and its variations. It shows the significant functions of this motif in Oña’s work,
and how he used the motives adapting them to the current needs and ideology of the
poem. The author makes an adaptation of the motif over a basis of historical events
besides its artistic recreation
UTILIZZO DEL TEST DA SFORZO CARDIOPOLMONARE (VO2MAX) NELLA STESURA DI UN PROGRAMMA MOTORIO NEL PAZIENTE AFFETTO DA SCOMPENSO CARDIACO
No full textNumerosi sono gli approcci con pazienti affetti da scompenso cardiaco. In questa relazione si utilizza il VO2MAX e il relativo test da sforzo per procedere alla stesura di un programma motorio in questa particolare. Dopo un’attenta analisi della letteratura scientifica e presi in considerazione i risultati dei test svolti siamo in grado di poter redigere ad personam un protocollo motorio creato per il singolo caso specifico ottenendo i massimi risultati lavorando sempre nella sicurezza del paziente
ASO Author Reflections: The Number of Involved Structures is a Promising Prognostic Factor in Thymic Epithelial
No full textASO Author Reflections: The Number of Involved Structures is a Promising Prognostic Factor in Thymic Epithelial Tumors
No full textLaser anemometry and pressure measurements in the endwall region of an annular turbine cascade utilizing a pressurized aerodynamic window
No full textThe purpose of this research was to compare previous laser anemometry measurements obtained through an unpressurized laser window with the results from a pressurized laser window and to validate this innovative measuring technique in the endwall region of a confined annulus. Two dimensional velocity, flow angle, and turbulence intensity measurements were obtained with a fiber optics laser Doppler velocimeter. The measurements were performed through a 1.09 mm opening in the endwall region of an annular turbine cascade at depths ranging from 0.01 mm to 0.89 mm with varying pressure applied to the chamber of the modified window. Cobra probe measurements were performed to validate the flow angles obtained by the laser anemometer. The cascade was modified to measure the inlet profile, which was performed with a three-hole probeApproved for public release; distribution is unlimited.Lieutenant, United States Navyhttp://archive.org/details/lasernemometrynd10945860
Reducing Burden of Learning Chinese through Cognitive Processing——a Case Study of American High School
No full text对外汉语教学因教学对象的国别化和区域化不同有认知上的不同。针对美国人学习汉语的情况,从降低学生学习汉语负担和同化理论对比分析的角度设计,配合美国ACTfl的5CS标准,国别化教学理论策略,从汉语词汇、语音、语法、语篇、歧义等方面产生的负担来讨论和研究分析汉语学习的差异性和文化特色,从而降低学生汉语学习过程中的认知负担。There are different cognitive processes that can be used to teach Chinese as a second/foreign language that portrays the target country' s language and cultural differences.Cognitive tools such as perception,attention,memory,motor,language,executive function and thinking skills can stimulate the senses to make learning a new language more appealing.This paper will share how to reduce the burden of learning Chinese through cognitive processing.This is a case study of an American School.The author will present suggestions for reducing the burden of speech,reducing the burden of grammar,learning Chinese sentences/paragraph and articles,meaning driven,music,ambiguities and errors,Chinese language and culture and American 5C s standards
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