2,592,896 research outputs found
MICE Raw Data
No full textMICE, the international Muon Ionization Cooling Experiment, is a project to design, construct, operate and test a cell of a muon ionisation cooling channel that may be used for a future Muon Collider or Neutrino Factory.The object of the MICE experiment is to take a beam of muons created from protons from the ISIS accelerator hitting a titanium target and to show that it is possible to create a narrow intense beam, using detector techniques from particle physics.The RAW data is the binary output from the principal MICE DAQ system, and will need unpacking and reconstructing with the appropriate software and geometry information. For many runs, the outputs of the real-time monitoring are included in the tarball. Tarballs of the RAW data output from MICE are available from:http://gfe02.grid.hep.ph.ic.ac.uk:8301/MICE/The layout of the MICE data hierarchy is described in MICE Note 255 and the data and re-use policy is described in MICE Note 396:http://www.mice.iit.edu/cgi-bin/note1LinePrintArchival copies of all MICE data are stored on tape at the GridPP Tier 1 at the Rutherford-Appleton Laboratory, Chilton, UK. Contact the MICE Data Manager: [email protected] available from MICE includes:The MICE RAW data: doi:10.17633/rd.brunel.3179644The MICE RECO data: doi:10.17633/rd.brunel.5955850The MICE Simulation data: doi:10.17633/rd.brunel.5972329The MAUS Software: doi:10.17633/rd.brunel.8337542The MICE Miscellaneous data: doi:10.17633/rd.brunel.5024885</p
Draft grid storage namespace guidelines
No full textThe Grid can provide MICE not only with computing (number-crunching) power, but also with a secure global framework allowing users access to data. Although the focus is usually on the mass of experiment data, the Grid also opens up new possibilities for the storage and sharing of other material within the collaboration.
This document provides an introduction to data storage on the Grid and describes the proposal for the directory structures to be used by MICE when registering data files stored on the Grid within a File Catalogue such as LFC
MICE Simulation Data
No full textMICE, the international Muon Ionization Cooling Experiment, is a project to design, construct, operate and test a cell of a muon ionisation cooling channel that may be used for a future Muon Collider or Neutrino Factory.The object of the MICE experiment is to take a beam of muons created from protons from the ISIS accelerator hitting a titanium target and to show that it is possible to create a narrow intense beam, using detector techniques from particle physics.Simulation of MICE is done in two steps: G4beamline is used to simulate the scattering from the Target and to propagate the resulting "Muon Beams" to a hand-over point just past the second momentum-selection dipole; and the separate "MC Production" process then uses MAUS to track the particles onwards through the Cooling Channel for a variety of beam settings and conditions.The simulation outputs are provided as tarballed ROOT files. Tarballs of the Simulation data output from MICE are available from:http://gfe02.grid.hep.ph.ic.ac.uk:8301/Simulation/The MICE data and re-use policy is described in MICE Note 396:http://www.mice.iit.edu/cgi-bin/note1LinePrintArchival copies of all MICE data are stored on tape at the GridPP Tier 1 at the Rutherford-Appleton Laboratory, Chilton, UK. Contact the MICE Data Manager: [email protected] available from MICE includes:The MICE RAW data: doi:10.17633/rd.brunel.3179644The MICE RECO data: doi:10.17633/rd.brunel.5955850The MICE Simulation data: doi:10.17633/rd.brunel.5972329The MAUS Software: doi:10.17633/rd.brunel.8337542The MICE Miscellaneous data: doi:10.17633/rd.brunel.5024885External software:G4beamline: http://g4beamline.muonsinc.com/ROOT: https://root.cern.ch/</div
MICE RECO Data
No full textMICE, the international Muon Ionization Cooling Experiment, is a project to design, construct, operate and test a cell of a muon ionisation cooling channel that may be used for a future Muon Collider or Neutrino Factory.The object of the MICE experiment is to take a beam of muons created from protons from the ISIS accelerator hitting a titanium target and to show that it is possible to create a narrow intense beam, using detector techniques from particle physics.The RECO data is the processed RAW output containing information about space points, particle tracks and so on, presented as tarballed ROOT files. It has been unpacked and reconstructed using the indicated version of the official software (MAUS) with the appropriate geometry information. Further analysis, e.g. derivation of beam parameters such as emittance, will again require MAUS. Tarballs of the RECO data output from MICE are available from:http://gfe02.grid.hep.ph.ic.ac.uk:8301/RECO/The MICE data and re-use policy is described in MICE Note 396:http://www.mice.iit.edu/cgi-bin/note1LinePrintArchival copies of all MICE data are stored on tape at the GridPP Tier 1 at the Rutherford-Appleton Laboratory, Chilton, UK. Contact the MICE Data Manager: [email protected] available from MICE includes:The MICE RAW data: doi:10.17633/rd.brunel.3179644The MICE RECO data: doi:10.17633/rd.brunel.5955850The MICE Simulation data: doi:10.17633/rd.brunel.5972329The MAUS Software: doi:10.17633/rd.brunel.8337542The MICE Miscellaneous data: doi:10.17633/rd.brunel.5024885External Software:ROOT: https://root.cern.ch/</div
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Full text linkIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Source code of MAUS - the MICE Analysis User Software
No full textMICE, the international Muon Ionization Cooling Experiment, is a project to design, construct, operate and test a cell of a muon ionisation cooling channel that may be used for a future Muon Collider or Neutrino Factory.The object of the MICE experiment is to take a beam of muons created from protons from the ISIS accelerator hitting a titanium target and to show that it is possible to create a narrow intense beam, using detector techniques from particle physics.MAUS is the software framework used by the MICE collaboration to provide Monte Carlo simulation of the beam and detector responses (via GEANT4), both offline and online data reconstruction, and various data analysis tools. It also provides a framework for collaborators to build their own offline data-analysis tools. MAUS is described in: R. Asfandiyarov et al.: “MAUS: the MICE Analysis User Software” Journal of Instrumentation 14 (4) T04005 (2019).The source code of MAUS is available from the Launchpad repository:https://launchpad.net/mausAll required third-party libraries are included with the source code. Guidance on compilation and use is provided at http://micewww.pp.rl.ac.uk/projects/maus/wikiMaterial available from MICE includes:The MICE RAW data: doi:10.17633/rd.brunel.3179644The MICE RECO data: doi:10.17633/rd.brunel.5955850The MICE Simulation data: doi:10.17633/rd.brunel.5972329The MAUS Software: doi:10.17633/rd.brunel.8337542The MICE Miscellaneous data: doi:10.17633/rd.brunel.5024885</p
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
Full text linkInsulin resistance and impaired glucose homoeostasis are important indicators of Type 2 diabetes and are early risk factors of AD (Alzheimer's disease). An essential feature of AD pathology is the presence of BACE1 (beta-site amyloid precursor protein-cleaving enzyme 1), which regulates production of toxic amyloid peptides. However, whether BACE1 also plays a role in glucose homoeostasis is presently unknown. We have used transgenic mice to analyse the effects of loss of BACE1 on body weight, and lipid and glucose homoeostasis. BACE1-/- mice are lean, with decreased adiposity, higher energy expenditure, and improved glucose disposal and peripheral insulin sensitivity than wild-type littermates. BACE1-/- mice are also protected from diet-induced obesity. BACE1-deficient skeletal muscle and liver exhibit improved insulin sensitivity. In a skeletal muscle cell line, BACE1 inhibition increased glucose uptake and enhanced insulin sensitivity. The loss of BACE1 is associated with increased levels of UCP1 (uncoupling protein 1) in BAT (brown adipose tissue) and UCP2 and UCP3 mRNA in skeletal muscle, indicative of increased uncoupled respiration and metabolic inefficiency. Thus BACE1 levels may play a critical role in glucose and lipid homoeostasis in conditions of chronic nutrient excess. Therefore strategies that ameliorate BACE1 activity may be important novel approaches for the treatment of diabetes
The MICE Experiment
No full textIonization Cooling is the only practical solution to preparing high brilliance muon beams for a neutrino factory or muon collider. The muon ionization cooling experiment (MICE) is under development at the Rutherford Appleton Laboratory (UK) by an international collaboration. The muon beam line has been commissioned and first measurements of emittance with particle physics detectors have been performed. The remaining apparatus is currently under construction. First results with a liquid-hydroge n absorber will be produced in 2013; a couple of years later a full cell of a representative ionization cooling channel, including RF re-acceleration, will be in operation. The design offers opportunities for tests with various absorbers and several optic s configurations. Results will be compared with detailed simulations of cooling channel performance to ensure full understanding of the cooling process
The MICE Muon Beam on ISIS and the beam-line instrumentation of the Muon Ionization Cooling Experiment
Full text linkThe international Muon Ionization Cooling Experiment (MICE), which is under construction at the Rutherford Appleton Laboratory (RAL), will demonstrate the principle of ionization cooling as a technique for the reduction of the phase-space volume occupied by a muon beam. Ionization cooling channels are required for the Neutrino Factory and the Muon Collider. MICE will evaluate in detail the performance of a single lattice cell of the Feasibility Study 2 cooling channel. The MICE Muon Beam has been constructed at the ISIS synchrotron at RAL, and in MICE Step I, it has been characterized using the MICE beam-instrumentation system. In this paper, the MICE Muon Beam and beam-line instrumentation are described. The muon rate is presented as a function of the beam loss generated by the MICE target dipping into the ISIS proton beam. For a 1 V signal from the ISIS beam-loss monitors downstream of our target we obtain a 30 KHz instantaneous muon rate, with a neglible pion contamination in the beam
Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation
Full text linkDeficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions. The level of VDR is reduced in lungs of patients with chronic obstructive pulmonary disease (COPD) which led us to hypothesize that deficiency of VDR leads to significant alterations in lung phenotype that are characteristics of COPD/emphysema associated with increased inflammatory response. We found that VDR knock-out (VDR(-/-)) mice had increased influx of inflammatory cells, phospho-acetylation of nuclear factor-kappaB (NF-κB) associated with increased proinflammatory mediators, and up-regulation of matrix metalloproteinases (MMPs) MMP-2, MMP-9, and MMP-12 in the lung. This was associated with emphysema and decline in lung function associated with lymphoid aggregates formation compared to WT mice. These findings suggest that deficiency of VDR in mouse lung can lead to an early onset of emphysema/COPD because of chronic inflammation, immune dysregulation, and lung destruction
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