539 research outputs found
Inteligencia emocional y aprendizaje autorregulado en estudiantes de una institución educativa de Huancapi, Ayacucho, 2023
No full textEl desarrollo de la investigación tuvo como objetivo determinar el nexo entre
la inteligencia emocional y el aprendizaje autorregulado en estudiantes de una
institución educativa de Huancapi, Ayacucho, 2023; llevado a cabo desde la
propuesto de una investigación de tipo básico, enfoque cuantitativo, método
hipotético-deductivo, nivel correlacional y de diseño no experimental, transversal,
donde la población la conformaron 154 estudiantes de secundaria y mediante la
aplicación de un muestreo probabilístico estratificado, se estableció que la muestra
la conformaron 111 estudiantes, además, para recoger información se consideró la
escala de inteligencia emocional propuesto por Merino-Soto et al. (2019) y la escala
para el aprendizaje autorregulado desarrollado por Chávez y Merino (2015).
Respecto a los resultados, se confirmó la existencia de nexo significativo entre las
variables, porque la Sig. < ,05; por ello se rechazó la Ho, asimismo, el coeficiente
rho = ,771; de tal manera se concluyó que, a mayor desarrollo de la inteligencia
emocional, mayor el fomento del aprendizaje autorregulado en los estudiantes
Texel and Dohne Merino highlight preweaning growth in the high andean highlands of Peru: A comparative study of six sheep breeds
No full textSheep production in the high Andean regions of Peru faces several challenges, including low productive performance, particularly during the pre-weaning stage. Therefore, the appropriate selection of breeds adapted to these conditions could significantly improve growth indicators and increase the profitability of the production system. The study aimed to compare the behavior of preweaning growth criteria in male and female lambs of six sheep breeds (Dohne Merino, Corriedale, Texel, Poll Dorset, Finnish Landrace, and East Friesian) raised in the high Andean conditions of Peru. A total of 199 live weight records of lambs were evaluated at birth, 25, 60, 90 days, and weaning. The analysis of variance revealed significant differences between breeds, separated by sex, and the Principal Component Analysis examined patterns of variation among variables and breeds. The results showed that males of the Texel breed had a higher average weight at 60 days, while the Dohne Merino breed stood out in terms of birth weight. In females, Texel and Dohne Merino were the breeds with the highest weights at 90 days and weaning. PCA analysis revealed a positive correlation between 60-day, 90-day, and weaning weights, although no clear grouping by breed or sex was evident. However, Texel and Dohne Merino showed better performance compared to the other breeds, suggesting their potential for inclusion in genetic improvement programs under high-altitude conditions, which could contribute to strengthening livestock systems in the high Andean regions of Peru.We extend our deepest gratitude to the National Institute for Agrarian Innovation (INIA), whose support through the Soils Project allowed our participation in this research. We acknowledge the efforts of Edilson Requena, leader of the Research Component of LABSAF Santa Ana, for his contributions, suggestions, and critical review of this work
Estudo da carga parasitária gastrointestinal num cruzamento rotacional de ovelhas Corriedale e Merino Dohne.
No full text
2.15.1.0Los parásitos gastrointestinales representan uno de los principales desafíos sanitarios en la producción ovina uruguaya. Generan importantes pérdidas económicas debido a la reducción de la productividad y los costos de tratamiento. En este estudio evaluamos la variación genética y ambiental de la carga parasitaria medida como recuento de huevos por gramo de materia fecal (HPG), en ovinos Corriedale (C) puras y cruzas provenientes de un sistema rotacional entre C y Merino Dohne (MD). El trabajo se desarrolló en la Estación Experimental Bernardo Rosengurtt (Uruguay), abarcando un período de nueve años (2015–2024). Se analizaron 1246 y 1056 HPG en hembras a los 6 y 8 meses de edad (HPG1 y HPG2, respectivamente). Transformamos los datos a logaritmo natural para cumplir con los supuestos estadísticos. Ajustamos un modelo lineal mixto en R. Como efectos fijos incluimos raza y cruzas (C puro y cruzas con variable proporción de C y MD), tipo de crianza (único o múltiple) y año de registro. Tratamos el efecto padre como aleatorio cruzado, e incluimos la edad del cordero como covariable. No hubo diferencia significativa entre C y las cruzas en HPG1 ni en HPG2. El efecto de año de registro fue significativo para ambas variables (p<0.01). La edad del animal tuvo efecto significativo en HPG1 (p<0.01), presentando mayor conteo los animales jóvenes. Tipo de crianza se acercó al nivel significativo en el caso de HPG2 (p=0.076). La varianza del efecto padre fue considerablemente menor que la residual, lo que sugiere baja variación genética en comparación con la ambiental.Los resultados sugieren que la incorporación de la raza MD en sistemas pastoriles locales no compromete el desempeño frente a los parásitos, mostrando las cruzas un comportamiento comparable al de la raza C pura, ampliamente adaptada a las condiciones nacionales. Demuestran además, significativos efectos ambientales sobre la carga parasitaria.
2.15.1.0
2.15.1.
Monitoreo y acompañamiento a la práctica pedagógica para mejorar el aprendizaje de los estudiantes en el Área de Ingles del ciclo avanzado del CEBA Elvira García Y García
No full textEste trabajo, es el Plan de Acción elaborado para revertir la situación problemática encontrada en el CEBA Elvira García y García del distrito de Pueblo Libre, en donde después de haber hecho el diagnóstico a través de la revisión de documentos institucionales, resultados de aprendizaje, la aplicación la CHAKANA del modelo de la escuela para identificar problemas institucionales y el recojo de información a través de entrevistas y cuestionarios a profesores y estudiantes, las evidencias obtenidas nos han permitido determinar que en este Centro Educativo existe un Nivel de logro debajo del satisfactorio en los aprendizajes del área de Inglés en el Ciclo Avanzado. La situación encontrada nos ha llevado a preguntarnos ¿De qué manera mejorar los aprendizajes del área de inglés en el Ciclo Avanzado del CEBA “Elvira García y García”? y proponer alternativas de solución que consideramos viables para revertir el problema, y que están relacionadas con las dimensiones del liderazgo pedagógico, los procesos de gestión, los compromisos de gestión escolar, el Marco del Buen Desempeño Directivo además de sustentase en aportes teóricos, y en experiencias realizadas sobre el tema. Esto nos ha facilitado diseñar el plan de acción estableciendo los objetivos, estrategias, propuestas de intervención, metas, actividades, responsables, cronograma, presupuesto y la propuesta de monitoreo y evaluación de este. El proceso de elaboración del Plan de Acción se ha sistematizado reconstruyendo la experiencia de su construcción así como se han reconocido las lecciones aprendidas en este tiempo. Estamos convencidos que su aplicación va a permitir Incrementar el nivel de logro satisfactorio en los aprendizajes del área de Inglés en el Ciclo Avanzado y que nuestros estudiantes se expresen fluidamente en forma oral y escrita en el idioma inglés, utilizándolo en otras actividades que su vida cotidiana lo requiera
A transitory regime : water supply in Conakry, Guinea
No full textBoth consumers and the government benefited from reform of the water system in Conakry, Guinea, whose deterioration since independence had become critical by the mid-1980s. Less than 40 percent of Conakry's population had access to piped water - low even by regional standards - and service was intermittent, at best, for the few who had connections. The public agency in charge of the sector was inefficient, overstaffed, and virtually insolvent. In several ways, the reform introduced to the sector in 1989 under a World Bank-led project was remarkable. It showed that even in a weak institutional environment, where contracts are hard to enforce and political interference is common, private sector participation can improve sector performance. The authors discuss the mechanismsthat made progress possible and identify factors that inhibit the positive effects of reform. Water has become very expensive, the number of connections has increased very slowly, and conflicts have developed between SEEG (the private operator) and SONEG (the state agency). Among the underlying problems: a) The lack of strong, stable institutions. b) The lack of an independent agency capable of restraining arbitrary government action, regulating the private operator, and enforcing contractual arrangements. c) The lack of adequate conflict resolution mechanisms for contract disputes. d) Weak administrative capacity.Environmental Economics&Policies,Water and Industry,Water Conservation,Decentralization,Water Supply and Systems,Town Water Supply and Sanitation,Water and Industry,Water Supply and Sanitation Governance and Institutions,Environmental Economics&Policies,Water Conservation
Strotarchus chamevazquezi Cubas-Rodriguez & Bonaldo & Brescovit 2023, sp. nov.
No full textStrotarchus chamevazquezi sp. nov. Type material. Holotype ♁ and paratype ♀ from La Bodega (13°56’40.7”N 87°13’23.9”W), Santa Ana, Francisco Morazán, Honduras, June 20, 2021, leg. A. Cubas (IBSP 324813). Paratype: one ♁ with same data as holotype (IBSP 324814). Other material examined. HONDURAS: Francisco Morazán: Santa Ana, La Bodega (13°56’40.7”N 87°13’23.9”W), 1♁ (IBSP 324816); 1♁ 1♀ (IBPS 324815, SEM). Etymology. The specific epithet is in honor of Dr. David Chamé-Vázquez (CIBNOR, México), for his great contributions to the study of the Mexican spider fauna and his great importance as a mentor in spider research for the first author. Diagnosis. The males of Strotarchus chamevazquezi sp. nov. resemble those of S. minor Banks, 1909 by the presence of a basal embolar fold that crosses the apical portion of the tegulum, by the long embolus that arises retrolaterally, and by an extremely long cymbium (see Bonaldo et al. 2012: figs 103–104). They are differentiated by the absence of either ppRTA and laRTA (see Bonaldo et al. 2012: figs 103–104), by the arrow-shaped retrolateral tibial apophysis apices in ventral view (square in retrolateral view), and by the balloon-shaped embolar base (Figs 1D, 3A, 3B, 4C). Females resemble those of S. minor by the elliptical atrium (see Bonaldo et al. 2012: fig. 105) but differ by the parallel copulatory ducts, converging abruptly toward the spermathecae, and by the lateral margin of anterior atrium superposed to the atrial posterior margin (Figs 3C, 3D). Description. Male (Holotype). Carapace light brown (Fig. 1A), labium, endites and sternum lighter than carapace, head region and chelicerae reddish-brown, legs light yellow, opisthosoma cream, striated with narrow yellowish-brown bands. Total length 5.19. Carapace 2.5 long, 1.74, wide. Eye diameters: AME 0.22, ALE 0.16, PME 0.19, PLE 0.20. Chelicerae with 3 promarginal teeth, the median largest, and 2 retromarginal teeth, separated by twice their width (Fig. 4A). Leg measurements: femur I 1.71/ II 1.22/ III 1.49/ IV 2.05. Leg spination: I—femur d1-1-1, p0-0-1, r0; tibia d0, p0, r0-0-1, v2-0-2; metatarsus d0, p1-1-1, r0-1-1, v2-2-2. II—femur d1-1-1, p0, r0-1-1; tibia d0-0-1, p0, r1-1-1, v1-2-0; metatarsus d0-1-0, p1-1-1, r1-1-1, v2-1-2. III—femur d1-1-1, p0-1-1, r1-1-1; tibia d0-0-1, p0-1-1, r0-1-1, v2-2-0; metatarsus d0-1-0, p1-1-1, r1-1-1, v2-2- 1m. IV—femur d1-0-1, p0-0-1, r0- 0-1; tibia d0, p0-1-1, r0-0-1, v2-2-2; metatarsus d0-1-1, p1-1-1, r0-1-1, v2-1-2. Palpal tibia ca. 1/3 of cymbium length, cymbium long, curved medially and ovoid-shaped in basal third; retrolateral tibial apophysis flattened and enlarged, apex sharp or blunt (Fig. 4B); ppRTA and laRTA absent. Tegulum rounded, proximal fold of reservoir thick, Vshaped; tegular apophysis inserted ventrally on prolateral side of tegulum; embolar base visible retrolaterally as concave area on expanded palp (Fig. 1D); basal embolar fold not clearly visible (Figs 1C, 3B), connecting with small portion of tegulum but displaced obliquely; embolar process small, rounded (Figs 1B, 3A, 4D). Female (Paratype, IBSP 324813). Coloration as in male, except with darker carapace (Fig. 2A). Total length 6.52. Carapace 2.62 long, 2.0. Eye diameters: AME 0.25, ALE 0.16, PME 0.20, PLE 0.24. Chelicerae with promarginal teeth as in male and 2 retromarginal teeth, separated by three times their width (Fig. 4E). Leg measurements: femur I 1.61/ II 1.57/ III 1.41/ IV 2.10. Leg spination: I—femur d1-0-1, p0-0-2, r0; tibia d0, p0-0-1, r0-0-1, v2-2- 0; metatarsus d0, p0-0-1, r0, v2-2-0. II—femur d1-1-1, p1-1-0, r0; tibia d0, p0-0-1, r0-0-1, v2-2-0; metatarsus d0, p0-0-1, r0-1-1, v2-2-1. III—femur d1-1-1, p1-1-1, r0-0-1, v0; tibia d0-0-1, p1-1-0, r1-1-0, v1p-2-0; metatarsus d0, p1-1-1, r1-1-1, v2-2- 0. IV—femur d1-1-1, p0-0-1, r0-0-1; tibia d0-0-1, p0-1-1, r0-1-1, v2-0-2; metatarsus d0-2-2, p1-1-1, r1-1-1, v2-2-2. Epigynum with wide, narrow atrium with laterally projecting edges (Fig. 2B); atrial pocket large, oval posteriorly, median slit without lateral notches, rounded anteriorly (Figs 2D, 3D). Copulatory ducts with helicoid folds; glandular knob small, nearly triangular, projected distally; spermathecae enlarged posteriorly, curved boot-shaped; spermathecae continuous with spermathecae stalk (Figs 2 C-D, 3E-F, 4F) Variation. Three males: Total length 5.19 − 5.60, carapace 2.50 − 2.70, femur I 1.71 − 1.85. Natural history. The specimens were captured manually in wild areas and inside houses in La Bodega. Distribution. Known only from the type locality, Santa Ana, Francisco Morazán, Honduras (Fig. 5).Published as part of Cubas-Rodriguez, Alex M., Bonaldo, Alexandre B. & Brescovit, Antonio D., 2023, A new species of Strotarchus Simon, 1888 from Honduras (Araneae, Cheiracanthiidae), pp. 582-588 in Zootaxa 5296 (4) on pages 584-588, DOI: 10.11646/zootaxa.5296.4.7, http://zenodo.org/record/798444
Improvement of the antihypertensive capacity of candesartan and trityl candesartan by their SOD mimetic copper(II) complexes
No full textTwo new complexes [Cu(Cand)(H2O)4] [1] and [Cu2(TCand)4(H2O)2]·4H2O [2] (Cand = candesartan; TCand = trityl candesartan) have been synthesized and thoroughly characterized. The FTIR, Raman, EPR and diffuse reflectance spectra of the solid compounds show a dimeric complex for [2] with carboxylate bridging of the type found in copper(II) acetate. Both elemental analysis and thermal measurements allow the determination of the total stoichiometries of both complexes. The stability measurements show that the compounds are stable in ethanolic solutions at least for 1 h, while the preservation of the overall stochiometry for both species in solution has been determined by spectrophotometric titrations. By metal complexation the absence of antioxidant behavior of both sartans has been improved. Complexes [1] and [2] are strong superoxidedismutase mimetic compounds and complex [2] also behaves as a peroxyl radical scavenger. Furthermore, this higher antioxidant activity works in parallel with the improvement of the expansive activity over the angiotensin II-induced contracted human mesangial cells. These new complexes exhibit even higher efficiency as drugs in comparison with the free non-complexed medication with increased antioxidant ability expressing higher capacity to block the angiotensin II contractile effect. This study provides a new insight into the development of copper(II) complexes as potential drugs.Fil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Rojo, Teófilo. Universidad del País Vasco; EspañaFil: Lezama, Luis. Universidad del País Vasco; EspañaFil: Griera Merino, Mercedes. Universidad de Alcalá; EspañaFil: Cortes, María A.. Universidad de Alcalá; EspañaFil: Rodriguez Puyol, Manuel. Universidad de Alcalá; EspañaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentin
Durability of fibre reinforced cementitious composites: Coupling mechanical and chloride environment loads
No full textFibre reinforced cementitious composites (FRCC) may be characterized by their improved performance namely in terms of tensile ductility, accompanied by multiple cracking, and potentially lower permeability to liquid and gas in cracked state. Cracking, which is nearly inevitable, can occur due to applied structural loading, shrinkage, chemical attack, thermal deformations and restrained condition. Even though might not be a structural problem, cracking could be a durability issue, since it considerably modifies the transport properties of the cementitious composite and, as consequence, accelerates the deterioration process, which can significantly impair the long term service life of a structure or element. Literature indicates that, particularly for chloride penetration, the presence of cracks and/or load condition, causes a more deleterious attack compared to standard durability test on sound specimens composites. Contributing to that concern a methodology for accessing chloride attack in loaded and/or cracked FRCC is proposed. Cracking procedure and specimen geometry were selected, considering that cracks produced in laboratory should resemble those in structural elements (beams). Thus, FRCC specimens were firstly pre-loaded under four point bending up to a pre-defined crack width. The crack width was kept using special stainless steel frame. In addition, cracked but not loaded specimens were considered and sound specimens were used as reference. Then, specimens were exposed to wet-dry cycles in a chloride solution. It is argued that the chloride penetration is definitively influenced by the load and cracking conditions, which promoted a higher penetration depth leading to a severe fibres corrosion, which also compromised the mechanical performance of FRCC.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Materials and Environmen
Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
No full textThe coordination compound of the antihypertensive ligand irbesartan (irb) with copper(II) (CuIrb) was synthesized and characterized by FTIR, FT-Raman, UV–visible, reflectance and EPR spectroscopies. Experimental evidence allowed the implementation of structural and vibrational studies by theoretical calculations made in the light of the density functional theory (DFT). This compound was designed to induce structural modifications on the ligand. No antioxidant effects were displayed by both compounds, though CuIrb behaved as a weak 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·) scavenger (IC50 = 425 μM). The measurements of the contractile capacity on human mesangial cell lines showed that CuIrb improved the antihypertensive effects of the parent medication. In vitro cell growth inhibition against prostate cancer cell lines (LNCaP and DU 145) was measured for CuIrb, irbesartan and copper(II). These cell lines have been selected since the angiotensin II type 1 (AT1) receptor (that was blocked by the angiotensin receptor blockers, ARB) has been identified in them. The complex exerted anticancer behavior (at 100 μM) improving the activity of the ligand. Flow cytometry determinations were used to determine late apoptotic mechanisms of cell death.Fil: Islas, María Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Luengo, Alicia. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Merino, Mercedes Griera. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Calleros, Laura. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Rodriguez Puyol, Manuel. Universidad de Alcalá; España. Universidad Carlos III de Madrid. Instituto de Salud; EspañaFil: Lezama, Luis Raul. Universidad del País Vasco; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; ArgentinaFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica ; Argentin
Synaptic dysfunction in Parkinson's Disease: functional and ultrastructural study of the striatal synapses in an animal model of progressive parkinsonism
No full text212 p.This Ph.D. project involves the temporal sequence of the earliest functional and structural events in the striatal synapses in a rat model of progressive parkinsonism induced by overexpression of human ¿-synuclein (h¿-syn) with A53T mutation (rAAV-h¿-syn) in the substantia nigra compacta (SNc), before parkinsoniasn motor features appear. We have observed a sequential pattern of events. The aggregation of h¿-syn in the striatal dopaminergic terminals firstly induces deregulation of proteins affecting metabolism followed by decreased mitochondrial respiration in striatal synaptosomes. Differential analysis by proteomics revealed significant deregulated proteins from biological pathways related to synaptic function and neurotransmission. These functional and proteostatic alterations precede the structural changes and the onset of degeneration of the dopaminergic axons in the striatum that precede the loss of neuronal soma in the SNc. Lastly, homeostatic changes in glutamatergic synapses are simultaneous to the onset of the synaptic functional deficit, and dendritic spine loss is accompanied by plastic events. These last findings could represent compensatory mechanisms to maintain normal function during the onset of dopaminergic degeneration. We count with a good model of progressive synaptopathy in the dopaminergic pathway linked to the accumulation of h¿-syn, providing an excellent preclinical model to develop new synapse-targeted therapies
- …
