1,711 research outputs found
Clinical prevalence and outcome impact of pituitary dysfunction after aneurysmal subarachnoid hemorrhage: a systematic review with meta-analysis
No full textAbstract
Purpose Pituitary dysfunction is reported to be a common
complication following aneurysmal subarachnoid hemor rhage (aSAH). The aim of this meta-analysis is to analyze
the literature on clinical prevalence, risk factors and out come impact of pituitary dysfunction after aSAH, and to
assess the possible need for pituitary screening in aSAH
patients.
Methods We performed a systematic review with meta analysis based on a comprehensive search of four databases
(PubMed/MEDLINE, ISI/Web of Science, Scopus and
Google Scholar).
Results A total of 20 papers met criteria for inclusion. The
prevalence of pituitary dysfunction in the acute phase
(within the first 6 months after aSAH) was 49.30 % (95 %
CI 41.6–56.9), decreasing in the chronic phase (after
6 months from aSAH) to 25.6 % (95 % CI 18.0–35.1)
DK conjecture for Grassmannian flips
No full textPh.D.We investigate the DK conjecture on derived categories of coherent sheaves stated by Bondal-Orlov and Kawamata: there should be a derived embedding for any flip and in particular a derived equivalence for any flop. Unlike the situations for flops, there are few examples of flips proven to satisfy the DK conjecture except for some toroidal flips.We construct new examples of flips from Grassmannians, called Grassmannian flips, that satisfy the DK conjecture.我們對由彭督-奧爾洛夫（Bondal-Orlov）和川又（Kawamata）提出關於凝聚層的導出範疇相關的DK猜測進行探討：即對於任何翻轉（flip），都應該有導出（範疇的）嵌入，尤其是對於任何平轉 （flop），都應該有導出（範疇的）等價。與平轉（flop）的情況不同，除了一些環形翻轉（toroidal flips） 之外，鮮有反轉的例子證明能夠被證明滿足DK猜想。我們從格拉斯曼簇出發構造了滿足DK猜想的新例子，稱為格拉斯曼翻轉（Grassmannian flips）。Xie, Ying.Thesis Ph.D. Chinese University of Hong Kong 2020.Includes bibliographical references (leaves 84-88).Abstracts also in Chinese.Title from PDF title page (viewed on February 7, 2022)
Neurological examination of critically ill patients: a pragmatic approach. Report of an ESICM expert panel.
No full textOBJECTIVE:
Many patients admitted to the intensive care unit (ICU) have pre-existing or acquired neurological disorders which significantly affect their short-term and long-term outcomes. The ESICM Neuro Intensive Care Section convened an expert panel to establish a pragmatic approach to neurological examination (NE) of the critically ill patient.
METHODS:
The group conducted a comprehensive review of published studies on the NE of patients with coma, delirium, seizures and neuromuscular weakness in critically ill patients. Quality of data was rated as high, moderate, low, or very low, and final recommendations as strong, weak, or best practice.
SUMMARY AND CONCLUSIONS:
The group made the following recommendations: (1) NE should be performed in all patients admitted to ICUs; (2) NE should include an assessment of consciousness and cognition, brainstem function, and motor function; (3) sedation should be managed to maximize the clinical detection of neurological dysfunction, except inpatients with reduced intracranial compliance in whom withdrawal of sedation may be deleterious; (4) the need for additional tests, including neurophysiological and neuroradiological investigations, should be guided by the NE; (5) selected features of the NE have prognostic value which should be considered in well-defined patient populations
Ovarian cancer screening in the general population.
No full textDespite significant improvements in therapy, ovarian cancer continues to be a leading cause of death amongst women with gynaecological malignancies. Advanced stage at diagnosis is thought to be a major contributor to mortality. Hence, there is considerable interest in early detection through screening. In the 1990s, Professor Jacobs pioneered the development of a multimodal ovarian cancer screening (OCS) strategy using serum CA125 as the first line screen and pelvic ultrasound as the second line test. This thesis summarises the next steps in the journey with refining of the screening algorithm, feasibility testing in a pilot randomised control trial (RCT) and finally setting up and recruiting 200,000 women into the largest ever RCT . The risk of ovarian cancer in postmenopausal women with elevated CA125 levels was established through a detailed analysis of 1219 pelvic scans from 741 women with raised CA125 levels in the completed trial of 22,000 women. Based on this, the multimodal 'Risk of Ovarian Cancer' (ROC) algorithm was refined and morphology instead of volume was used to interpret the ovarian scans. The refined ROC algorithm was then prospectively evaluated in a pilot RCT of 13,582 postmenopausal women. The trial established that screening using the ROC algorithm was feasible and could achieve high specificity and positive predictive value. The improved performance characteristics of the screening strategy and the experience accumulated in running and organising the pilot trial led to the design and successful implementation of a RCT - the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) - to assess the impact of early detection on disease mortality. The trial commenced in 2001 with recruitment of 202,638 postmenopausal women by September 2005. The issues involved in setting up the trial, recruitment of 202,000 women and the baseline characteristics of this population are described
Nu-DESC DK: the Danish version of the nursing delirium screening scale (nu-DESC)
No full textAbstract Background Delirium is one of the most common complications among elderly hospitalized patients, postoperative patients and patients on intensive care units with a prevalence between 11 and 80%. Delirium is associated with higher morbidity and mortality. Reliable instruments are required to detect delirium at an early time point. The Nursing-Delirium Screening Scale (Nu-DESC) is a screening tool with high sensitivity and good specificity. However, there is currently no official translation after ISPOR guidelines of any Danish delirium assessment tools available. Thereby hampering the implementation of 2017 ESA-Guidelines on postoperative Delirium in the clinical routine. The aim of this study is to provide an official translation and evaluation of the Nu-DESC into Danish following the ISPOR process. Methods The Nu-DESC was translated after International Society for Pharmacoecomonics and Outcome Research (ISPOR) guidelines to Danish after permission of the original author, and is evaluated by medical staff and finally approved by the original author. Results All steps of the ISPOR guideline were consecutively followed, without any major problems. The evaluation of the Nu-DESC DK regarding its intelligibility and feasibility showed no statistically significant differences between nurses and medical doctors ratings. The translation was authorized and approved by the original author. Conclusion This study provides the Nu-DESC DK, an official Danish delirium screening instrument, which can detect all psychomotor types of delirium
Relativistic segmented contraction basis sets with core-valence correlation effects for atoms 57La through 71Lu : Sapporo-DK-nZP sets (n = D, T, Q)
No full textFor the 15 lanthanide atoms 57La through 71Lu, we report Sapporo-DK-nZP sets (n = D, T, Q), which are natural extensions of the Sapporo-(DK)-nZP sets for lighter atoms and efficiently incorporate the correlation among electrons in the N through P shells as well as the relativistic effect. The present sets well describe the correlation among the 4s and 4p electrons, which are important in the excitation of 4f electrons. Atomic test calculations of 57La, 58Ce, 59Pr, and 60Nd at configuration interaction with the Davidson correction level of theory confirm high performance of the present basis sets. Molecular test calculations are carried out for 57LaF and 70YbF diatomics at the coupled cluster level of theory. The calculated spectroscopic constants approach smoothly to the experimental values as the quality of the basis set increases
The Gender Gap in Political Knowledge: Is It All About Guessing? An Experimental Approach
No full textThis article analyzes the extent to which the format and the “Do not know” (DK) protocol of political knowledge questions influence the size of the gender gap. By using a set of experiments that manipulated the DK protocol and the format (open vs. closed ended) of political knowledge questions in a face-to-face representative survey of the Spanish population, we show that the format of the questions (open vs. closed ended) is not relevant in explaining the gender gap. DK protocols, however, influence outspoken levels of political knowledge differently for men and women. DK-discouraging protocols tend to encourage the emergence of hidden knowledge among women, whereas they mostly boost guessing among men. This finding suggests that the meaning and the use of the DK option appear to be gender biased
Search for the decay B-0 -> DK*(0) followed by D -> K- pi(+)
No full textWe report a study of the decay B-0 -> DK+ pi(-) followed by D -> K- pi(+) , where D indicates D-0 or (D) over bar (0). We reconstruct the DK+ pi(-) state in a phase space corresponding to DK*(892)(0). The CP-violating angle phi(3) affects its decay rate via the interference between b -> u and b -> c transitions. The result is obtained from a 711 fb(-1) data sample that contains 772 X 10(6)B (B) over bar pairs collected at the Y(4S) resonance with the Belle detector at the KEKB asymmetric-energy e(+) e(-) collider. We measure the ratio R-DK*0 Gamma(B-0 -> [K- pi(+) ](D)K+ pi(-))/Gamma(B-0 -> [K+ pi(-)](D)K+ pi(-)) to be (4.5(-5.0-1.8)(+5.6+2.8)) X 10(-2), and set an upper limit of R-DK*0 < 0.16 at the 95% credible interval.LPH
Reinterpretation of the Fragment DK B6 of Parmenides’ Poem
No full textU ovom članku razmatra se fragment DK B6 Parmenidove poeme. Autor zastupa tezu da bi najkoherentnija interpretacija DK B6 bila sljedeća: na početku fragmenta boginja izlaže kriterij istinitoga govora i mišljenja te zahtijeva od učenika da ga se pridržava; potom zahtijeva od učenika da prijeđe oba puta istraživanja – put istine i put smrtnika; poslije toga izlaže neka svojstva mnijenja smrtnika, kao i njihovu osnovnu zabludu; na kraju ona kaže da za smrtnike postoji put natrag ili izlaz, koji bi se sastojao u njihovom povratku na ono što je rečeno na početku fragmenta ili u njihovom povratku na kriterij istinitoga govora i mišljenja. Pomno čitanje toga fragmenta uzima se kao osnova za širu reinterpretaciju Parmenidove misli. U radu se brani teza da Parmenid u poemi u osnovi govori o dva, a ne o tri puta istraživanja. Također se brani teza da okosnicu izlaganja u poemi predstavlja sukob između dvije prima facie prihvatljive intuicije: intuicije o kriteriju istinitoga govora i mišljenja te intuicije nastale na našem osjetilnom iskustvu o događajima u svijetu, koju Parmenid naziva mnijenjem smrtnika. Općenito gledano, Parmenid prihvaća prvu intuiciju, ali njegova radikalna interpretacija te intuicije vodi do odbacivanja druge.This paper discusses the fragment DK B6 of Parmenides’ poem. The author defends the thesis that the most coherent interpretation of DK B6 were as follows: at the beginning of the fragment the goddess offers the criterion of truthful talking and thinking, and demands from her student to follow it; then, she requires the student to traverse both ways of inquiry, the way of truth and the way of mortals. After that, she exhibits some characteristics of the opinion of the mortals, as well as their crucial mistake; at the end she says that for the mortals there is a backward way, or a way out, which would consist in their return to what was said at the beginning of the fragment, or in their return to the criterion of truthful talking and thinking. Advanced reading of this fragment is taken as the basis for a more general reinterpretation of the thoughts of the famous Greek philosopher. The paper defends the thesis that Parmenides in his poem basically talks about two, not about three ways of inquiry. The paper also defends the thesis that the backbone of exposition of the poem represents a conflict between two prima facie acceptable intuitions: intuition about the criterion of truthful talking and thinking, and intuition incurred on our sensory experience of the events in the world, which Parmenides called the opinion of the mortals. In general, the thesis is that Parmenides accepted the first intuition, but that his radical interpretation of it lead to the rejection of the second
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