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The elongated styloid process: Eagle Syndrome
Full text linkFil: Menichini, María Laura. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentina.Fil: Marini, Jerónimo. Sanatorio Británico de Rosario. Rosario; Argentina.Fil: Menichini, Reynaldo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Rosario; Argentina
Evaluation of phototoxic potential of aerial components of the fig tree against human melanoma
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Cell Proliferation
Volume 45, Issue 3, June 2012, Pages 279-285
Evaluation of phototoxic potential of aerial components of the fig tree against human melanoma (Article)
Conforti, F.a ,
Menichini, G.b,
Zanfini, L.a,
Tundis, R.a,
Statti, G.A.a,
Provenzano, E.c,
Menichini, F.a,
Somma, F.b,
Alfano, C.b
a Department of Pharmaceutical Sciences, Faculty of Pharmacy Nutrition and Health Sciences, University of Calabria, Rende (CS), Italy
b Department of Plastic and Reconstructive Surgery, Perugia University, Perugia, Italy
c Operative Unit of Dermatology, A.O. of Cosenza, Cosenza, Italy
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Abstract
Objectives: To date, Ficus carica L. cultivar Dottato (F. carica) has not been studied from a phototoxic point of view. In the present work, aerial components of F. carica from Italy, were examined to assess their antioxidant and phototoxic activity on human melanoma cells. A relationship between antioxidant, phototoxic activities and chemical composition has also been investigated. Materials and methods: Coumarin and fatty acid content in F. carica leaves, bark and woody parts were examined and compared by capillary GC and GC/MS. Polyphenolic content was also determined. Linoleic acid peroxidation and DPPH test were used to assess antioxidant activities, and MTT assay was used to evaluate anti-proliferative activity, on C32 human melanoma cells, after irradiation with a UVA dose of 1.08 J/cm 2. Results: Leaves demonstrated the best antioxidant and anti-proliferative activity in comparison to bark and wood. In particular, leaves were shown to possess the highest anti-radical activity and inhibition of peroxidation, with IC 50 values of 64 and 1.48 μg/ml respectively. The leaves had highest anti-proliferative activity with IC 50 value of 3.92 μg/ml. The phytochemical investigation revealed different composition between the coumarins, psoralen and bergapten, fatty acids, polyphenols and flavonoid content among plant parts. Conclusions: Data obtained indicate that this type of fig tree may constitute an excellent source of bioactive compounds, such as phenolics, coumarins and fatty acids. This study offers a new perspective in developing others formulations potentially useful in photodynamic therapy for treatment of non-melanoma skin cancer
Poz
No full textPieghevole della mostra del pittore friulano Arrigo Poz (1929-2015), tenuta presso la Galleria del Girasole di Udine dal 21 gennaio al 3 febbraio 1967. Il documento presenta un\u27introduzione a cura di Dino Menichini e cenni biografici sull\u27artista
CONTESTI TERRITORI E PAESAGGI
No full textIl libro delinea un percorso progettuale che innova il progetto stradale, non più da intendere come una struttura estranea da nascondere (mitigazione). La strada trae le sue configurazioni dai contesti e paesaggi che attraversa l’obbiettivo è quello di connettere e integrare esigenze funzionali e peculiarità spaziali differenti attraverso l’adozione di una sequenza trans-scalare di operazioni relative ai contesti territoriali e ai paesaggi coinvolti nel progetto. Il libro tenta di dare forma a un mutamento di fondo ormai largamente diffuso nel “progetto di strada”, da considerarsi non più come l’applicazione meccanicistica di soluzioni tecniche e normative precostituite, ma come un processo creativo ingrado di rinnovare lo spazio, le funzioni e i paesaggi della strada stessa
Linee Guida per una progettazione integrata delle infrastrutture stradali della Regione Emilia Romagna – progetto vincitore del concorso nazionale indetto dalla Regione Emilia Romagna Progetto pubblicato in: L. Caravaggi, S. Menichini, R. Pavia, Stradepaesaggi, Meltemi Editore, Roma 2004; L. Caravaggi, S.Menichini, Linee guida per la progettazione integrata delle strade, Alinea Editrice, Firenze 2007
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Third Parties, Information Disclosure and Monitoring Incentives
No full textWithin an incomplete contract setting, the paper analyses the role of third parties in ameliorating incentive problems arising in the context of financial contracts with costly verification and lender’s bargaining power. Contrary to the findings of the bilateral lender–borrower relationship, characterised by no information revelation and possibly a breakdown of the market, it is shown that, in the presence of third parties, an optimal contract exists featuring partial information revelation and random monitoring. The importance of third parties is therefore not limited to improving efficiency, as it is when the contract offer comes from the informed party, but to ensure project realisation, and thus to ensure that the surplus that can arise from the project does not get lost
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