125,424 research outputs found
29th annual Spring Conference on Wind and Percussion Music. Final concert
No full textRecorded during a live performance at Miller Auditorium, Western Michigan University, Kalamazoo, Michigan, April. 11, 1997, 7:30 p.m., the 515th concert of the School of Music's 1996-1997 season.1st work: Western Michigan University Brass Choir ; Robert Whaley, conductor. 2nd-4th works: Western Michigan University Symphonic Band ; Robert Spradling and Stephen Melillo, conductors. 5th-6th works: Stephen Melillo All-Star Band ; Robert Spradling and Stephen Melillo, conductors.Information from performance program.Traditional ceremonial opening: Symphony from Fairy Queen / Henry Purcell ; arranged Roger M. Smith -- Jig / Daniel Godfrey -- David (Stormworks) / Stephen Melillo -- A tribute to Stephen Foster / Sammy Nestico -- March, op. 99 / Sergei Prokofieff ; arranged [for concert band by] Paul Yoder -- Erich! (Stormworks) / Stephen Melillo
Heart rate variability and target organ damage in hypertensive patients
No full textBackground:
We evaluated the association between linear standard Heart Rate Variability (HRV) measures and vascular, renal and cardiac target organ damage (TOD).
Methods:
A retrospective analysis was performed including 200 patients registered in the Regione Campania network (aged 62.4 ± 12, male 64%). HRV analysis was performed by 24-h holter ECG. Renal damage was assessed by estimated glomerular filtration rate (eGFR), vascular damage by carotid intima-media thickness (IMT), and cardiac damage by left ventricular mass index.
Results:
Significantly lower values of the ratio of low to high frequency power (LF/HF) were found in the patients with moderate or severe eGFR (p-value < 0.001). Similarly, depressed values of indexes of the overall autonomic modulation on heart were found in patients with plaque compared to those with a normal IMT (p-value <0.05). These associations remained significant after adjustment for other factors known to contribute to the development of target organ damage, such as age. Moreover, depressed LF/HF was found also in patients with left ventricular hypertrophy but this association was not significant after adjustment for other factors.
Conclusions:
Depressed HRV appeared to be associated with vascular and renal TOD, suggesting the involvement of autonomic imbalance in the TOD. However, as the mechanisms by which abnormal autonomic balance may lead to TOD, and, particularly, to renal organ damage are not clearly known, further prospective studies with longitudinal design are needed to determine the association between HRV and the development of TOD
Nonlinear heart rate variability features for real-life stress detection. Case study : students under stress due to university examination
No full textBackground:
This study investigates the variations of Heart Rate Variability (HRV) due to a real-life stressor and proposes a classifier based on nonlinear features of HRV for automatic stress detection.
Methods:
42 students volunteered to participate to the study about HRV and stress. For each student, two recordings were performed: one during an on-going university examination, assumed as a real-life stressor, and one after holidays. Nonlinear analysis of HRV was performed by using Poincaré Plot, Approximate Entropy, Correlation dimension, Detrended Fluctuation Analysis, Recurrence Plot. For statistical comparison, we adopted the Wilcoxon Signed Rank test and for development of a classifier we adopted the Linear Discriminant Analysis (LDA).
Results:
Almost all HRV features measuring heart rate complexity were significantly decreased in the stress session. LDA generated a simple classifier based on the two Poincaré Plot parameters and Approximate Entropy, which enables stress detection with a total classification accuracy, a sensitivity and a specificity rate of 90%, 86%, and 95% respectively.
Conclusions:
The results of the current study suggest that nonlinear HRV analysis using short term ECG recording could be effective in automatically detecting real-life stress condition, such as a university examination
Selection Effects in Entrepreneurship
No full textMy work is positioned within an emerging trend in entrepreneurial research which revises prior work by considering the impact of selection effects. Prior research on the individual-level determinants of start-up size, performance, and exit has ignored that individuals select into entrepreneurship and this might seriously bias our understanding of the post-entry process. I'm particularly well positioned to investigate the nature, the extent, and the consequences of these selection effects because I could access extraordinary data on the Swedish population, which allows me to incorporate information on individuals who were at risk but did not enter entrepreneurship. Yet, the overall contribution of my dissertation goes beyond flagging a selection problem and developing a method to cope with it. It comes up with reexamining and even questioning some of the most prominent theoretical explanations to fundamental issues in entrepreneurship, such as the notion of initial size, the liability of smallness, and the interplay between entrepreneurial performance and firm exit.My work is positioned within an emerging trend in entrepreneurial research which revises prior work by considering the impact of selection effects. Prior research on the individual-level determinants of start-up size, performance, and exit has ignored that individuals select into entrepreneurship and this might seriously bias our understanding of the post-entry process. I'm particularly well positioned to investigate the nature, the extent, and the consequences of these selection effects because I could access extraordinary data on the Swedish population, which allows me to incorporate information on individuals who were at risk but did not enter entrepreneurship. Yet, the overall contribution of my dissertation goes beyond flagging a selection problem and developing a method to cope with it. It comes up with reexamining and even questioning some of the most prominent theoretical explanations to fundamental issues in entrepreneurship, such as the notion of initial size, the liability of smallness, and the interplay between entrepreneurial performance and firm exit.LUISS PhD Thesi
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
On the existence of a travelling wave solution for a model of actin-based bacterial movement
No full textSome bacteria like Listeria monocytogenes, Shigella and Rickettsia Rickettsii can move inside the host cell thanks to an actin tail. In this paper a one-dimensional model for the motion of these bacteria, introduced by B. Bazaliy, Y. Bazaliy, and A. Friedman (2007) in [2], is studied. In particular, the model is a system of partial differential equation with two moving boundaries for which we prove the existence of a travelling wave solution. (C) 2010 Elsevier Inc. All rights reserved
Pupillometric analysis for assessment of gene therapy in Leber Congenital Amaurosis patients
No full textBackground:
Objective techniques to assess the amelioration of vision in patients with impaired visual function are needed to standardize efficacy assessment in gene therapy trials for ocular diseases. Pupillometry has been investigated in several diseases in order to provide objective information about the visual reflex pathway and has been adopted to quantify visual impairment in patients with Leber Congenital Amaurosis (LCA). In this paper, we describe detailed methods of pupillometric analysis and a case study on three Italian patients affected by Leber Congenital Amaurosis (LCA) involved in a gene therapy clinical trial at two follow-up time-points: 1 year and 3 years after therapy administration.
Methods:
Pupillary light reflexes (PLR) were measured in patients who had received a unilateral subretinal injection in a clinical gene therapy trial. Pupil images were recorded simultaneously in both eyes with a commercial pupillometer and related software. A program was generated with MATLAB software in order to enable enhanced pupil detection with revision of the acquired images (correcting aberrations due to the inability of these severely visually impaired patients to fixate), and computation of the pupillometric parameters for each stimulus. Pupil detection was performed through Hough Transform and a non-parametric paired statistical test was adopted for comparison.
Results:
The developed program provided correct pupil detection also for frames in which the pupil is not totally visible. Moreover, it provided an automatic computation of the pupillometric parameters for each stimulus and enabled semi-automatic revision of computerized detection, eliminating the need for the user to manually check frame by frame. With reference to the case study, the amplitude of pupillary constriction and the constriction velocity were increased in the right (treated eye) compared to the left (untreated) eye at both follow-up time-points, showing stability of the improved PLR in the treated eye.
Conclusions:
Our method streamlined the pupillometric analyses and allowed rapid statistical analysis of a range of parameters associated with PLR. The results confirm that pupillometry is a useful objective measure for the assessment of therapeutic effect of gene therapy in patients with LCA
Pragmatic Case Studies as a Source of Unity in Applied Psychology
No full textTo unify or not to unify applied psychology: that is the question. In this article we review pendulum swings in the historical efforts to answer this question—from a comprehensive, positivist, “top-down,” deductive yes between the 1930s and the early 60s, to a postmodern no since then. A rationale and proposal for a limited, “bottom-up,” inductive yes in applied psychology is then presented, employing a case-based paradigm that integrates both positivist and postmodern themes and components. This paradigm is labeled “pragmatic psychology” and, its specific use of case studies, the “Pragmatic Case Study Method” (“PCS Method”). We call for the creation of peer-reviewed journal-databases of pragmatic case studies as a foundational source of unifying applied knowledge in our discipline. As one example, the potential of the PCS Method for unifying different angles of theoretical regard is illustrated in an area of applied psychology, psychotherapy, via the case of Mrs. B. The article then turns to the broader historical and epistemological arguments for the unifying nature of the PCS Method in both applied and basic psychology.Peer reviewe
Dr. Edwin Wright Collection: Author Unknown
No full textNotes - The author relates several short stories about his neighbours including Alex McDonell, homesteading and life around Meanook and Athabasca (1 page
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