1,985 research outputs found
Etälukutapahtuman tehostaminen BB Logisticsilla
No full textTämän opinnäytetyön tavoitteena oli osoittaa viivakoodillisten pallettien käsittelyprosessien lukutapahtumien näkökulmasta ilmenevät ongelmat. Työ tehtiin toimeksiantolähtöisenä BB Logisticsin Haminan toimipisteelle. Asetettujen tutkimuskysymysten myötä tekijän piti dokumentoida viivakoodien lukutapahtumaan liittyvät ongelmat ja löytää ratkaisut todettuihin ongelmiin. Työn aihe sai alkunsa syksyllä 2019, kun viivakoodit otettiin ensimmäistä kertaa käyttöön. Tutkimuksen virikkeenä toimi aiheen ajankohtaisuus.
Opinnäytetyö ja teoreettinen viitekehys rakentuivat kvalitatiivista tutkimusmenetelmää käyttäen. Työssä käytettiin kirjallisten lähteiden lisäksi tekijän omia käytännön kokemuksia, verkkosivustoja sekä kirjallisia haastatteluita. Haastatteluiden tarkoituksena oli ensisijaisesti lisätä työssä ilmi tuotujen näkökulmien luotettavuutta. Haastattelut tehtiin suullisesti ja epävirallisesti marraskuussa 2019 työn alkuvaiheessa. Virallinen dokumentointi suoritettiin helmikuussa 2020 kirjallisten haastatteluiden muodossa. Haastattelun kysymykset olivat avoimia kysymyksiä, joihin vastasi kuusi työtoveria. Haastattelujen toteutusta voidaan opinnäytetyön tulosten kannalta pitää erittäin onnistuneena, koska haastattelussa esiin tuoduissa näkökulmissa oli yhtäläisyyksiä tekijän omien näkemysten kanssa.
Tutkimuksen tavoitteet saavutettiin tyydyttävästi. Tavoitteisiin päästiin löytämällä optimaalisin tapa viivakoodilukutapahtuman toteutukseen nykyisessä tilassa ja tarjoamalla ratkaisuja nykyisen etälukutapahtuman tuomiin ongelmiin. Opinnäytetyössä ilmi tulleet ongelmat luokiteltiin aikahäviöiden aiheuttajiksi. Päätös käsittelyprosessien aikana syntyvien aikahäviöiden minimoimisesta on tehty ja liittyy viivakooditarrojen määrän lisäämiseen tuotteessa. Päätös viivakoodien määrän lisäämisestä ajoittuu todennäköisesti vuoden 2020 jälkipuoliskolle. Tämän lisäksi työssä mainittiin RFID:n käyttöönottomahdollisuus, jonka tarkoituksena oli antaa toimeksiantajalle ja asiakkaalle laajempi näkökulma aiheeseen.The objective of this thesis was to pinpoint key issues regarding the current state of remote reading as it is done during the pallet handling processes at BB Logistics Oy’s Hamina office. The set research questions also required the author to document these issues and find possible solutions to them. The topic of this thesis originated during the fall of 2019 when the barcodes were first introduced into the handling processes with a few hindrances. The reaction to handling barcodes was initially flawed, which sparked the topic and its pitching to the author.
This thesis and its theory were structured by using qualitative methods. In addition to using usual sources such as books, own practical experience and many websites, interviews were used to boost reliability of the perspectives that were highlighted in this thesis. Written interviews were conducted towards the end of the study in February 2020; however, the same interviews were conducted orally during the research process in November 2019. The questionnaire included open questions that were answered by 6 different fellow employees. The use of interviews can be considered very successful in terms of results, because the interview’s results concur with the author’s results.
The goals of this thesis were met with satisfying results, this was achieved by locating the most optimal way of reading barcodes in their current state and by suggesting solutions to obstacles faced during the remote reading. In the thesis it was discovered that hindrances cause time losses. A step towards implementing a solution to reduce time losses during handling processes was suggested. A decision to increase the number of barcodes has been made and it is likely to take place in the second half of 2020. The aim of this is to improve the general quality of work. Additionally, the possibility of implementing RFID technology was mentioned briefly – this was mainly done to raise some follow-up questions and give the commissioner and the customer broader perspectives on remote reading
Buffett book author and Forbes newsletter editor to give BB&T Lecture
No full textForbes newsletter editor and book author Vahan Janjigian will give a talk on Wednesday, Oct. 22, 3:30 to 4:30 p.m., as the featured speaker in the BB&T Distinguished Lecture Series on Capitalism, hosted by Virginia Tech's Pamplin College of Business
Talk to BB
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/317497Unidentified author, audience presumably a Jewish organisation in Australia owing to subject matter in text.280918
item: [2010.0053.01110] "Talk to BB
In vivo role of platelet-derived growth factor-BB in airway smooth muscle proliferation in mouse lung
No full textAirway smooth muscle (ASM) hyperplasia in asthma likely contributes considerably to functional changes. Investigating the mechanisms behind proliferation of these cells may lead to therapeutic benefit. Platelet-derived growth factor (PDGF)-BB is a well known ASM mitogen in vitro but has yet to be directly explored using in vivo mouse models in the context of ASM proliferation and airway responsiveness. To determine the in vivo influence of PDGF-BB on gene transcripts encoding contractile proteins, ASM proliferation, and airway physiology, we used an adenovirus overexpression system and a model of chronic allergen exposure. We used adenovirus technology to selectively overexpress PDGF-BB in the airway epithelium of mice. Outcome measurements, including airway physiology, real time RT-PCR measurements, proliferating cell nuclear antigen staining, and airway smooth muscle quantification, were performed 7 days after exposure. The same outcome measurements were performed 24 hours and 4 weeks after a chronic allergen exposure model. PDGF-BB overexpression resulted in airway hyperresponsiveness, decreased lung compliance, increased airway smooth muscle cell numbers, positive proliferating cell nuclear antigen-stained airway smooth muscle cells, and a reduction in genes encoding contractile proteins. Chronic allergen exposure resulted in elevations in lung lavage PDGF-BB, which were observed in conjunction with changes in gene transcript expression encoding contractile proteins and ASM proliferation. We demonstrate for the first time in vivo that PDGF-BB induces ASM hyperplasia and changes in lung mechanics in mice and that, during periods of allergen exposure changes in lung, PDGF-BB are associated with changes in airway structure and function
The chemopreventive polyphenol Curcumin prevents hematogenous breast cancer metastases in immunodeficient mice
No full textDissemination of metastatic cells probably occurs long before diagnosis of the primary tumor. Metastasis during early phases of carcinogenesis in high risk patients is therefore a potential prevention target. The plant polyphenol Curcumin has been proposed for dietary prevention of cancer. We therefore examined its effects on the human breast cancer cell line MDA-MB-231 in vitro and in a mouse metastasis model. Curcumin strongly induces apoptosis in MDA- MB- 231 cells in correlation with reduced activation of the survival pathway NF kappa B, as a consequence of diminished I kappa B and p65 phosphorylation. Curcumin also reduces the expression of major matrix metalloproteinases (MMPs) due to reduced NF kappa B activity and transcriptional downregulation of AP-1. NF kappa B/p65 silencing is sufficient to downregulate c-jun and MMP expression. Reduced NF kappa B/AP-1 activity and MMP expression lead to diminished invasion through a reconstituted basement membrane and to a significantly lower number of lung metastases in immunodeficient mice after intercardiac injection of 231 cells (p=0.0035). 68% of Curcumin treated but only 17% of untreated animals showed no or very few lung metastases, most likely as a consequence of down-regulation of NF kappa B/AP-1 dependent MMP expression and direct apoptotic effects on circulating tumor cells but not on established metastases. Dietary chemoprevention of metastases appears therefore feasible. Copyright (c) 2007 S. Karger AG, Basel
Photometric study of two detached binaries FW Vel and BB Mon
No full text32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEYWe present the first analysis of photometric observations of two detached binary stars, FW Vel and BB Mon. Their V light curves from the All Sky Automated Survey were solved using Monte Carlo Search Method. The final solutions describe these two systems as Algol-like binary stars with detached configurations. The absolute parameters of the components of the systems were also estimated.Turkish Phys So
Measurement of the energy dependence of the e + e − → BB¯ , BB¯ ∗ and B∗B¯ ∗ exclusive cross sections
No full textWe report the first measurement of the exclusive cross sections e+e− → BB¯ , e+e− → BB¯ ∗, and e+e− → B∗B¯ ∗ in the energy range from 10.63 GeV to 11.02 GeV. The B mesons are fully reconstructed in a large number of hadronic final states and the three channels are identified using a beam-constrained-mass variable. The shapes of the exclusive cross sections show oscillatory behavior with several maxima and minima. The results are obtained using data collected by the Belle experiment at the KEKB asymmetric-energy e+e− collider. [Figure not available: see fulltext.] © 2021, The Author(s)
Effectiveness of BMP-2 and PDGF-BB Adsorption onto a Collagen/Collagen-Magnesium-Hydroxyapatite Scaffold in Weight-Bearing and Non-Weight-Bearing Osteochondral Defect Bone Repair: In Vitro, Ex Vivo and In Vivo Evaluation
No full textDespite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has demonstrated less optimal subchondral bone repair. This study aimed to improve the bone repair potential of this scaffold by adsorbing bone morphogenetic protein 2 (BMP-2) and/or platelet-derived growth factor-BB (PDGF-BB) onto said scaffold. The in vitro release kinetics of BMP-2/PDGF-BB demonstrated that PDGF-BB was burst released from the collagen-only layer, whereas BMP-2 was largely retained in both layers. Cell ingrowth was enhanced by BMP-2/PDFG-BB in a bovine osteochondral defect ex vivo model. In an in vivo semi-orthotopic athymic mouse model, adding BMP-2 or PDGF-BB increased tissue repair after four weeks. After eight weeks, most defects were filled with bone tissue. To further investigate the promising effect of BMP-2, a caprine bilateral stifle osteochondral defect model was used where defects were created in weight-bearing femoral condyle and non-weight-bearing trochlear groove locations. After six months, the adsorption of BMP-2 resulted in significantly less bone repair compared with scaffold-only in the femoral condyle defects and a trend to more bone repair in the trochlear groove. Overall, the adsorption of BMP-2 onto a Col/Col-Mg-HAp scaffold reduced bone formation in weight-bearing osteochondral defects, but not in non-weight-bearing osteochondral defects.Biomaterials & Tissue Biomechanic
Measurement of the energy dependence of the e + e − → BB¯ , BB¯ ∗ and B∗B¯ ∗ exclusive cross sections
No full textWe report the first measurement of the exclusive cross sections e+e− → BB¯ , e+e− → BB¯ ∗, and e+e− → B∗B¯ ∗ in the energy range from 10.63 GeV to 11.02 GeV. The B mesons are fully reconstructed in a large number of hadronic final states and the three channels are identified using a beam-constrained-mass variable. The shapes of the exclusive cross sections show oscillatory behavior with several maxima and minima. The results are obtained using data collected by the Belle experiment at the KEKB asymmetric-energy e+e− collider. [Figure not available: see fulltext.] © 2021, The Author(s)
Zb tetraquark channel and BB¯? interaction
No full text37th International Symposium on Lattice Field Theory, LATTICE 2019 -- 16 June 2019 through 22 June 2019 -- Wuhan -- 166411Two tetraquark candidates Zb(10610) and Zb(10650) with flavor structure bb ¯ du ¯ were discovered by Belle experiment in 2011. We present a preliminary Nf = 2 lattice study of the bb ¯ du ¯ system in the approximation of static b quarks, where the total spin of heavy quarks is fixed to one. The ground and the excited eigen-energies are determined as a function of separation r between b and b¯. The lower eigenstates are related to a bottomonium and a pion. One of the higher eigenstates is dominated by BB¯?: its energy is significantly below mB + mB? for r=[0.1,0.4] fm, which suggests sizable attraction. The attractive potential V(r) between B and B¯? is extracted assuming that this eigenstate is related exclusively to BB¯?. Assuming a certain form of the potential at small r < 0.1 fm and solving non-relativistic Schrodinger equation, we find a virtual bound state pole 32?+295 MeV below BB¯? threshold. This pole leads to a narrow peak in the cross-section just above threshold that could be perhaps related to experimental Zb resonances. Given all these approximations, we surprisingly find also a deep bound state 403 ±70 MeV below BB¯? threshold. If such a Zb state exists, it could be experimentally searched in the accurate dependence of rates on ?(1S)?+ invariant mass. © Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).Research Agency ARRS, (J1-8137, P1-0035); TUBITAK; Deutsche Forschungsgemeinschaft, DFG; Türkiye Bilimsel ve Teknolojik Araştirma Kurumu, TÜBITA
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