3,939 research outputs found
Shelley Stokes-Hammond interview, 15 September 2017
No full textShelley Stokes-Hammond is the oldest daughter of Louis Stokes. She is a graduate of The Ohio State University and Goucher College. She is a historic preservationist, author and public relations manager at Howard University. This 2017 interview was collected as part of a yearlong, community-wide commemoration of the 50th anniversary of Carl Stokes\u27 election as mayor of Cleveland
Shelley Stokes-Hammond interview, 15 September 2017
No full textShelley Stokes-Hammond is the oldest daughter of Louis Stokes. She is a graduate of The Ohio State University and Goucher College. She is a historic preservationist, author and public relations manager at Howard University. This 2017 interview was collected as part of a yearlong, community-wide commemoration of the 50th anniversary of Carl Stokes\u27 election as mayor of Cleveland
Large-time behavior of the weak solution to 3D Navier-Stokes equations
No full textThe weak solution to the Navier–Stokes equations in a bounded domain D ⊂ R[superscript 3] with a smooth boundary is proved to be unique provided that it satisfies an additional requirement. This solution exists for all t ≥ 0. In a bounded domain D the solution decays exponentially
fast as t → ∞if the force term decays at a suitable rat
¿Qué Pasa, OSU? (Spring 1999)
No full textIssue includes: "Latino Studies: A Heated Discussion at Ohio State" by Monica Frias; "Latino Studies Towards the XXI Century: An Interdisciplinary Colloquium Some Reflections" by Ignacio Corona and Lawrence LaFountain-Stokes; "Provost and Executive Vice President, Edward Ray to Hispanics of Ohio State: 'Give us Time to Make Changes'" by Victor Mora and Monica Frias; and "Prof. Carlos Muñoz, Keynote Speaker at the Colloquium: A Call to 'educarnos, criticar, discutir'" by Melissa Nemeth and Matthew Camacho-Edwards.Hispanic Awareness Week -- Provost Edward Ray Meets with the Hispanic Community -- Colloquium on Latino/a Studies -- Diego Rivera Exhibit -- Are You in a Financial Red Zone
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Supporting Information: On-Cell Saturation Transfer Difference NMR Spectroscopy on Ion Channels: Characterizing Negative Allosteric Modulator Binding Interactions of P2X7
No full textDouble difference STD NMR spectra for AZ10606120 and JNJ-47965567 with WT hP2X7 (Figures S1 and S2); comparison of AZ10606120 and JNJ-47965567 positions in the binding pocket from XRD of pdP2X7 (Figure S3); comparison of docking poses for AZ10606120 and JNJ-47965567 docked to WT or NAM-site mutant hP2X7 (Figures S4 and S5)P2X7 receptors are important drug targets involved in pathologies ranging from psychiatric disorders to cancer. Being membrane embedded receptors, they are more challenging for structural characterization, and at present, we only have a small number of X-ray and cryo-EM structures for P2X7 bound to antagonists. We demonstrate that saturation transfer difference (STD) NMR on live mammalian cells (on-cell STD NMR) overexpressing P2X7 receptors allows further structural insight on the complexes of P2X7 with two potent negative allosteric modulators, namely, AZ10606120 and JNJ-47965567, via the determination of the binding epitope mapping of the interactions, e.g., the main region of contact between the ligand and the binding pocket. This approach, reported for the first time on membrane-embedded ion channels, in combination with molecular docking, allows us to propose the first NMR-validated ligand binding models for two antagonists as bound to human P2X7 receptors and to correlate the structural knowledge acquired with the pharmacology data. We highlight the transformative potential of this application to aid drug design efforts in a less resource-demanding fashion than X-ray crystallography and cryo-EM, and we envisage on-cell STD NMR to fast become an asset for structure–activity relationship studies helping knowledge-based development of efficient drugs targeting P2X7 and other ion channels/membrane-embedded proteinsPeer reviewe
Chart of Terra Australis. Sheet I, South coast [cartographic material] /
No full text1848. "Plate II".; At foot of title: Corrected from the surveys of Comr. Stokes, 1843.; Map of the south coast of Western Australia from Cape Leeuwin to Cape Arid showing tracks of Investigator, 1801-1803. Relief shown by hachures and bathymetric soundings.; Originally published: [London] : Published as the Act directs by Capt. Hurd, R.N. Hydrographer to the Admiralty, 1814 Jan. 1.; Prime meridian: Greenwich.; Ingleton, Geoffrey C. Matthew Flinders, navigator and chartmaker, p. 444.; Tooley, 587; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.map-t587. Insets: King Geo. Sound with its harbours. Scale [ca. 1:190 080] -- Archipelago of the Recherche. Scale [ca. 1:368 000] -- Koombanah Bay and Leschenault Inlet. Scale [ca. 1:97 816].South coas
Simplified Navier-Stokes equations (SNSE)
No full textTen kinds of the simplified Navier-Stokes equations (SNSE) are reviewed and also used to calculate the Jeffery-Hamel flow as well as to analyze briefly the seven kinds of flows to which the exact solutions of the complete Navier-Stokes equations (CNSE) have been found. Analysis shows that the actual differences among the solutions of the different SNSE can go beyond the range of the order of magnitude of Re-1/2 and result even in different flow patterns, therefore, how to choose the viscous terms included in the SNSE is worthy of notice where Re=S∞u∞ L/μ∞ is the Reynolds numbers. For the aforesaid eight kinds of flows, the solutions to the inner-outer-layer-matched SNSE and to the thin-layer-2-order SNSE agree completely with the exact solutions to CNSE. But the solutions to all the other SNSE are not completely consistent with the exact solutions to CNSE and not a few of them are actually the solutions of the classical boundary layer theory. The innerouter-layer-matched SNSE contains the shear stress causing angular displacement of the inormal axis with respect to the streamwise axis and the normal stress causing expansion-contraction in the direction of the normal axis and the viscous terms being of the order of magnitude of the normal stress; and it can also reasonably treat the inertial terms as well as the relation between the viscous and inertial terms. Therefore, it seems promising in respects of both mechanics and mathematics
The Development of a Partially Averaged Navier-Stokes KSKL Model
No full textA new partially averaged Navier-Stokes (PANS) closure is derived based on the k-kL (KSKL) model. The aim of this new model is to incorporate the desirable features of the KSKL model, compared to the k-ω shear stress transport model, into the PANS framework. These features include reduced eddy-viscosity levels, a lower dependency on the cell height at the wall, well-defined boundary conditions, and improved iterative convergence. As well as the new model derivation, the paper demonstrates that these desirable features are indeed maintained, for a range of modeled-to-total turbulence kinetic energy ratios (fk), and even for multiphase flow.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Ship Hydromechanics and Structure
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