105 research outputs found
Removal of a Dental Implant Displaced into the Maxillary Sinus by Means of the Bone Lid Technique
No full textBackground. Rehabilitation of edentulous jaws with implant-supported prosthesis has become a common practice among oral surgeons in the last three decades. This therapy presents a very low incidence of complications. One of them is the displacement of dental implants into the maxillary sinus. Dental implants, such as any other foreign body into the maxillary sinus, should be removed in order to prevent sinusitis. Methods. In this paper, we report a case of dental implant migrated in the maxillary sinus and removed by means of the bone lid technique. Results and Conclusion. The migration of dental implants into the maxillary sinus is rarely reported. Migrated implants should be considered for removal in order to prevent possible sinusal diseases. The implant has been removed without any complications, confirming the bone lid technique to be safe and reliable
ALTERAZIONI DELLA BARRIERA EPITELIALE INTESTINALE NELLA MALATTIA DI PARKINSON: RUOLO DEL RECETTORE LRRK2
No full textLa malattia di Parkinson (MP) è una patologia neurodegenerativa multifattoriale caratterizzata da disfunzioni del tratto gastrointestinale (GI) già nelle fasi precoci della malattia. Studi recenti sostengono che l’insorgenza della MP sia riconducibile ad alterazioni che originano nell’apparato digerente, per poi diffondersi progressivamente a livello centrale, attraverso determinate vie nervose e immunitarie che collegano l’intestino al cervello. Negli ultimi anni è stato dimostrato che l’accumulo enterico di α-sinucleina, visibile già nelle fasi prodromiche della malattia, promuove l’attivazione di processi immuno-infiammatori enterici. Tali processi infiammatori contribuiscono alla compromissione dell’integrità della barriera epiteliale intestinale (BEI) con conseguente traslocazione di batteri nocivi dalla mucosa intestinale al compartimento interno, generando, così, un circolo vizioso che contribuisce sia alla cronicizzazione dei processi infiammatori intestinali che allo sviluppo di disfunzioni enteriche tipiche dei pazienti affetti da MP. In tale contesto, recenti studi hanno dimostrato che le cellule gliali enteriche (EGCs), componente fondamentale del Sistema Nervoso Enterico, sono regolatori fondamentali dei processi infiammatori enterici, facendo supporre un loro coinvolgimento nella patogenesi delle disfunzioni GI associate alle fasi iniziali della MP. In particolare, le ultime ricerche scientifiche si sono concentrate nel comprendere il ruolo del recettore Leucine-rich repeat kinase 2 (LRRK2), espresso sia a livello enterogliale che a livello epiteliale, nella patogenesi della MP. Tale recettore, le cui mutazioni sono la causa più frequente di MP ereditaria, è coinvolto in molte vie di segnalazione immuno-infiammatorie ed in condizioni patologiche si attiva esasperando la risposta immuno-infiammatoria con conseguente danno all’organismo. Sulla base di queste considerazioni, la presente tesi ha avuto come obiettivo quello di investigare il ruolo delle EGCs nell’alterazione della BEI nella MP, utilizzando sia un modello murino transgenico A53T che un modello di co-coltura cellulare EGCs/IEC-6 (cellule epiteliali intestinali). In particolare, la ricerca si è focalizzata nel comprendere il ruolo del recettore LRRK2 nel cross-talk tra le EGCs e le IEC-6. Dagli esperimenti in vivo condotti sui topi A53T è emerso che, già nelle fasi prodromiche della malattia è visibile un accumulo di α-sinucleina a livello enterico e un aumento dell’espressione del recettore LRRK2. Inoltre, è stata osservato un aumento del marker gliale enterico (GFAP) e una riduzione dell’espressione della proteina giunzionale (tight junction, TJ) occludina, fondamentale per l’integrità della BEI, nei topi affetti da MP. Al fine di valutare una possibile correlazione tra questi eventi, sono stati condotti esperimenti su co-colture cellulari tra EGCs e IEC-6. Il trattamento con lipopolisaccaride (LPS) e α-sinucleina, utilizzato per mimare in vitro la condizione patologica della MP, ha indotto un incremento nell’espressione dei marcatori gliali GFAP e S100β, suggerendo la presenza di gliosi reattiva. E’ interessante notare, come le cellule gliali attivate hanno mostrato un incremento significativo del recettore LRRK2; tale effetto risulta abolito in presenza dell’antagonista di tale recettore. Come conseguenza dell’attivazione gliale e dell’aumento dell’espressione del recettore LRRK2, è stata osservata una riduzione dell’espressione della TJ nelle IEC-6 trattate con LPS e α-sinucleina. Questi risultati mostrano per la prima volta una correlazione tra attivazione enterogliale, recettore LRRK2 e le alterazioni della BEI in presenza della MP. In particolare, i nostri esperimenti suggeriscono che l’accumulo di α-sinucleina a livello enterico induce attivazione enterogliale e un aumento del recettore LRRK2, con conseguente incremento della permeabilità intestinale nella MP.
In conclusione, questi eventi fisiopatologici rappresentano uno dei primi segni della MP che potrebbero contribuire alle alterazioni intestinali tipiche dei pazienti con MP, e attraverso l’asse intestino-cervello, alla neurodegenerazione e neuroinfiammazione centrale
Oscillation of tissue oxygen index in non-exercising muscle during exercise
No full textThe purpose of the present study was to examine how oscillation of tissue oxygen index (TOI) in non-exercising exercise is affected during high-intensity and low-intensity exercises. Three exercises were performed with exercise intensities of 30% and 70% peak oxygen uptake ((V)over doto(2)peak) for 12 min and with exercise intensity of 70% (V)over doto(2)peak for 30 s. TOI in non-exercising muscle (biceps brachii) during the exercises for 12 min was determined by nearinfrared spectroscopy. TOI in the non-exercising muscle during the exercises was analyzed by fast Fourier transform (FFT) to obtain power spectra density (PSD). The frequency at which maximal PSD appeared (Fmax) during the exercise with 70% (V)over doto(2)peak for 12 min (0.00477 +/- 0.00172 Hz) was significantly lower than that during the exercise with 30% (V)over doto(2)peak for 12 min (0.00781 +/- 0.00338 Hz). There were significant differences in blood pH and blood lactate between the exercise with 70% V.o2peak and the exercise with 30% (V)over doto(2)peak. It is concluded that TOI in nonexercising muscle oscillates during low-intensity exercise as well as during high-intensity exercise and that the difference in Fmax between the two exercises is associated with the difference in increase in blood lactate derived from the exercise
NOTES ON VELIGERS OF JAPANESE OPISTHOBRANCHS (6)
No full textThe author has already made detailed descriptions of veligers of sixteen Japanese opisthobranchs in five papers (1960-1962) and here is presented a new paper of the same series on veligers of the following two more species : Stiliger (Stiliger) berghi BABA of Fam. Stiligeridae of Ord. Sacoglossa and Doto (Doto) japonica ODHNER of Fam. Dotonidae of Ord. Nudibranchia. The former is collected from the shore of Tannowa on the southeastern coast of Osaka Bay, while the latter is collected from the shore of Okawa situated about 8.5 km south to Tannowa and the shore of Ezura near the Seto Marine Biological Laboratory
Interannual fluctuations in recruitment of walleye pollock in the Oyashio region related to environmental changes
No full textThe Japanese Pacific walleye pollock (Theragra chalcogramma) stock is the largest stock of this species in Japanese waters. It is a key component of the Oyashio ecosystem. In southern Hokkaido waters, these fish spawn mainly during January and February near the mouth of Funka Bay (FB), and most eggs and larvae are transported into FB. During midsummer juvenile pollock migrate along the southern coast of Hokkaido to a nursery ground on the continental shelf off eastern Hokkaido (Doto area). However, some eggs and larvae are transported southward to the Tohoku region (TR). Transport depends largely on the Oyashio, which generally flows southward along the eastern coasts of Hokkaido and Tohoku. Thus, this stock has two different recruitment routes: FB–Doto and FB–TR. In the 1980s, when the southward flow of the Oyashio was strong, the number of age-2 pollock estimated from a virtual population analysis (VPA) indicated that recruitment to the entire stock remained at a medium level. In the 1990s, when the Oyashio weakened, strong year-classes occurred in 1991, 1994, and 1995, but not in the latter half of the 1990s. Juvenile catches in the TR by commercial fisheries, which can be taken as indices of recruitment level via FB-TR, were high during the 1980s and decreased in the 1990s. Although there was no significant difference in the average number of recruits between the 1980s and the 1990s as estimated from a VPA, the recruitment patterns differed between the two decades. Here, we propose that recruitment routes of this stock shifted in response to environmental changes
Couronian cremation graves of teritory of Latvia
No full textBakalaura darba ietvaros tiek analizētas kuršu ugunskapu apbedīšanas kultūras izmaiņas un attīstību kā arī atrašanās vietu topogrāfiskās pazīmes Latvijas teritorijā. Darbā tiek apskatītas un izvērtētas 50 vietas, kurās atrodas kuršu ugunskapi, vai ar tiem saistīti savrupatradumi, analizējot apbedīšanas tradīcijas, līdzi doto kapu inventāru. Izvērtēta senkapu teritoriju topogrāfija, analizējot kopīgās iezīmes, kuras šajā laika periodā tika ievērotas izvēloties vietu, kurā apglabāja mirušos.In this bachelor’s thesis author researched couronian cremation graves and burial traditions. Within the framework of this research author analysed changes and development of the Curonian burial culture as well as the topographic features of the graves locations in the territory of Latvia. In this work author analysed 50 curonian cremation burial sites or sites where can be found archeological findings belonging to curonian culture. Main focus of research was topography of burial sites with special focus on similarities of burial locations. Secondary focus was burial traditions and grave sacrifices
An extension of the Bianchi-Egnell stability estimate to Bakry, Gentil, and Ledoux's generalization of the Sobolev inequality to continuous dimensions and applications
No full textThe main result of this dissertation is an extension of a stability estimate of the Sobolev Inequality established by Bianchi and Egnell in cite{BiEg}. Bianchi and Egnell's Stability Estimate answers the question raised by H. Brezis and E. H. Lieb in cite{BrLi}: ``Is there a natural way to bound from below in terms of the `distance' of from the manifold of optimizers in the Sobolev Inequality?'' Establishing stability estimates - also known as quantitative versions of sharp inequalities - of other forms of the Sobolev Inequality, as well as other inequalities, is an active topic. See cite{CiFu}, cite{DoTo}, and cite{FiMa}, for stability estimates involving Sobolev inequalities and cite{CaFi}, cite{DoTo}, and cite{FuMa} for stability estimates on other inequalities. In this dissertation, we extend Bianchi and Egnell's Stability Estimate to a Sobolev Inequality for ``continuous dimensions.'' Bakry, Gentil, and Ledoux have recently proved a sharp extension of the Sobolev Inequality for functions on , which can be considered as an extension to ``continuous dimensions.'' V. H. Nguyen determined all cases of equality. The dissertation extends the Bianchi-Egnell stability analysis for the Sobolev Inequality to this ``continuous dimensional'' generalization. The secondary result of this dissertation is a sketch of the proof of an extension of a stability estimate of a single case of a sharp Gagliardo-Nirenberg inequality to a whole family of Gagliardo-Nirenberg inequalities, whose sharp constants and extremals were calculated by Del Pino and Dolbeault in cite{DeDo}. The original stability estimate for the Gagliardo-Nirenberg inequality was stated and proved by E. Carlen and A. Figalli in cite{CaFi}. The proof for its extension to the entire class of sharp Gagliardo-Nirenberg inequalities of Del Pino and Dolbeault is a direct application of the extension of the Bianchi-Egnell Stability Estimate to Bakry, Gentil, and Ledoux's extension of the Sobolev Inequality to continuous dimensions.Ph.D.Includes bibliographical referencesby Francis Seuffer
Landscape in the Short-Story Cycle A Sportsman’s Sketches by I. S.Turgenev
No full textDarbs ir veltīts ainavas uzbūves studēšanai I.S.Turgeņeva stāstu ciklā «Mednieka piezīmes».
Autors kā savu mērķi izvirza aplūkot jēdzienus, kas saistīti ar dabas pasaules attēlojumu un tās funkcijām literāros tekstos, atrast visus ainaviskus aprakstus I.S Turgeņeva stāstu ciklā, klasificēt atlasīto materiālu, kā arī izanalizēt to un apkopot pētījuma rezultātus.
Darbs ir paredzēts speciālistiem un personām, kas interesējas par doto jautājumu.
Atslēgas vārdi: ainava, palete, Turgeņevs, Mednieka Piezīmes
Darbs ir veltīts ainavas uzbūves studēšanai I.S.Turgeņeva stāstu ciklā «Mednieka piezīmes».
Autors kā savu mērķi izvirza aplūkot jēdzienus, kas saistīti ar dabas pasaules attēlojumu un tās funkcijām literāros tekstos, atrast visus ainaviskus aprakstus I.S Turgeņeva stāstu ciklā, klasificēt atlasīto materiālu, kā arī izanalizēt to un apkopot pētījuma rezultātus.
Darbs ir paredzēts speciālistiem un personām, kas interesējas par doto jautājumu.
Atslēgas vārdi: ainava, palete, Turgeņevs, Mednieka PiezīmesThe study considers the construction of landscape in the short-story cycle «The Hunter's Sketches» by I. S. Turgenev.
The author aims to consider fundamental to the study of the concepts associated with the mapping of the natural world and its role in literary texts, to find all the descriptions of scenery in a series of I.S. Turgenev stories, to classify the selected material, as well as to analyze and synthesize the results of his study.
The study intends for specialists and persons, who are interested in the matter.
Keywords: landscape, colour, Turgenev, The Hunter's Sketche
Ivan Shmelyov in the Russian Periodicals of Latvia: 1920-1940s.
No full textPētījums ir veltīts literārā I.S.Šmeļeva tēla uzbūvei krievu periodiskos izdevumos Latvijā 20-40 gados.
Autors analīzē recenzijas, rakstus, kā arī atsevišķus rakstnieka fragmenta darbus, kuri tika publicēti krievu Latvijas periodikā 20.-40. gados ar mērķi noteikt galvenas īpašības rakstnieka tēla uzbuvē.
Darbs ir paredzēts gan literatūrzinātniekiem, gan tiem, kuri interesējas par doto jautājumu.
Pētījums ir veltīts literārā I.S.Šmeļeva tēla uzbūvei krievu periodiskos izdevumos Latvijā 20-40 gados.
Autors analīzē recenzijas, rakstus, kā arī atsevišķus rakstnieka fragmenta darbus, kuri tika publicēti krievu Latvijas periodikā 20.-40. gados ar mērķi noteikt galvenas īpašības rakstnieka tēla uzbuvē.
Darbs ir paredzēts gan literatūrzinātniekiem, gan tiem, kuri interesējas par doto jautājumu.
Atslēgvārdi: īpatnības, tēls, I.S.Šmeļevs, Latvija, krievu periodika 20-40 gadosThe study is dedicated to analyze to research features of formation of the literary image I.S.Shmeleva in Russian periodicals in Latvia 20-40s.
The author analyzes reviews, articles, as well as fragments, published works of the writer in the pages of Russian periodicals in Latvia 20-40 years to identify the main features of the formation of the personality of the writer.
Key words: features, image, I.S.Šmeļevs, Latvia, Russian periodicals 20-40 years
painting as the means of emotional expression at visual art lessons in Grades 4-5 of basic school
No full textAutore savā diplomdarbā analizēja skolēnu emocionālās izpausmes iespējas ar abstraktās glezniecības palīdzību.
Attīstīt emocionālo sfēru palīdzēja vizuālie attēli, mūzika un pasaka. Ar doto palīgelementu palīdzību izdevās dziļāk atklāt skolēnu iekšējo pasauli, uzmodināt viņu jūtas un emocijas.
Skolēnu radītie abstraktie darbi ietvēra sevī visu bērnu emocionalitātes, atklātības un sapņainības kopumu.
Radošie darbi liecina par skolēnu emocionālās izpausmes iespējamību caur abstrakto glezniecību.The author in her diploma thesis has analysed the possibility of the pupils’ emotional expression with the help of abstract painting.
Visual observation, music and tales helped to develop the emotional sphere.
With the help of these auxiliary elements it became possible to discover the pupils’ inner world, to arouse their feelings and emotions.
The abstract paintings created by the pupils have absorbed in themselves the whole set of the nursery emotions, liberation and dreams.
The creative works witness about the possibility of pupils’ emotional expression through abstract painting
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