57 research outputs found
sj-docx-1-msj-10.1177_13524585211054006 – Supplemental material for Validation of a Brief Computerized Cognitive Assessment in Multiple Sclerosis (BCCAMS) and comparison with reference batteries
No full textSupplemental material, sj-docx-1-msj-10.1177_13524585211054006 for Validation of a Brief Computerized Cognitive Assessment in Multiple Sclerosis (BCCAMS) and comparison with reference batteries by Nicolas Maubeuge, Mathilde SA Deloire, Bruno Brochet, Julie Charré-Morin, Aurore Saubusse and Aurélie Ruet in Multiple Sclerosis Journal</p
sj-docx-1-msj-10.1177_13524585221101470 – Supplemental material for Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome
No full textSupplemental material, sj-docx-1-msj-10.1177_13524585221101470 for Altered functional brain states predict cognitive decline 5 years after a clinically isolated syndrome by Ismail Koubiyr, Tommy AA Broeders, Mathilde Deloire, Bruno Brochet, Thomas Tourdias, Jeroen JG Geurts, Menno Michiel Schoonheim and Aurélie Ruet in Multiple Sclerosis Journal</p
MSJ813108_supplementary_material – Supplemental material for Longitudinal study of functional brain network reorganization in clinically isolated syndrome
No full textSupplemental material, MSJ813108_supplementary_material for Longitudinal study of functional brain network reorganization in clinically isolated syndrome by Ismail Koubiyr, Mathilde Deloire, Pierre Besson, Pierrick Coupé, Cécile Dulau, Jean Pelletier, Thomas Tourdias, Bertrand Audoin, Bruno Brochet, Jean-Philippe Ranjeva and Aurélie Ruet in Multiple Sclerosis Journal</p
MSJ813108_STROBE_checklist – Supplemental material for Longitudinal study of functional brain network reorganization in clinically isolated syndrome
No full textSupplemental material, MSJ813108_STROBE_checklist for Longitudinal study of functional brain network reorganization in clinically isolated syndrome by Ismail Koubiyr, Mathilde Deloire, Pierre Besson, Pierrick Coupé, Cécile Dulau, Jean Pelletier, Thomas Tourdias, Bertrand Audoin, Bruno Brochet, Jean-Philippe Ranjeva and Aurélie Ruet in Multiple Sclerosis Journal</p
MSJ813108_supplementary_appendix – Supplemental material for Longitudinal study of functional brain network reorganization in clinically isolated syndrome
No full textSupplemental material, MSJ813108_supplementary_appendix for Longitudinal study of functional brain network reorganization in clinically isolated syndrome by Ismail Koubiyr, Mathilde Deloire, Pierre Besson, Pierrick Coupé, Cécile Dulau, Jean Pelletier, Thomas Tourdias, Bertrand Audoin, Bruno Brochet, Jean-Philippe Ranjeva and Aurélie Ruet in Multiple Sclerosis Journal</p
A multicentric real-world observational study to describe the use and efficacy of follitropin delta for IVF/ICSI procedures in patients at risk of hypo-response
No full textBackgroundAround 20% of patients undergoing assisted reproductive technology are at risk of hypo-response to ovarian stimulation. The aim of this study was to describe the real-world use of follitropin delta for ovarian stimulation in these patients, as defined by POSEIDON groups 3 and 4 [an anti-Müllerian hormone (AMH) level of <1.2 ng/ml].Materials and methodsThis study was a post-hoc analysis of participants from DELTA, a multi-centre, prospective, observational study conducted in normal care settings in fertility clinics at 14 active sites in France. A subset of 35 patients at risk of hypo-response to ovarian stimulation (mean AMH 0.7 ± 0.29 ng/ml) and treated with follitropin delta were included. Patients were followed for 10–11 weeks after the first fresh or frozen embryo transfer in case of subsequent pregnancy, and data on real-world follitropin delta use collected.ResultsMost patients (92.9%) had undergone their first IVF or ICSI. The prescribed daily dose was usually based on the approved algorithm (N = 26; 74.3%) with a mean daily dose of 14.2 ± 4.1 mcg, resulting in a mean total dose of 187.7 ± 135.6 mcg. The mean duration of ovarian stimulation was 11.6 ± 6.7 days with no premature discontinuations, while the mean number of oocytes retrieved among patients that started stimulation was 6.3 ± 4.3. A fresh transfer was performed for 21 patients (84.0%), with a mean of 1.04 ± 0.98 embryos transferred per patient. Seven patients (20.0%) achieved an ongoing pregnancy (28% per transfer). No adverse drug reactions were reported.ConclusionsThe results describe the real-world use of follitropin delta and demonstrate its suitability for POSEIDON group 3 and 4 patients. These data complement clinical trial outcomes, supporting clinician decision-making and improving IVF/ICSI outcomes
Mult Scler.
No full textBackground: The Brief Computerized Cognitive Assessment in Multiple Sclerosis (BCCAMS) is a short neuropsychological battery for persons with multiple sclerosis (PwMS). Objectives: The main objective of the study is to validate the BCCAMS. Methods: PwMS and healthy subjects (HS) were evaluated using the BCCAMS which include two computerized tests, the Computerized Speed Cognitive Test and the Computerized Episodic Visual Memory Test (CEVMT), a newly developed visuospatial memory test, and the French learning test. The Minimal Assessment of Cognitive Function in MS (MACFIMS), including the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) tests, was also administered. Regression-based norms of the BCCAMS were calculated in 276 HS. BCCAMS was compared with BICAMS and MACFIMS for detection of cognitive impairment (CI). Results: Out of 120 PwMS, CI was detected using the BCCAMS, BICAMS (one impaired test), and MACFIMS (two impaired tests) in 59.1%, 50%, and 37.9%, respectively. The BCCAMS produced the same predictive value as that of the BICAMS battery for detecting CI in the MACFIMS. Conclusion: This study validated the BCCAMS as a validated computerized short assessment for information processing speed and learning in MS. © The Author(s), 2021
Microstructural alterations precede subcortical deep grey matter volume loss in patients with clinically isolated syndrome
No full textInternational audienc
Relationships between reorganization of functional brain network topology and cognition in clinically isolated syndrome: A 1 year Resting-state fMRI longitudinal study
No full textInternational audienc
Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to <scp>CA</scp> 1
No full text"This is the peer reviewed version of the following article: Planche, V., Koubiyr, I., Romero, J. E., Manjon, J. V., Coupé, P., Deloire, M., ... & Tourdias, T. (2018). Regional hippocampal vulnerability in early multiple sclerosis: Dynamic pathological spreading from dentate gyrus to CA 1. Human brain mapping, 39(4), 1814-1824., which has been published in final form at https://doi.org/10.1002/hbm.23970. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."[EN] Background: Whether hippocampal subfields are differentially vulnerable at the earliest stages of multiple sclerosis (MS) and how this impacts memory performance is a current topic of debate.
Method: We prospectively included 56 persons with clinically isolated syndrome (CIS) suggestive of MS in a 1-year longitudinal study, together with 55 matched healthy controls at baseline. Participants were tested for memory performance and scanned with 3T MRI to assess the volume of 5 distinct hippocampal subfields using automatic segmentation techniques.
Results: At baseline, CA4/dentate gyrus was the only hippocampal subfield with a volume significantly smaller than controls (p < .01). After one year, CA4/dentate gyrus atrophy worsened (-6.4%, p < .0001) and significant CA1 atrophy appeared (both in the stratum-pyramidale and the stratum radiatum-lacunosum-moleculare, -5.6%, p < .001 and -6.2%, p < .01, respectively). CA4/dentate gyrus volume at baseline predicted CA1 volume one year after CIS (R-2 = 0.44 to 0.47, p < .001, with age, T2 lesion-load, and global brain atrophy as covariates). The volume of CA4/dentate gyrus at baseline was associated with MS diagnosis during follow-up, independently of T2-lesion load and demographic variables (p < .05). Whereas CA4/dentate gyrus volume was not correlated with memory scores at baseline, CA1 atrophy was an independent correlate of episodic verbal memory performance one year after CIS (beta = 0.87, p < .05).
Conclusion: The hippocampal degenerative process spread from dentate gyrus to CA1 at the earliest stage of MS. This dynamic vulnerability is associated with MS diagnosis after CIS and will ultimately impact hippocampal-dependent memory performance.ARSEP Foundation; Bordeaux University Hospital; TEVA Laboratories; French Agence Nationale de la Recherche, Grant/Award Numbers: ANR-10-LABX-57, ANR-10-LABX-43, ANR-10-IDEX-03-02, ANR-10-COHO-002; UPV, Grant/Award Numbers: UPV2016-0099, TIN2013-43457-R; Ministerio de Economia y competitividadPlanche, V.; Koubiyr, I.; Romero Gómez, JE.; Manjón Herrera, JV.; Coupe, P.; Deloire, M.; Dousset, V.... (2018). Regional hippocampal vulnerability in early multiple sclerosis: a dynamic pathological spreading from dentate gyrus to CA1. Human Brain Mapping. 39(4):1814-1824. https://doi.org/10.1002/hbm.23970S18141824394Avants, B. B., Tustison, N. J., Song, G., Cook, P. A., Klein, A., & Gee, J. C. (2011). 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