357 research outputs found
Dataset for Novel Fabrication Technique for Highly Efficient Tm-doped Fibers
No full textData for the paper:
Ramírez-Martínez, N. J., Núñez-Velázquez, M., Umnikov, A. A., & Sahu, J. K. (2018). Novel fabrication technique for highly efficient Tm-doped fibers. In CLEO: Science and Innovations, CLEO_SI 2018 (Vol. Part F94-CLEO_SI 2018). Washington D.C.: OSA. DOI: 10.1364/CLEO_SI.2018.SF3I.2</span
Neurovoz - Rasta PLP - V2 - Scientific Reports Publication: Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson's Disease
No full textThis repository contains the Rasta-PLP features of six different speech recordings (sentences) from Neurovoz corpus (47 parkinsonian and 32 control speakers whose mother tongue is Spanish Castillian.)
Number of PLP coefficients: [6, 8, 10, 12, 14, 16, 18, 20].
Delta coefficients: Yes
Delta Delta coefficients: Yes
Sampling rate: 16 kHz
Frame size: 15 ms
Frame overlapping: 50%
This subset of the Neurovoz corpus was recorded between 2015 and 2017 by Universidad Politécncia de Madrid and Hospital General Universitario Gregorio Marañón.
This version includes the same files as the previous version and information about UPDRS, H&Y, years since diagnosis and age of each participant.
How to cite:
[1] Moro-Velazquez, L., Gomez-Garcia, J. A., Godino-Llorente, J. I., Grandas-Perez, F., Shattuck-Hufnagel, S. Yagüe-Jimenez, V., and Dehak, N. (2019). Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s disease.Scientific reports 9, 19066.
[2] Moro-Velazquez, L., Gomez-Garcia, J. A., Godino-Llorente, J. I., Villalba, J., Rusz, J., Shattuck-Hufnagel, S. and Dehak, N. (2019). A forced Gaussians based methodology for the differential evaluation of Parkinson's Disease by means of speech processing. Biomedical Signal Processing and Control, 48, 205-220.
BibTeX:
@article{moro2019phonetic,
title={Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson's Disease},
author={Moro-Velazquez, Laureano and Gomez-Garcia, Jorge A. and Godino-Llorente, Juan I. and Grandas-Perez, Francisco and Shattuck-Hufnagel, Stefanie and Yague-Jimenez, Virginia and Dehak, Najim},
journal={Scientific Reports},
volume={9},
pages={19066},
year={2019},
publisher={Nature Research Publishing}
}
@article{moro2019forced,
title={A forced Gaussians based methodology for the differential evaluation of Parkinson's Disease by means of speech processing},
author={Moro-Velazquez, Laureano and Gomez-Garcia, Jorge Andres and Godino-Llorente, Juan Ignacio and Dehak, Najim},
journal={Biomedical Signal Processing and Control},
pages={205--220},
volume={48},
year={2019},
publisher={Elsevier}
}
</p
Neurovoz - Rasta PLP - Scientific Reports Publication: Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson's Disease
No full textThis repository contains the Rasta-PLP features of six different speech recordings (sentences) from Neurovoz corpus (47 parkinsonian and 32 control speakers whose mother tongue is Spanish Castillian.)
Number of PLP coefficients: [6, 8, 10, 12, 14, 16, 18, 20].
Delta coefficients: Yes
Delta Delta coefficients: Yes
Sampling rate: 16 kHz
Frame size: 15 ms
Frame overlapping: 50%
This subset of the Neurovoz corpus was recorded between 2015 and 2017 by Universidad Politécnica de Madrid and Hospital General Universitario Gregorio Marañón.
The information about UPDRS, H&Y, years since diagnosis and age of each participant can be found in Version 2 of this dataset. The Rasta-PLP features files are the same in Version 1 and Version 2.
How to cite:
[1] Moro-Velazquez, L., Gomez-Garcia, J. A., Godino-Llorente, J. I., Grandas-Perez, F., Shattuck-Hufnagel, S. Yagüe-Jimenez, V., and Dehak, N. (2019). Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson’s disease.Scientific reports 9, 19066.
[2] Moro-Velazquez, L., Gomez-Garcia, J. A., Godino-Llorente, J. I., Villalba, J., Rusz, J., Shattuck-Hufnagel, S. and Dehak, N. (2019). A forced Gaussians based methodology for the differential evaluation of Parkinson's Disease by means of speech processing. Biomedical Signal Processing and Control, 48, 205-220.
BibTeX:
@article{moro2019phonetic,
title={Phonetic relevance and phonemic grouping of speech in the automatic detection of Parkinson's Disease},
author={Moro-Velazquez, Laureano and Gomez-Garcia, Jorge A. and Godino-Llorente, Juan I. and Grandas-Perez, Francisco and Shattuck-Hufnagel, Stefanie and Yague-Jimenez, Virginia and Dehak, Najim},
journal={Scientific Reports},
volume={9},
pages={19066},
year={2019},
publisher={Nature Research Publishing}
}
@article{moro2019forced,
title={A forced Gaussians based methodology for the differential evaluation of Parkinson's Disease by means of speech processing},
author={Moro-Velazquez, Laureano and Gomez-Garcia, Jorge Andres and Godino-Llorente, Juan Ignacio and Dehak, Najim},
journal={Biomedical Signal Processing and Control},
pages={205--220},
volume={48},
year={2019},
publisher={Elsevier}
Dataset for Highly Efficient Thulium-doped High-power Laser Fibers Fabricated by MCVD
No full textData for the paper:
Ramírez-Martínez, N. J., Núñez-Velázquez, M., Umnikov, A. A., & Sahu, J. K. (2019). Highly efficient thulium-doped high-power laser fibers fabricated by MCVD. Optics Express, 27(1), 196-201. DOI: 10.1364/OE.27.000196
We report a hybrid process by combining both vapor-phase and solution-doping techniques of rare-earth doped preform fabrication in conjunction with MCVD technique to fabricate highly efficient Tm-doped laser fibers. The proposed fabrication route takes the advantage of co-doping silica with high alumina content through vapor-phase doping process, which is otherwise difficult to achieve using conventional solution doping technique. In addition, by employing the solution doping method, high-purity thulium halide precursors having low vapor pressures at room temperature can be used to dope the fiber core region with high thulium concentrations that is optimized for an efficient two-for-one cross-relaxation process for 79xnm diode pumped thulium-doped fiber laser. Fibers fabricated using the hybrid approach show more homogeneous and flat-top dopant profiles compared with the conventional approach, where both aluminum and thulium are incorporated in the core through solution doping. This will ensure more doped region to take part in the cross-relaxation process. Superior laser performance with a slope efficiency of >70% in the two-micron band has been demonstrated when diode pumped at ~790nm. </span
Large conductance voltage- and Ca2+-gated potassium (BK) channel beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases
No full textTolerance is a well described component of alcohol abuse and addiction. The large conductance voltage- and Ca(2+)-gated potassium channel (BK) has been very useful for studying molecular tolerance. The influence of association with the beta4 subunit can be observed at the level of individual channels, action potentials in brain slices, and finally, drinking behavior in the mouse. Previously, we showed that 50 mm alcohol increases both alpha and alphabeta4 BK channel open probability, but only alpha BK develops acute tolerance to this effect. Currently, we explore the possibility that the influence of the beta4 subunit on tolerance may result from a striking effect of beta4 on kinase modulation of the BK channel. We examine the influence of the beta4 subunit on PKA, CaMKII, and phosphatase modulation of channel activity, and on molecular tolerance to alcohol. We record from human BK channels heterologously expressed in HEK 293 cells composed of its core subunit, alpha alone (Insertless), or co-expressed with the beta4 BK auxiliary subunit, as well as, acutely dissociated nucleus accumbens neurons using the cell-attached patch clamp configuration. Our results indicate that BK channels are strongly modulated by activation of specific kinases (PKA and CaMKII) and phosphatases. The presence of the beta4 subunit greatly influences this modulation, allowing a variety of outcomes for BK channel activity in response to acute alcohol.Neuroscienc
Index-Based Cost-Effectiveness Analysis vs. Least-Cost River Basin Optimization Model: Comparison in the Selection of a Programme of Measures at the River Basin Scale
No full textIncreasing water scarcity challenges conventional approaches to managing water resources. More holistic tools and methods are required to support the integrated planning and management of fresh water resources at the river basin level. This paper compares an index-based cost-effectiveness analysis (IBCEA) with a least-cost river basin optimization model (LCRBOM). Both methods are applied to a real case study to design a cost-effective portfolio of water demand and supply management measures that ensures compliance with water supply and environmental targets. The IBCEA is a common approach to select programmes of measures in the implementation of the EU Water Framework Directive. We describe its limitations in finding a least-cost solution at the river basin level and highlight the benefits from implementing a LCRBOM. Both methods are compared in a real case study, the Orb river basin, in the south of France. The performances of the programmes of measures selected by the two methods are compared for the same annual equivalent cost. By ignoring the spatial and temporal variability of water availability and water demands in the river basin and the interconnection among its elements, the aggregated approach used in the standard IBCEA can miss more cost-effective solutions at the river basin scale.This paper is based on work conducted as part of several projects over more than 6 years. It benefited from the financial and technical support of the Agence de l'Eau Rhone Mediteranee et Corse; Conseil General de l'Herault; Conseil Regional du Languedoc Roussillon et ONEMA. Funding was partly provided by the IMPADAPT project /CGL2013-48424-C2-1-R) from the Spanish ministry MINECO (Ministerio de Economia y Competitividad) and European FEDER funds. Corentin Girard is supported by a grant from the University Lecturer Training Programme (FPU12/03803) of the Ministry of Education, Culture and Sports of Spain. We are very grateful to Y. Caballero (BRGM), S. Chazot (BRLi), E. Vier and F. Aigoui (GINGERGROUP) and L. Rippert and his team from the SMVOL for their help during the project and for the data provided. We thank as well the two anonymous reviewers, the Associated Editor and Editor-in-Chief of Water Resources Management, for their useful and encouraging comments during the review process.Girard-Martin, CDP.; Rinaudo, J.; Pulido-Velazquez, M. (2015). Index-Based Cost-Effectiveness Analysis vs. Least-Cost River Basin Optimization Model: Comparison in the Selection of a Programme of Measures at the River Basin Scale. 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Sharing the cost of river basin adaptation portfolios to climate change: Insights from social justice and cooperative game theory
No full text[EN] The adaptation of water resource systems to the potential impacts of climate change requires
mixed portfolios of supply and demand adaptation measures. The issue is not only to select efficient, robust, and flexible adaptation portfolios but also to find equitable strategies of cost allocation among the stakeholders. Our work addresses such cost allocation problems by applying two different theoretical approaches: social justice and cooperative game theory in a real case study. First of all, a cost-effective portfolio of adaptation measures at the basin scale is selected using a least-cost optimization model. Cost allocation solutions are then defined based on economic rationality concepts from cooperative game theory (the Core). Second, interviews are conducted to characterize stakeholders perceptions of social justice principles associated with the definition of alternatives cost allocation rules. The comparison of the cost allocation scenarios leads to contrasted insights in order to inform the decision-making process at the river basin scale and potentially reap the efficiency gains from cooperation in the design of river basin adaptation portfolios.The study has been partially supported by the IMPADAPT project (CGL2013-48424-C2-1-R) from the Spanish ministry MINECO (Ministerio de Economia y Competitividad) with European FEDER funds. The first author is supported by a grant from the University Lecturer Training Program (FPU12/03803) of the Ministry of Education, Culture and Sports of Spain. The second author is financially supported by BRGM's research program 30 (environmental and risk economics). Readers interested in the data can request those by e-mail to Corentin Girard, [email protected], CDP.; Rinaudo, J.; Pulido-Velazquez, M. (2016). Sharing the cost of river basin adaptation portfolios to climate change: Insights from social justice and cooperative game theory. 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The Relationship between Duration of Initial Alcohol Exposure and Persistence of Molecular Tolerance Is Markedly Nonlinear
No full textThe neuronal calcium- and voltage-activated BK potassium channel is modulated by ethanol, and plays a role in behavioral tolerance in vertebrates and invertebrates. We examine the influence of temporal parameters of alcohol exposure on the characteristics of BK molecular tolerance in the ventral striatum, an important component of brain reward circuitry. BK channels in striatal neurons of C57BL/6J mice exhibited molecular tolerance whose duration was a function of exposure time. After 6 h exposure to 20 mm(0.09 mg%) ethanol, alcohol sensitivity was suppressed beyond 24 h after withdrawal, while after a 1 or 3 h exposure, sensitivity had significantly recovered after 4 h. This temporally controlled transition to persistent molecular tolerance parallels changes in BK channel isoform profile. After withdrawal from 6 h, but not 3 h alcohol exposure, mRNA levels of the alcohol-insensitive STREX (stress axis-regulated exon) splice variant were increased. Moreover, the biophysical properties of BK channels during withdrawal from 6 h exposure were altered, and match the properties of STREX channels exogenously expressed in HEK 293 cells. Our results suggest a temporally triggered shift in BK isoform identity. Once activated, the transition does not require the continued presence of alcohol. We next determined whether the results obtained using cultured striatal neurons could be observed in acutely dissociated striatal neurons, after alcohol administration in the living mouse. The results were in remarkable agreement with the striatal culture data, showing persistent molecular tolerance after injections producing 6 h of intoxication, but not after injections producing only 3 h of intoxication.</jats:p
Coronary bypass surgery with or without surgical ventricular reconstruction
No full textCoronary bypass surgery with or without surgical ventricular reconstruction.
Jones RH, Velazquez EJ, Michler RE, Sopko G, Oh JK, O'Connor CM, Hill JA, Menicanti L, Sadowski Z, Desvigne-Nickens P, Rouleau JL, Lee KL; STICH Hypothesis 2 Investigators.
Collaborators (379)Bochenek A, Krejca M, Trusz-Gluza M, Wita K, Zembala M, Przybylski R, Kukulski T, Cherniavsky A, Marchenko A, Romanov A, Wos S, Deja M, Golba K, Kot J, Rao V, Iwanochko M, Renton J, Hemeon S, Rogowski J, Rynkiewicz A, Betlejewski P, Sun B, Crestanello J, Binkley P, Chang J, Ferrazzi P, Gavazzi A, Senni M, Sadowski J, Kapelak B, Sobczyk D, Wrobel K, Pirk J, Jandova R, Velazquez E, Smith P, Milano C, Adams P, Menicanti L, Di Donato M, Castelvecchio S, Dagenais F, Dussault G, Dupree C, Sheridan B, Schuler C, Yii M, Prior D, Mack J, Racine N, Bouchard D, Ducharme A, Lavoignat J, Maurer G, Grimm M, Lang I, Adlbrecht C, Religa Z, Biederman A, Szwed H, Sadowski Z, Rajda M, Ali I, Howlett J, MacFarlane M, Siepe M, Beyersdorf F, Cuerten C, Wiechowski S, Mokrzycki K, Hill J, Beaver T, Olitsky D, Bernstein V, Janusz M, O'Neill V, Grayburn P, Hebeler R, Hamman B, Aston S, Gradinac S, Vukovic M, Djokovic L, Benetis R, Jankauskiene L, Friedrich I, Buerke M, Paraforos A, Quaini E, Cirillo M, Chua L, Lim C, Kwok B, Kong S, Stefanelli G, Labia C, Bergh C, Gustafsson C, Daly R, Rodeheffer R, Nelson S, Maitland A, Isaac D, Holland M, Di Benedetto G, Attisano T, Sievers H, Schunkert H, Stierle U, Haddad H, Hendry P, Donaldson J, Birjiniuk V, Harrington M, Nawarawong W, Woragidpunpol S, Kuanprasert S, Mekara W, Konda S, Neva C, Hathaway W, Groh M, Blakely J, Lamy A, Demers C, Rizzo T, Drazner M, DiMaio J, Joy J, Benedik J, Marketa K, Beghi C, De Blasi M, Helou J, Dallaire S, Kron I, Kern J, Bergin J, Phillips J, Aldea G, Verrier E, Harrison L, Piegas L, Paulista P, Farsky P, Veiga-Kantorowitz C, Philippides G, Shemin R, Thompson J, White H, Alison P, Stewart R, Clapham T, Rich J, Herre J, Pine L, Kalil R, Nesralla I, Santos M, Pereira de Moraes M, Michler R, Swayze R, Arnold M, McKenzie N, Smith J, Nicolau J, Oliveira S, Stolf N, Ferraz M, Filgueira J, Batlle C, Rocha A, Gurgel Camara A, Huynh T, Cecere R, Finkenbine S, St-Jacques B, Ilton M, Wittstein I, Conte J, Breton E, Panza J, Boyce S, McNulty M, Starnes V, Lopez B, Biederman R, Magovern J, Dean D, Grant S, Hammon J, Wells G, De Pasquale C, Knight J, Healy H, Maia L, Souza A, McRae R, Pierson M, Gullestad L, Sorensen G, Murphy E, Ravichandran P, Avalos K, Horowitz J, Owen E, Ascheim D, Naka Y, Yushak M, Gerometta P, Arena V, Borghini E, Johnsson P, Ekmehag B, Engels K, Rosenblum W, Swayze R, Amanullah A, Krzeminska-Pakula M, Drozdz J, Larbalestier R, Wang X, Busmann C, Horkay F, Szekely L, Keltai M, Hetzer R, Knosalla C, Nienkarken T, Chiariello L, Nardi P, Arom K, Ruengsakulrach P, Hayward C, Jansz P, Stuart S, Oto O, Sariomanoglu O, Dignan R, French J, Gonzalez M, Edes I, Szathmarine V, Yakub M, Sarip S, Alotti N, Lupkovics G, Smedira N, Pryce J, Cokkinos D, Palatianos G, Kremastinos D, Stewart R, Rinkes L, Esrig B, Baptiste M, Booth D, Ramaiah C, Ferraris V, Menon S, Martin L, Couper G, Rosborough D, Vanhaecke J, Strijckmans A, Carson P, Dupree C, Miller A, Pina I, Selzman C, Wertheimer J, Goldstein S, Cohn F, Hlatky M, Kennedy K, Rankin S, Robbins R, Zaret B, Rouleau J, Desvigne-Nickens P, Jones R, Lee K, Michler R, O'Connor C, Oh J, Rankin G, Velazquez E, Hill J, Beyersdorf F, Bonow R, Desvigne-Nickens P, Jones R, Lee K, Oh J, Panza J, Rouleau J, Sadowski Z, Velazquez E, White H, Jones R, Velazquez E, O'Connor C, Rankin G, Sellers M, Sparrow-Parker B, McCormick A, Albright J, Dandridge R, Rittenhouse L, Wagstaff D, Wakeley N, Burns S, Williams M, Bailey D, Parrish L, Daniels H, Grissom G, Medlin K, Lee K, She L, McDaniel A, Lokhnygina Y, Greene D, Moore V, Pohost G, Agarwal S, Apte P, Bahukha P, Chow M, Chu X, Doyle M, Forder J, Ocon M, Reddy V, Santos N, Tripathi R, Varadarajan P, Oh J, Blahnik F, Bruce C, Lin G, Manahan B, Miller D, Miller F, Pellikka P, Springer R, Welper J, Wiste H, Mark D, Anstrom K, Baloch K, Burnette A, Clapp-Channing N, Cowper P, Davidson-Ray N, Drew L, Harding T, Hunt V, Knight D, Patterson A, Redick T, Sanderford B, Feldman A, Bristow M, Chan T, Diamond M, Maisel A, Mann D, McNamara D, Bonow R, Berman D, Helmer D, Holly T, Leonard S, Woods M, Panza J, McNulty M, Grayburn P, Aston S.
SourceDuke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA. [email protected]
Abstract
BACKGROUND: Surgical ventricular reconstruction is a specific procedure designed to reduce left ventricular volume in patients with heart failure caused by coronary artery disease. We conducted a trial to address the question of whether surgical ventricular reconstruction added to coronary-artery bypass grafting (CABG) would decrease the rate of death or hospitalization for cardiac causes, as compared with CABG alone.
METHODS: Between September 2002 and January 2006, a total of 1000 patients with an ejection fraction of 35% or less, coronary artery disease that was amenable to CABG, and dominant anterior left ventricular dysfunction that was amenable to surgical ventricular reconstruction were randomly assigned to undergo either CABG alone (499 patients) or CABG with surgical ventricular reconstruction (501 patients). The primary outcome was a composite of death from any cause and hospitalization for cardiac causes. The median follow-up was 48 months.
RESULTS: Surgical ventricular reconstruction reduced the end-systolic volume index by 19%, as compared with a reduction of 6% with CABG alone. Cardiac symptoms and exercise tolerance improved from baseline to a similar degree in the two study groups. However, no significant difference was observed in the primary outcome, which occurred in 292 patients (59%) who were assigned to undergo CABG alone and in 289 patients (58%) who were assigned to undergo CABG with surgical ventricular reconstruction (hazard ratio for the combined approach, 0.99; 95% confidence interval, 0.84 to 1.17; P=0.90).
CONCLUSIONS: Adding surgical ventricular reconstruction to CABG reduced the left ventricular volume, as compared with CABG alone. However, this anatomical change was not associated with a greater improvement in symptoms or exercise tolerance or with a reduction in the rate of death or hospitalization for cardiac causes. (ClinicalTrials.gov number, NCT00023595.
System Dynamics Modeling for Supporting Drought-Oriented Management of the Jucar River System, Spain
No full text[EN] The management of water in systems where the balance between resources and demands is already precarious can pose a challenge and it can be easily disrupted by drought episodes. Anticipated drought management has proved to be one of the main strategies to reduce their impact. Drought economic, environmental, and social impacts affect different sectors that are often interconnected. There is a need for water management models able to acknowledge the complex interactions between multiple sectors, activities, and variables to study the response of water resource systems to drought management strategies. System dynamics (SD) is a modeling methodology that facilitates the analysis of interactions and feedbacks within and between sectors. Although SD has been applied for water resource management, there is a lack of SD models able to regulate complex water resource systems on a monthly time scale and considering multiple reservoir operating rules, demands, and policies. In this paper, we present an SD model for the strategic planning of drought management in the Jucar River system, incorporating dynamic reservoir operating rules, policies, and drought management strategies triggered by a system state index. The DSS combines features from early warning and information systems, allowing for the simulation of drought strategies, evaluating their economic impact, and exploring new management options in the same environment. The results for the historical period show that drought early management can be beneficial for the performance of the system, monitoring the current state of the system, and activating drought management measures results in a substantial reduction of the economic impact of droughts.The data used in this study was obtained from the references included. We acknowledge the European Research Area for Climate Services consortium (ER4CS) and the Agencia Estatal de Investigacion for their financial support to this research under the INNOVA project (Grant Agreement: 690462; PCIN-2017-066). This study has also been partially funded by the ADAPTAMED project (RTI2018-101483-B-I00) from the Ministerio de Ciencia, Innovacion y Universidades (MICIU) of Spain.Rubio-Martin, A.; Pulido-Velazquez, M.; Macian-Sorribes, H.; Garcia-Prats, A. (2020). System Dynamics Modeling for Supporting Drought-Oriented Management of the Jucar River System, Spain. Water. 12(5):1-19. https://doi.org/10.3390/w12051407S119125Mishra, A. K., & Singh, V. P. (2010). A review of drought concepts. Journal of Hydrology, 391(1-2), 202-216. doi:10.1016/j.jhydrol.2010.07.012Momblanch, A., Paredes-Arquiola, J., Munné, A., Manzano, A., Arnau, J., & Andreu, J. (2015). Managing water quality under drought conditions in the Llobregat River Basin. 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