2,928 research outputs found
Dataset Validation of seven type 2 diabetes mellitus risk scores in a population-based cohort. The CoLaus Study
No full textThis dataset is related to "Validation of seven type 2 diabetes mellitus risk scores in a population-based cohort. The CoLaus Study".
Vanessa Kraege*, Janko Fabecic*, Pedro Marques Vidal, Gérard Waeber and Marie Méan
*Contributed equally; co-first authors</p
A forma da cidade e sua apropriação: análise propositiva de diretrizes de arquitetura da cidade para Cumbayá em Quito/Equador
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Urbanismo, História e Arquitetura da CidadeEste trabalho busca entender a relação entre as diversas formas que a cidade vem adquirindo com o passar do tempo e as formas de apropriação contemporâneas, a partir de discussão teórica de conceitos e critérios de autores que discutem o desempenho da forma da cidade em relação à apropriação dos espaços públicos. Com base neste debate, elegemos critérios relacionados à apropriação nas escalas da estrutura da cidade e da configuração dos lugares, e procedeu-se à caracterização e análise da cidade contemporânea de Quito para verificar padrões espaciais diretamente associados com uma apropriação positiva da cidade na cultura quitenha. A partir dos critérios selecionados e dos padrões positivos identificados, lançamos diretrizes de projeto de arquitetura da cidade para uma área de expansão da cidade contemporânea de Quito no Equador - a Paróquia de Cumbayá - buscando responder a critérios de bom desempenho da forma urbana que potencializem a apropriação de seus espaços públicos.The research seeks to understand the relationship between the different forms that the city has acquired over time and contemporary forms of appropriation, based on a theoretical discussion of concepts and criteria of authors who discuss the performance of the form of the city in relation to the appropriation of public spaces. Based on this debate, we selected criteria related to appropriation, both at the scale of city structure and at the scale of place configuration, and proceeded to the characterization and analysis of the contemporary city of Quito in a search to identify spatial patterns directly associated with a positive appropriation of the city in Quito´s culture. The selected criteria and the positive patterns identified oriented the design guidelines here proposed for the architectural design of the Paróquia of Cumbayá - an area of expansion in the city of Quito, Ecuador - in an attempt to comply with the criteria of good urban form performance so as to enhance the appropriation of its public spaces
WEIGHT TRAJECTORIES DO NOT INFLUENCE DIABETES CONTROL. A PROSPECTIVE STUDY IN SWITZERLAND (COLAUS STUDY).
No full textThe objective was to identify anthropometric trajectories among subjects with type 2 diabetes, and associate them with glycaemic control.
A prospective study including 268 community-dwelling participants with type 2 diabetes (34% women, mean age 68.7±8.9 years) followed for 10.7 years (range: 8.8-13.6 years). Type 2 diabetes control was considered for 1) fasting plasma glucose (FPG) <7.0 mmol/L, or 2) HbA1c<7.0% (53 nmol/mol). Changes in weight or waist and weight variability were considered.
One half (FPG) and one third (HbA1c) of participants presented with uncontrolled type 2 diabetes. Half of the participants presented with obesity and 75% with abdominal obesity. During follow-up, half of the participants maintained their weight, 25% gained >5 kg, and 25% lost 5 cm. Using FPG as criterion, participants who lost >5 cm waist were more likely to be controlled: multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI): 3.10 (1.23-7.78). Participants with controlled diabetes also presented with a higher weight variability: multivariable adjusted mean±standard error 4.8±0.3 vs. 3.9±0.3 kg, p=0.028. Using HbA1c as criterion, participants who lost >5 kg were less likely to be controlled: OR and (95% CI): 0.35 (0.18-0.66). Similar findings were obtained when restricting the analysis to participants with type 2 diabetes throughout the whole study period. In a Swiss community-based sample of participants with type 2 diabetes, diabetes control rates are low; neither weight nor waist changes were significantly and consistently associated with type 2 diabetes control
Troubles du contrôle des impulsions et syndrome des jambes sans repos dans la maladie de Parkinson : étude transversale
No full textLuis Mariano Vidal (1842-1922) rudist taxa revisited
No full textThe revision of the 323 register numbers of rudist bivalves in the Vidal Collection, kept at the Museu de Geologia de Barcelona (MCNB), allowed the identification and re-figuration of thirty-three holotype or syntype specimens corresponding to twenty species established by Vidal. Among them, thirteen are considered as valid species, four resulted to be synonymous with other senior species, and three (one not figured) do not display enough characters to be properly identified. The four syntypes of Hippurites castroi, currently attributed to genus Hippuritella, have not been localised, nor the other two specimens subsequently figured by the author. Similarly, three of the four syntypes of Hippurites maestrei, type species of Hippuritella, have not been localised. Contrarily, the specimens described as Sphaerulites posae but not figured, were localised. On the other hand, twelve specimens, syntypes or figured as new species by other authors (Matheron and Douvillé), have also been identified and are re-figured; most of them are part of the specimens that were sectioned for study and then returned to Vidal. In addition, other seventeen specimens figured by Douvillé have been identified and are documented; most of them also being part of a sectioned specimen
PSYCHO-BEHAVIORAL PROFILE OF PARKINSON'S DISEASE PATIENTS WITH RESTLESS LEGS SYNDROME/WILLIS-EKBOM DISEASE
No full textTRENDS IN HOSPITAL MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION IN SWITZERLAND, 1998 TO 2008 THE REGION MAKES THE DIFFERENCE: DISPARITIES IN MANAGEMENT OF ACUTE MYOCARDIAL INFARCTION WITHIN SWITZERLAND
No full textThe aim of this master's thesis was to assess the ten- year trends and regional differences in management and outcome of acute myocardial infarction (AMI) within Switzerland. The thesis is composed of two articles.
First, in the article "Trends in hospital management of acute myocardial infarction in Switzerland, 1998 to 2008" over 102,700 cases of AMI with corresponding management and revascularization procedures were assessed. The results showed a considerable increase in the numbers of hospital discharges for AMI, namely due to the increase of between- hospital transfers. Rates of intensive care unit admissions remained stable. All types of revascularization procedures showed an increase. In particular, overall stenting rates increased with drug-eluting stents partly replacing bare stents.
Second, in the article "The region makes the difference: disparities in management of acute myocardial infarction within Switzerland" around 25,600 cases of AMI with corresponding management were assessed for the period of 2007-2008 and according to seven Swiss regions. As reported by our results, considerable regional differences in AMI management were stated within Switzerland. Although each region showed different trends regarding revascularization interventions, Leman and Ticino contrast significantly by presenting the minimum and maximum rates in almost all assessed parameters. As a consequence these two regions differ the most from the Swiss average.
The impact of the changes in trends and the regional differences in AMI management on Swiss patient's outcome and economics remains to be assessed. Purpose: To assess ten-year trends in management and outcome of acute myocardial infarction (AMI) in Switzerland. Methods: Swiss hospital discharge database for the 1998 to 2008 period. AMI was defined as a primary discharge diagnosis code I21 according to the CIM-10 classification of the World Health Organization. Management and revascularization procedures were assessed.
Results: Overall, 102,729 hospital discharges with a diagnosis of AMI were analyzed. The number of hospital discharges increased almost three-fold from 5530 in 1998 to 13,834 in 2008, namely due to a considerable increase in between-hospital transfers (1352 in 1998, 6494 in 2008). Relative to all hospital discharges, Intensive Care Unit admission rate was 38.0% in 1998 and remained stable (36.2%) in 2008 (p for trend=0.25). Percutaneous revascularization rates increased from 6.0% to 39.9% (p for trend<0.001). Non-drug-eluting stent use increased from 1.3% to 16.6% (p for trend<0.05). Drug eluting stents appeared in 2004 and increased to 23.5% of hospital discharges in 2008 (p for trend=0.07). Coronary artery bypass graft increased from 1.0% to 3.0% (p for trend<0.001). Circulatory assistance increased from 0.2% to 1.7% (p for trend<0.001). Thrombolysis showed no significant changes, from 0.5% to 1.9% (p for trend=0.64). Most of these trends were confirmed after multivariate adjustment.
Conclusion: Between 1998 and 2008 the number of hospital discharges for AMI increased considerably in Switzerland, namely due to between-hospital transfers. Overall stenting rates increased, drug-eluting stents partly replacing bare stents. The impact of these changes on outcome and economics remains to be assessed
Coronary artery disease incidence, risk factors, awareness, and medication utilization in a 10-year cohort study.
No full textSarebanhassanabadi M, Mirjalili SR, Marques-Vidal P, Krämer A, Namayandeh SM. Coronary artery disease incidence, risk factors, awareness, and medication utilization in a 10-year cohort study. BMC cardiovascular disorders. 2024;24(1): 101.BACKGROUND: There is a substantial disparity in coronary artery disease (CAD) burden between Iran and other nations that place a strong emphasis on the assessment of CAD risk factors and individuals' awareness and ability to control them.; METHODS: Two thousand participants of a community-based Iranian population aged 20-74 years were investigated with a mean follow-up of 9.9 years (range: 7.6 to 12.2). An analysis of Cox regression was conducted to determine the association between CAD development and classic risk factors such as age, sex, smoking, physical activity, education, obesity, dyslipidemia, hypertension, and diabetes mellitus. Furthermore, we computed the population attributable fraction for these risk factors.; RESULTS: After a follow-up period of nearly 10 years, 225 CAD events were reported, constituting 14.5% of the overall incidence. Nighty three percent of participants had more than one risk factor. Age was the most predictive risk factor, with a hazard ratio (HR) and confidence interval (CI) of 5.56 (3.87-7.97, p<0.001) in men older than 45 and females older than 55 compared to lower ages. In comparison to females, males had an HR of 1.45 (CI: 1.11-1.90, p value=0.006) for developing CAD. Nearly 80% of the patients had dyslipidemia, with a hazard ratio of 2.19 (CI: 1.40-3.44, p=0.01). Among the participants, 28.9% had hypertension, and 52% had prehypertension, which had HRs of 4.1 (2.4-7.2, p<0.001) and 2.4 (1.4-4.2, p<0.001), respectively. Diabetes, with a prevalence of 17%, had an HR of 2.63 (CI: 2 -3.47, p<0.001), but prediabetes was not significantly associated with CAD. Awareness of diabetes, dyslipidemia, and hypertension was 81%, 27.9%, and 48.1%, respectively. Regarding medication usage, the corresponding percentages were 51% for diabetes, 13.2% for dyslipidemia, and 41% for hypertension.; CONCLUSIONS: Compared to previous studies in Iran and neighboring countries, the current study found a higher incidence of CAD, more prevalent risk factors, and a lower awareness and ability to control these risk factors. Thus, an effective preventive strategy is needed to reduce the CAD burden in Iran. © 2024. The Author(s)
Dietary behaviors influence inflammatory markers: results from the CoLaus study
No full textBackground: The effect of different dietary markers on inflammatory markers has seldom been assessed in a general population setting. We assessed the effect of single foods, nutrients, dietary patterns and scores on inflammatory markers (CRP, IL-6, TNF-α and leucocyte count). Methods: Cross-sectional study including 4027 participants (46.5% men, 57.2±10.2 years) in Lausanne, Switzerland (CoLaus study). Dietary intake was collected between 2009-2012 using a semi-quantitative food frequency questionnaire. Besides single foods and nutrients, three naive (using principal components analysis - PCA) and four oriented (Mediterranean, Alternative Healthy Eating Index - AHEI) dietary scores were used. Results: Three dietary patterns explaining 20% of total variance were obtained and named “Meat & chips” (positive loadings for meat and French fries); “Pastries & fat” (positive loadings for hard fats, pastries and sugar) and “Fruits & vegetables” (positive loadings for fruits & vegetables). After multivariate adjustment on total energy intake, gender and other socio-demographic factors, fruit intake, the “Fruits & vegetables” pattern, the Mediterranean and the AHEI scores were negatively associated with CRP levels (standardized regression scores: -0.043, -0.054, -0.043 and -0.067, respectively, all p<0.01). The “Fruits & vegetables” pattern was also negatively associated with leucocyte count (standardized regression score: -0.057, p<0.01). Conversely, no association between nutrients and inflammatory markers and between all dietary markers and IL-6 or TNF-α was found. Conclusion: global dietary behaviours have a small but significant impact on inflammatory markers in the general population. The effect of individual nutrients or foods (fruits excepted) is of less clinical importance
Inacabamento e Cotidiano: um ensaio sobre o contista Marques Rebelo
No full textAo longo de sua trajetória como escritor, Marques Rebelo circulou pelos mais variados gêneros literários. A despeito disso, é notável sua inclinação para o conto, com o qual marcou sua estreia no mundo das letras com o volume intitulado Oscarina (1931), seguido por Três caminhos (1933) e Stela me abriu a porta (1942). Mas, mais do que isso: pelo ritmo ágil de suas narrativas e por seus desfechos abertos, é possível identificar o contista Marques Rebelo mesmo em seus romances, especialmente Marafa (1935) e A estrela sobe (1939). Nesse sentido, o presente artigo tem como objetivo analisar a obra rebeliana produzida nesse período levando em consideração, por um lado, certo inacabamento da forma e, por outro, a dimensão da vida cotidiana em suas tramas. Nossa hipótese é a de que, em Rebelo, esses elementos não apenas se correlacionam como concorrem para uma literatura que lhe possibilita: a) escapar ao cânone ensaístico e sociológico – sem necessariamente confrontá-lo; b) criar para si mesmo uma espécie de entrelugar na história da literatura; c) puir qualquer linha hierárquica entre grandes e pequenos dramas humanos no devir histórico
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