22 research outputs found
Blockade of [C-11](+)-PHNO binding in human subjects by the dopamine D-3 receptor antagonist ABT-925
No full textDopamine D-3 receptors are preferentially localized in the limbic system and midbrain, and thus may be involved in the pathophysiology of neuropsychiatry disorders. [C-11](+)-PHNO is the first preferential D-3 receptor radioligand in humans, yet there are no blockade studies with a D-3 receptor antagonist in humans. This study characterized the blockade of [C-11](+))-PHNO binding by ABT-925, a D-3 receptor antagonist, in healthy male subjects. Sixteen subjects underwent 2-3 positron emission tomography (PET) scans, at baseline and following one or two doses of ABT-925 ranging from 50 mg to 600 mg. Receptor occupancies were estimated for globus pallidus, substantia nigra, caudate, putamen, and ventral striatum. At the 600-mg dose (n=9), ABT-925 receptor occupancy (mean +/- S.D.) was higher in substantia nigra (75 +/- 10%) and globus pallidus (64 +/- 22%) than in ventral striatum (44 +/- 17%), caudate (40 +/- 18%) and putamen (38 +/- 17%) (ANOVA: F-4,F-140 = 15.02,
Neurochemical characterization of embryonic brain development in trisomy 19 (Ts19) mice: Implications of selective deficits observed for abnormal neural development in aneuploidy
No full textA randomized, double-blind, placebo-controlled Phase 2 study of α4β2 agonist ABT-894 in adults with ADHD
No full textExiste realmente semivogal no Português?: uma abordagem gerativa natural pura
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Florianópolis, 1978
P2‐221: ABT‐089, a neuronal nicotinic receptor partial agonist, reverses scopolamine‐induced cognitive deficits in healthy normal subjects
No full textA Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of α4β2 Agonist ABT-894 in Adults with ADHD
No full textParts of speech systems as a basic typological parameter.
No full textThis paper argues that the word order possibilities of a language are partly determined by the parts-of-speech system of that language. In languages in which lexical items are specialized for certain functionally defined syntactic slots (e.g. the modifier slot within a noun phrase), the identifiability of these slots is ensured by the nature of the lexical items (e.g. adjectives) themselves. As a result, word order possibilities are relatively unrestricted in these languages. In languages in which lexical items are not specialized for certain syntactic slots, in that these items combine the functions of two or more of the traditional word classes, other strategies have to be invoked to enhance identifiability. In these languages word order constraints are used to make syntactic slots identifiable on the basis of their position within the clause or phrase. Hence the word order possibilities are rather restricted in these languages. Counterexamples to the latter claim all involve cases in which identifiability is ensured by morphological rather than syntactic means. This shows that there is a balanced trade-off between the syntactic, morphological, and lexical structure of a language
O4‐04‐04: ABT‐089 demonstrates efficacy in a human model of cognition and good tolerability in subjects with Alzheimer's disease taking acetylcholinesterase inhibitors
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