1,721 research outputs found
Filip Spannbrucker
No full textFilip Spannbrucker Filip Spannbrucker, česká barokní architektura, hrabě František Josef Schlik, Jean Baptiste Mathey, Jičínsko The main aim of this thesis is to present the life and work of Filip Spannbrucker (approximately 1672?1729), Prague architect and builder, in the context of contemporary artistic and social course of events. In the first part of this work there will be outlined Spannbrucker's life and professional career based on elaborate archival research. Special attention will be devoted to proprietors and a patronage of building projects wherein Spannbrucker participated or whereof was an author. In the connection, his work will be brought in contiguity of contemporaneous cultural, socioeconomical and aesthetical notions and relations. In the second part of this thesis there will be pointed out a characteristic and spring of inspiration of Spannbrucker's architecture by means of an accurate formal analysis. Final part will be a catalog of Filip Spannbrucker's works. Filip Spannbrucker, Czech baroque architecture, count František Josef Schlik, Jean Baptiste Mathey, region of Jičí
Location-Based Discovery and Network Handover Management for Heterogeneous IEEE 802.11ah IoT Applications
No full textThis research was funded by the Flemish IDEAL-IoT project (FWO SBO, grant nr. S004017N). The author Serena Santi is funded by the Flemish FWO SB grant (nr. 1S82120N). The author Filip Lemic was supported by the EU MSCA grant (nr. 893760). The computational resources were provided by the VSC (Flemish Supercomputer Center), funded by FWO and the Flemish Government -department EWI
Modular System for Distributed User Data Management
No full textTitle: Modular System for Distributed User Data Management Author: Filip Pavliš, Author's email: [email protected] Department: Department of Distributed and Dependable Systems Supervisor: Mgr. Pavel Ježek, Department of Distributed and Dependable Systems Abstract: The main objective of this project was to create a multiplatform modular system for distributed data management. The system supports both local and remote accessible data storage. Therefore a part of the solution is also a server for remote data access. System also provides parallel usage of a local and remote storage which guarantees that the storage is accessible also when connection to server is lost. In this case, system is capable to synchronize changes between the server and a client. A client can use multiple instances of his storage and our system is able to synchronize them through central server. The system provides abstraction over data model to separate plugin developers from its specific behavior. As practical preview of system usability was created an extension application called TuaLoca. The application will contain implementation of preview plugins and basic user interaction. Keywords: Distributed Data Management, Modular system, Synchronization on the SQL Queries Level, Distributed Solution for Interface LIN
Heritage book from Mircea Filip collection
No full textMircea Filip collection were integrated in the Scientific Library in 2016. It contains patrimony of great importance. The author invites readers to an exciting journey into the world of books, gathered in a life of Man, to discover together their charm and wisdom, the spirit of the characters created in different time spaces. True biblical values have today become the books on which the dedication or Ex-Libris of the author is preserved
COMPARISON OF EXPRESSION AND SIGNIFICANCE OF PROGRAMMED DEATH LIGAND 1 IN PREINVASIVE LESIONS AND LARYNGEAL SQUAMOUS CELL CARCINOMA
No full textCilj istraživanja: Unatoč značajnom napretku u području medicine, karcinom grkljana i dalje
predstavlja izazov obzirom da se petogodišnje preživljenje nije značajnije mijenjalo u zadnjim
desetljećima. Područje imunološke onkologije stvorilo je obećavajuće imunomodulacijske
terapije i otvorilo nove načine liječenja. Programirani ligand smrti 1 (PD-L1) transmembranski
je protein koji se veže na protein programirane stanične smrti 1 (PD-1) smješten na površini
citotoksičnih limfocita. Vezivanje uzrokuje niz kaskadnih reakcija koje dovode do smanjenog
imunološkog odgovora. Cilj ove studije je utvrditi razinu izražaja PD-L1 kao i stanica
mikrookoliša (CD4, CD8, CD68 i CD163) u skvamoznim lezijama grkljana, njihov međusobni
odnos te utjecaj na preživljenje kod skvamoznih karcinoma ili progresiju bolesti u slučaju
displazija.
Ispitanici i metode: Ova retrospektivna studija uključila je 179 bolesnika, a od toga 102 s
dijagnozom skvamoznog karcinoma grkljana, 41 s displazijom grkljana te 36 s polipima
glasnica. Za procjenu izražaja PD-L1 kao i stanica tumorskog mikrookoliša (CD4, CD8, CD68
i CD163) korištena je imunohistokemijska analiza.
Rezultati: PD-L1 izražaj kao i izražaj stanica tumorskog mikrookoliša statistički je značajno
veći u karcinomima grkljana u odnosu na displazije te u displazijama u odnosu na benigne
lezije. Nije nađena statistički značajna razlika u PD-L1 izražaju niti u izražaju stanica tumorskog
mikrookoliša između displazija koje su progredirale u karcinom i onih koje to nisu. Dokazana
je statistički značajna pozitivna korelacija PD-L1 sa svim ispitivanim stanicama tumorskog
mikrookoliša. Bolesnici s visokim intraepitelnim izražajem CD68 i CD163 (p=0.0005 i p=0.006)
imali su statistički značajno kraće preživljenje specifično za bolest. Nadalje, statistički kraće
vrijeme do pojave recidiva bolesti pronađeno je u bolesnika s visokim intratepitelnim CD68 i
visokim ukupnim CD8 (p=0.049 i p=0.019). Pojačan ukupni izražaj CD8 (>23%) i pojačan
intraepitelni izražaj CD68 (>2,7%) također su bili statistički značajni prediktori recidiva
(p=0.028, OR=3.11 i p=0.019, OR=3.13).
Zaključak: Rezultati ove studije ukazuju da su stanice mikrookoliša tumora značajni
prognostički čimbenici kod skvamoznog karcinoma grkljana. Pojačani izražaji CD68 i CD163
prediktori su lošijeg preživljenja kod bolesnika sa skvamoznim karcinomom grkljana.Objectives: Despite significant progress in the field of medicine, laryngeal cancer continues
to represent a challenge, given that the five-year survival rate has not significantly changed in
recent decades. The field of immune oncology has created promising immunomodulation
therapies and opened up new ways of treatment. Programmed death ligand 1 (PD-L1) is a
transmembrane protein that binds to the programmed cell death protein 1 (PD-1) located on
the surface of cytotoxic lymphocytes. The binding causes a series of cascade reactions that
lead to a reduced immune response. The aim of this study is to determine the expression level
of PD-L1 as well as microenvironmental cells (CD4, CD8, CD68 and CD163) in laryngeal
squamous lesions, their mutual relation and influence on survival in squamous carcinomas or
disease progression in the case of dysplasia.
Patients and methods: This retrospective study included 179 patients, of which 102 were
diagnosed with squamous laryngeal carcinoma, 41 with laryngeal dysplasia, and 36 with vocal
fold polyps. Immunohistochemical methods were used to evaluate the expression of PD-L1 as
well as the cells of the tumor microenvironment (CD4, CD8, CD68 and CD163).
Results: PD-L1 expression as well as the expression of cells in the tumor microenvironment
is statistically significantly higher in laryngeal carcinomas compared to dysplasias and in
dysplasias compared to benign lesions. No statistically significant difference was found in PD
L1 expression or in the expression of cells in the tumor microenvironment between dysplasias
that progressed to cancer and those that didn’t. A statistically significant positive correlation of
PD-L1 with all examined cells of the tumor microenvironment was demonstrated. Patients with
high intraepithelial expression of CD68 and CD163 (p=0.0005 and p=0.006) had statistically
significantly shorter disease-specific survival. Furthermore, a statistically shorter time to
recurrence was found in patients with high intraepithelial CD68 and high overall CD8 (p=0.049
and p=0.019). Increased overall expression of CD8 (>23%) and increased intraepithelial
expression of CD68 (>2.7%) were also statistically significant predictors of recurrence
(p=0.028, OR=3.11 and p=0.019, OR=3.13).
Conclusion: The results of this study indicate that tumor microenvironment cells are significant
prognostic factors in squamous laryngeal carcinoma. Increased expression of CD68 and
CD163 are predictors of worse survival in patients with squamous laryngeal carcinoma
Ignác Filip Semmelweis - his life and contribution to obstetrics
No full textAuthor: Anežka Pikmanová Institution: Charles University, Faculty od Medicine in Hradec Králové, Department of Non-medical Studies Title: Ignác Filip Semmelweis - his life and contribution to obstetrics Supervisor: doc. PhDr. Jana Kutnohorská, CSc. Number of pages: 73 Number of attachements: 1 Year od defense: 2025 Keywords: Ignác Filip Semmelweis, obstetrics in the 18th and 19th centuries, puerperal fever, mothers, midwives, obstetricians, obstetric education, obstetric clinics, prevention, treatment, hygiene measures, death The bachelor thesis is about the life of Ignác Filip Semmelweis and his contribution to obstetrics. The thesis consists of a theoretical and an empirical part. The theoretical part focuses on obstetrics in the 18th and 19th centuries, the life of Ignác Filip Semmelweis - his childhood, studies, work at the Klein clinic in Wien, Semmelweis' discovery, publishing activities, his work at the Saint Roch Hospital in Pest and the end of his life. The empirical part deals with the analysis of a survey that focused on the awareness of the professional public (students of general nursing, certified general nurse, midwifery, pediatric nurse) about Ignác Fillip Semmelweis and his professional activity. The survey was participated by students of Faculty of Medicine in Hradec Králové and..
Filip Buonaccorsi Kallimach „De legitimo amore”
No full textThe article is an analysis of three works by Filip Kallimach (Filippo Buonaccorsi) regarding marriage (elegy XXII, Epithalamium Fanniae ac Musaei, carmen Ad se ipsum). In the collections of Roman elegies from the Augustian era, there are no wedding pieces. The source of Callimachus’ idea is found by the author of the article in Epithalamium in Stellam et Violentillam by P. Papinius Statius and, indirectly, through the epithalamium of Statius – in the unpreserved elegies of L. Arruntius Stella, a poet of Domitian times.The article is an analysis of three works by Filip Kallimach (Filippo Buonaccorsi) regarding marriage (elegy XXII, Epithalamium Fanniae ac Musaei, carmen Ad se ipsum). In the collections of Roman elegies from the Augustian era, there are no wedding pieces. The source of Callimachus’ idea is found by the author of the article in Epithalamium in Stellam et Violentillam by P. Papinius Statius and, indirectly, through the epithalamium of Statius – in the unpreserved elegies of L. Arruntius Stella, a poet of Domitian times
Review and analysis of Instrumentaria tehnological processes
No full textU radu je dan teorijski pregled proizvodnog sustava i njegovog projektiranja, nakon čega je dan opis poduzeća Instrumentaria d.o.o. Analiziran je tehnološki proces reprezentanata odabranih ABC analizom, prikazan je prostorni raspored elemenata i odjela, opisani su tokovi materijala te su predložene dvije vrste unaprjeđenja. Jedno unaprjeđenje se temelji na poboljšanju prostornog rasporeda, dok se drugo oslanja na unaprjeđenje planiranja na temelju zadanih vremena izrade i proizvodnih količina.The paper gives a theoretical overview of the production sytem and its design, followed by description of company Instrumentaria d.o.o. The tehnological process of representative products, selected by ABC analysis, is analyzed, the spatial arrangement of elements and departments is presented, material flows are described and two types of improvements are proposed. One improvement is based on improving spatial layout, while the other relies on improving planning based on given production times and production quantities
COMPARISON OF EXPRESSION AND SIGNIFICANCE OF PROGRAMMED DEATH LIGAND 1 IN PREINVASIVE LESIONS AND LARYNGEAL SQUAMOUS CELL CARCINOMA
No full textCilj istraživanja: Unatoč značajnom napretku u području medicine, karcinom grkljana i dalje
predstavlja izazov obzirom da se petogodišnje preživljenje nije značajnije mijenjalo u zadnjim
desetljećima. Područje imunološke onkologije stvorilo je obećavajuće imunomodulacijske
terapije i otvorilo nove načine liječenja. Programirani ligand smrti 1 (PD-L1) transmembranski
je protein koji se veže na protein programirane stanične smrti 1 (PD-1) smješten na površini
citotoksičnih limfocita. Vezivanje uzrokuje niz kaskadnih reakcija koje dovode do smanjenog
imunološkog odgovora. Cilj ove studije je utvrditi razinu izražaja PD-L1 kao i stanica
mikrookoliša (CD4, CD8, CD68 i CD163) u skvamoznim lezijama grkljana, njihov međusobni
odnos te utjecaj na preživljenje kod skvamoznih karcinoma ili progresiju bolesti u slučaju
displazija.
Ispitanici i metode: Ova retrospektivna studija uključila je 179 bolesnika, a od toga 102 s
dijagnozom skvamoznog karcinoma grkljana, 41 s displazijom grkljana te 36 s polipima
glasnica. Za procjenu izražaja PD-L1 kao i stanica tumorskog mikrookoliša (CD4, CD8, CD68
i CD163) korištena je imunohistokemijska analiza.
Rezultati: PD-L1 izražaj kao i izražaj stanica tumorskog mikrookoliša statistički je značajno
veći u karcinomima grkljana u odnosu na displazije te u displazijama u odnosu na benigne
lezije. Nije nađena statistički značajna razlika u PD-L1 izražaju niti u izražaju stanica tumorskog
mikrookoliša između displazija koje su progredirale u karcinom i onih koje to nisu. Dokazana
je statistički značajna pozitivna korelacija PD-L1 sa svim ispitivanim stanicama tumorskog
mikrookoliša. Bolesnici s visokim intraepitelnim izražajem CD68 i CD163 (p=0.0005 i p=0.006)
imali su statistički značajno kraće preživljenje specifično za bolest. Nadalje, statistički kraće
vrijeme do pojave recidiva bolesti pronađeno je u bolesnika s visokim intratepitelnim CD68 i
visokim ukupnim CD8 (p=0.049 i p=0.019). Pojačan ukupni izražaj CD8 (>23%) i pojačan
intraepitelni izražaj CD68 (>2,7%) također su bili statistički značajni prediktori recidiva
(p=0.028, OR=3.11 i p=0.019, OR=3.13).
Zaključak: Rezultati ove studije ukazuju da su stanice mikrookoliša tumora značajni
prognostički čimbenici kod skvamoznog karcinoma grkljana. Pojačani izražaji CD68 i CD163
prediktori su lošijeg preživljenja kod bolesnika sa skvamoznim karcinomom grkljana.Objectives: Despite significant progress in the field of medicine, laryngeal cancer continues
to represent a challenge, given that the five-year survival rate has not significantly changed in
recent decades. The field of immune oncology has created promising immunomodulation
therapies and opened up new ways of treatment. Programmed death ligand 1 (PD-L1) is a
transmembrane protein that binds to the programmed cell death protein 1 (PD-1) located on
the surface of cytotoxic lymphocytes. The binding causes a series of cascade reactions that
lead to a reduced immune response. The aim of this study is to determine the expression level
of PD-L1 as well as microenvironmental cells (CD4, CD8, CD68 and CD163) in laryngeal
squamous lesions, their mutual relation and influence on survival in squamous carcinomas or
disease progression in the case of dysplasia.
Patients and methods: This retrospective study included 179 patients, of which 102 were
diagnosed with squamous laryngeal carcinoma, 41 with laryngeal dysplasia, and 36 with vocal
fold polyps. Immunohistochemical methods were used to evaluate the expression of PD-L1 as
well as the cells of the tumor microenvironment (CD4, CD8, CD68 and CD163).
Results: PD-L1 expression as well as the expression of cells in the tumor microenvironment
is statistically significantly higher in laryngeal carcinomas compared to dysplasias and in
dysplasias compared to benign lesions. No statistically significant difference was found in PD
L1 expression or in the expression of cells in the tumor microenvironment between dysplasias
that progressed to cancer and those that didn’t. A statistically significant positive correlation of
PD-L1 with all examined cells of the tumor microenvironment was demonstrated. Patients with
high intraepithelial expression of CD68 and CD163 (p=0.0005 and p=0.006) had statistically
significantly shorter disease-specific survival. Furthermore, a statistically shorter time to
recurrence was found in patients with high intraepithelial CD68 and high overall CD8 (p=0.049
and p=0.019). Increased overall expression of CD8 (>23%) and increased intraepithelial
expression of CD68 (>2.7%) were also statistically significant predictors of recurrence
(p=0.028, OR=3.11 and p=0.019, OR=3.13).
Conclusion: The results of this study indicate that tumor microenvironment cells are significant
prognostic factors in squamous laryngeal carcinoma. Increased expression of CD68 and
CD163 are predictors of worse survival in patients with squamous laryngeal carcinoma
COMPARISON OF EXPRESSION AND SIGNIFICANCE OF PROGRAMMED DEATH LIGAND 1 IN PREINVASIVE LESIONS AND LARYNGEAL SQUAMOUS CELL CARCINOMA
No full textCilj istraživanja: Unatoč značajnom napretku u području medicine, karcinom grkljana i dalje
predstavlja izazov obzirom da se petogodišnje preživljenje nije značajnije mijenjalo u zadnjim
desetljećima. Područje imunološke onkologije stvorilo je obećavajuće imunomodulacijske
terapije i otvorilo nove načine liječenja. Programirani ligand smrti 1 (PD-L1) transmembranski
je protein koji se veže na protein programirane stanične smrti 1 (PD-1) smješten na površini
citotoksičnih limfocita. Vezivanje uzrokuje niz kaskadnih reakcija koje dovode do smanjenog
imunološkog odgovora. Cilj ove studije je utvrditi razinu izražaja PD-L1 kao i stanica
mikrookoliša (CD4, CD8, CD68 i CD163) u skvamoznim lezijama grkljana, njihov međusobni
odnos te utjecaj na preživljenje kod skvamoznih karcinoma ili progresiju bolesti u slučaju
displazija.
Ispitanici i metode: Ova retrospektivna studija uključila je 179 bolesnika, a od toga 102 s
dijagnozom skvamoznog karcinoma grkljana, 41 s displazijom grkljana te 36 s polipima
glasnica. Za procjenu izražaja PD-L1 kao i stanica tumorskog mikrookoliša (CD4, CD8, CD68
i CD163) korištena je imunohistokemijska analiza.
Rezultati: PD-L1 izražaj kao i izražaj stanica tumorskog mikrookoliša statistički je značajno
veći u karcinomima grkljana u odnosu na displazije te u displazijama u odnosu na benigne
lezije. Nije nađena statistički značajna razlika u PD-L1 izražaju niti u izražaju stanica tumorskog
mikrookoliša između displazija koje su progredirale u karcinom i onih koje to nisu. Dokazana
je statistički značajna pozitivna korelacija PD-L1 sa svim ispitivanim stanicama tumorskog
mikrookoliša. Bolesnici s visokim intraepitelnim izražajem CD68 i CD163 (p=0.0005 i p=0.006)
imali su statistički značajno kraće preživljenje specifično za bolest. Nadalje, statistički kraće
vrijeme do pojave recidiva bolesti pronađeno je u bolesnika s visokim intratepitelnim CD68 i
visokim ukupnim CD8 (p=0.049 i p=0.019). Pojačan ukupni izražaj CD8 (>23%) i pojačan
intraepitelni izražaj CD68 (>2,7%) također su bili statistički značajni prediktori recidiva
(p=0.028, OR=3.11 i p=0.019, OR=3.13).
Zaključak: Rezultati ove studije ukazuju da su stanice mikrookoliša tumora značajni
prognostički čimbenici kod skvamoznog karcinoma grkljana. Pojačani izražaji CD68 i CD163
prediktori su lošijeg preživljenja kod bolesnika sa skvamoznim karcinomom grkljana.Objectives: Despite significant progress in the field of medicine, laryngeal cancer continues
to represent a challenge, given that the five-year survival rate has not significantly changed in
recent decades. The field of immune oncology has created promising immunomodulation
therapies and opened up new ways of treatment. Programmed death ligand 1 (PD-L1) is a
transmembrane protein that binds to the programmed cell death protein 1 (PD-1) located on
the surface of cytotoxic lymphocytes. The binding causes a series of cascade reactions that
lead to a reduced immune response. The aim of this study is to determine the expression level
of PD-L1 as well as microenvironmental cells (CD4, CD8, CD68 and CD163) in laryngeal
squamous lesions, their mutual relation and influence on survival in squamous carcinomas or
disease progression in the case of dysplasia.
Patients and methods: This retrospective study included 179 patients, of which 102 were
diagnosed with squamous laryngeal carcinoma, 41 with laryngeal dysplasia, and 36 with vocal
fold polyps. Immunohistochemical methods were used to evaluate the expression of PD-L1 as
well as the cells of the tumor microenvironment (CD4, CD8, CD68 and CD163).
Results: PD-L1 expression as well as the expression of cells in the tumor microenvironment
is statistically significantly higher in laryngeal carcinomas compared to dysplasias and in
dysplasias compared to benign lesions. No statistically significant difference was found in PD
L1 expression or in the expression of cells in the tumor microenvironment between dysplasias
that progressed to cancer and those that didn’t. A statistically significant positive correlation of
PD-L1 with all examined cells of the tumor microenvironment was demonstrated. Patients with
high intraepithelial expression of CD68 and CD163 (p=0.0005 and p=0.006) had statistically
significantly shorter disease-specific survival. Furthermore, a statistically shorter time to
recurrence was found in patients with high intraepithelial CD68 and high overall CD8 (p=0.049
and p=0.019). Increased overall expression of CD8 (>23%) and increased intraepithelial
expression of CD68 (>2.7%) were also statistically significant predictors of recurrence
(p=0.028, OR=3.11 and p=0.019, OR=3.13).
Conclusion: The results of this study indicate that tumor microenvironment cells are significant
prognostic factors in squamous laryngeal carcinoma. Increased expression of CD68 and
CD163 are predictors of worse survival in patients with squamous laryngeal carcinoma
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