131 research outputs found
Performance Evaluation of Asphalt Concrete Modified by Polyolefins Through Dry and Wet Process
No full textAbstractPolymer modification in road paving applications enables significant improvement in road service life as regards main distresses such as rutting, fatigue and thermal cracking. Polymer modification can be performed through a dry or wet process, and it may lead to mixtures with different mechanical properties depending on the modification process employed. In this context, this paper presents a laboratory investigation concerning the effect of a polyolefinic additive (PO) on the mechanical response of asphalt concrete produced by dry and wet process. Mechanical characterization consisted of wheel tracking tests at 40 and 60°C for rutting resistance analysis and semi-circular bending tests at 10°C for cracking behaviour analysis. Results showed higher rutting resistance of PO modified asphalt concretes (AC) compared to the control mixtures, but they were found to be more temperature sensitive denoting a penalized rutting response at higher temperature. PO modified ACs also showed higher fracture toughness and reduced fracture energy. In particular, the dry process seems to guarantee an ability of deformation such as better endurance of cracking propagation with respect to the mixture produced by the wet process
Rifondare il tempo: il cinema di Chiara Cremaschi tra memorie fluttuanti e instabili presenti
No full textContributo dedicato alla pratica filmica e alla produzione di Chiara Cremaschi nel volume "CINEma oltre. Donne e pratiche audiovisive" in Italia volto ad indagare il panorama, ancora poco esplorato, delle attività delle artiste italiane che "dagli anni Settanta a oggi hanno scelto l'immagine in movimento come medium di espressione e talvolta di lotta". Muovendo tra Film Studies e Women's Studies, in un approccio multidisciplinare, il volume propone una selezione di artiste – dalle più conosciute alle emergenti note, emergenti – in un dialogo che interseca le esperienze storiche del cinema di ricerca e degli albori della videoarte, fino all'attualità degli ultimi anni, tenendo insieme le pioniere delle origini e le audaci sperimentatrici d'oggi. Il volume rappresenta uno degli output delle linee di ricerca che fanno perno nell'attività del Forum delle studiose di cinema e audiovisivi.
Con saggi di: Luisa Cutzu, Lucia Di Girolamo, Francesca Gallo, Sandra Lischi, Jennifer Malvezzi e Bianca Trevisan, Raffaella Perna, Simona Pezzano, Farah Polato, Maria Teresa Soldani, Deborah Toschi, Lucia Tralli
The New Era of Systemic Treatment for Hepatocellular Carcinoma: From the First Line to the Optimal Sequence
No full textHepatocellular carcinoma (HCC) represents the most common primary liver cancer and is considered a major global health problem as one of the leading causes of cancer-related death in the world. Due to the increase in life expectancy and the epidemiological growth of specific risk factors, such as metabolic dysfunction-associated steatotic liver disease (MASLD), the incidence of HCC is growing globally, and mortality rates are still high. Moreover, patients frequently present at an intermediate or advanced tumor stage, when curative treatments, such as surgical resection, liver transplantation or ablation are no longer applicable. In these cases, trans-arterial chemoembolization (TACE), trans-arterial radioembolization (TARE), and systemic therapy are the only suitable options to achieve disease control. The multi-kinase inhibitor Sorafenib has been the only systemic treatment available for unresectable advanced HCC for almost a decade, but in the last couple of years new therapeutic options have emerged. Recent advances in understanding the interactions between the tumor and its microenvironment, especially cancer immune escape, led to the advent of immunotherapy. Currently, first-line systemic treatment for HCC is represented by the combination of the immune checkpoint inhibitor (ICI) Atezolizumab plus Bevacizumab, an anti-vascular endothelial growth factor (VEGF) monoclonal antibody, but many other ICIs have been investigated, such as Nivolumab, Pembrolizumab, Durvalumab and Ipilimumab. However, the problem of second- and third-line therapies, and the correct sequence of treatments remains open and is not addressed in most studies. This explains the urge to find new systemic treatments that can improve the survival and quality of life in patients that can go beyond the first line of treatment. The aim of this paper is to offer a complete overview of the most recent innovations in systemic treatments for unresectable locally advanced and metastatic HCC, including emerging therapies, with a particular focus on treatment sequences. Moreover, we will provide an outlook on possible future approaches to patients who progress beyond first-line therapies
Video Presentazione online DV 16: Narrare il Medioevo
No full textPresentazione online del nuovo fascicolo della rivista Doctor Virtualis: n. 16 Narrare il Medioevo a cura di A. Salvestrini.
19 Novembre 2021
Vedi a lato: Locandina (PDF) e Video (URL)
Introducono:
Massimo Parodi, Amalia Salvestrini
Intervengono:
Luca Cardone, Marco Damonte, Gregorio Fiori Carones, Daphne Grieco, Rossana Guglielmetti, Costantino Marmo, Roberto Rossi, Marco Rossini, Marzio Zanantoni
Partecipano:
Maria Cristina Bartolomei, Alessandra Capacchione, Carla Casagrande, Aldo Andrea Cassi, Alfio Ferrara, Francesca Forte
Imperfezioni. In forma di introduzione
No full textLuogo dello scarto e del ritardo, della mancata corrispondenza a modelli intesi come assoluti, l’imperfezione può diventare uno spazio di libertà dove elaborare pratiche impensate e impreviste, lontane dagli standard e fuori dal canone.
A partire da questa idea di imperfezione, il volume propone letture e attraversamenti della storia del cinema e dell’audiovisivo dal punto
di vista delle donne, muovendosi dal muto alla contemporaneità. Ciò che emerge è un inedito paesaggio mediale, discontinuo e ttamente abitato, capace di restituire la di erenza femminile in azione
On the Way to the Technological Development of Newly Selected Non-<i>Saccharomyces</i> Yeasts Selected as Innovative Biocontrol Agents in Table Grapes
No full textPost-harvest decay of fresh table grapes causes considerable annual production losses. The main fungal agents of decay both in pre- and post-harvest are B. cinerea, Penicillium spp., Aspergillus spp., Alternaria spp., and Cladosporium spp. To date, the use of agrochemicals and SO2 are the main methods to control grape molds in pre- and postharvest, respectively. Significant improvements, however, have already been made in to apply innovative and more environmentally sustainable control strategies, such as Biological Control Agents (BCAs), which can reduce disease severity in both pre- and post-harvest. In this study, 31 new non-Saccharomyces yeast strains, isolated from berries of native Apulian table grape genotypes, were tested for their in vivo effectiveness against grey mold of table grapes, resulting in two St. bacillaris (‘N22_I1’ and ‘S13_I3’), one S. diversa (‘N22_I3’), one A. pullulans (‘OLB_9.1_VL’) and one H. uvarum (‘OLB_9.1_BR’) yeast strains that were marked as efficient and good BCAs. Their mechanisms of action were characterized through in vitro assays, and additional characteristics were evaluated to assess the economic feasibility and viability for future technological employment. Their effectiveness was tested by reducing the working concentration, their antagonistic effect on a wide range of fungal pathogens, their ability to survive in formulations with long shelf life, and their safety to human health
Somatic Embryogenesis in Vitis for Genome Editing: Optimization of Protocols for Recalcitrant Genotypes
No full textNew Plant Breeding Techniques (NPBTs) protocols have been developed to produce new grape varieties with improved quantitative and qualitative characteristics. Reliable transformation protocols for grapes are based on the generation/induction of embryogenic callus cells that are then transformed. Varieties such as Italia have proven to be very recalcitrant to regeneration via somatic embryogenesis. In this work, the development of a protocol for improved production of embryogenic calluses is described. Two sterilization protocols were tested: (a) a lower active chlorine concentration for a longer time (LS); and (b) a higher chlorine concentration for a shorter time (HS), in combination with the absence or presence of citric acid in the growing substrate in the first growth media. The embryogenic calluses formation in Chardonnay, a cv. with a high embryogenic response, was significantly higher in presence of citric acid in the initial growing substrate regardless of the sterilization protocol. In Aglianico, a cv. with a lower embryogenic response, no significant differences were observed. Instead, in a recalcitrant cv. as Italia, we obtained a 13-fold increase in embryogenic calluses formation performing sterilization of flowers with the HS protocol compared to LS
Genomic technologies uncover inter-varietalstructural variation in grapevine
No full textGrapevine (Vitis vinifera L.) is one of the most important crop plants in the world because of its economically valuable role in fruit and wine production; for this reason, great interest has recently been shown in identifying genomic variations and their functional effects on inter-varietal phenotypic differences. Discovery and characterization of all genetic variations is critical to reach a full understanding of the genetic basis of phenotypic differences. Using an approach developed for the analysis of human and mammalian genomes, which combines high-throughput sequencing (HTS), array comparative genomic hybridization (aCGH), fluorescent in situ hybridization (FISH), and quantitative PCR (qPCR), we were able to create an inter-varietal atlas of structural variations and single nucleotide variants (SNVs) for the grapevine genome analyzing four economically and genetically relevant table grapevine varieties. We found 4.8 million SNVs and detected roughly 8% of the grapevine genome affected by genomic variations. We identified more than 700 copy number variation (CNV) regions, and searching for gene content in these regions, we were able to find more than 2000 genes subjected to CNV as potential candidates for phenotypic differences between varieties. For example, we found a polymorphic region at chromosome 18_random containing six different genes belonging to the germacrene D synthase family and a flavonol synthase gene, which showed the highest rate of duplication in the Italia cultivar. Since Italia is the only cultivar (among those analyzed in this study) showing aromatic taste, this finding could be related to berry flavor trait. Likewise, comparison among the different grape genomes showed differences in gene dosages playing critical roles in response to biotic and abiotic stresses. Overall our data highlight the significance of these genome-wide studies on CNVs in the grapevine genome and identify candidate genes for some of the most complex and desired traits in breeding. We paired-end sequenced four table grape cultivars: Autumn royal (AR), Italia (It), Red globe (RG), and Thompson seedless (TS) and alignment of the obtained reads against the PN40024 Pinot noir reference genome (Table 1 and Figure 1). SNPs identification and WSSD analysis We identified 4,478,098 SNPs and 262,395 INDELs. Similar percentages of duplication (average 16%) and deletion (average 3%) were found in the four table grape varieties and in the PN40024 reference
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