1,356,706 research outputs found
Tra anima e fabbrica. Quartieri popolari, preti operai e comunità cristiane di base dagli anni Cinquanta ai nostri giorni
No full textLa ricerca indaga le vicende del movimento dei preti operai e del movimento delle comunità cristiane di base in Italia, con particolare attenzione alla comunità di base di San Paolo di Roma e dell’Isolotto di Firenze, poiché rappresentative delle caratteristiche fondanti di tale esperienza, soprattutto rispetto al rapporto tra comunità, territorio e mondo del lavoro. Entrambi i movimenti affondano le loro radici nel più ampio fenomeno del fermento cattolico del secondo dopoguerra e si strutturarono negli anni della contestazione cattolica tra i decenni Sessanta e Settanta. La ricerca non si concentra esclusivamente su questi due decenni, seppure centrali, ma propone una periodizzazione più lunga che arriva fino ai nostri giorni, e che inserisce questi fenomeni nei processi di secolarizzazione del Novecento, nelle risposte elaborate dalla Chiesa cattolica di fronte alle sfide della contemporaneità e nei cambiamenti nel modo di vivere la fede e la religione da parte dei credenti. L’obiettivo della ricerca è di porre le due esperienze, preti operai e comunità cristiane di base, a confronto ed evidenziarne i punti di contatto, metterne in luce le relazioni, gli scambi, gli intrecci, per appurare se questi ci furono o meno e, in caso affermativo, di quale entità e rilevanza, e in che forme si strutturarono. Tutto questo grazie all’utilizzo di numerose e diverse fonti archivistiche, orali e a stampa
Regenerative treatment using a radioelectric asymmetric conveyor as a novel tool in antiaging medicine: an in vitro beta-galactosidase study
No full textSalvatore Rinaldi,1,2 Margherita Maioli,1,3,4 Sara Santaniello,3,4 Alessandro Castagna,1,2 Gianfranco Pigliaru,3,4 Sara Gualini,3,4 Matteo Lotti Margotti,5 Arturo Carta,6 Vania Fontani,1,2 Carlo Ventura1,4,71Department of Regenerative Medicine, Rinaldi Fontani Institute, Florence; 2Department of Neuro Psycho Physio Pathology and Neuro Psycho Physical Optimization, Rinaldi Fontani Institute, Florence; 3Department of Biomedical Sciences, University of Sassari, Sassari; 4Laboratory of Molecular Biology and Stem Cell Engineering, National Institute of Biostructures and Biosystems, Bologna; 5Department of Information Technology and Statistical Analysis, Rinaldi Fontani Institute, Florence; 6Ophthalmology Section, University of Parma, Parma; 7Cardiovascular Department, S Orsola Malpighi Hospital, University of Bologna, Bologna, ItalyBackground: Beta-galactosidase is the most widely used biomarker for highlighting the processes of cellular aging, including neurodegeneration. On this basis, we decided to test in vitro whether a set of rescuing/reparative events previously observed by us in subjects treated with radioelectric asymmetric conveyor (REAC) technology may also involve antagonism of a marker of aging-related degenerative processes, as assessed by a reduction in beta-galactosidase at the cellular level.Methods: Human adipose-derived stem cells were cultured at different passages, ranging from 5 to 20, with or without REAC exposure for 12 hours. The cells were then processed for biochemical beta-galactosidase staining and morphological microscopy analysis.Results: We observed a significant reduction in expression of senescence associated-beta-galactosidase, and a persistence of fibroblast-like morphology typical of human adipose-derived stem cells, even at late passages.Conclusion: Our results indicate the ability of REAC technology to counteract in vitro senescence of human adipose-derived stem cells, and prompt the hypothesis that such technology may be exploited to antagonize in vivo senescence of tissue-resident or transplanted stem cells playing an important role in clinical treatment of age-related processes.Keywords: aging, adipose-derived stem cells, neurodegenerative disease
O Comportamento das vogais médias pretônicas no Espírito Santo
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão, Programa de Pós-Graduação em Lingüística, Florianópolis, 2010Utilizando dados do ALES - Atlas Linguístico do Espírito Santo e do ALiB - Atlas Linguístico do Brasil este, com dados restritos à capital, Vitória propusemo-nos, neste trabalho, a analisar o uso variável (manutenção, abaixamento ou alçamento) das vogais médias pretônicas /e/ e /o/ no referido Estado. Considerando que o Espírito Santo tem estados limítrofes com fortes marcas linguísticas Bahia, Minas Gerais e Rio de Janeiro, objetivamos analisar possíveis influências do português falado nesses estados no falar capixaba. Pautados na Geografia Linguística e na Sociolinguística, verificamos, em relação às vogais médias em contexto pretônico, que são raras as ocorrências de vogais abaixadas. Todavia, os casos de manutenção e, principalmente, de alçamento das vogais médias são bastante recorrentes no Estado. Os dados indicam, em graus distintos, possíveis influências advindas dos estados limítrofes ao Espírito Santo
TRKB Signaling Controls the Developmental Expression of NMDAR Subunits in Rat and Mouse Visual Cortex
No full textNMDA receptors (NMDARs) are multimeric proteins whose biological and functional
characteristics depend on differential subunits assembly during postnatal development. In
the present work we deal 'Nith the question as to whether the expression of the different
NMDAR subunits is influenced by neurotrophins in developing visual cortex. We used a
soluble form of TrkB receptor engineered as an immunoadhesin (TrkB-IgG) in order to
block TrkB ligands in the rat visual cortex. TrkB-IgG was released through a cannula
implanted in the occipital pole and connected to a mini-osmotic pump. TrkB-IgG was
continuously released from postnatal day 20-21 (P20-21) to P36-37. These two post-natal
ages were chosen for the beginning and the end of the treatment because they represent
the peak and the end of the critical period in the visual cortex respectively. In a different
group of animals used as controls osmotic pumps were filled with saline. Different
antibodies were used to stain neurons expressing NRl, NR2A and NR2B. We counted
the number of neurons stained for NR2A and NR2B subunits and expressed it as
percentage with respect to the total number of cresyl-violet stained neurons in each
cortical layer. In the visual cortex of TrkB-IgG treated rats the percentage of neurons
expressing NR2A was significantly increased in all cortical layers. Concerning NR2B
subunit, the percentage of stained neurons was not significantly different between TrkBIgG
treated and control rats. The intensity of staining for both NR2A and NR2B was
reduced in all cortical layers in TrkB-IgG treated animals with respect to controls. In
accordance with these results, the endogenous levels of NR2A and NR2B subunits were
reduced in TrkB-IgG treated animals as shown by western blot.
Application of TrkB-IgG presented the disadvantage to block at the same time both TrkB
ligands: BDNF and NT-4/5. In order to study separately the effects of deprivation of
these neurotrophins we acquired knock-out (ko) mice for BDNF and NT-4/5. We
considered 3 post-natal ages (P12-14, before eye-opening; P21-23, peak of critical
period; adulthood) and we compared the levels of expression of NMDAR subunits NRl,
NR2A and NR2B by immunocyology and western blot, in wild type and in ko animals.
The absence of BDNF determines a reduction in the level of NR2A at an early stage of post-natal development, while NT-4/5 more likely exerts a modulatory action on both
subunits.
Thus, TrkB signalling controls the cellular expression of NMDAR subunits in rat and
mouse visual cortical neurons during postnatal development and its action is specific for
NR2A and NR2B subunits without affecting NRl, whose development is almost over at
the time we started our analysis
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Giovani a Torino. Una storia del Centro di attività sociali (1959-1971)
No full textIl libro ricostruisce la nascita e lo sviluppo delle attività del Centro di attività sociali, un gruppo spontaneo di ispirazione cattolica, attivo a Torino dalla fine degli anni Cinquanta agli anni Settanta del Novecento. Le attività del gruppo giovanile intendeva unire impegno culturale e militanza sociale, con una spiccata attenzione alle riflessioni politiche emerse negli ambienti della "sinistra cristiana"
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Synthesis and characterization of a paramagnetic receptor based on cyclobis(paraquat-p-phenylene) tetracation
No full textA 0.18μm CMOS low-power radiation sensor for asynchronous event-driven UWB wireless transmission
No full textThe paper describes the design of a readout element, proposed as a radiation monitor, which implements an embedded sensor based on a floating-gate transistor. The paper shows the design of a microelectronic circuit composed of a sensor, an oscillator, a modulator, a transmitter and an integrated antenna. A prototype chip has recently been fabricated and tested exploiting a commercial 180 nm, four metal CMOS technology. Simulation results of the entire behavior of the circuit before submission are presented along with some measurements of the actual chip response. In addition, preliminary tests of the performance of the Ultra-Wide Band transmission via the integrated antenna are summarized. As the complete chip prototype area is less than 1 mm2, the chip fits a large variety of applications, from spot radiation monitoring systems in medicine to punctual measurements of radiation level in High-Energy Physics experiments. A sensitivity of 1 mV/rad was estimated within an absorbed dose range up to 10 krad and a total power consumption of about 165 μ
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