445 research outputs found
James's Turn of the Screw
No full text[sound recording] / John Smith. Hardy's Tess of the d'Urbervilles by J.J. Coyle.; 1 sound cassette (60 minutes); Broadcast on CFCY Radio, Charlottetown, December 16 & 20, 1971.; Hardy's Tess of the d'Urberville
Book review: how to speak money by John Lanchester
No full textJohn Lanchester, the bestselling author of Capital and Whoops!, aims to decode the global language of money for all of us, in an amusing and jargon-free read. Diane Coyle finds this is a very entertaining read and a clear guide to the kind of economics spoken in the financial markets and the media. Those who already speak the language would do well to read the initial essay and reflect on it, and in particular on what normal people hear when they are using the jargon
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Remains
No full text'Remains' is a text composed by Annabel Frearson using the last words from the remaining books of a recently deceased artist. It was performed by the author at the launch event for the publication of Issue 2 of '...Or maybe it's the same for everyone' with contributing artists: Martin Westwood, Annabel Frearson, Patrick Coyle and Lizzy Kane.
A launch event was held with performances by the authors at Cafe Oto, London 6 May 2014
Urban Community Center
No full textUniversity of Minnesota M.Arch. thesis. August 2013. Major: Architecture. Advisor: Steve Weeks. 1 computer file (PDF); v, 43 pages.My thesis project will be to design an urban community center that has a strong educational component. The keyword in that last statement was "urban", meaning to engage the community on a physical and spiritual level and to evoke a sense of place. The word urban is used a contrast to suburban. One could argue that the Brian Coyle Community Center is suburban in that it fails to engage the community by using the suburban model of buffer parking between the sidewalk and the building. The design of the Brian Coyle is such that it has no real connection or reflection of the community. I would even go further to state that one could take this community center and place it in virtually any park in the city and it would "fit". I am proposing a more urban solution that identifies directly with the community at hand and that resonates the identity and character of the community.An urban community center that is a designator of space and ideals and not merely an object building in the park as is the Brian Community Center. There are many inherent social and transit components associated with this site which will profoundly affect the design of an urban community center. These are some of the propositions that must be addressed in the design: An architecture/ building/ program that reflects the composition and character of the community while at the same time being responsive to its urban context.Designing an applicable architecture that serves the community, given the community's social, transit and urban energies.Designing an Urban Solution for an Urban Oasis (Currie Park)Webb, Marcus David. (2013). Urban Community Center. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/162410
Osteopontin as a regulator of leukemia inhibitory factor mRNA levels in the AtT-20 mouse pituitary cell line
No full textThe highly phosphorylated glycoprotein Osteopontin (OPN) is a multifaceted protein with a diversity of roles in many immunological processes, and has recently been found to have a significant role in the Hypothalamus-Pituitary-Adrenal (HPA) axis. Its role was discovered when unstressed OPN-knockout mice were found to have abnormally high basal corticosterone levels, which is the hormone typically elevated following stress induction of the HPA axis. Another protein rigorously studied and repeatedly identified in the successful functioning of the HPA axis is Leukemia Inhibitory Factor (LIF). I propose that OPN may possess a regulatory role in the expression of LIF, with the absence of OPN leading to a greater abundance of LIF mRNA, and consequently, over-production of corticosterone in non-stressful situations. Using the mouse anterior pituitary cell-line AtT-20, a common and highly useful model in HPA axis research, I have found evidence that treatment of these cells with OPN partially inhibits the expression of LIF mRNA. The dose-dependency of this inhibition appears to behave as either positive or negative depending on the cellular density of the culture treated with OPN. Should OPN turn out to be a regulator of LIF mRNA expression, then absence of OPN may lead to an over-abundance of LIF, therefore affecting the expression of several proteins downstream of LIF that potently stimulate corticosterone production, such as the cholesterol transport protein StAR. It may turn out that OPN has an especially significant and indispensable role in the HPA axis via regulation of LIF mRNA levels.M.S.Includes bibliographical referencesby Luke Coyl
Developing compact and innovative dual-band thermal imagers using multi-layer diffractive optical elements
No full textInfrared (IR) remote sensing offers a huge range of applications, mostly addressing make-or-break issues of our century (wildfires, irrigation monitoring, etc.). Multispectral spaceborne instruments require bulky optical systems designed for a specific scientific goal and have very low revisit time. Thereby, constellations of small satellites embarking compact dual-band IR imagers are very promising solutions. We study a dual-band IR diffractive element called multilayer diffractive optical elements (MLDOE). It replaces classical diffractive lenses (DOEs) that cannot operate simultaneously in two distinct wavebands. An MLDOE design is studied using the rigorous finite difference time domain (FDTD) method. Its performance at the ”best” focal plane is deduced using free-space Fourier optics wave propagation. The presented MLDOE design has over 80% Strehl ratio in both bands, outperforming classical DOEs. Its chromatic focal shift has a negative variation, in opposition to refractive lenses, allowing efficient and compact dual-band hybrid lenses.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Spaceborne Instrumentatio
Estudos de reatividade de complexos de Fe (II) / Fe (III) amino-imino-oxima
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Fisicas e MatematicasOs ligantes oxima são ligantes relativamente novos. Uma característica muito importante destes ligantes é a existência de uma concentração localizada de carga negativa sobre o átomo metálico central e de um N- cromóforo provido de uma forte ligação sigma metal-ligante. O objetivo fundamental deste trabalho foi o desenvolvimento dos estudos de síntese caracterização cinética e eletroquímica de complexos de ferro com ligantes oximatos. Os complexos sintetizados foram caracterizados por espectroscopia eletrônica vibracional e Mössbauer. A determinação das constantes de protonação para o complexo tridentado foi feita através da voltametria cíclica. Estudos cinéticos da oxidação da L-cisteína pelo complexo de ferro (II) com o ligante oxima haxadentado foram realizados e um mecanismo de esfera externa foi sugerido com base na Teoria de Marcus
Estudos cineticos das reações redox entre complexos de ferro com o ligante hexadentado amino-imino-oxima e policarboxilato de cobalto
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Fisicas e MatematicasOs complexos FeIILH22+ e FeIIILH2+ onde LH2 é um ligante hexadentado, 3,14-dimetil-4,7,10,13-tetraazahexedeca-3,13-dieno-2,15-diona dioxima, foram estudados através das reações cruzadas com os complexos, CoIII(EDTA)-, CoII(EDTA)2- , CoIII(OX)33- e CoIII(dipic)2- . Para as reações com o CoIII(EDTA)- e CoIII(dipic)2-, em condições de pseudo-primeira ordem as cinÉticas exibiram um comportamento linearmente dependente das concentrações dos oxidantes, enquanto que para as reações com o CoIII(OX)33- , as cinéticas apresentaram um desvio no comportamento linear com relação as concentrações do oxidante. Com um potencial variável de 0,12 V a 0,90 V, o complexo de ferro pode ser usado, tanto como redutor, ou como oxidante. No sistema de reação com o CoIII(EDTA)- , foi determinada uma dependência de pH para o complexo FeIILH22+, em uma faixa compreendida entre 5,60 e 9,50 unidades de pH e um pKa de 7,83. A redução do complexo de ferro(III) foi conduzida através do complexo CoII(EDTA) 2- numa faixa compreendida entre 3,0 e 5,0 unidades de pH. Para este sistema foi determinada cineticamente a constante de equilíbrio termodinâmica com um valor de 1,41 x 104, para a região onde a reação ocorre com a espécie completamente deprotonada do complexo de ferro. Foi determinada , também cinéticamente a constante de equilíbrio termodinâmica onde predomina a espécie monoprotonada igual a 28,78, confirmando-se também o potencial da espécie monoprotonada, (FeIII/IILH)+2/+, 0,47 V. Para o sistema de reação com o complexo CoIII(OX)33- , foi detectada a formação de um par iônico na faixa compreendida entre 2,60 e 4,50 unidades de pH, com uma constante de formação de par iônico de 22,77 M-1. A reação para este sistema foi realizada entre 2,60 e 6,98 unidades de pH, na qual foram observadas duas dependências de pH, a primeira branda e a segunda bastante acentuada, sendo determinado o primeiro pKa do complexo de ferro, igual a 4,97. Para o sistema com o CoIII(dipic)2, a reação foi realizada na faixa entre 1,0 e 4,0 unidades de pH, na qual foi também detectada uma dependência de pH. As reações são discutidas nos termos da Teoria de Marcus, onde para a espécie deprotonada FeIIL, a transferência de elétron ocorre por um mecanismo de esfera externa, com um valor para k11 médio de 3,23x106 M-1 s-1. Entretanto, o mecanismo de reação para a espécie monoprotonada não está em total concordância com a Teoria de Marcus, onde a transferência de elétrons, provavelmente ocorre por um mecanismo diferente daquele verificado com a espécie deprotonada. Já para a espécie diprotonada FeIILH22+, a concordância apresentada entre os valores calculados através das equações de Marcus e os obtidos experimentalmente, para as razões das constantes de velocidade de segunda ordem entre as reações das constantes de velocidade de segunda ordem entre as reações com Co(EDTA)- , Co(OX)33- e Co(dipic)2-, indica que o provável mecanismo de reação seja realizado por esfera - externa
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